AIM:To evaluate the effects of antiglaucoma eye drops on corneal nerves by in vivo confocal microscopy(IVCM).METHODS:This study comprised 79 patients diagnosed with glaucoma and 16 healthy control individuals.Among th...AIM:To evaluate the effects of antiglaucoma eye drops on corneal nerves by in vivo confocal microscopy(IVCM).METHODS:This study comprised 79 patients diagnosed with glaucoma and 16 healthy control individuals.Among the glaucoma patients,54 were treated with medication,while 25 remained untreated.Central corneal images were evaluated by IVCM,and then ACCMetrics was used to calculate the following parameters:corneal nerve fiber density(CNFD),branch density(CNBD),fiber length(CNFL),total branch density(CTBD),fiber area(CNFA),fiber width(CNFW),and fractal dimension(CNFrD).The correlation between IVCM parameters and drugs was evaluated using non-parametric measurements of Spearman’s rank correlation coefficient.RESULTS:The CNFD was reduced in glaucoma groups compared to healthy subjects(P<0.01).Patients using anti-glaucoma medications exhibited poorer confocal parameters compared to untreated patients.As the number of medications and usage count increased,CNFD,CNBD,CNFL,CTBD,CNFA,and CNFrD experienced a decline,while CNFW increased(all P<0.01).For the brinzolamide-therapy group,there was a significant decrease in CNFD and CNFL compared to the other monotherapy groups(P<0.001).In the absence of medication,CNFD in males was lower than that in females(P<0.05).Among patients under medication therapy,CNFD remained consistent between males and females.CONCLUSION:Antiglaucoma eye drops affect the microstructure of corneal nerves.IVCM and ACCMetrics are useful tools that could be used to evaluate the corneal nerve changes.展开更多
Parkinson's disease(PD)is a chronic,progressive neurodegenerative disease affecting about 2%-3% of population above the age of 65.In recent years,Parkinson's research has mainly focused on motor and non-motor ...Parkinson's disease(PD)is a chronic,progressive neurodegenerative disease affecting about 2%-3% of population above the age of 65.In recent years,Parkinson's research has mainly focused on motor and non-motor symptoms while there are limited studies on neurodegeneration which is associated with balance problems and increased incidence of falls.Corneal confocal microscopy(CCM)is a real-time,non-invasive,in vivo ophthalmic imaging technique for quantifying nerve damage in peripheral neuropathies and central neurodegenerative disorders.CCM has shown significantly lower corneal nerve fiber density(CNFD)in patients with PD compared to healthy controls.Reduced CNFD is associated with decreased intraepidermal nerve fiber density in PD.This review provides an overview of the ability of CCM to detect nerve damage associated with PD.展开更多
AIMTo evaluate the possible relationship of optic disc area with retina nerve fiber layer in different glaucoma subtypes.METHODSOne eye each was chosen from 45 patients with ocular hypertension, 45 patients with prima...AIMTo evaluate the possible relationship of optic disc area with retina nerve fiber layer in different glaucoma subtypes.METHODSOne eye each was chosen from 45 patients with ocular hypertension, 45 patients with primary open angle glaucoma, 45 patients with pseudoexfoliation glaucoma and 45 healthy controls followed in our hospital. The records of the patients were reviewed retrospectively. Optic disc area and circumpapillary retina nerve fiber layer measurements were obtained using optical coherence tomography. Central corneal thickness was measured by ultrasound pachymetry.RESULTSThe