Under the constant amplitude and pro- grammed loading conditions the fatigued fracture surfaces of 2024-T3 sheet are examined by SEM and TEM.A corrected method,in which the effects of loading sequence are taken into a...Under the constant amplitude and pro- grammed loading conditions the fatigued fracture surfaces of 2024-T3 sheet are examined by SEM and TEM.A corrected method,in which the effects of loading sequence are taken into account,has been developed for the retrieval of effective stress spectrum.The parameters including d,a,C,n,R,α and σ_y are evaluated according to their influences on the retrieved results.Several computer programs have been produced for the fractographic quantita- tive analysis,and the application of image pro- cessing technique in the fractographic analysis is al- so interpreted.展开更多
The determination of structural dynamic stress spectrum distribution is of great signifi- cance in the structural fatigue strength evaluation as well as reliability design. In previous empirical data processing method...The determination of structural dynamic stress spectrum distribution is of great signifi- cance in the structural fatigue strength evaluation as well as reliability design. In previous empirical data processing methods, the data grouping and distribution fitting were excessively coarse and contained distinctive defects. This paper proposed an effective approach to statistically group actual measured dynamic stress data and validly extrapolate the combined distribution to fit the dynamic stress spectrum distribution. This approach has been verified its effectiveness through chi-square test, stress spectrum extrapolation and damage calculation in dynamic stress study.展开更多
It has been analyzed the influence of the tectonic ambient shear stress value on response spectrum based on the previous theory. Based on the prediction equation BJF94 presented by the famous American researchers, CLB...It has been analyzed the influence of the tectonic ambient shear stress value on response spectrum based on the previous theory. Based on the prediction equation BJF94 presented by the famous American researchers, CLB20, a new prediction formula is proposed by us, where it is introduced the influence of tectonic ambient shear stress value on response spectrum. BJF94 is the prediction equation, which mainly depends on strong ground motion data from western USA, while the prediction equation SEA99 is based on the strong ground motion data from exten-sional region all over the world. Comparing these two prediction equations in detail, it is found that after BJF94′s prediction value lg(Y) minus 0.16 logarithmic units, the value is very close to SEA99′s one. This case demonstrates that lg(Y) in extensional region is smaller; the differences of prediction equation are mainly owe to the differences of tectonic ambient shear stress value. If the factor of tectonic ambient shear stress value is included into the pre-diction equation, and the magnitude is used seismic moment magnitude to express, which is universal used around the world, and the distance is used the distance of fault project, which commonly used by many people, then re-gional differences of prediction equation will become much less, even vanish, and it can be constructed the uni-versal prediction equation proper to all over the world. The error in the earthquake-resistant design in China will be small if we directly use the results of response spectrum of USA (e.g. BJF94 or SEA99).展开更多
为探讨菊茎叶总黄酮(total flavonoids from stems and leaves of Chrysanthemum morifolium,TFCSL)抗氧化应激的活性成分,阐明其药效物质基础和作用机制。采用HPLC建立不同批次TFCSL指纹图谱;以高浓度葡萄糖诱导人脐静脉内皮细胞建立...为探讨菊茎叶总黄酮(total flavonoids from stems and leaves of Chrysanthemum morifolium,TFCSL)抗氧化应激的活性成分,阐明其药效物质基础和作用机制。采用HPLC建立不同批次TFCSL指纹图谱;以高浓度葡萄糖诱导人脐静脉内皮细胞建立氧化损伤模型,将丙二醛含量、乳酸脱氢酶含量和超氧化物歧化酶活性作为药效指标;采用灰色关联度和偏最小二乘法分析其谱-效关系确定抗氧化药效物质基础;基于网络药理学结合分子对接探究核心靶点及作用通路。从12批次TFCSL指纹图谱中确定12个共有峰,指认其中9个化学成分;各批次总黄酮样品均可减少细胞凋亡、降低丙二醛及乳酸脱氢酶含量、提高超氧化物歧化酶活性;综合2种数学模型确定峰5(芹菜素-7-O-β-D-葡萄糖苷)、峰6(异绿原酸C)、峰7(香叶木素-7-O-β-D-葡萄糖苷)为抗氧化物质基础;筛选出的3个活性成分作用于抗氧化应激的33个靶点;关键靶点为TNF、CASP3、EDNRA、XDH、PTGS2、MMP2,主要涉及脂质和动脉粥样硬化信号通路、IL-17信号通路、糖尿病并发症AGE-RAGE信号通路、TNF通路、MPKA通路等信号通路;分子对接结果显示活性成分与关键靶点之间均有较好的结合力。表明TFCSL抗氧化应激的物质基础可能为芹菜素-7-O-β-D-葡萄糖苷、异绿原酸C、香叶木素-7-O-β-D-葡萄糖苷,推测通过TNF、CASP3等靶点作用动脉粥样硬化信号通路、IL17信号通路发挥作用,体现菊茎叶多成分、多靶点抗氧化的作用特点。展开更多
针对阶梯块谱下的材料疲劳寿命预测问题,尤其是已有相关非线性模型的计算参数依赖大量试验数据或较难选取合适的基准值,导致在实际工程中应用有一定局限性。提出了一种新的基于相邻载荷的作用系数α_(i)=(S_(i+1)/S_(i))1/b lg K,该系...针对阶梯块谱下的材料疲劳寿命预测问题,尤其是已有相关非线性模型的计算参数依赖大量试验数据或较难选取合适的基准值,导致在实际工程中应用有一定局限性。提出了一种新的基于相邻载荷的作用系数α_(i)=(S_(i+1)/S_(i))1/b lg K,该系数中两个参数b、K来自材料疲劳寿命关系式S=KN^(-b)。结合前人的二级、三级、四级应力加载试验结果,分别计算并对比了与多种疲劳损伤模型的结果。结果表明,新模型在疲劳寿命/损伤的预测结果优于Miner模型、Manson模型、Subramanyan模型及Hashin模型,可更为准确地预测阶梯块谱下的疲劳寿命/损伤。展开更多
文摘Under the constant amplitude and pro- grammed loading conditions the fatigued fracture surfaces of 2024-T3 sheet are examined by SEM and TEM.A corrected method,in which the effects of loading sequence are taken into account,has been developed for the retrieval of effective stress spectrum.The parameters including d,a,C,n,R,α and σ_y are evaluated according to their influences on the retrieved results.Several computer programs have been produced for the fractographic quantita- tive analysis,and the application of image pro- cessing technique in the fractographic analysis is al- so interpreted.
