In this paper, we obtain a distortion theorem of Jacobian matrix for biholomorphic subclasses of starlike mappings along a unit direction on the unit polydisc. These results extend the classical distortion theorem of ...In this paper, we obtain a distortion theorem of Jacobian matrix for biholomorphic subclasses of starlike mappings along a unit direction on the unit polydisc. These results extend the classical distortion theorem of starlike mappings to higher dimensions. We then give an upper bound estimate for biholomorphic subclasses of starlike mappings along a unit direction in a complex Banach space.展开更多
In this paper,We mainly discuss some subclasses of analytic functions for operators onac, and determine a representation formula and sufficient condition for the class 4;(a.p,r,E,7) and prove a sufficient and necessar...In this paper,We mainly discuss some subclasses of analytic functions for operators onac, and determine a representation formula and sufficient condition for the class 4;(a.p,r,E,7) and prove a sufficient and necessary condition.coefficient estimates and distortiontheorem for the subclass O;o (a,p,Y,e,9) of the class ac;(a,p,y,c,V).Furthermore,the analogues also are true for operators on Hilbert space.展开更多
Background: Various genetic technologies have been employed in the identification of genomic complexity and refinement of prognostic classification of clinically heterogeneous disease of chronic lymphocytic leukemia (...Background: Various genetic technologies have been employed in the identification of genomic complexity and refinement of prognostic classification of clinically heterogeneous disease of chronic lymphocytic leukemia (CLL). Objective: The present study of interphase cytogenetics and conventional karyotyping was undertaken to perform comprehensive analysis of CLL genetics with an approach to refine early prognostication of disease. Material & Methods: Retrospective analysis by fluorescence in situ hybridization (FISH) was carried out on total 671 patients of CLL at diagnosis between 2008 and 2015. Conventional cytogenetics studies were performed in 50 of 671 patients using CPG Oligonucleotide + IL-2 and TPA (12-O-Tetradecanyl Phorbol 13-acetate) for stimulation of lymphocytes cultures. Results: Interphase cytogenetics could detect recurrent abnormalities such as del(13q14), +12, del(17p13), del(11q22), del(6q23) in 71% of cases. The incidence of del(13q) was higher in Rai stage 0, I, II (p = 0.0005);whereas patients with ≥2 aberrations were more common in advance stage III, IV (p = 0.001). Frequency of IgH translocation was 7%. Morphology and immunophenotypic analysis revealed atypical CLL with higher frequency of t(14;19) than t(14;18). Conventional karyotype could detect abnormal karyotype in 97% of cases which displayed targeted FISH abnormalities along with additional non-targeted chromosomal abnormalities. Patients with negative FISH markers showed clonal non-recurrent numerical and structural changes. The complex karyotype was identified in 24% cases which included targeted FISH aberrations as well as non-targeted numerical and structural abnormalities like deletions, and unbalanced translocations. A significant association was observed between complex karyotype and coexistence of ≥2 FISH markers (p = 0.009) and del(11q22) &/or del(17p) (p = 0.03). Conclusion: Our data of interphase FISH with integration of conventional karyotyping revealed genomic complexity that helped identification of biological subclasses with clinical impact at diagnosis. Further, these cytogenetic subclasses along with molecular markers are likely to evolve more refined prognostic groups, which will help design risk-adapted therapies in B-CLL.展开更多
Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f(z) be a normalized locally biholomorphic mapping on Ω such that Jf^-1 (z...Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f(z) be a normalized locally biholomorphic mapping on Ω such that Jf^-1 (z) f(z) ∈Mg and z = 0 is the zero of order k+1 of f(z) - z. We obtain the growth and covering theorems for f(z). Especially, as corollaries, we unify and generalize many known results. Moreover, in view of proofs of corollaries, the essential relations among the subclasses of starlike mappings are shown.展开更多
Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of...Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of cervical lesions.Methods:The expressions of IgG subclasses in 32 cases of human papillomavirus(HPV) infection,30 cervical intraepithelial neoplasia(CIN I),43 CIN Ⅱ-Ⅲ,and 24 hysteromyoma and chronic cervicitis were examined by ELISA.Results:The absorbance values of HPV16VLPs-IgG,IgG1 increased with the grade of CIN(P < 0.05).The IgG2 dominance(IgG2/IgG1 ratio > 1) from control group was 100%,87.50% for HPV infection group,75% for CIN I group,compared with that from CIN Ⅱ-Ⅲ patients(9.52%)(P < 0.05).The positive rates and absorbance values of HPV16VLPs-IgG,IgG1 and IgG2 from HPV16-DNA positive group were significantly higher than those from non-HPV16-DNA positive group(P < 0.05).There was a moderate correlation between the HPV16-DNA testing and detection of HPV16VLPs-IgG(r = 0.531,P < 0.05).Conclusion:An increase of the expressions of HPV16VLPs-IgG and its subclasses in the serum of the patients with cervical precancerous lesions,especially those with CIN II-III,might be associated with duration of HPV infection and severity of cervical lesions.An increase of the IgG2 dominance(IgG2/IgG1 > 1) in serum from low grade cervical lesions group and normal control group,might indicate the clearance of HPV infection and the regression of cervical lesions.展开更多
The issue of document management has been raised for a long time, especially with the appearance of office automation in the 1980s, which led to dematerialization and Electronic Document Management (EDM). In the same ...The issue of document management has been raised for a long time, especially with the appearance of office automation in the 1980s, which led to dematerialization and Electronic Document Management (EDM). In the same period, workflow management has experienced significant development, but has become more focused on the industry. However, it seems to us that document workflows have not had the same interest for the scientific community. But nowadays, the emergence and supremacy of the Internet in electronic exchanges are leading to a massive dematerialization of documents;which requires a conceptual reconsideration of the organizational framework for the processing of said documents in both public and private administrations. This problem seems open to us and deserves the interest of the scientific community. Indeed, EDM has mainly focused on the storage (referencing) and circulation of documents (traceability). It paid little attention to the overall behavior of the system in processing documents. The purpose of our researches is to model document processing systems. In the previous works, we proposed a general model and its specialization in the case of small documents (any document processed by a single person at a time during its processing life cycle), which represent 70% of documents processed by administrations, according to our study. In this contribution, we extend the model for processing small documents to the case where they are managed in a system comprising document classes organized in subclasses;which is the case for most administrations. We have thus observed that this model is a Markovian <i>M<sup>L×K</sup>/M<sup>L×K</sup>/</i>1 queues network. We have analyzed the constraints of this model and deduced certain characteristics and metrics. <span style="white-space:normal;"><i></i></span><i>In fine<span style="white-space:normal;"></span></i>, the ultimate objective of our work is to design a document workflow management system, integrating a component of global behavior prediction.展开更多
A general theorem on the limiting distribution of the generalized t-distribution is obtained,many applications of this theorem to some subclasses of elliptically contoured distributions in cluding multivariate normal ...A general theorem on the limiting distribution of the generalized t-distribution is obtained,many applications of this theorem to some subclasses of elliptically contoured distributions in cluding multivariate normal and multivariate t distributions are discussed.Further,their limiting distributions by density function are derived.展开更多
Objective To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA) Methods IgG subclasses were tested in 40 patients with idiopathic or secondary A...Objective To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA) Methods IgG subclasses were tested in 40 patients with idiopathic or secondary AIHA by Coombs test with monoclonal antibodies Hb, TBil, RC and FHb, as hemolytic parameters, were used to analyze the clinical implications of subclasses of AIHA warm autoantibody IgG Results In most patients IgG incomplete warm autoantibody was IgG1(27 patients), but IgG3(20 patients), rarely IgG2(14 patients) and IgG4(9 patients) also occurred Three groups were analyzed: Group A included 20 patients with IgG3; Group B included 14 patients with IgG1 but without IgG3; Group C included 6 patients without IgG1 and IgG3 There were significant differences ( P <0 01) between groups in Hb, TBil, RC and FHb Moreover, we also found that the sensitivity of Coombs test with polyclonal antiserums was 90 0%, while that of Coombs test with monoclonal antibodies was 97 5% The effect of treatment was worst in patients with positive IgG3 autoantibody, whose hemolysis recurred frequently Conclusion IgG3 autoantibody was the most effective in bringing about red cell destruction, IgG1 autoantibody was less effective, IgG2 even less, whereas IgG4 autoantibody was shown to hardly affect red cell survival Coombs test with monoclonal antibodies was more sensitive than that with polyclonal antiserums Patients’ respondence to treatment correlated with the type of IgG subclasses展开更多
AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH features.METHODS:Liver needle biopsies of 41 PBC with AIH fe...AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH features.METHODS:Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were examined.The activity of periportal and lobular inflammation was scored0(none or minimal activity)to 4(severe),and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored 0-3.The infiltration of mononuclear cells positive for CD20,CD38,CD3,CD4,and CD8 and positive for immunoglobulins(IgG,IgM,and IgA)at the periportal areas(interface hepatitis)and in the hepatic lobules(lobular hepatitis)were semiquantitatively scored in immunostained liver sections(score 0-6).Serum aspartate aminotransferase(AST),immunoglobulins,and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual lesions.RESULTS:Lobular hepatitis,hepatitic rosette formation,and emperipolesis were more extensive and frequent in AIH than in PBC.CD3+,CD4+,and CD8+cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in PBC.The degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC,but to a lesser degree in AIH.CD20+cells were mainly found in the portal tracts and,occasionally,at the interface in both diseases.Elevated AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration,specifically CD38+cells in PBC.No correlation existed between autoantibodies and inflammatory cell infiltration in PBC or AIH.While most AIH cases were IgG-predominant at the interface,PBC cases were divided into IgM-predominant,IgM/IgGequal,and IgG-predominant types,with the latter sharing several features with AIH.CONCLUSION:These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with interface hepatitis may not be identical.展开更多
Let K be the familiar class of normalized convex functions in the unit disk.In[14],Keogh and Merkes proved that for a function f(z)=z+∑k=2∞a k z k in the class K,|a 3−λa 22|≤max{13,|λ−1|},λ∈C.The above estimate...Let K be the familiar class of normalized convex functions in the unit disk.In[14],Keogh and Merkes proved that for a function f(z)=z+∑k=2∞a k z k in the class K,|a 3−λa 22|≤max{13,|λ−1|},λ∈C.The above estimate is sharp for eachλ.In this article,we establish the corresponding inequality for a normalized convex function f on U such that z=0 is a zero of order k+1 of f(z)−z,and then we extend this result to higher dimensions.These results generalize some known results.展开更多
Objective Hyperspectral remote sensing has attracted much attention in remote sensing research during recent years. It can elaborately identiry spectral characteristics of different objects by acquiring continuous sp...Objective Hyperspectral remote sensing has attracted much attention in remote sensing research during recent years. It can elaborately identiry spectral characteristics of different objects by acquiring continuous spectral curves of ground objects, and can thus provide more information for geological research (Zhao Yingjun et al., 2015). With the deepening hyperspectral remote sensing research, scholars have focused from the classification of alteration minerals to the identification of subclass minerals in order to explore their significance fbr ore prospecting. This work utilized hyperspectral remote sensing technology in the Xitan region of Gansu Province to identify limonite and two types of sericite subclass minerals, and conducted field verification and geochemical survey. In addition, we analyzed the geological environment of subclass sericite minerals (Van Ruitenbeek et al., 2006) to provide evidence for gold ore prospecting.展开更多
Let S~* be the familiar class of normalized univalent functions in the unit disk.In [9], Keogh and Merkes proved that for a function f(z) = z +∑k=2∞ a_kz^k in the class S~*,then |a_3-λa_2~2| ≤ max{1, |3-4λ|}, λ...Let S~* be the familiar class of normalized univalent functions in the unit disk.In [9], Keogh and Merkes proved that for a function f(z) = z +∑k=2∞ a_kz^k in the class S~*,then |a_3-λa_2~2| ≤ max{1, |3-4λ|}, λ∈ C. In this article, we investigate the corresponding problem for the subclass of starlike mappings defined on the unit ball in a complex Banach space, on the unit polydisk in Cnand the bounded starlike circular domain in C~■, respectively.展开更多
