目的研究单次亚麻醉剂量艾司氯胺酮对全身麻醉下结直肠癌根治术患者术后早期情绪反应及恢复情况的影响。方法采用回顾性分析,选取2022年10月至2023年4月南京大学医学院附属鼓楼医院收治的120例全身麻醉下结直肠癌根治术患者为观察对象,...目的研究单次亚麻醉剂量艾司氯胺酮对全身麻醉下结直肠癌根治术患者术后早期情绪反应及恢复情况的影响。方法采用回顾性分析,选取2022年10月至2023年4月南京大学医学院附属鼓楼医院收治的120例全身麻醉下结直肠癌根治术患者为观察对象,按照麻醉方式不同分为研究组(n=60)与对照组(n=60)。研究组全身麻醉诱导之前给予0.3 mg/kg体重艾司氯胺酮一次性静脉推注,对照组正常麻醉;两组患者全身麻醉诱导、手术过程中麻醉维持、手术完成之后静脉镇痛药物及方式一致。比较两组患者手术前后焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分与术后(24、48 h)恢复质量评分量表(QOR40)评分、术后(1、3、6、18、24 h)视觉模拟评分法(VAS)评分、术后(24、48 h)改良警觉/镇静评分(MOAA/S)量表评分、术后苏醒时间、术后首次排气时间、术后下床时间及术后不良反应发生率。结果术后48 h,研究组患者SAS、SDS评分均明显低于术前,差异均有统计学意义(P<0.05);对照组手术前后SAS、SDS评分比较,差异均无统计学意义(P>0.05);研究组术后48 h SAS、SDS评分分别为(44.21±4.58)、(41.26±5.09)分,均低于对照组[(52.84±5.69)、(51.03±6.48)分],差异均有统计学意义(P<0.05)。研究组患者术后24、48 h QOR40评分分别为(142.51±4.86)、(150.84±5.73)分,均高于对照组[(134.06±5.17)、(142.49±5.52)分],差异均有统计学意义(P<0.05)。研究组患者术后1、3、6、18、24 h VAS评分分别为(2.49±0.74)、(2.27±0.68)、(2.11±0.64)、(1.97±0.63)、(1.86±0.65)分,均低于对照组[(2.97±0.81)、(2.71±0.75)、(2.58±0.69)、(2.47±0.65)、(2.33±0.67)分],差异均有统计学意义(P<0.05)。研究组患者术后24、48 h MOAA/S评分分别为(141.42±14.51)、(150.28±14.86)分,均低于对照组[(133.19±13.18)、(142.22±13.47)分],差异均有统计学意义(P<0.05)。研究组患者术后首次排气、下床时间分别为(39.01±4.73)、(33.31±4.57)h,均明显短于对照组[(43.86±5.25)、(37.65±5.19)h],差异均有统计学意义(P<0.05);两组患者术后苏醒时间比较,差异无统计学意义(P>0.05)。两组患者术后总不良反应发生率比较,差异无统计学意义(P>0.05)。结论单次亚麻醉剂量艾司氯胺酮用于全身麻醉下结直肠癌根治术麻醉可有效缓解患者情绪反应,提升术后早期镇痛、镇静效果,缓解疼痛程度,提高术后恢复质量及速度,且不良反应少。展开更多
The lethal dose LD<sub>50</sub> represents the most important experimental value for acute toxicity. The simple logarithmic calculation of -log<sub>10</sub> LD<sub>50</sub> = value ...The lethal dose LD<sub>50</sub> represents the most important experimental value for acute toxicity. The simple logarithmic calculation of -log<sub>10</sub> LD<sub>50</sub> = value leads to the possible poison power pLD. As with the pH or pK value, respectively, for acid or the scale of earthquake intensities the logarithm helps making large differences of orders of magnitude easier to understand since they are more comparable. The higher the pLD value, the higher is the power of poison. An increase of the pLD value by 1 stands for a tenfold increase in toxicity. The lethal acute dose for water, one of the most important and at the same time non-toxic substances of all, is about one tenth of the body weight. This leads to a possible pLD value for water of 1, an ideal starting value for a logarithmic poison scale.展开更多
Background: The PET/CT imaging studies have two doses components the dose from the PET radiopharmaceutical and the other from the low dose CT used for PET images attenuation correction. We have one PET/CT scanner at o...Background: The PET/CT imaging studies have two doses components the dose from the PET radiopharmaceutical and the other from the low dose CT used for PET images attenuation correction. We have one PET/CT scanner at our institution a Philips Time of Flight scanner. Our local patient’s radiation protection rules requires continuous assessment of radiation doses delivered to our patients. Purposes: The objectives of this study are to develop a weight- based facility DRLs for paediatric F-18-FDG PET-CT imaging for oncology in a large tertiary hospital and to determine whether the calculated DRLs compares with internationally published DRLs. Materials & Methods: Radiation dose data and patient demographics of two-hundreds and sixteen paediatric PET-CT oncology patients imaging procedures from one large tertiary hospital were selected and analysed in order to establish a facility paediatric DRLs. Statistical analysis was performed. Results: The PET dose reference levels ranged between [62 - 525] MBq of injected activity for a range of pediatric age groups. The CTDI<sub>vol</sub> values were between 3.5 and 16.5 mGy for all age groups. Comparison with current EANM and SNMMI recommendations of patient’s dose are discussed. Conclusion: Our pediatric PET/CT reference levels are higher than the ones reported internationally with notable variations. .展开更多
