TiB_(2p)/Cu composites with high reinforcement content(φ_(p)=50%,58%and 65%)for electronic packaging applications were fabricated by squeeze casting technology.The microstructures and thermo-physical properties of th...TiB_(2p)/Cu composites with high reinforcement content(φ_(p)=50%,58%and 65%)for electronic packaging applications were fabricated by squeeze casting technology.The microstructures and thermo-physical properties of the TiB_(2p)/Cu composites were investigated.The results show that TiB2 particles are homogeneous and distribute uniformly,and the TiB2-Cu interfaces are clean and free-from interfacial reaction products and amorphous layers,the densifications of the TiB_(2p)/Cu composites are higher than 98.2%. The mean linear coefficients of thermal expansion at 20-100℃for TiB_(2p)/Cu composites range from 8.3×10^(-6)to 10.8×10^(-6)/K and decrease with increasing volume fraction of TiB2.The experimental coefficients of thermal expansion agree well with the predicted values based on Turner’s model.The thermal conductivities of TiB_(2p)/Cu composites range from 167.3 to 215.4 W/(m·K),decreasing with increasing volume fraction TiB2.展开更多
With the development of smart home energy management technology,prosumers are endowed with increased initiative in peer-to-peer(P2P)transactions,bringing new potential for cost savings.In this study,a novel strategic ...With the development of smart home energy management technology,prosumers are endowed with increased initiative in peer-to-peer(P2P)transactions,bringing new potential for cost savings.In this study,a novel strategic P2P energy trading framework is proposed considering the impact of network constraints on personal transaction strategies.Prosumers can estimate the allowed power injection before engaging in the P2P energy trading,which is solved in a distributed manner based on the sharing form alternating direction method of multipliers(ADMM)algorithm.To quantify the network usage cost for each prosumer and promote local transactions among prosumers at the same bus,a modified continuous double auction(CDA)matching algorithm is proposed including a transaction fee.An adaptive aggressiveness-based bidding strategy is generated considering the risk of uncertainty in real-time energy delivery amount under the limitations of the distribution network.The proposed strategic P2P energy trading framework is tested with the IEEE 37-bus distribution network and it is effective in creating profits for prosumers and supporting distribution network operations.展开更多
In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2(MDM2)and murine double minute X(MDMX) has been proved to be a promising approach for tumor therapy.However, the poor prot...In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2(MDM2)and murine double minute X(MDMX) has been proved to be a promising approach for tumor therapy.However, the poor proteolytical stability and low intracellular delivery efficiency of peptide inhibitors limit their clinical application. Here, we designed and synthesized the bicyclic stapled peptides based on p53 by combining all-hydrocarbon stapling and lactam stapling strategies. We demonstrated that bicyclic stapled peptide p53-16 significantly improved α-helicity and proteolytic stability. Especially, p53-16showed nanomolar binding affinity for MDM2 and MDMX. In addition, p53-16 could penetrate the cell membrane, and selectively inhibited the activity of tumor cells via activating p53 pathway in vitro. Our data suggest that p53-16 is a potential dual inhibitor of MDM2 and MDMX interactions. The bicyclic stapling strategy is a promising drug design strategy for protein–protein interactions inhibitors.展开更多
Different from the single paths between controllers and plants of networked control systems(NCSs), the complex network provides widespread links and brings plenty of paths from the controller side to the plant side. B...Different from the single paths between controllers and plants of networked control systems(NCSs), the complex network provides widespread links and brings plenty of paths from the controller side to the plant side. Benefit from this advantage, a novel data transmission dispatching strategy is proposed. When the direct path can not satisfy the condition of system demand, neither stability nor performance, some specified paths compose a concurrent-path to transmit the control signal concurrently. Firstly, the networked control systems(NCSs) are expressed by the switched systems model with the constant network-induced delay, and the network communication is described as a packet-loss process. Secondly, taking system's exponential decay rate as its performance indicator, the relationship between control signal transmission paths and system performance is quantitatively given by considering packet losses as the compound poisson process and the alternating renewal process. Then, due to that different combination of paths induces the different statistical properties of packet losses, the approach to find an appropriate concurrent-path is proposed concerning two mutually constrained factors, the system performance demand and the utilization of network resources. After the theoretical analysis, a distributed communication platform based on peer-to-peer(P2P) network technology is designed and implemented to realize the concurrent-path transmission on internet. Finally, the practical experiment on the platform demonstrates the validity and effectiveness of proposed approach.展开更多
基金Project(20080430895)supported by China Postdoctoral Science FoundationProject(2008RFQXG045)supported by the Special Fund of Technological Innovation of Harbin,China。
文摘TiB_(2p)/Cu composites with high reinforcement content(φ_(p)=50%,58%and 65%)for electronic packaging applications were fabricated by squeeze casting technology.The microstructures and thermo-physical properties of the TiB_(2p)/Cu composites were investigated.The results show that TiB2 particles are homogeneous and distribute uniformly,and the TiB2-Cu interfaces are clean and free-from interfacial reaction products and amorphous layers,the densifications of the TiB_(2p)/Cu composites are higher than 98.2%. The mean linear coefficients of thermal expansion at 20-100℃for TiB_(2p)/Cu composites range from 8.3×10^(-6)to 10.8×10^(-6)/K and decrease with increasing volume fraction of TiB2.The experimental coefficients of thermal expansion agree well with the predicted values based on Turner’s model.The thermal conductivities of TiB_(2p)/Cu composites range from 167.3 to 215.4 W/(m·K),decreasing with increasing volume fraction TiB2.