The pneumococcal septic arthritis is uncommon in healthy adults. In most cases, it occurs in patients with immune deficiency. Its exceptional location at the wrist can maintain doubt with rheumatic causes which are mo...The pneumococcal septic arthritis is uncommon in healthy adults. In most cases, it occurs in patients with immune deficiency. Its exceptional location at the wrist can maintain doubt with rheumatic causes which are more frequent. IgG4 deficiency found in this patient was the only cause that could be impugned. We report the case of a young woman of 46 years without any evident cause of immunodeficiency and any particular risk factor, managed for septic arthritis of the wrist due to Streptococcus pneumoniae. This case without any apparent risk factors demonstrates that pneumococcal infection in a more distant articulation of the ENT is still possible. Scan has been a very significant contribution in confirming the positive diagnosis that leads to surgical drainage. The approach of the systematic search for the gateway must be done. In the study of the patient’s immune status, the realization of the protein profile could be interesting and then guide the practitioner in the decision to vaccinate the patient against Streptococcus pneumoniae if he was not. We recommend looking always for a cause of immunodeficiency including primary Ig defiencies even among adult.展开更多
Inactivated coronavirus disease 2019(COVID-19)vaccines such as CoronaVac and BBIBP-CorV have been widely used in China.However,more investigation is still needed to understand antibodies'duration and effectiveness...Inactivated coronavirus disease 2019(COVID-19)vaccines such as CoronaVac and BBIBP-CorV have been widely used in China.However,more investigation is still needed to understand antibodies'duration and effectiveness against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants in the real world.In this study,575 participants who had been vaccinated with two or three doses of the inactivated vaccine were recruited.Serum samples were collected and tested for anti-spike IgG and neutralizing antibodies against SARS-CoV-2(original strain,Dela,and Omicron).Unsurprisingly,a third dose of the vaccine significantly enhanced antibody responses against SARS-CoV-2 and its variants.However,despite a booster dose,the neutralizing antibody levels against Omicron,particularly the BA.5.2 subvariant,remained low.There was no sex bias,but an age bias was observed.Notably,the predominant IgG subclass antibodies were IgG1 and IgG2,with a much lower level of IgG4.After the booster shot,the ratio of IgG4 to IgG1 significantly increased.The observation of IgG1 to the IgG4 class switch after repeated inactivated vaccinations underscores the importance of continuous monitoring of subclass antibody responses.Further clinical investigations are required to understand the implications of this class switch for optimizing immunization strategies.展开更多
Accurate high-resolution maps of oil palm plantations underpin effective management of environmental and socio-economic impacts at global,regional,and national levels.However,young industrial and highly irregular smal...Accurate high-resolution maps of oil palm plantations underpin effective management of environmental and socio-economic impacts at global,regional,and national levels.However,young industrial and highly irregular small-holder plantations are mostly unmapped and not included in official FAO statistics.This issue is addressed here by discriminating global oil palm plantation in 2020 into four subclasses:Industrial Mature Oil Palm(IMOP);Industrial Young Oil Palm(IYOP);Smallholder Mature Oil Palm(SMOP);and Smallholder Young Oil Palm(SYOP).Data,resolved to 4.77 m,from Planet&NICFI,Sentinel-1/2,were combined with other layers using the image-oriented classification and regression tree(CART)algorithm which performed best in classification tests.Results show that SMOP dominates distributional extent,but it was also the most accurately mapped subclass typically found at 500–1000 m altitude.IMOP had the most extensive altitude range of 500–1300 m,while IYOP and SYOP were found at similar altitudes of 500–800 m and 500–900 m respectively.Recent developments in South East Asia show oil palm plantations expanding into new areas with a slope of 24 degrees.Results provide data to support Sustainable Development Goal by assisting future oil palm-related development planning and monitoring in the world’s major oil palm-growing countries.展开更多
In this paper, we establish the Fekete and Szego inequality for a class of holomorphic functions in the unit disk, and then we extend this result to a class of holomorphic mappings on the unit ball in a complex Banach...In this paper, we establish the Fekete and Szego inequality for a class of holomorphic functions in the unit disk, and then we extend this result to a class of holomorphic mappings on the unit ball in a complex Banach space or on the unit polydisk in Cn.展开更多
基金supported by NSF of Zhejiang Province(D7080080, Y6090036, Y6090694, Y6100219)the National Natural Science Foundation of China (10971063,11001246, 11031008, 11101139)
文摘In this paper, we obtain a distortion theorem of Jacobian matrix for biholomorphic subclasses of starlike mappings along a unit direction on the unit polydisc. These results extend the classical distortion theorem of starlike mappings to higher dimensions. We then give an upper bound estimate for biholomorphic subclasses of starlike mappings along a unit direction in a complex Banach space.