median disc area in the patients with primary open angle glaucoma was significantly higher than the patients with ocular hypertension (2.19 vs 1.90 mm<sup>2</sup>, P=0.030). The median retina nerve fiber layer was thinner in the patients with primary open angle glaucoma and pseudoexfoliation glaucoma than the patients with ocular hypertension for superior, inferior and temporal quadrants. After adjustment for age, no difference in central corneal thickness was found between the groups. Greater disc area was associated with thicker retinal nerve fiber layer for superior, inferior and nasal quadrants in the patients with primary open angle glaucoma. There was no correlation between disc area and central corneal thickness measurements of the groups.CONCLUSIONDisc size affects the retinal nerve fiber layer thickness in eyes with primary open angle glaucoma and is a possible risk factor for glaucomatous optic nerve damage.展开更多
目的通过角膜中央厚度分组,观察正常眼和高眼压患者的角膜厚度和视网膜神经纤维层(RNFL)厚度之间的关系,并通过相干光断层扫描成像(OCT)和偏振激光扫描仪联合个体化角膜补偿技术(GDx-VCC)检查高眼压患者是否存在RNFL的异常,并分析OCT和G...目的通过角膜中央厚度分组,观察正常眼和高眼压患者的角膜厚度和视网膜神经纤维层(RNFL)厚度之间的关系,并通过相干光断层扫描成像(OCT)和偏振激光扫描仪联合个体化角膜补偿技术(GDx-VCC)检查高眼压患者是否存在RNFL的异常,并分析OCT和GDx-VCC测得的RNFL厚度之间的相关性。方法对眼压高于21 mm Hg(1 mm Hg=0.133 kPa)的患者测量其中央角膜厚度(CCT),根据CCT值对眼压进行校正。OCTOPUS-101自动视野仪检查及视盘观察入选高眼压组患者180只眼,均予OCT、GDx-VCC测量视盘一周视网膜神经纤维层厚度,另设正常人180只眼作为对照,获得数据进行统计学分析。结果高眼压患者的平均CCT为(536.14±35.99)(433～609)μm,正常组患者的平均CCT为(516.68±38.27)(368～598)μm。根据平均中央角膜厚度555μm分组,组间平均视网膜神经纤维层厚度(Average RNFL)、上方(S)、下方(I)的RNFL厚度以及其它参数有显著性差异,高眼压组CCT≤555μm的患者平均视网膜神经纤维层厚度要低于CCT>555μm的患者。结论高眼压患者RNFL厚度GDx-VCC与OCT的检测值低于正常人。高眼压组CCT与平均视网膜神经纤维层厚度正相关。GDx-VCC与OCT有着较好的一致性。展开更多
基金Supported by the National Natural Science Foundation of China(No.82371058)the Natural Science Foundation of Shandong Province(No.ZR2020MH172)+2 种基金the Ophthalmology New Technology Incubation Fund Program(Ophthalmology Incubation Fund Phase II Project[2022]No.[005])Medicine Science and Technology Development Program of Shandong Province(No.202107020108)Qingdao Science and Technology Beneficiary Program(No.24-1-8-smjk-16-nsh).
文摘AIM:To evaluate the effects of antiglaucoma eye drops on corneal nerves by in vivo confocal microscopy(IVCM).METHODS:This study comprised 79 patients diagnosed with glaucoma and 16 healthy control individuals.Among the glaucoma patients,54 were treated with medication,while 25 remained untreated.Central corneal images were evaluated by IVCM,and then ACCMetrics was used to calculate the following parameters:corneal nerve fiber density(CNFD),branch density(CNBD),fiber length(CNFL),total branch density(CTBD),fiber area(CNFA),fiber width(CNFW),and fractal dimension(CNFrD).The correlation between IVCM parameters and drugs was evaluated using non-parametric measurements of Spearman’s rank correlation coefficient.RESULTS:The CNFD was reduced in glaucoma groups compared to healthy subjects(P<0.01).Patients using anti-glaucoma medications exhibited poorer confocal parameters compared to untreated patients.As the number of medications and usage count increased,CNFD,CNBD,CNFL,CTBD,CNFA,and CNFrD experienced a decline,while CNFW increased(all P<0.01).For the brinzolamide-therapy group,there was a significant decrease in CNFD and CNFL compared to the other monotherapy groups(P<0.001).In the absence of medication,CNFD in males was lower than that in females(P<0.05).Among patients under medication therapy,CNFD remained consistent between males and females.CONCLUSION:Antiglaucoma eye drops affect the microstructure of corneal nerves.IVCM and ACCMetrics are useful tools that could be used to evaluate the corneal nerve changes.
