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International study of the Complex Stress Reaction Syndrome:Implications for transdiagnostic clinical practice
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作者 Sari Goldstein Ferber Aron Weller +15 位作者 Adele M Hayes Tracy D Vannorsdall Yaroup Ajlouni Mo'nes Qudah Gil Zalsman Gal Shoval Tommaso Benedetto Jannini Racquel Fiedler Lily X Chen Danielle R Shayani Elin Kachuki Dory Dana Stolowicz-Melman Connor Evans Megan Trow Giorgio Di Lorenzo Rodolfo Rossi 《World Journal of Psychiatry》 SCIE 2023年第10期803-815,共13页
BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress reactions.We previously... BACKGROUND The debate regarding diagnostic classification systems in psychiatry(categorial vs dimensional systems)has essential implications for the diagnosis,prevention and treatment of stress reactions.We previously found a unique pattern of stress reaction in a study executed during the coronavirus disease 2019 pandemic using large representative samples in two countries,and termed it the Complex Stress Reaction Syndrome(CSRS).AIM To investigate CSRS,Type A(psychiatric symptoms,spanning anxiety,depression,stress symptoms,and posttraumatic stress disorder(PTSD)),with or without long-coronavirus disease(COVID)residuals(CSRS,Type B,neuropsychiatric symptoms spanning cognitive deficits and fatigue,excluding systemic symptoms).Our two-tailed hypothesis was that CSRS is a condition related to an unrecognized type of stress reaction in daily life in the general population(Type A)or that it is related to the severe acute respiratory syndrome coronavirus 2 infection and its long-COVID residuals(Type B).METHODS 977 individuals in four continents(North America,Europe,Australia and the Middle East)completed the online study questionnaire in six languages using the Qualtrics platform.The study was managed by six teams in six countries that promoted the study on social media.The questionnaire assessed anxiety,depression,stress symptoms and PTSD(CSRS,Type A),cognitive deficits and fatigue(CSRS,Type B).The data were analyzed using Proportion Analyses,Multivariate Analysis of Co-Variance(MANCOVA),linear regression analyses and validated clinical cutoff points.RESULTS The results of the Proportion Analyses showed that the prevalence of 4 symptoms spanning anxiety,depression,stress symptoms,and PTSD was significantly higher than the most prevalent combinations of fewer symptoms across 4 continents,age groups,and gender.This supports the transdiagnostic argument embedded in the CSRS(Type A).The same pattern of results was found in infected/recovered individuals.The prevalence of the 4 psychiatric symptoms combination was significantly greater than that of 5 and 6 symptoms,when adding cognitive deficits and fatigue,respectively.MANCOVA showed a significant three-way interaction(age×gender×continent).Further analyses showed that the sources of this three-way interaction were threefold relating to two sub-populations at-risk:(1)Individuals that self-identified as non-binary gender scored significantly higher on all 4 psychiatric symptoms of the CSRS,Type A at young age groups(<50 years old)in North America compared to(self-identified)women and men located in the 4 continents studied,and to other ages across the adult life span;and(2)This pattern of results(CSRS,Type A)was found also in women at young ages(<40 years old)in North America who scored higher compared to men and women in other continents and other ages.Linear regression analyses confirmed the MANCOVA results.CONCLUSION These results show a combined mental health risk factor related to stress reactivity,suggesting that the CSRS is sensitive to populations at risk and may be applied to future identification of other vulnerable sub-populations.It also supports the transdiagnostic approach for more accurate prevention and treatment.Time will tell if such transdiagnostic syndromes will be part of the discussions on the next revisions of the traditional classification systems or whether the crisis in psychiatry further evolves. 展开更多
关键词 TRANSDIAGNOSTIC Complex stress reaction Syndrome stress reactivity Affective disorders Debate in psychiatry
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CLINICAL APPLICATION OF ACUPUNCTURE ON ALLEVIATION OF STRESS REACTION INDUCED BY TRACHEAL INTUBATION IN GENERAL ANESTHESIA
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作者 时金华 《World Journal of Acupuncture-Moxibustion》 2006年第2期43-48,共6页
By summarizing the formation of stress reaction induced by tracheal intubation and method of medicinal control, the recognition of Chinese medicine in treatment of cardiac arrhythmia and hypertension with acupuncture ... By summarizing the formation of stress reaction induced by tracheal intubation and method of medicinal control, the recognition of Chinese medicine in treatment of cardiac arrhythmia and hypertension with acupuncture and the clinical application of acupuncture on stress reaction induced by tracheal intubation, it is concluded that the side effects of tracheal intubation are inevitable, even though there are many methods presented for the prevention and treatment for it. In recent years, the functions of acupuncture in anesthesia, especially in regulation of circulatory properties have been developed gradually and have been applied by many physicians in controlling the stress reaction induced by tracheal intubation in general anesthesia. Being a kind of dual-directional and positive regulation and stimulation, acupuncture provides definite and safe effects on controlling the stress reaction induced by tracheal intubation. 展开更多