基金supported by the National Natural Science Foundation of China (U1134201)
文摘The determination of structural dynamic stress spectrum distribution is of great signifi- cance in the structural fatigue strength evaluation as well as reliability design. In previous empirical data processing methods, the data grouping and distribution fitting were excessively coarse and contained distinctive defects. This paper proposed an effective approach to statistically group actual measured dynamic stress data and validly extrapolate the combined distribution to fit the dynamic stress spectrum distribution. This approach has been verified its effectiveness through chi-square test, stress spectrum extrapolation and damage calculation in dynamic stress study.
基金National Natural Science Foundation of China (49874010)
文摘It has been analyzed the influence of the tectonic ambient shear stress value on response spectrum based on the previous theory. Based on the prediction equation BJF94 presented by the famous American researchers, CLB20, a new prediction formula is proposed by us, where it is introduced the influence of tectonic ambient shear stress value on response spectrum. BJF94 is the prediction equation, which mainly depends on strong ground motion data from western USA, while the prediction equation SEA99 is based on the strong ground motion data from exten-sional region all over the world. Comparing these two prediction equations in detail, it is found that after BJF94′s prediction value lg(Y) minus 0.16 logarithmic units, the value is very close to SEA99′s one. This case demonstrates that lg(Y) in extensional region is smaller; the differences of prediction equation are mainly owe to the differences of tectonic ambient shear stress value. If the factor of tectonic ambient shear stress value is included into the pre-diction equation, and the magnitude is used seismic moment magnitude to express, which is universal used around the world, and the distance is used the distance of fault project, which commonly used by many people, then re-gional differences of prediction equation will become much less, even vanish, and it can be constructed the uni-versal prediction equation proper to all over the world. The error in the earthquake-resistant design in China will be small if we directly use the results of response spectrum of USA (e.g. BJF94 or SEA99).
文摘为探讨菊茎叶总黄酮(total flavonoids from stems and leaves of Chrysanthemum morifolium,TFCSL)抗氧化应激的活性成分,阐明其药效物质基础和作用机制。采用HPLC建立不同批次TFCSL指纹图谱;以高浓度葡萄糖诱导人脐静脉内皮细胞建立氧化损伤模型,将丙二醛含量、乳酸脱氢酶含量和超氧化物歧化酶活性作为药效指标;采用灰色关联度和偏最小二乘法分析其谱-效关系确定抗氧化药效物质基础;基于网络药理学结合分子对接探究核心靶点及作用通路。从12批次TFCSL指纹图谱中确定12个共有峰,指认其中9个化学成分;各批次总黄酮样品均可减少细胞凋亡、降低丙二醛及乳酸脱氢酶含量、提高超氧化物歧化酶活性;综合2种数学模型确定峰5(芹菜素-7-O-β-D-葡萄糖苷)、峰6(异绿原酸C)、峰7(香叶木素-7-O-β-D-葡萄糖苷)为抗氧化物质基础;筛选出的3个活性成分作用于抗氧化应激的33个靶点;关键靶点为TNF、CASP3、EDNRA、XDH、PTGS2、MMP2,主要涉及脂质和动脉粥样硬化信号通路、IL-17信号通路、糖尿病并发症AGE-RAGE信号通路、TNF通路、MPKA通路等信号通路;分子对接结果显示活性成分与关键靶点之间均有较好的结合力。表明TFCSL抗氧化应激的物质基础可能为芹菜素-7-O-β-D-葡萄糖苷、异绿原酸C、香叶木素-7-O-β-D-葡萄糖苷,推测通过TNF、CASP3等靶点作用动脉粥样硬化信号通路、IL17信号通路发挥作用,体现菊茎叶多成分、多靶点抗氧化的作用特点。
文摘针对阶梯块谱下的材料疲劳寿命预测问题,尤其是已有相关非线性模型的计算参数依赖大量试验数据或较难选取合适的基准值,导致在实际工程中应用有一定局限性。提出了一种新的基于相邻载荷的作用系数α_(i)=(S_(i+1)/S_(i))1/b lg K,该系数中两个参数b、K来自材料疲劳寿命关系式S=KN^(-b)。结合前人的二级、三级、四级应力加载试验结果,分别计算并对比了与多种疲劳损伤模型的结果。结果表明,新模型在疲劳寿命/损伤的预测结果优于Miner模型、Manson模型、Subramanyan模型及Hashin模型,可更为准确地预测阶梯块谱下的疲劳寿命/损伤。
