The Stokes shift response function, which is related to the time dependent solvation energy, is calculated with the dielectric response function and a novel expression of nonequilibrium solvation energy. In the deriva...The Stokes shift response function, which is related to the time dependent solvation energy, is calculated with the dielectric response function and a novel expression of nonequilibrium solvation energy. In the derivation, relationship between the polarization and the dielectric response function is used. With the dipole-in-a-sphere model applied to the system coumarin 343 and water as the solvent, encouraging agreement with the experimental data from Jimenez et al. is obtained [Nature 369, 471 （1994）].展开更多
With the gradual improvement of Chinese women’s status in the 21st century,gender studies and gender relations have become one of the hottest topics in Chinese society,which consequently prompted Chinese Women’s Cin...With the gradual improvement of Chinese women’s status in the 21st century,gender studies and gender relations have become one of the hottest topics in Chinese society,which consequently prompted Chinese Women’s Cinema to attract the attention of larger audiences.With regard to the box office performance of Chinese Women’s Cinema,there seems to be a gap in research in finding an association between women’s status and the relevant films’box office performance.The purpose of this research is to outline the underlying reasons for the changes in gender roles and gender representation in the Chinese film industry over the past few decades in order to better understand this expansive social change in the 21st century.This study provides a comprehensive analysis through the use of questionnaires to better understand society’s attitude towards gender representation within the film industry.The questionnaire findings indicate that there is a direct correlation between people’s awareness of women’s changing status and gender equality and their acceptance of materials produced by Chinese Women’s Cinema.At the some time,it highlights that the Chinese government’s support and initiatives for gender equality have had a significant impact on the general popularity of Chinese Women’s Cinema.The significance of this research is to effectively popularize Chinese Women’s Cinema culture and the box office growth by understanding the social attitude towards gender representation in the Chinese film industry and to provide relevant information about the development direction and trend of Chinese Women’s Cinema.Furthermore,this research aims to provide foundational support for gender equality and help to understand the underlying factors that society needs to promote gender equality.展开更多
Sikkim Himalaya hosts critical water resources such as glacial,rain,and snow-fed springs and lakes.Climate change is adversely affecting these resources in various ways,and elevation-dependent warming is prominent amo...Sikkim Himalaya hosts critical water resources such as glacial,rain,and snow-fed springs and lakes.Climate change is adversely affecting these resources in various ways,and elevation-dependent warming is prominent among them.This study is a discussion of the elevation-dependent warming(EDW),snowfall shift,and precipitation variability over Sikkim Himalaya using a high-resolution ERA5-land dataset.Furthermore,the findings show that the Sikkim Himalaya region is experiencing a warming trend from south to north.The majority of the Sikkim Himalayan region shows a declining trend in snowfall.A positive advancement in snowfall trend(at a rate of 1 mm per decade)has been noticed above 4500 meters.The S/P ratio indicates a shift in snowfall patterns,moving from lower elevations to much higher regions.This suggests that snowfall has also transitioned from Lachung and Lachen(3600 m)to higher elevated areas.Moreover,the seasonal shifting of snowfall in the recent decade is seen from January-March(JFM)to February-April(FMA).Subsequently,the preceding 21 years are being marked by a significant spatiotemporal change in temperature,precipitation,and snowfall.The potent negative correlation coefficient between temperature and snowfall(–0.9),temperature and S/P ratio(–0.5)suggested the changing nature of snowfall from solid to liquid,which further resulted in increased lower elevation precipitation.The entire Sikkim region is transitioning from a cold-dry to a warm-wet weather pattern.In the climate change scenario,a drop in the S/P ratio with altitude will continue to explain the rise in temperature over mountainous regions.展开更多
Chrornophore structures inspired by natural green fluorescent protein （GFP） play an im- portant role in the field of bio-irnaging. In this work, photochemical properties of a new class of GFP-like chromophores are i...Chrornophore structures inspired by natural green fluorescent protein （GFP） play an im- portant role in the field of bio-irnaging. In this work, photochemical properties of a new class of GFP-like chromophores are investigated using computational approaches. Thermo- dynamically stable isomers are identified in vacuum and in solvent. Spectral Stokes shifts are computed and compared to experiments. An inverted solvatochromic shift between absorption and emission emerging in this new class of GFP-like chromophores is observed, and attributed to the stabilized charge transfer and inhibited rotational structural reorganization in solvent.展开更多
Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been report...Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been reported,the development of H2O2 ratiometric fluorescent probe with large Stokes shift remains rather limited.Such probes have shown distinct advantages,such as minimized interference from environment and improved signal-to noise ratio.In this work,we reported a new pyrene-based compound Py-VPB as H2O2 fluorescent probe in vitro.The probe demonstrated ratiometric detection behavior,large Stokes shift and large emission shift.In addition,the probe showed high sensitivity and selectivity towards H2O2 in vitro.Based on these excellent properties,we successfully applied Py-VPB to the visualization of exogenous and endogenous H2O2 in living cells.Cell imaging study also showed that our probe was localized in the mitochondria.We envision that the probe can provide a useful tool for unmasking the biological roles of mitochondrial H2O2 in living systems.展开更多
