Effect of TCM Combined with Chemotherapy on Immune Function and Quality of Life of Patients with Non-small Cell Lung Cancer inStage Ⅲ-Ⅳ

Objective: To observe and compare the effect of traditional Chinese medicine (TCM) combined with chemotherapy (CT) on immune function and quality of life (QOL)of patients with non-small cell lung cancer (NSCLC) in stage Ⅲ-Ⅳ. Methods: One hundred cases with stage Ⅲ-Ⅳ NSCLC were randomly divided into two groups. The treated group (n=50) received CT combined with TCM, and the control group received CT alone. The percentage of T lymphocyte subset in peripheral blood and the change of natural killer (NK) cell count were observed after treatment. The QOL and tolerance of CT were also compared between the two groups after treatment. Results: In the treated group, CD3 cell count, CD4 cell count, CD4/ CDg ratio and NK cell activity were higher than those in control group, while CD8 cell count in the treated group was lower than that in the control group (P<0.05), and QOL and tolerance of CT in the treated group were also better (P<0.05). Conclusion: TCM combined with CT could raise the patients' ability in tolerating CT in stage Ⅲ-ⅣNSCLC.

眼底激光联合羟苯磺酸钙治疗Ⅲ～Ⅳ期糖尿病视网膜病变临床观察

目的:对眼底激光联合羟苯磺酸钙治疗Ⅲ~Ⅳ期糖尿病视网膜病变临床效果进行分析。方法:将2015年2月-2017年1月Ⅲ~Ⅳ期糖尿病视网膜病变患者48例随机分两组,各24例。激光组采用单纯眼底激光治疗,联合组采用眼底激光联合羟苯磺酸钙治疗。比较两组患者Ⅲ~Ⅳ期糖尿病视网膜病变治疗效果、不良反应;治疗前和治疗后患者黄斑厚度、视力情况、血糖水平的差异。结果:联合组患者Ⅲ~Ⅳ期糖尿病视网膜病变总有效率优于激光组,差异有统计学意义(P<0.05);两组不良反应差异无统计学意义(P>0.05);治疗前两组黄斑厚度、视力情况、血糖水平比较差异无统计学意义(P>0.05);治疗后联合组黄斑厚度、视力情况、血糖水平改善幅度更大,差异有统计学意义(P<0.05)。结论:眼底激光联合羟苯磺酸钙治疗Ⅲ~Ⅳ期糖尿病视网膜病变临床确切,可更好改善视力和血糖,无明显不良反应,值得推广。

糖尿病肾病患者Ⅲ、Ⅳ、Ⅴ期中医证候及分布规律

目的探讨280例糖尿病肾病(DN)患者Ⅲ、Ⅳ、Ⅴ期中医证候规律及证候分布规律,以期为DN的规范化诊治提供新的思路及理论支持。方法采用回顾性方法研究分析280例符合中西医诊断标准的Ⅲ、Ⅳ、Ⅴ期DN患者,针对各期患者主要及次要临床表现及问卷调查结果,采用德尔菲法总结DNⅢ、Ⅳ、Ⅴ期中医证候规律,采用聚类分析法探讨DNⅢ、Ⅳ、Ⅴ期中医证候分布规律,并进行描述性统计分析中医证候规律及其证候分布规律的特点。结果Ⅲ期和大量蛋白尿期DN患者中医症候特点为本虚标实,气阴两虚夹瘀型,Ⅴ期逐渐发展至气血阴阳俱虚,兼见湿浊、瘀血夹杂重症。结论随着DN的不断进展,中医症状出现相应频次的变化,其中医证候规律及其分布规律各有特点,对本病的临床诊治研究意义重大。

益气固摄浓缩丸配合灸法治疗糖尿病肾病Ⅲ~Ⅳ期临床观察

目的探讨九江市中医医院院内制剂益气固摄丸配合灸法治疗糖尿病肾病Ⅲ~Ⅳ期的临床疗效。方法对照组在常规治疗的基础上服用ARB类药物(本组病例使用厄贝沙坦),观察组在常规的基础上加服九江市中医医院院内制剂益气固摄浓缩丸配合艾灸疗法,比较2组治疗前后临床症状积分及实验室检查指标(尿微量白蛋白、血肌酐)的变化。结果治疗前2组患者在性别、年龄、病程及症状积分以及实验室指标上比较,差异无统计学意义(P>0.05);治疗后2组比较,观察组患者症状积分明显减轻,经统计处理,观察组低于对照组(P<0.05),对比2组实验室指标变化,观察组减少程度高于对照组(P<0.05),2组患者治疗过程中无明显不良反应。结论益气固摄丸配合灸法治疗糖尿病肾病Ⅲ~Ⅳ期能有效改善患者症状,减少尿微量白蛋白,保护肾功能,治疗效果好且安全性高。

参麦注射液联合西药治疗Ⅲ～Ⅳ期糖尿病肾病气阴两虚型随机平行对照研究

[目的]观察参麦注射液联合西药治疗Ⅲ~Ⅳ期糖尿病肾病气阴两虚型疗效。[方法]使用随机平行对照方法,将40例患者按抽签法分为两组。对照组20例基础治疗:糖尿病健康教育、饮食。二甲双胍,0.5g/次,3次/d,口服。或注射胰岛素,10u/次,2次/d。依那普利,10mg/次,2次/d,口服。治疗组20例参麦注射液,60mL/次,1次/d,静滴。西药治疗同对照组。连续治疗15d为1疗程。观测临床症状、尿微量白蛋白、血肌酐(SCr)、血尿素氮(BUN)、尿酸、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组治愈3例,显效6例,有效6例,无效5例,总有效率75.00%。对照组治愈0例,显效5例,有效6例,无效9例,总有效率55.00%。尿微量白蛋白和肾功能指标(肌酐、尿素氮、尿酸)两组均有改善,治疗组改善优于对照组(P【0.05)。[结论]参麦注射液联合西药治疗Ⅲ~Ⅳ期糖尿病肾病气阴两虚型效果显著,值得推广。