文摘In this paper,We mainly discuss some subclasses of analytic functions for operators onac, and determine a representation formula and sufficient condition for the class 4;(a.p,r,E,7) and prove a sufficient and necessary condition.coefficient estimates and distortiontheorem for the subclass O;o (a,p,Y,e,9) of the class ac;(a,p,y,c,V).Furthermore,the analogues also are true for operators on Hilbert space.
文摘Background: Various genetic technologies have been employed in the identification of genomic complexity and refinement of prognostic classification of clinically heterogeneous disease of chronic lymphocytic leukemia (CLL). Objective: The present study of interphase cytogenetics and conventional karyotyping was undertaken to perform comprehensive analysis of CLL genetics with an approach to refine early prognostication of disease. Material & Methods: Retrospective analysis by fluorescence in situ hybridization (FISH) was carried out on total 671 patients of CLL at diagnosis between 2008 and 2015. Conventional cytogenetics studies were performed in 50 of 671 patients using CPG Oligonucleotide + IL-2 and TPA (12-O-Tetradecanyl Phorbol 13-acetate) for stimulation of lymphocytes cultures. Results: Interphase cytogenetics could detect recurrent abnormalities such as del(13q14), +12, del(17p13), del(11q22), del(6q23) in 71% of cases. The incidence of del(13q) was higher in Rai stage 0, I, II (p = 0.0005);whereas patients with ≥2 aberrations were more common in advance stage III, IV (p = 0.001). Frequency of IgH translocation was 7%. Morphology and immunophenotypic analysis revealed atypical CLL with higher frequency of t(14;19) than t(14;18). Conventional karyotype could detect abnormal karyotype in 97% of cases which displayed targeted FISH abnormalities along with additional non-targeted chromosomal abnormalities. Patients with negative FISH markers showed clonal non-recurrent numerical and structural changes. The complex karyotype was identified in 24% cases which included targeted FISH aberrations as well as non-targeted numerical and structural abnormalities like deletions, and unbalanced translocations. A significant association was observed between complex karyotype and coexistence of ≥2 FISH markers (p = 0.009) and del(11q22) &/or del(17p) (p = 0.03). Conclusion: Our data of interphase FISH with integration of conventional karyotyping revealed genomic complexity that helped identification of biological subclasses with clinical impact at diagnosis. Further, these cytogenetic subclasses along with molecular markers are likely to evolve more refined prognostic groups, which will help design risk-adapted therapies in B-CLL.
基金Supported by NNSF of China(10571164)Supported by SRFDP of Higher Education(20050358052)
文摘Let Ω∈ C^n be a bounded starlike circular domain with 0 ∈ Ω. In this paper, we introduce a class of holomorphic mappings Mg on Ω. Let f(z) be a normalized locally biholomorphic mapping on Ω such that Jf^-1 (z) f(z) ∈Mg and z = 0 is the zero of order k+1 of f(z) - z. We obtain the growth and covering theorems for f(z). Especially, as corollaries, we unify and generalize many known results. Moreover, in view of proofs of corollaries, the essential relations among the subclasses of starlike mappings are shown.
