435 heroin addicts were treated for 10 days to evaluate the therapeutic effectiveness ofabstinence capsule on heroin withdrawal symptoms and its main adverse actions.Lofexidine was applied in a control group of 48 add...435 heroin addicts were treated for 10 days to evaluate the therapeutic effectiveness ofabstinence capsule on heroin withdrawal symptoms and its main adverse actions.Lofexidine was applied in a control group of 48 addicts.The single blind method and somedetermination methods used internationally were employed to evaluate the therapeuticeffectiveness and adverse actions of the drugs.The results showed that the abstinence capsulehas better therapeutic effectiveness,with less adverse actions,wider safety range,longer timeof action and less cost than lofexidine.展开更多
Adrenocortical hormone (ACH) has antiinflammatory and antiallergic actions, changes stress state and controls the attack of some severe and obstinate diseases. The treatment of chronic diseases with ACH often leads to...Adrenocortical hormone (ACH) has antiinflammatory and antiallergic actions, changes stress state and controls the attack of some severe and obstinate diseases. The treatment of chronic diseases with ACH often leads to its dependence; especially oral administration of ACH for a long time is liable to inhibit the function of hypothalamus-pituitary-adrenocortical-thymic axis (HPAT), and results in the hypo-reservation of adrenal cortex. Hence, sudden ACH withdrawal or decrease often causes the disease recurrence, even adrenocortical crisis. Academician Shen Ziyin has a wealth of clinical experience in both the withdrawal and reduction of ACH and the keeping of therapeutical effectiveness to form his unique remedy in the application of drugs. Shen's rich experience is described as follows.展开更多
目的观察电针治疗尼古丁依赖的临床疗效。方法将60例尼古丁依赖者用随机数字表法分为电针组和对照组,每组30例。对照组采用口服酒石酸伐尼克兰片治疗,电针组予电针治疗。分别于治疗前以及治疗第3天、治疗第1周、治疗第2周、治疗第3周、...目的观察电针治疗尼古丁依赖的临床疗效。方法将60例尼古丁依赖者用随机数字表法分为电针组和对照组,每组30例。对照组采用口服酒石酸伐尼克兰片治疗,电针组予电针治疗。分别于治疗前以及治疗第3天、治疗第1周、治疗第2周、治疗第3周、治疗第4周和第16周随访时,观察两组吸烟量、烟草依赖评估量表(fagerstorm test for nicotine dependence,FTND)、吸烟严重度指数(heaviness of smoking index,HSI)、吸烟渴求简短问卷(brief questionnaire of smoking urges,QSU-Brief)和明尼苏达尼古丁戒断症状量表(Minnesota nicotine withdrawal scale,MNWS)评分的变化。结果治疗第4周及第16周随访时,两组吸烟量、FTND、HSI、QSU-Brief和MNWS的评分均较治疗前降低(P<0.05)。治疗第3天以及治疗第1、第2和第3周,电针组吸烟量评分低于对照组(P<0.05);治疗第4周,两组吸烟量评分比较,差异无统计学意义(P>0.05)。治疗第3天以及治疗第1、第2和第3周,电针组QSU-Brief评分低于对照组(P<0.05);治疗第4周及第16周随访时,两组QSU-Brief评分比较,差异无统计学意义(P>0.05)。结论电针可改善尼古丁依赖者的戒断症状,临床疗效优于口服酒石酸伐尼克兰片,电针疗效的累积效应与时间呈正相关。展开更多
Objective： To assess the efficacy of acupuncture plus Methadone in treating heroin withdrawal syndrome. Methods： According to the requirements of evidence-based medicine, the inclusion criteria, exclusion criteria a...Objective： To assess the efficacy of acupuncture plus Methadone in treating heroin withdrawal syndrome. Methods： According to the requirements of evidence-based medicine, the inclusion criteria, exclusion criteria and retrieval strategy were set for original documents. Randomized controlled trials（RCTs） involving acupuncture plus Methadone in treating heroin withdrawal syndrome were retrieved from China National Knowledge Infrastructure Database（CNKI）,Wanfang Academic Journal Full-text Database（Wanfang）, Chinese Biomedical Literature Database（CBM）, Chongqing VIP Database（CQVIP）, PubM ed, Cochrane Library and EMBASE. According to the Cochrane Handbook for Systematic Reviews of Interventions, each included trial was assessed strictly including risk of bias and quality evaluation. Meta-analysis and descriptive-analysis were conducted using the RevM an 5.3 software. Results： A total of 8 trials involving 