关键词 针灸治疗 中医 气管插管 麻醉方法
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Effect of Reaction Layers on the Residual Stress of the Brazed TiC Cermets/Steel Joints 被引量:1
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作者 Lixia Zhang Jicai Feng 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2009年第2期203-207,共5页
For the first time, considering the effect of reaction layers, numerical simulation calculation of residual stress on brazed TiC cermets/steel joint was studied by finite element method (FEIVl). The calculation resu... For the first time, considering the effect of reaction layers, numerical simulation calculation of residual stress on brazed TiC cermets/steel joint was studied by finite element method (FEIVl). The calculation results show that, when the joint is brazed at 1123 K for 300 s (low brazing parameters), the maximum shear stress value occurs on (Cu, Ni) layer near TiC cermets, which is 92.16 MPa as the temperature is 300 K. When the joint is brazed at 1273 K for g00 s (high brazing parameters), the maximum shear stress value occurs on (Cu, Ni)+(Fe, Ni) layer, which is 39.18 MPa as the temperature is 300 K. The fracture sites of the joints obtained from numerical simulation calculation accord with experimental results. 展开更多
关键词 Numerical simulation Residual stress reaction layer BRAZING
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Effects of stress dependent electrochemical reaction on voltage hysteresis of lithium ion batteries 被引量:3
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作者 Haoliang LI Yicheng SONG +1 位作者 Bo LU Junqian ZHANG 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2018年第10期1453-1464,共12页
Intercalation of lithium ions into the electrodes of lithium ion batteries is affected by the stress of active materials, leading to energy dissipation and stress dependent voltage hysteresis. A reaction-diffusion-str... Intercalation of lithium ions into the electrodes of lithium ion batteries is affected by the stress of active materials, leading to energy dissipation and stress dependent voltage hysteresis. A reaction-diffusion-stress coupling model is established to investigate the stress effects under galvanostatic and potentiostatic operations. It is found from simulations that the stress hysteresis contributes to the voltage hysteresis and leads to the energy dissipation. In addition, the stress induced voltage hysteresis is small in low rate galvanostatic operations but extraordinarily significant in high rate cases. In potentiostatic operations, the stresses and stress induced overpotentials increase to a peak value very soon after the operation commences and decays all the left time. Therefore,a combined charge-discharge operation is suggested, i.e., first the galvanostatic one and then the potentiostatic one. This combined operation can not only avoid the extreme stress during operations so as to prevent electrodes from failure but also reduce the voltage hysteresis and energy dissipation due to stress effects. 展开更多
关键词 electrochemical reaction stress voltage hysteresis lithium ion battery
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EFFECT OF STRESS-INDUCED REACTIONS ON MORPHOLOGICAL STRUCTURE AND PROCESSABILITY OF PVC DURING PAN-MILLING 被引量:1
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作者 Hua-weiZou WenXu Qing-fenFeng XiXu 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2005年第2期227-234,共8页
The effect of pan-milling on morphological structure,processability and properties of PVC was studied throughSEM,FTIR,granulometer,GPC and mechanical properties test in the hope of gaining ease in operation,needless o... The effect of pan-milling on morphological structure,processability and properties of PVC was studied throughSEM,FTIR,granulometer,GPC and mechanical properties test in the hope of gaining ease in operation,needless ofplasticizers,a clean and efficient route for improving the processability of PVC through stress-induced reactions,fulfilling the idea of“plasticizing PVC by itself”.The experimental results show that during pan-milling at ambienttemperature,within 2-3 min,the microcrystalline structure of PVC becomes indistinct,the grain size of PVC is reducedfrom 130-160 μm to 1-50 μm the molecular weight of PVC is slightly decreased,the variation of molecular weightdistribution is indistinct,the plasticizing time and torque at balance drop a great deal from 71-132 s to 31-33 s and from18.2-22.1 Nm to 14.7-18.4 Nm,respectively,the processability of PVC is markedly improved,and the mechanicalproperties get enhanced too. 展开更多
关键词 Poly(vinyl chloride) stress-induced reaction Morphological structure Processability.