We consider semiconductor heterostructures in nanometric quantum wells, which as a consequence of the growth process display at the rugged interfaces fractal characteristics, and largely influence optical and transpor...We consider semiconductor heterostructures in nanometric quantum wells, which as a consequence of the growth process display at the rugged interfaces fractal characteristics, and largely influence optical and transport properties of the carriers system. The photoluminescence and excited photoluminescence spectra in such fractal conditions are theoretically analyzed, obtaining good agreement with the experimental results. The Stokes shift and linewidth are strongly dependent on the nonequilibrium thermomechanical-statistical state of the system. The Stokes shift has its origin in the presence of a gain region in the absorption spectrum, only present when the carriers system is in a statistical degenerate state.展开更多
As a hydrolase,chymotrypsin(CHT)is involved in many physiological activities,and its abnormal activity is closely related to diabetes,pancreatic fibrosis,chronic pancreatitis and pancreatic cancer.In this work,an inno...As a hydrolase,chymotrypsin(CHT)is involved in many physiological activities,and its abnormal activity is closely related to diabetes,pancreatic fibrosis,chronic pancreatitis and pancreatic cancer.In this work,an innovative long-wavelength emission fluorescent probe TCF-CHT was designed and synthesized for the high specificity detection of CHT,which utilized TCF-OH and a mimetic peptide substrate 4-bromobutyryl as chromogenic group and recognition group,respectively.TCF-CHT exhibited excellent selectivity and eye-catching sensitivity(8.91 ng/m L)towards CHT,“off-on”long-wavelength emission at 670 nm and large Stokes shift(140 nm).Furthermore,the successful fulfillment and perfect performance in imaging endogenous CHT in complex organisms(P815 cells,HepG2 cells,zebrafish and tumor-bearing mice)verified its potential as a powerful tool for the recognition of CHT in complicated biological environments.展开更多
文摘The Stokes shift response function, which is related to the time dependent solvation energy, is calculated with the dielectric response function and a novel expression of nonequilibrium solvation energy. In the derivation, relationship between the polarization and the dielectric response function is used. With the dipole-in-a-sphere model applied to the system coumarin 343 and water as the solvent, encouraging agreement with the experimental data from Jimenez et al. is obtained [Nature 369, 471 （1994）].
文摘With the gradual improvement of Chinese women’s status in the 21st century,gender studies and gender relations have become one of the hottest topics in Chinese society,which consequently prompted Chinese Women’s Cinema to attract the attention of larger audiences.With regard to the box office performance of Chinese Women’s Cinema,there seems to be a gap in research in finding an association between women’s status and the relevant films’box office performance.The purpose of this research is to outline the underlying reasons for the changes in gender roles and gender representation in the Chinese film industry over the past few decades in order to better understand this expansive social change in the 21st century.This study provides a comprehensive analysis through the use of questionnaires to better understand society’s attitude towards gender representation within the film industry.The questionnaire findings indicate that there is a direct correlation between people’s awareness of women’s changing status and gender equality and their acceptance of materials produced by Chinese Women’s Cinema.At the some time,it highlights that the Chinese government’s support and initiatives for gender equality have had a significant impact on the general popularity of Chinese Women’s Cinema.The significance of this research is to effectively popularize Chinese Women’s Cinema culture and the box office growth by understanding the social attitude towards gender representation in the Chinese film industry and to provide relevant information about the development direction and trend of Chinese Women’s Cinema.Furthermore,this research aims to provide foundational support for gender equality and help to understand the underlying factors that society needs to promote gender equality.
文摘Sikkim Himalaya hosts critical water resources such as glacial,rain,and snow-fed springs and lakes.Climate change is adversely affecting these resources in various ways,and elevation-dependent warming is prominent among them.This study is a discussion of the elevation-dependent warming(EDW),snowfall shift,and precipitation variability over Sikkim Himalaya using a high-resolution ERA5-land dataset.Furthermore,the findings show that the Sikkim Himalaya region is experiencing a warming trend from south to north.The majority of the Sikkim Himalayan region shows a declining trend in snowfall.A positive advancement in snowfall trend(at a rate of 1 mm per decade)has been noticed above 4500 meters.The S/P ratio indicates a shift in snowfall patterns,moving from lower elevations to much higher regions.This suggests that snowfall has also transitioned from Lachung and Lachen(3600 m)to higher elevated areas.Moreover,the seasonal shifting of snowfall in the recent decade is seen from January-March(JFM)to February-April(FMA).Subsequently,the preceding 21 years are being marked by a significant spatiotemporal change in temperature,precipitation,and snowfall.The potent negative correlation coefficient between temperature and snowfall(–0.9),temperature and S/P ratio(–0.5)suggested the changing nature of snowfall from solid to liquid,which further resulted in increased lower elevation precipitation.The entire Sikkim region is transitioning from a cold-dry to a warm-wet weather pattern.In the climate change scenario,a drop in the S/P ratio with altitude will continue to explain the rise in temperature over mountainous regions.