文摘目的研究单次亚麻醉剂量艾司氯胺酮对全身麻醉下结直肠癌根治术患者术后早期情绪反应及恢复情况的影响。方法采用回顾性分析,选取2022年10月至2023年4月南京大学医学院附属鼓楼医院收治的120例全身麻醉下结直肠癌根治术患者为观察对象,按照麻醉方式不同分为研究组(n=60)与对照组(n=60)。研究组全身麻醉诱导之前给予0.3 mg/kg体重艾司氯胺酮一次性静脉推注,对照组正常麻醉;两组患者全身麻醉诱导、手术过程中麻醉维持、手术完成之后静脉镇痛药物及方式一致。比较两组患者手术前后焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分与术后(24、48 h)恢复质量评分量表(QOR40)评分、术后(1、3、6、18、24 h)视觉模拟评分法(VAS)评分、术后(24、48 h)改良警觉/镇静评分(MOAA/S)量表评分、术后苏醒时间、术后首次排气时间、术后下床时间及术后不良反应发生率。结果术后48 h,研究组患者SAS、SDS评分均明显低于术前,差异均有统计学意义(P<0.05);对照组手术前后SAS、SDS评分比较,差异均无统计学意义(P>0.05);研究组术后48 h SAS、SDS评分分别为(44.21±4.58)、(41.26±5.09)分,均低于对照组[(52.84±5.69)、(51.03±6.48)分],差异均有统计学意义(P<0.05)。研究组患者术后24、48 h QOR40评分分别为(142.51±4.86)、(150.84±5.73)分,均高于对照组[(134.06±5.17)、(142.49±5.52)分],差异均有统计学意义(P<0.05)。研究组患者术后1、3、6、18、24 h VAS评分分别为(2.49±0.74)、(2.27±0.68)、(2.11±0.64)、(1.97±0.63)、(1.86±0.65)分,均低于对照组[(2.97±0.81)、(2.71±0.75)、(2.58±0.69)、(2.47±0.65)、(2.33±0.67)分],差异均有统计学意义(P<0.05)。研究组患者术后24、48 h MOAA/S评分分别为(141.42±14.51)、(150.28±14.86)分,均低于对照组[(133.19±13.18)、(142.22±13.47)分],差异均有统计学意义(P<0.05)。研究组患者术后首次排气、下床时间分别为(39.01±4.73)、(33.31±4.57)h,均明显短于对照组[(43.86±5.25)、(37.65±5.19)h],差异均有统计学意义(P<0.05);两组患者术后苏醒时间比较,差异无统计学意义(P>0.05)。两组患者术后总不良反应发生率比较,差异无统计学意义(P>0.05)。结论单次亚麻醉剂量艾司氯胺酮用于全身麻醉下结直肠癌根治术麻醉可有效缓解患者情绪反应,提升术后早期镇痛、镇静效果,缓解疼痛程度,提高术后恢复质量及速度,且不良反应少。
文摘The lethal dose LD<sub>50</sub> represents the most important experimental value for acute toxicity. The simple logarithmic calculation of -log<sub>10</sub> LD<sub>50</sub> = value leads to the possible poison power pLD. As with the pH or pK value, respectively, for acid or the scale of earthquake intensities the logarithm helps making large differences of orders of magnitude easier to understand since they are more comparable. The higher the pLD value, the higher is the power of poison. An increase of the pLD value by 1 stands for a tenfold increase in toxicity. The lethal acute dose for water, one of the most important and at the same time non-toxic substances of all, is about one tenth of the body weight. This leads to a possible pLD value for water of 1, an ideal starting value for a logarithmic poison scale.
文摘Background: The PET/CT imaging studies have two doses components the dose from the PET radiopharmaceutical and the other from the low dose CT used for PET images attenuation correction. We have one PET/CT scanner at our institution a Philips Time of Flight scanner. Our local patient’s radiation protection rules requires continuous assessment of radiation doses delivered to our patients. Purposes: The objectives of this study are to develop a weight- based facility DRLs for paediatric F-18-FDG PET-CT imaging for oncology in a large tertiary hospital and to determine whether the calculated DRLs compares with internationally published DRLs. Materials & Methods: Radiation dose data and patient demographics of two-hundreds and sixteen paediatric PET-CT oncology patients imaging procedures from one large tertiary hospital were selected and analysed in order to establish a facility paediatric DRLs. Statistical analysis was performed. Results: The PET dose reference levels ranged between [62 - 525] MBq of injected activity for a range of pediatric age groups. The CTDI<sub>vol</sub> values were between 3.5 and 16.5 mGy for all age groups. Comparison with current EANM and SNMMI recommendations of patient’s dose are discussed. Conclusion: Our pediatric PET/CT reference levels are higher than the ones reported internationally with notable variations. .