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Influence of chemical reaction on heat and mass transfer of non-Newtonian fluid with yield stress by free convection from vertical surface in porous medium considering Soret effect 被引量:2
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作者 F. S. IBRAHIM F. M. HADY +1 位作者 S. M. ABDEL-GAIED M. R. EID 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2010年第6期675-684,共10页
The effect of chemical reaction on free convection heat and mass transfer for a non-Newtonian power law fluid over a vertical flat plate embedded in a fluid-saturated porous medium has been studied in the presence of ... The effect of chemical reaction on free convection heat and mass transfer for a non-Newtonian power law fluid over a vertical flat plate embedded in a fluid-saturated porous medium has been studied in the presence of the yield stress and the Soret effect. The governing boundary layer equations and boundary conditions are cast into a dimen- sionless form by similarity transformations, and the resulting system of equations is solved by a finite difference method. The results are preSented and discussed for concentration profiles, as well as the Nusselt number and the Sherwood number for various values of the parameters, which govern the problem. The results obtained show that the flow field is influenced appreciably by the presence of the chemical reaction parameter γ the order of.the chemical reaction parameter m, the Soret number St, the buoyancy ratio N, the Lewis number Le, and the dimensionless rheological parameter Ω. 展开更多
关键词 non-Newtonian fluid free convection chemical reaction yield stress Soret effect
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Effects of Neuroticism on Partial and Whole Body Reactions under Stress
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作者 Kanaka Yatabe Hiroto Fujiya +13 位作者 Naoko Yui Keisuke Tateishi Yuka Murofushi Fumiko Terawaki Atsuhiro Yoshida Hirotaka Yoshioka Koh Terauchi Hajime Kobayashi Takaaki Kudo Mahiro Ohno Aya Uchino Hisao Miyano Tadasu Oyama Haruki Musha 《Journal of Sports Science》 2015年第4期155-164,共10页
关键词 运动科学 体育 运动训练 体育训练
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The Roots of Psychological Trauma and Post-TraumaticStress Reaction/Disorders and the Intervention
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作者 Jing Zeng 《International Journal of Technology Management》 2014年第12期100-102,共3页
关键词 心理反应 创伤性 应激反应 人为因素 事件 心理学 雪灾
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血府逐瘀汤联合胸腔镜手术治疗创伤性血气胸的临床疗效及对应激反应和凝血功能的影响
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作者 于涛 齐拥军 +2 位作者 张秋生 付景伟 周世杰 《中国中西医结合外科杂志》 CAS 2024年第2期243-247,共5页