文摘Objective:The paper aimed to study the relationship between the expressions of immunoglobulin G(IgG) subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients and different grades of cervical lesions.Methods:The expressions of IgG subclasses in 32 cases of human papillomavirus(HPV) infection,30 cervical intraepithelial neoplasia(CIN I),43 CIN Ⅱ-Ⅲ,and 24 hysteromyoma and chronic cervicitis were examined by ELISA.Results:The absorbance values of HPV16VLPs-IgG,IgG1 increased with the grade of CIN(P < 0.05).The IgG2 dominance(IgG2/IgG1 ratio > 1) from control group was 100%,87.50% for HPV infection group,75% for CIN I group,compared with that from CIN Ⅱ-Ⅲ patients(9.52%)(P < 0.05).The positive rates and absorbance values of HPV16VLPs-IgG,IgG1 and IgG2 from HPV16-DNA positive group were significantly higher than those from non-HPV16-DNA positive group(P < 0.05).There was a moderate correlation between the HPV16-DNA testing and detection of HPV16VLPs-IgG(r = 0.531,P < 0.05).Conclusion:An increase of the expressions of HPV16VLPs-IgG and its subclasses in the serum of the patients with cervical precancerous lesions,especially those with CIN II-III,might be associated with duration of HPV infection and severity of cervical lesions.An increase of the IgG2 dominance(IgG2/IgG1 > 1) in serum from low grade cervical lesions group and normal control group,might indicate the clearance of HPV infection and the regression of cervical lesions.
文摘The issue of document management has been raised for a long time, especially with the appearance of office automation in the 1980s, which led to dematerialization and Electronic Document Management (EDM). In the same period, workflow management has experienced significant development, but has become more focused on the industry. However, it seems to us that document workflows have not had the same interest for the scientific community. But nowadays, the emergence and supremacy of the Internet in electronic exchanges are leading to a massive dematerialization of documents;which requires a conceptual reconsideration of the organizational framework for the processing of said documents in both public and private administrations. This problem seems open to us and deserves the interest of the scientific community. Indeed, EDM has mainly focused on the storage (referencing) and circulation of documents (traceability). It paid little attention to the overall behavior of the system in processing documents. The purpose of our researches is to model document processing systems. In the previous works, we proposed a general model and its specialization in the case of small documents (any document processed by a single person at a time during its processing life cycle), which represent 70% of documents processed by administrations, according to our study. In this contribution, we extend the model for processing small documents to the case where they are managed in a system comprising document classes organized in subclasses;which is the case for most administrations. We have thus observed that this model is a Markovian <i>M<sup>L×K</sup>/M<sup>L×K</sup>/</i>1 queues network. We have analyzed the constraints of this model and deduced certain characteristics and metrics. <span style="white-space:normal;"><i></i></span><i>In fine<span style="white-space:normal;"></span></i>, the ultimate objective of our work is to design a document workflow management system, integrating a component of global behavior prediction.
基金This project is supported by the National Natural Science Foundation of Chinaby Grant DA01070 from U.S. Public Health Service
文摘A general theorem on the limiting distribution of the generalized t-distribution is obtained,many applications of this theorem to some subclasses of elliptically contoured distributions in cluding multivariate normal and multivariate t distributions are discussed.Further,their limiting distributions by density function are derived.