基金supported in part by the National Key R&D Program of China(No.2018YFB0905000)in part by the National Natural Science Foundation of China(No.51877189)+1 种基金the Joint Program of National Natural Science Foundation of China(No.U2166203)in part by the Zhejiang Provincial Natural Science Foundation of China(No.LR22E070003)。
文摘With the development of smart home energy management technology,prosumers are endowed with increased initiative in peer-to-peer(P2P)transactions,bringing new potential for cost savings.In this study,a novel strategic P2P energy trading framework is proposed considering the impact of network constraints on personal transaction strategies.Prosumers can estimate the allowed power injection before engaging in the P2P energy trading,which is solved in a distributed manner based on the sharing form alternating direction method of multipliers(ADMM)algorithm.To quantify the network usage cost for each prosumer and promote local transactions among prosumers at the same bus,a modified continuous double auction(CDA)matching algorithm is proposed including a transaction fee.An adaptive aggressiveness-based bidding strategy is generated considering the risk of uncertainty in real-time energy delivery amount under the limitations of the distribution network.The proposed strategic P2P energy trading framework is tested with the IEEE 37-bus distribution network and it is effective in creating profits for prosumers and supporting distribution network operations.
基金supported by National Natural Science Foundation of China-Shandong Joint Fund (No. U1606403)Innovation Project of Qingdao National Laboratory for Marine Science and Technology (No. 2015ASKJ02)。
文摘In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2(MDM2)and murine double minute X(MDMX) has been proved to be a promising approach for tumor therapy.However, the poor proteolytical stability and low intracellular delivery efficiency of peptide inhibitors limit their clinical application. Here, we designed and synthesized the bicyclic stapled peptides based on p53 by combining all-hydrocarbon stapling and lactam stapling strategies. We demonstrated that bicyclic stapled peptide p53-16 significantly improved α-helicity and proteolytic stability. Especially, p53-16showed nanomolar binding affinity for MDM2 and MDMX. In addition, p53-16 could penetrate the cell membrane, and selectively inhibited the activity of tumor cells via activating p53 pathway in vitro. Our data suggest that p53-16 is a potential dual inhibitor of MDM2 and MDMX interactions. The bicyclic stapling strategy is a promising drug design strategy for protein–protein interactions inhibitors.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.61333003 and 61690212
文摘Different from the single paths between controllers and plants of networked control systems(NCSs), the complex network provides widespread links and brings plenty of paths from the controller side to the plant side. Benefit from this advantage, a novel data transmission dispatching strategy is proposed. When the direct path can not satisfy the condition of system demand, neither stability nor performance, some specified paths compose a concurrent-path to transmit the control signal concurrently. Firstly, the networked control systems(NCSs) are expressed by the switched systems model with the constant network-induced delay, and the network communication is described as a packet-loss process. Secondly, taking system's exponential decay rate as its performance indicator, the relationship between control signal transmission paths and system performance is quantitatively given by considering packet losses as the compound poisson process and the alternating renewal process. Then, due to that different combination of paths induces the different statistical properties of packet losses, the approach to find an appropriate concurrent-path is proposed concerning two mutually constrained factors, the system performance demand and the utilization of network resources. After the theoretical analysis, a distributed communication platform based on peer-to-peer(P2P) network technology is designed and implemented to realize the concurrent-path transmission on internet. Finally, the practical experiment on the platform demonstrates the validity and effectiveness of proposed approach.