目的:探讨血府逐瘀汤联合胸腔镜手术治疗创伤性血气胸的临床疗效及对应激反应和凝血功能的影响。方法:将72例创伤性血气胸患者按照随机数字表法分为对照组和观察组,各36例。对照组采用胸腔镜进行手术并给予机械通气,观察组在对照组基础... 目的:探讨血府逐瘀汤联合胸腔镜手术治疗创伤性血气胸的临床疗效及对应激反应和凝血功能的影响。方法:将72例创伤性血气胸患者按照随机数字表法分为对照组和观察组,各36例。对照组采用胸腔镜进行手术并给予机械通气,观察组在对照组基础上联合血府逐瘀汤进行治疗。比较两组临床治疗总有效率、气滞血瘀症状评分、肺功能指标[第1秒用力呼气量(FEV1)、肺活量(VC)、最大通气量(MVV)、用力肺活量(FVC)]、应激反应指标[皮质醇(Cor)、去甲肾上腺素(NE)、胰岛素(Ins)、血管紧张素Ⅱ(AT-Ⅱ)]、凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-二聚体(D-D)],以及术后并发症发生率。结果:观察组患者临床治疗总有效率为97.22%,高于对照组的83.33%,有统计学意义(P<0.05);治疗后,对照组及观察组患者气滞血瘀症状评分、Cor、NE、Ins、AT-Ⅱ、FIB水平均降低,FEV1、VC、MVV、FVC、PT、APTT、TT和D-D均升高,有统计学意义(P<0.05);与对照组比较,观察组患者气滞血瘀症状评分、Cor、NE、Ins、AT-Ⅱ、FIB水平均降低,FEV1、VC、MVV和FVC显著升高,有统计学意义(P<0.05)。结论:血府逐瘀汤联合胸腔镜手术治疗创伤性血气胸效果理想,可显著改善患者肺功能和凝血功能,减少应激反应。 展开更多
关键词 血府逐瘀汤 胸腔镜手术 创伤性血气胸 应激反应 凝血功能
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How Emotion Nurtures Mentality:The Influencing Mechanism of Social-Emotional Competency on the Mental Health of University Students
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作者 Yulei Chen Zhaojun Chen +2 位作者 Shichao Wang Yang Hang Jianpeng Guo 《International Journal of Mental Health Promotion》 2024年第4期303-315,共13页
Social-Emotional Competency(SEC),regarded as a critical psychological resource for individuals to adapt to social environments,is an effective protective factor for students’mental health,impacting their future succe... Social-Emotional Competency(SEC),regarded as a critical psychological resource for individuals to adapt to social environments,is an effective protective factor for students’mental health,impacting their future success and well-being.Analyzing the impact of SEC on university students’mental health can offer valuable insights for nurturing talents with healthy psychological and physical development.Based on data from two large-scale surveys of Chinese university students,this study designed two comprehensive Multiple Mediation Models involving SEC,stress,coping strategies,and stress reaction to explore the pathway of emotion nurturing mentality.Study 1 utilized a parallel mediation model to examine the relationships between SEC,academic stress,interpersonal stress,and stress reactions.The results indicated that SEC negatively predicted academic stress,interpersonal stress,and stress reactions.Additionally,academic and interpersonal stress mediated the relationships between SEC and stress reactions in parallel.Extending these findings,Study 2 further investigated the role of coping strategies.By constructing a multiple-chain mediation model,it examined the predictive relationships among SEC,academic stress,interpersonal stress,three types of coping strategies,and stress reactions.The findings indicated that SEC negatively predicted stress,problemavoiding strategy,and stress reactions,while positively predicting problem-solving and assistant-seeking strategies.Furthermore,the two stress types and three coping strategies significantly mediated the relationship between SEC and stress reactions.This indicated that higher SEC was associated with reduced stress and more adaptive coping strategies and subsequently contributed to more favorable stress reactions.This research explored the impact of university students’SEC on mental health and its relational mechanisms,aiming to provide theoretical reference and practical insights for future efforts in cultivating SEC among university students to adjust academic and interpersonal stress,to enhance problem-solving and stress resistance capabilities,and to maintain their mental health. 展开更多
