The androgen receptor （AR） plays an important role in the development and progression of prostate cancer （PCa）. Androgen deprivation therapy is initially effective in blocking tumor growth, but it eventually leads...The androgen receptor （AR） plays an important role in the development and progression of prostate cancer （PCa）. Androgen deprivation therapy is initially effective in blocking tumor growth, but it eventually leads to the hormonerefractory state. The detailed mechanisms of the conversion from androgen dependence to androgen independence remain unclear. Several PCa cell lines were established to study the role of AR in PCa, but the results were often inconsistent or contrasting in different cell lines, or in the same cell line grown under different conditions. The cellular and molecular alteration of epithelial cells and their microenvironments are complicated, and it is difficult to use a single cell line to address this important issue and also to study the pathophysiological effects of AR. In this paper, we summarize the different effects of AR on multiple cell lines and show the disadvantages of using a single human PCa cell line to study AR effects on PCa. We also discuss the advantages of widely used epithelium-stroma co-culture systems, xenograft mouse models, and genetically engineered PCa mouse models. The combination of in vitro cell line studies and in vivo mouse models might lead to more credible results and better strategies for the study of AR roles in PCa.展开更多
In recent years, university exchanges between China and Japan is more active, we can see that in the joint efforts of China and Japan, the scale of cooperation is expanding, understanding and friendship between the yo...In recent years, university exchanges between China and Japan is more active, we can see that in the joint efforts of China and Japan, the scale of cooperation is expanding, understanding and friendship between the young people are gradually deepened. The long- term stability of University conducted exchanges and cooperation in education with Japan is the concrete manifestation of China＇ s opening-up. Therefore, what＇ s the meaning of joint training of undergraduate education in universities？ This paper studies on ＂2 ＋ 2＂ program between our college and the west of the international University of Japan. We analysis the favorable and unfavorable factors in joint training programs, clarify the necessity and feasibility of acting joint training programs, and provide some reference for the development of our joint training program.展开更多
文摘The androgen receptor （AR） plays an important role in the development and progression of prostate cancer （PCa）. Androgen deprivation therapy is initially effective in blocking tumor growth, but it eventually leads to the hormonerefractory state. The detailed mechanisms of the conversion from androgen dependence to androgen independence remain unclear. Several PCa cell lines were established to study the role of AR in PCa, but the results were often inconsistent or contrasting in different cell lines, or in the same cell line grown under different conditions. The cellular and molecular alteration of epithelial cells and their microenvironments are complicated, and it is difficult to use a single cell line to address this important issue and also to study the pathophysiological effects of AR. In this paper, we summarize the different effects of AR on multiple cell lines and show the disadvantages of using a single human PCa cell line to study AR effects on PCa. We also discuss the advantages of widely used epithelium-stroma co-culture systems, xenograft mouse models, and genetically engineered PCa mouse models. The combination of in vitro cell line studies and in vivo mouse models might lead to more credible results and better strategies for the study of AR roles in PCa.
基金Acknowledgement This research was financially supported by the Xi＇an Social Science Foundation of Year 2015 （Grant NO. 15WL07）
文摘In recent years, university exchanges between China and Japan is more active, we can see that in the joint efforts of China and Japan, the scale of cooperation is expanding, understanding and friendship between the young people are gradually deepened. The long- term stability of University conducted exchanges and cooperation in education with Japan is the concrete manifestation of China＇ s opening-up. Therefore, what＇ s the meaning of joint training of undergraduate education in universities？ This paper studies on ＂2 ＋ 2＂ program between our college and the west of the international University of Japan. We analysis the favorable and unfavorable factors in joint training programs, clarify the necessity and feasibility of acting joint training programs, and provide some reference for the development of our joint training program.
