Objective To investigate the factors for standard TAC - related nephrotoxicity in Tac - related nephrotoxicity in renal transplant recipients. Methods Clinical data of 132 patients in TAC - based regiment with a dose ...Objective To investigate the factors for standard TAC - related nephrotoxicity in Tac - related nephrotoxicity in renal transplant recipients. Methods Clinical data of 132 patients in TAC - based regiment with a dose of 0. 15 - 0. 3 mg.kg -1.day -1and a trough level of 8 - 11 ug /L during the first 2 years post renal transplanta-展开更多
Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS) has become a powerful tool for analyzing the detailed composition of petroleum samples. However, the correlation between the numerous peaks obtain...Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS) has become a powerful tool for analyzing the detailed composition of petroleum samples. However, the correlation between the numerous peaks obtained by FT-ICR MS and bulk properties of petroleum samples is still a challenge. In this study, the internal standard method was applied for the quantitative analysis of four straight-run vacuum gas oils(VGO) by atmospheric pressure photoionization(APPI) FT-ICR MS. The heteroatom class distribution of these VGO samples turned to be different when the concentration changed. Linear relationship between the normalized abundance and the concentration of VGO samples was identified for the total aromatic compounds, aromatic hydrocarbons, S1 and N1 species. The differences of the response factors were also discussed. The sulfur contents of a series of crude oils were proved to be linear with the FT-ICR MS data calibrated by the response factor of S1 species. This study demonstrated the feasibility of the internal standard method in quantitative analysis with APPI FT-ICR MS, and the bulk properties of petroleum samples could be correlated directly with the FT-ICR MS data.展开更多
文摘Objective To investigate the factors for standard TAC - related nephrotoxicity in Tac - related nephrotoxicity in renal transplant recipients. Methods Clinical data of 132 patients in TAC - based regiment with a dose of 0. 15 - 0. 3 mg.kg -1.day -1and a trough level of 8 - 11 ug /L during the first 2 years post renal transplanta-
基金supported by the Major State Basic Research Development Program of China(973 Program,No.2012CB224801)
文摘Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR MS) has become a powerful tool for analyzing the detailed composition of petroleum samples. However, the correlation between the numerous peaks obtained by FT-ICR MS and bulk properties of petroleum samples is still a challenge. In this study, the internal standard method was applied for the quantitative analysis of four straight-run vacuum gas oils(VGO) by atmospheric pressure photoionization(APPI) FT-ICR MS. The heteroatom class distribution of these VGO samples turned to be different when the concentration changed. Linear relationship between the normalized abundance and the concentration of VGO samples was identified for the total aromatic compounds, aromatic hydrocarbons, S1 and N1 species. The differences of the response factors were also discussed. The sulfur contents of a series of crude oils were proved to be linear with the FT-ICR MS data calibrated by the response factor of S1 species. This study demonstrated the feasibility of the internal standard method in quantitative analysis with APPI FT-ICR MS, and the bulk properties of petroleum samples could be correlated directly with the FT-ICR MS data.