关键词 Social-Emotional Competency academic stress interpersonal stress stress reaction coping strategies Multiple Mediation Model
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玄参提取物对脑缺血再灌注损伤小鼠氧化应激及炎症反应的影响
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作者 游敏吉 单伟锋 +2 位作者 吴继敏 蓝海燕 代虹 《浙江医学》 CAS 2024年第13期1351-1356,共6页
目的探讨玄参提取物对脑缺血再灌注损伤(CRI)小鼠氧化应激及炎症反应的影响。方法将60只SPF级雄性C57BL/6小鼠按随机数字表法分为模型组、正常组、阳性对照组、低剂量组和高剂量组,每组各12只。模型组、阳性对照组、低剂量组和高剂量组... 目的探讨玄参提取物对脑缺血再灌注损伤(CRI)小鼠氧化应激及炎症反应的影响。方法将60只SPF级雄性C57BL/6小鼠按随机数字表法分为模型组、正常组、阳性对照组、低剂量组和高剂量组,每组各12只。模型组、阳性对照组、低剂量组和高剂量组建立小鼠CRI模型。建模前,低、高剂量组小鼠术前分别给予5、20 mL/kg玄参提取物灌胃;阳性对照组给予20 mL/kg辛伐他汀灌胃;模型组和正常组术前分别给予等量0.9%氯化钠注射液灌胃,均1次/d,连续5 d。采用Bederson评分法和Longa评分法评价小鼠神经功能;采用Morris水迷宫实验测定小鼠找到平台的时间(潜伏期)和穿越平台次数;采用硫代巴比妥酸比色法测定血清丙二醛(MDA)水平,采用黄嘌呤氧化酶法测定血清超氧化歧化酶(SOD)水平;采用ELISA法测定血清IL-6、IL-8和TNF-α水平;测量小鼠脑梗死体积百分比。结果与正常组比较,其他各组Bederson评分、Longa评分、MDA水平、IL-6、IL-8和TNF-α水平、脑梗死体积百分比均明显增高,而SOD水平明显降低(均P<0.05);与模型组比较,阳性对照组、低剂量组与高剂量组Bederson评分、Longa评分、MDA水平、IL-6、IL-8和TNF-α水平、脑梗死体积百分比均明显降低,而SOD水平明显增高(均P<0.05);与阳性对照组和低剂量组比较,高剂量组Bederson评分、Longa评分、脑梗死体积百分比、MDA水平、IL-6、IL-8和TNF-α水平均明显降低,而SOD水平明显增高(均P<0.05)。其他各组第1、2、3、4天潜伏期均长于正常组(均P<0.05);阳性对照组、低剂量组与高剂量组第1、2、3、4天潜伏期均短于模型组(均P<0.05);高剂量组第1、2、3、4天潜伏期均短于阳性对照组和低剂量组(均P<0.05)。结论玄参提取物对脑缺血再灌注损伤小鼠有较好的保护作用,可显著改善小鼠神经功能,明显缩小小鼠脑梗死体积,其机制可能与改善氧化应激及减轻炎症反应有关。 展开更多
关键词 玄参提取物 脑缺血再灌注损伤 氧化应激 炎症反应
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药物治疗联合前庭功能训练对前庭神经炎患者平衡功能、炎症因子及氧化应激水平的影响
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作者 李斌 纪茹英 +2 位作者 陆艳卉 郭佳 郭君君 《临床和实验医学杂志》 2024年第12期1245-1249,共5页
目的探讨药物治疗联合前庭功能训练对前庭神经炎患者平衡功能、炎症因子及氧化应激水平的影响。方法前瞻性选取2021年2月至2023年2月唐山市人民医院前庭神经炎患者70例,依据随机数字表法将其分为对照组与训练组,每组各35例。对照组采用... 目的探讨药物治疗联合前庭功能训练对前庭神经炎患者平衡功能、炎症因子及氧化应激水平的影响。方法前瞻性选取2021年2月至2023年2月唐山市人民医院前庭神经炎患者70例,依据随机数字表法将其分为对照组与训练组,每组各35例。对照组采用醋酸泼尼松、甲磺酸盐酸倍他司汀等药物治疗,训练组在对照组的基础上进行前庭功能训练。比较两组患者治疗前和治疗4周后的眩晕程度[眩晕残障程度评定量表(DHI)]、前庭功能检查参数[半规管轻瘫值(CP)和优势偏向(DP)、自发性眼震角度(SN)]、平衡功能[Berg平衡量表(BBS)、日常活动前庭功能障碍等级量表(VADL)]、前庭功能状态、脑血流速度、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]及氧化应激[25羟维生素D3(25(OH)D3)、丙二醛、超氧化物歧化酶(SOD)]水平、临床疗效及不良反应发生情况。结果治疗4周后,训练组患者的躯体性、情感性、功能性评分及DHI总分分别为(2.26±0.37)、(2.18±0.34)、(2.02±0.33)、(6.48±1.12)分,均低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,训练组患者的CP、DP、SN分别为(52.75±6.45)%、(23.25±3.46)%、(0.35±0.10)°/s,均低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,训练组的BBS评分为(32.36±3.02)分,明显高于对照组,VADL评分为(28.65±4.12)分,明显低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,训练组的血清IL-6、TNF-α、CRP水平分别为(12.30±1.57)g/mL、(11.41±1.05)pg/mL、(10.24±2.05)mg/L,均明显低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,训练组血清25(OH)D3、SOD水平为(22.03±3.02)ng/mL、(65.67±6.43)U/mL,高于对照组,丙二醛水平分别为(3.97±0.35)nmoL/mL,均明显低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,训练组的基底动脉、左椎动脉、右椎动脉血流速度分别为(36.01±1.55)、(33.44±1.62)、(34.60±2.17)cm/s,均明显高于对照组,差异均有统计学意义(P<0.05)。