文摘Objective To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA) Methods IgG subclasses were tested in 40 patients with idiopathic or secondary AIHA by Coombs test with monoclonal antibodies Hb, TBil, RC and FHb, as hemolytic parameters, were used to analyze the clinical implications of subclasses of AIHA warm autoantibody IgG Results In most patients IgG incomplete warm autoantibody was IgG1(27 patients), but IgG3(20 patients), rarely IgG2(14 patients) and IgG4(9 patients) also occurred Three groups were analyzed: Group A included 20 patients with IgG3; Group B included 14 patients with IgG1 but without IgG3; Group C included 6 patients without IgG1 and IgG3 There were significant differences ( P <0 01) between groups in Hb, TBil, RC and FHb Moreover, we also found that the sensitivity of Coombs test with polyclonal antiserums was 90 0%, while that of Coombs test with monoclonal antibodies was 97 5% The effect of treatment was worst in patients with positive IgG3 autoantibody, whose hemolysis recurred frequently Conclusion IgG3 autoantibody was the most effective in bringing about red cell destruction, IgG1 autoantibody was less effective, IgG2 even less, whereas IgG4 autoantibody was shown to hardly affect red cell survival Coombs test with monoclonal antibodies was more sensitive than that with polyclonal antiserums Patients’ respondence to treatment correlated with the type of IgG subclasses
基金Supported by Primary Biliary Cirrhosis Subdivision of Intrac-table Hepatobiliary Diseases Study Group of Japan(Chairman,Hirohito TsubouchiDepartment of Human and Environmental Sciences,Graduate School of Medical and Dental Sciences,Ka-goshima University,Kagoshima,Japan)
文摘AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH features.METHODS:Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were examined.The activity of periportal and lobular inflammation was scored0(none or minimal activity)to 4(severe),and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored 0-3.The infiltration of mononuclear cells positive for CD20,CD38,CD3,CD4,and CD8 and positive for immunoglobulins(IgG,IgM,and IgA)at the periportal areas(interface hepatitis)and in the hepatic lobules(lobular hepatitis)were semiquantitatively scored in immunostained liver sections(score 0-6).Serum aspartate aminotransferase(AST),immunoglobulins,and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual lesions.RESULTS:Lobular hepatitis,hepatitic rosette formation,and emperipolesis were more extensive and frequent in AIH than in PBC.CD3+,CD4+,and CD8+cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in PBC.The degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC,but to a lesser degree in AIH.CD20+cells were mainly found in the portal tracts and,occasionally,at the interface in both diseases.Elevated AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration,specifically CD38+cells in PBC.No correlation existed between autoantibodies and inflammatory cell infiltration in PBC or AIH.While most AIH cases were IgG-predominant at the interface,PBC cases were divided into IgM-predominant,IgM/IgGequal,and IgG-predominant types,with the latter sharing several features with AIH.CONCLUSION:These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with interface hepatitis may not be identical.
基金National Natural Science Foundation of China(11971165,11561030)。
文摘Let K be the familiar class of normalized convex functions in the unit disk.In[14],Keogh and Merkes proved that for a function f(z)=z+∑k=2∞a k z k in the class K,|a 3−λa 22|≤max{13,|λ−1|},λ∈C.The above estimate is sharp for eachλ.In this article,we establish the corresponding inequality for a normalized convex function f on U such that z=0 is a zero of order k+1 of f(z)−z,and then we extend this result to higher dimensions.These results generalize some known results.
基金financially supported by the research project of China National Uranium Limited Company(grant No.201498)the China Geological Survey Project(grant No.12120113072900)
文摘Objective Hyperspectral remote sensing has attracted much attention in remote sensing research during recent years. It can elaborately identiry spectral characteristics of different objects by acquiring continuous spectral curves of ground objects, and can thus provide more information for geological research (Zhao Yingjun et al., 2015). With the deepening hyperspectral remote sensing research, scholars have focused from the classification of alteration minerals to the identification of subclass minerals in order to explore their significance fbr ore prospecting. This work utilized hyperspectral remote sensing technology in the Xitan region of Gansu Province to identify limonite and two types of sericite subclass minerals, and conducted field verification and geochemical survey. In addition, we analyzed the geological environment of subclass sericite minerals (Van Ruitenbeek et al., 2006) to provide evidence for gold ore prospecting.
基金This work was supported by NNSF of China(Grant Nos. 11561030, 11261022), the Jiangxi Provincial Natural Science Foundation of China (Grant Nos. 20152ACB20002, 20161BAB201019), Natural Science Foundation of Department of Education of Jiangxi Province, China (Grant No. GJJ150301), and the Jiangxi Provincial graduate student innovation project (Grant No. YC2016-S159)
文摘Let S~* be the familiar class of normalized univalent functions in the unit disk.In [9], Keogh and Merkes proved that for a function f(z) = z +∑k=2∞ a_kz^k in the class S~*,then |a_3-λa_2~2| ≤ max{1, |3-4λ|}, λ∈ C. In this article, we investigate the corresponding problem for the subclass of starlike mappings defined on the unit ball in a complex Banach space, on the unit polydisk in Cnand the bounded starlike circular domain in C~■, respectively.