基金This study was supported by Henan Medical Science and Technology Project(201503153)Talent project of Henan Provincial People's Hospital(23456-4).
文摘Parkinson's disease(PD)is a chronic,progressive neurodegenerative disease affecting about 2%-3% of population above the age of 65.In recent years,Parkinson's research has mainly focused on motor and non-motor symptoms while there are limited studies on neurodegeneration which is associated with balance problems and increased incidence of falls.Corneal confocal microscopy(CCM)is a real-time,non-invasive,in vivo ophthalmic imaging technique for quantifying nerve damage in peripheral neuropathies and central neurodegenerative disorders.CCM has shown significantly lower corneal nerve fiber density(CNFD)in patients with PD compared to healthy controls.Reduced CNFD is associated with decreased intraepidermal nerve fiber density in PD.This review provides an overview of the ability of CCM to detect nerve damage associated with PD.
文摘AIMTo evaluate the possible relationship of optic disc area with retina nerve fiber layer in different glaucoma subtypes.METHODSOne eye each was chosen from 45 patients with ocular hypertension, 45 patients with primary open angle glaucoma, 45 patients with pseudoexfoliation glaucoma and 45 healthy controls followed in our hospital. The records of the patients were reviewed retrospectively. Optic disc area and circumpapillary retina nerve fiber layer measurements were obtained using optical coherence tomography. Central corneal thickness was measured by ultrasound pachymetry.RESULTSThe median disc area in the patients with primary open angle glaucoma was significantly higher than the patients with ocular hypertension (2.19 vs 1.90 mm<sup>2</sup>, P=0.030). The median retina nerve fiber layer was thinner in the patients with primary open angle glaucoma and pseudoexfoliation glaucoma than the patients with ocular hypertension for superior, inferior and temporal quadrants. After adjustment for age, no difference in central corneal thickness was found between the groups. Greater disc area was associated with thicker retinal nerve fiber layer for superior, inferior and nasal quadrants in the patients with primary open angle glaucoma. There was no correlation between disc area and central corneal thickness measurements of the groups.CONCLUSIONDisc size affects the retinal nerve fiber layer thickness in eyes with primary open angle glaucoma and is a possible risk factor for glaucomatous optic nerve damage.
文摘目的通过角膜中央厚度分组,观察正常眼和高眼压患者的角膜厚度和视网膜神经纤维层(RNFL)厚度之间的关系,并通过相干光断层扫描成像(OCT)和偏振激光扫描仪联合个体化角膜补偿技术(GDx-VCC)检查高眼压患者是否存在RNFL的异常,并分析OCT和GDx-VCC测得的RNFL厚度之间的相关性。方法对眼压高于21 mm Hg(1 mm Hg=0.133 kPa)的患者测量其中央角膜厚度(CCT),根据CCT值对眼压进行校正。OCTOPUS-101自动视野仪检查及视盘观察入选高眼压组患者180只眼,均予OCT、GDx-VCC测量视盘一周视网膜神经纤维层厚度,另设正常人180只眼作为对照,获得数据进行统计学分析。结果高眼压患者的平均CCT为(536.14±35.99)(433～609)μm,正常组患者的平均CCT为(516.68±38.27)(368～598)μm。根据平均中央角膜厚度555μm分组,组间平均视网膜神经纤维层厚度(Average RNFL)、上方(S)、下方(I)的RNFL厚度以及其它参数有显著性差异,高眼压组CCT≤555μm的患者平均视网膜神经纤维层厚度要低于CCT>555μm的患者。结论高眼压患者RNFL厚度GDx-VCC与OCT的检测值低于正常人。高眼压组CCT与平均视网膜神经纤维层厚度正相关。GDx-VCC与OCT有着较好的一致性。