训练组患者的总有效率为91.43%,明显高于对照组(71.43%),差异有统计学意义(P<0.05)。两组患者的总不良反应发生率比较,差异无统计学意义(P>0.05)。结论药物治疗联合前庭神经炎治疗中前庭功能训练能够提升患者的平衡功能,改善炎症因子及氧化应激水平,值得临床推广应用。 展开更多
关键词 前庭神经炎 前庭功能训练 平衡功能 炎症因子 氧化应激 不良反应
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七氟烷预处理对1-甲基-4苯基-1,2,3,4-四氢吡啶诱导的急性帕金森病小鼠的神经保护作用
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作者 卓明 邓子豪 +7 位作者 刘金龙 钟茂林 李盈 管俊辉 李斌 梁伟东 李艺 叶军明 《当代医学》 2024年第7期1-5,共5页
目的探讨七氟烷预处理对1-甲基-4苯基-1,2,3,4-四氢吡啶(MPTP)诱导的急性帕金森病(PD)小鼠的神经保护作用。方法选取36只SPF级雄性C57BL/6小鼠并随机分为4组,每组9只。七氟烷组暴露于2%七氟烷2h,PD组腹腔注射MPTP20mg/kg,七氟烷预处理+P... 目的探讨七氟烷预处理对1-甲基-4苯基-1,2,3,4-四氢吡啶(MPTP)诱导的急性帕金森病(PD)小鼠的神经保护作用。方法选取36只SPF级雄性C57BL/6小鼠并随机分为4组,每组9只。七氟烷组暴露于2%七氟烷2h,PD组腹腔注射MPTP20mg/kg,七氟烷预处理+PD组预先暴露于2%七氟烷2h,复苏后于小鼠腹腔注射MPTP,对照组腹腔注射等剂量0.9%氯化钠溶液。比较4组行为学指标、黑质区酪氨酸羟化酶(TH)阳性神经元数量、脑组织炎症因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、氧化应激指标[丙二醛(MDA)、谷胱甘肽(GSH)]水平。结果PD组、七氟烷预处理+PD组悬挂试验掉落潜伏期均短于对照组、七氟烷组,悬挂试验评分低于对照组、七氟烷组,爬杆试验转向时间、总时间均长于对照组、七氟烷组,且七氟烷预处理+PD组悬挂试验掉落潜伏期长于PD组,悬挂试验评分高于PD组,爬杆试验转向时间、总时间均短于PD组,差异有统计学意义(P<0.05)。PD组、七氟烷预处理+PD组黑质区TH阳性神经元数量均少于对照组、七氟烷组,七氟烷预处理+PD组黑质区TH阳性神经元数量多于PD组,差异有统计学意义(P<0.05)。PD组、七氟烷预处理+PD组脑组织IL-1β、IL-6、TNF-α水平均高于对照组、七氟烷组,七氟烷预处理+PD组脑组织IL-1β、IL-6、TNF-α水平低于PD组,差异有统计学意义(P<0.05)。PD组、七氟烷预处理+PD组脑组织MDA水平均高于对照组、七氟烷组,GSH水平低于对照组、七氟烷组,且七氟烷预处理+PD组脑组织MDA水平低于PD组,GSH水平高于PD组,差异有统计学意义(P<0.05)。结论七氟烷预处理对MPTP诱导的急性PD模型小鼠具有保护作用,可改善运动功能,其作用机制可能与七氟烷预处理的抗炎、抗氧化应激相关。 展开更多
关键词 七氟烷 预处理 帕金森病 炎症反应 氧化应激
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血清miR-29b miR-320表达水平与烧伤患者增生性瘢痕组织炎性反应和氧化应激反应的关系
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作者 李庆华 肖雄木 +1 位作者 祖红旭 任永强 《临床心身疾病杂志》 CAS 2024年第4期36-41,共6页
目的探讨血清miR-29b、miR-320表达水平与烧伤患者增生性瘢痕组织炎性反应和氧化应激反应的关系。方法选取94例烧伤患者设为研究组,另选取同期42名健康体检者设为对照组。检测并比较两组受试者血清mi R-29b、miR-320表达水平,炎性反应指... 目的探讨血清miR-29b、miR-320表达水平与烧伤患者增生性瘢痕组织炎性反应和氧化应激反应的关系。方法选取94例烧伤患者设为研究组,另选取同期42名健康体检者设为对照组。检测并比较两组受试者血清mi R-29b、miR-320表达水平,炎性反应指标[肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]和氧化应激反应指标[超氧化物歧化酶(SOD)、丙二醛(MDA)],采用Pearson法分析研究组患者血清mi R-29b、miR-320表达水平与炎性反应和氧化应激反应指标关系。结果研究组患者血清miR-29b、miR-320、SOD表达水平均低于对照组(P<0.01),血清TNF-α、IL-6、MDA表达水平均高于对照组(P<0.01)。研究组患者血清miR-29b、miR-320表达水平分别与TNF-α、IL-6、MDA表达水平呈负相关,与SOD表达水平呈正相关(P<0.01)。结论烧伤患者血清miR-29b、miR-320呈低表达水平,且其表达水平与增生性瘢痕组织炎性反应和氧化应激反应具有相关性,mi R-29b、miR-320可能通过调控应激反应和炎性反应指标因子参与烧伤患者增生性瘢痕组织发生与进展。 展开更多
关键词 烧伤 增生性瘢痕组织 炎性反应 氧化应激 相关性
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地佐辛联合丙泊酚麻醉在胃癌根治术患者中的应用效果
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作者 董晓辉 王琦博 张轩宇 《中国民康医学》 2024年第8期51-53,57,共4页