文摘The pneumococcal septic arthritis is uncommon in healthy adults. In most cases, it occurs in patients with immune deficiency. Its exceptional location at the wrist can maintain doubt with rheumatic causes which are more frequent. IgG4 deficiency found in this patient was the only cause that could be impugned. We report the case of a young woman of 46 years without any evident cause of immunodeficiency and any particular risk factor, managed for septic arthritis of the wrist due to Streptococcus pneumoniae. This case without any apparent risk factors demonstrates that pneumococcal infection in a more distant articulation of the ENT is still possible. Scan has been a very significant contribution in confirming the positive diagnosis that leads to surgical drainage. The approach of the systematic search for the gateway must be done. In the study of the patient’s immune status, the realization of the protein profile could be interesting and then guide the practitioner in the decision to vaccinate the patient against Streptococcus pneumoniae if he was not. We recommend looking always for a cause of immunodeficiency including primary Ig defiencies even among adult.
基金the Key Project of the Natural Science Foundation of Tianjin,China(No.20JCZDJC00090).The funders played no role in the study design,data collection and analysis,decision to publish,or manuscript preparation.
文摘Inactivated coronavirus disease 2019(COVID-19)vaccines such as CoronaVac and BBIBP-CorV have been widely used in China.However,more investigation is still needed to understand antibodies'duration and effectiveness against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants in the real world.In this study,575 participants who had been vaccinated with two or three doses of the inactivated vaccine were recruited.Serum samples were collected and tested for anti-spike IgG and neutralizing antibodies against SARS-CoV-2(original strain,Dela,and Omicron).Unsurprisingly,a third dose of the vaccine significantly enhanced antibody responses against SARS-CoV-2 and its variants.However,despite a booster dose,the neutralizing antibody levels against Omicron,particularly the BA.5.2 subvariant,remained low.There was no sex bias,but an age bias was observed.Notably,the predominant IgG subclass antibodies were IgG1 and IgG2,with a much lower level of IgG4.After the booster shot,the ratio of IgG4 to IgG1 significantly increased.The observation of IgG1 to the IgG4 class switch after repeated inactivated vaccinations underscores the importance of continuous monitoring of subclass antibody responses.Further clinical investigations are required to understand the implications of this class switch for optimizing immunization strategies.
基金supported by the National Key Research and Development Program of China(No.2022YFC3103103)the Strategic Priority Research Program of Chinese Academy of Sciences(grant number XDA19060304).
文摘Accurate high-resolution maps of oil palm plantations underpin effective management of environmental and socio-economic impacts at global,regional,and national levels.However,young industrial and highly irregular small-holder plantations are mostly unmapped and not included in official FAO statistics.This issue is addressed here by discriminating global oil palm plantation in 2020 into four subclasses:Industrial Mature Oil Palm(IMOP);Industrial Young Oil Palm(IYOP);Smallholder Mature Oil Palm(SMOP);and Smallholder Young Oil Palm(SYOP).Data,resolved to 4.77 m,from Planet&NICFI,Sentinel-1/2,were combined with other layers using the image-oriented classification and regression tree(CART)algorithm which performed best in classification tests.Results show that SMOP dominates distributional extent,but it was also the most accurately mapped subclass typically found at 500–1000 m altitude.IMOP had the most extensive altitude range of 500–1300 m,while IYOP and SYOP were found at similar altitudes of 500–800 m and 500–900 m respectively.Recent developments in South East Asia show oil palm plantations expanding into new areas with a slope of 24 degrees.Results provide data to support Sustainable Development Goal by assisting future oil palm-related development planning and monitoring in the world’s major oil palm-growing countries.
基金supported by National Natural Science Foundation of China(Grant Nos.11561030,11261022 and 11471111)the Jiangxi Provincial Natural Science Foundation of China(Grant Nos.20152ACB20002 and 20161BAB201019)Natural Science Foundation of Department of Education of Jiangxi Province of China(Grant No.GJJ150301)
文摘In this paper, we establish the Fekete and Szego inequality for a class of holomorphic functions in the unit disk, and then we extend this result to a class of holomorphic mappings on the unit ball in a complex Banach space or on the unit polydisk in Cn.