基金supported by US National Science Foundation(CHE-1565520) to X. Lifunded by the STF at the University of Washingtonthe National Science Foundation (MRI-1624430).
文摘Chrornophore structures inspired by natural green fluorescent protein （GFP） play an im- portant role in the field of bio-irnaging. In this work, photochemical properties of a new class of GFP-like chromophores are investigated using computational approaches. Thermo- dynamically stable isomers are identified in vacuum and in solvent. Spectral Stokes shifts are computed and compared to experiments. An inverted solvatochromic shift between absorption and emission emerging in this new class of GFP-like chromophores is observed, and attributed to the stabilized charge transfer and inhibited rotational structural reorganization in solvent.
基金This work was supported by the Science Technology and Innovation Committee of Shenzhen Municipality(JCYJ20180507181654823)the National Natural Science Foundation of China(21778044)and Sichuan Science and Technology Program(2018JY0360).
文摘Hydrogen peroxide(H2O2)plays a significant role in regulating a variety of biological processes.Dysregulation of H2O2 can lead to various diseases.Although numerous fluorescent imaging probes for H2O2 have been reported,the development of H2O2 ratiometric fluorescent probe with large Stokes shift remains rather limited.Such probes have shown distinct advantages,such as minimized interference from environment and improved signal-to noise ratio.In this work,we reported a new pyrene-based compound Py-VPB as H2O2 fluorescent probe in vitro.The probe demonstrated ratiometric detection behavior,large Stokes shift and large emission shift.In addition,the probe showed high sensitivity and selectivity towards H2O2 in vitro.Based on these excellent properties,we successfully applied Py-VPB to the visualization of exogenous and endogenous H2O2 in living cells.Cell imaging study also showed that our probe was localized in the mitochondria.We envision that the probe can provide a useful tool for unmasking the biological roles of mitochondrial H2O2 in living systems.
文摘We consider semiconductor heterostructures in nanometric quantum wells, which as a consequence of the growth process display at the rugged interfaces fractal characteristics, and largely influence optical and transport properties of the carriers system. The photoluminescence and excited photoluminescence spectra in such fractal conditions are theoretically analyzed, obtaining good agreement with the experimental results. The Stokes shift and linewidth are strongly dependent on the nonequilibrium thermomechanical-statistical state of the system. The Stokes shift has its origin in the presence of a gain region in the absorption spectrum, only present when the carriers system is in a statistical degenerate state.
文摘近年来,数值波浪水槽在海洋工程研究中发挥着越来越为重要的作用,成为了水波动力学研究的焦点之一。为此,基于Navier-Stokes(N-S)方程组,首先完成了二维数值波浪水槽的构建。对于N-S方程,采用FVM(Finite Volume Method)法进行离散求解;在入口边界处,模拟活塞推板运动产生了入射波;同时,利用VOF(Volume of Fluid)法对波浪自由面进行了捕捉;在数值波浪水槽尾部,通过设置人工阻尼区实现了消波。利用该二维数值波浪水槽,对典型非线性二阶Stokes波进行了仿真模拟,通过设置虚拟波高监测仪,获取了非线性二阶Stokes波发生、发展和消亡的全过程。对比校验表明,所有仿真结果均与理论精确解相吻合。
基金financial support provided by National Natural Science Foundation of China(Nos.21775005,41430641 and 41140032)the Start-Up Fund of Qingdao University of Science and Technology(No.12030430010883)。
文摘As a hydrolase,chymotrypsin(CHT)is involved in many physiological activities,and its abnormal activity is closely related to diabetes,pancreatic fibrosis,chronic pancreatitis and pancreatic cancer.In this work,an innovative long-wavelength emission fluorescent probe TCF-CHT was designed and synthesized for the high specificity detection of CHT,which utilized TCF-OH and a mimetic peptide substrate 4-bromobutyryl as chromogenic group and recognition group,respectively.TCF-CHT exhibited excellent selectivity and eye-catching sensitivity(8.91 ng/m L)towards CHT,“off-on”long-wavelength emission at 670 nm and large Stokes shift(140 nm).Furthermore,the successful fulfillment and perfect performance in imaging endogenous CHT in complex organisms(P815 cells,HepG2 cells,zebrafish and tumor-bearing mice)verified its potential as a powerful tool for the recognition of CHT in complicated biological environments.