目的:观察地佐辛联合丙泊酚麻醉在胃癌根治术患者中的应用效果。方法:选取2019年5月至2022年5月该院收治的92例胃癌根治术患者进行前瞻性研究,按照随机数字表法将其分为对照组与观察组各46例。对照组采用芬太尼联合丙泊酚麻醉,观察组采... 目的:观察地佐辛联合丙泊酚麻醉在胃癌根治术患者中的应用效果。方法:选取2019年5月至2022年5月该院收治的92例胃癌根治术患者进行前瞻性研究,按照随机数字表法将其分为对照组与观察组各46例。对照组采用芬太尼联合丙泊酚麻醉,观察组采用地佐辛联合丙泊酚麻醉,比较两组不同时间[麻醉诱导前(T_(0))、术后0.5 h(T_(1))、术毕(T_(2))]血流动力学指标[平均动脉压(MAP)、心率]水平,手术前后应激反应指标(皮质醇、促肾上腺皮质激素)水平、认知功能[简易精神状态检查量表(MMSE)]评分,以及不良反应发生率。结果:T_(0)、T_(1)、T_(2)时,两组MAP、心率呈先降低后升高的趋势,T_(0)、T_(2)时,两组MAP、心率水平比较,差异均无统计学意义(P>0.05);T_(1)时,观察组心率、MAP水平均高于对照组,差异有统计学意义(P<0.05);术后24 h,两组皮质醇、促肾上腺皮质激素水平均高于术前,但观察组低于对照组,差异有统计学意义(P<0.05);术后24 h,两组MMSE评分均低于术前,但观察组高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:地佐辛联合丙泊酚麻醉可提高胃癌根治术患者认知功能评分和血流动力学指标水平,降低应激反应指标水平和不良反应发生率,其效果优于芬太尼联合丙泊酚麻醉。 展开更多
关键词 胃癌根治术 丙泊酚 地佐辛 血流动力学 认知功能 应激反应 不良反应
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阶梯性镇痛在妇科腹腔镜术患者中的应用效果
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作者 苗杨 雷伟 +1 位作者 张金良 宫宏宇 《河南医学研究》 CAS 2024年第7期1228-1231,共4页
目的探讨阶梯性镇痛方案及加速康复外科理念对妇科腹腔镜术患者疼痛、应激反应及胃肠道反应的影响。方法选取2021年9月至2023年5月在郑州市妇幼保健院行妇科腹腔镜术的280例患者作为研究对象,依据镇痛护理方案分为研究组(阶梯性镇痛方... 目的探讨阶梯性镇痛方案及加速康复外科理念对妇科腹腔镜术患者疼痛、应激反应及胃肠道反应的影响。方法选取2021年9月至2023年5月在郑州市妇幼保健院行妇科腹腔镜术的280例患者作为研究对象,依据镇痛护理方案分为研究组(阶梯性镇痛方案和加速康复外科理念,120例)和对照组(传统术后镇痛方案和加速康复外科理念,160例)。比较两组术后12~48 h的疼痛数字评分(NRS)、5点口头评分法(VRS-5)、Ramasay镇静评分,以及胃肠道反应。结果NRS、VRS-5评分的时间因素、组间因素、时间因素与组间因素交互作用均有统计学意义(P<0.05);术后12~48 h研究组的NRS、VRS-5评分低于对照组(P<0.05)。Ramasay镇静评分的时间因素、组间因素、时间因素与组间因素交互作用均有统计学意义(P<0.05);术后12~48 h研究组的Ramasay镇静评分低于对照组(P<0.05)。研究组恶心、呕吐、瘙痒评分低于对照组(P<0.05)。结论阶梯性镇痛方案及加速康复外科理念应用于妇科腹腔镜术患者,可有效减轻术后疼痛、应激反应以及胃肠道反应。 展开更多
关键词 阶梯性镇痛 加速康复外科理念 妇科腹腔镜术 疼痛 应激反应 胃肠道反应
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基于ERAS理念的手术室护理模式在全髋关节置换术患者中的应用效果
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作者 李瑞 党杉 《临床医学研究与实践》 2024年第16期178-181,共4页
目的探讨基于加速康复外科(ERAS)理念的手术室护理模式在全髋关节置换术患者中的应用效果。方法选取2021年7月至2022年7月于本院接受诊治的80例全髋关节置换术患者作为研究对象,以随机数字表法将其分为对照组和观察组,各40例。对照组予... 目的探讨基于加速康复外科(ERAS)理念的手术室护理模式在全髋关节置换术患者中的应用效果。方法选取2021年7月至2022年7月于本院接受诊治的80例全髋关节置换术患者作为研究对象,以随机数字表法将其分为对照组和观察组,各40例。对照组予以常规手术室护理,观察组予以基于ERAS理念的手术室护理模式。比较两组的术后恢复指标、并发症发生情况、髋关节功能、疼痛程度以及应激反应指标。结果观察组的术后下地活动时间、首次排气时间、首次排便时间以及住院时间均短于对照组,并发症总发生率低于对照组(P<0.05)。护理后,观察组的Harris评分高于对照组,视觉模拟评分法(VAS)评分低于对照组(P<0.05)。护理后,两组的去甲肾上腺素(NE)、C反应蛋白(CRP)、皮质醇(Cor)水平均升高,但观察组低于对照组(P<0.05)。结论基于ERAS理念的手术室护理模式能明显降低全髋关节置换术患者术后疼痛感及应激反应,改善髋关节功能,促进康复,提升预后效果。 展开更多
关键词 全髋关节置换术 加速康复外科理念 手术室护理 髋关节功能 应激反应
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依帕司他联合常规药物治疗糖尿病肾病患者的效果
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作者 张申 《中国民康医学》 2024年第10期37-40,共4页
目的:观察依帕司他联合常规药物治疗糖尿病肾病患者的效果。方法:选取2021年1月至2023年1月该院收治的116例糖尿病肾病患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各58例。两组均进行基础治疗,在此基础上,对照组予以常... 目的:观察依帕司他联合常规药物治疗糖尿病肾病患者的效果。方法:选取2021年1月至2023年1月该院收治的116例糖尿病肾病患者进行前瞻性研究,按照随机数字表法将其分为研究组和对照组各58例。两组均进行基础治疗,在此基础上,对照组予以常规药物(吡格列酮+前列地尔)治疗,研究组在对照组基础上联合依帕司他治疗,两组均治疗3个月。比较两组临床疗效,治疗前后肾功能指标[血肌酐(Scr)、24 h尿蛋白定量(24h UP)、血尿素氮(BUN)]水平、炎性指标[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]水平,以及不良反应发生率。结果:研究组治疗总有效率为89.66%(52/58),高于对照组的75.86%(44/58),差异有统计学意义(P<0.05);治疗后,研究组Scr、BUN、24h UP水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组CRP、IL-6水平均低于对照组,差异有统计学意义(P<0.05);治疗后,研究组SOD水平高于对照组,MDA水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:依帕司他联合常规药物治疗糖尿病肾病患者可提高治疗总有效率,降低肾功能指标、炎性指标水平,改善氧化应激指标水平,效果优于单纯常规药物治疗。 展开更多
关键词 依帕司他 吡格列酮 前列地尔 糖尿病肾病 肾功能 氧化应激 不良反应
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采用miR-148a低表达人绒毛膜滋养细胞构建的子痫前期模型细胞活力、焦亡、炎性和氧化应激反应观察
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作者 郭艳萍 栾媛媛 +1 位作者 周巾 蒋天从 《山东医药》 CAS 2024年第18期1-5,共5页
目的观察采用微小RNA-148a(miR-148a)低表达人绒毛膜滋养细胞系HTR-8/SVneo构建的子痫前期(Preeclampsia,PE)模型细胞的细胞活力、焦亡、炎症和氧化应激反应。方法取对数生长期人绒毛膜滋养细胞系HTR-8/SVneo,分为甲、乙、丙、丁组:甲... 目的观察采用微小RNA-148a(miR-148a)低表达人绒毛膜滋养细胞系HTR-8/SVneo构建的子痫前期(Preeclampsia,PE)模型细胞的细胞活力、焦亡、炎症和氧化应激反应。方法取对数生长期人绒毛膜滋养细胞系HTR-8/SVneo,分为甲、乙、丙、丁组:甲组细胞用抑制miR-148a表达的miR-148a inhibitor转染24 h,加入100 ng/L的LPS培养24 h(建立PE模型);乙组细胞用空白对照NC-inhibitor转染24 h,加入100 ng/L的LPS培养24 h;丙组加入100 ng/L的LPS培养24 h;丁组不做任何处理。培养48 h时,采用qRT-PCR法检测各组细胞miR-148a,采用CCK8法检测各组细胞活力,采用TUNEL法测算各组细胞焦亡率,采用Western Blotting法检测各组细胞焦亡相关蛋白Caspase-1、GSDMD,采用ELISA法检测各组上清液炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)、IL-6]及氧化应激指标[谷胱甘肽过氧化物酶(GSH)、超氧化物歧化酶(SOD)、丙二醛(MDA)]。结果与丁组相比,丙组细胞miR-148a相对表达量高,培养24、48、72 h时OD值低,细胞焦亡率高,细胞Caspase-1、GSDMD蛋白相对表达量高(P均<0.05);与乙组相比,甲组细胞miR-148a相对表达量低,培养24、48、72 h时OD值高,细胞焦亡率低,细胞Caspase-1、GSDMD和NLRP3蛋白相对表达量低(P均<0.05)。与丁组相比,丙组细胞上清液TNF-α、IL-1β及IL-6水平高,细胞GSH和SOD表达降低、MDA表达升高(P均<0.05);与乙组相比,甲组细胞上清液TNF-α、IL-1β及IL-6水平低,细胞GSH和SOD表达升高、MDA表达降低(P均<0.05)。结论miR-148a低表达HTR-8/SVneo细胞构建的PE模型细胞活力高,细胞焦亡程度、炎性反应及氧化应激反应低。miR-148a可能是PE的治疗靶点之一。 展开更多
关键词 微小RNA 微小RNA-148a 子痫前期 人绒毛膜滋养细胞 细胞活力 细胞焦亡 炎性反应 氧化应激
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甲磺酸瑞马唑仑麻醉对腹腔镜子宫切除术患者炎症应激反应和认知功能的影响
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作者 徐天 马兰 《中国计划生育学杂志》 2024年第6期1283-1289,共7页
目的:探究甲磺酸瑞马唑仑麻醉对腹腔镜子宫切除术患者炎症应激反应和认知功能的影响。方法:纳入2021年8月-2023年1月本院收治拟行腹腔镜子宫切除术患者85例,信封法随机分为瑞马唑仑组(n=46例,甲磺酸瑞马唑仑麻醉)和丙泊酚组(n=39例,丙... 目的:探究甲磺酸瑞马唑仑麻醉对腹腔镜子宫切除术患者炎症应激反应和认知功能的影响。方法:纳入2021年8月-2023年1月本院收治拟行腹腔镜子宫切除术患者85例,信封法随机分为瑞马唑仑组(n=46例,甲磺酸瑞马唑仑麻醉)和丙泊酚组(n=39例,丙泊酚麻醉)。比较两组术前未麻醉时(T0)、麻醉后5 min(T1)、气管插管后10 min(T2)、拔管后即刻(T3)和手术结束前5 min时(T4)的血流动力学指标[心率(HR)、收缩压(SBP)和舒张压(DBP)],术前1 h和术后12 h炎症应激指标[白介素(IL-6)、C蛋白反应(CRP)、肿瘤坏死因子(TNF-α)、去甲肾上腺素(NE)水平],认知能力[蒙特利尔认知评估(MoCA)分数、简明精神状态(MMSE)评分]以及术后不良发生率。结果:瑞马唑仑组HR水平在T3(86.6±7.4次/min)、T4(78.6±6.2次/min)均低于丙泊酚组(94.1±7.0次/min、82.6±6.9次/min),SBP水平T3时(132.9±7.1mmHg)高于丙泊酚组(128.5±6.8mmHg),DBP在T3、T4时(78.6±6.8mmHg、80.3±8.3mmHg)高于丙泊酚组(85.6±6.0mmHg、85.7±8.8mmHg)(均P<0.05)。瑞马唑仑组术后12 h,IL-6、CRP、TNF-α和NE水平(92.87±13.75ng/L、15.61±2.99mg/L、7.42±1.96ng/ml、74.14±11.96ng/L)均低于丙泊酚组(121.81±13.99ng/L、18.79±3.67mg/L、8.76±2.17ng/ml、82.57±15.53ng/L),术后3 d MoCA(29.85±1.66分)和MMSE(29.46±1.11分)均高于丙泊酚组(28.92±1.36分、28.62±1.06分),不良反应发生率(19.6%)低于丙泊酚组(41.0%)(均P<0.05)。结论:腹腔镜子宫切除术应用甲磺酸瑞马唑仑麻醉对患者有稳定血流动力学、改善炎症应激负荷、保护认知的功效。 展开更多
关键词 腹腔镜子宫切除术 麻醉 甲磺酸瑞马唑仑 炎症应激 认知功能 不良反应
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