931 patients were included. Meta-analysis showed that there was no statistical significance [RR=1.05; 95%CI（0.99, 1.11）; P=0.11] in comparing total effective rate between the acupuncture plus Methadone and Methadone alone; the cure rate of acupuncture plus Methadone was higher than that of Methadone alone[RR=1.45; 95%CI（1.19, 1.78）; P=0.0003]; the relapse rate of the acupuncture plus Methadone was lower [RR=0.691;95%CI（0.60, 0.80）; P〈0.00001]. On the basis of these results, the method recommended by the Grading of Recommendations Assessment, Development and Evaluation（GRADE） was taken to evaluate the quality of the evidence. It showed that the level of the evidence was low and it was weakly recommended. Conclusion： According to the included trials, acupuncture plus Methadone in treating heroin withdrawal syndrome is more effective and better than Methadone alone, but it still needs more high-quality, large sample, and polycentric researches to confirm it.展开更多
Obj ective： To observe and analyze the intervention effects of needling different points for post- withdrawal syndrome of heroin dependence, and thus provide clinical basis for screening specific points. Methods： A ...Obj ective： To observe and analyze the intervention effects of needling different points for post- withdrawal syndrome of heroin dependence, and thus provide clinical basis for screening specific points. Methods： A total of 60 males with heroin dependence were randomly allocated into 3 groups, the Neiguan （PC 6） group, the Shenmen （HT 7） group and the control group. The results were observed and evaluated before, during, and 3 weeks after treatment using the rating scale for post-withdrawal syndrome and Hamilton anxiety scale （HAMA）. Results： In regards to the control of post-withdrawal symptoms, the groups of Neiguan （PC 6） and Shenmen （HT 7） showed statistical difference when compared with the control group （P〈0.05, P〈0.01）; however, there was no statistical difference between the Neiguan （PC 6） group and Shenmen （HT 7） group （P〉0.05）. Conclusion： Acupuncture can alleviate the post-withdrawal syndrome and anxiety of heroin dependence. Although both Neiguan （PC 6） and Shenmen （HT 7） have equally remarkable effects, Shenmen （HT 7） have a better tendency for marked effect for heart-mind related symptoms.展开更多
Objective： To observe the effects of electroacupuncture on withdrawal anxiety in heroin-dependent patients. Methods： Sixty heroin-withdrawal subjects with negative urine morphine were digitally randomized into two g...Objective： To observe the effects of electroacupuncture on withdrawal anxiety in heroin-dependent patients. Methods： Sixty heroin-withdrawal subjects with negative urine morphine were digitally randomized into two groups： acupuncture group in which 30 cases were treated by electroacupuncture and control group in which 30 cases were given no treatment. The patients were assessed by Hamilton anxiety scale before treatment and one week, two weeks and three weeks after treatment. Results： After treatment, the anxiety symptoms of heroin-dependent patients were improved more significantly in the acupuncture group than in the control group （P〈0.01）. Conclusion： Electroacupuncture has good effects on anxiety symptoms and emotions of heroin-dependent patients.展开更多
Objective：To observe the effect of reward alteration following acupuncture for morphine withdrawal rats on the behavior and neuronal discharges in the medial prefrontal cortex （mPFC）. Methods：The Sprague-Dawley ...Objective：To observe the effect of reward alteration following acupuncture for morphine withdrawal rats on the behavior and neuronal discharges in the medial prefrontal cortex （mPFC）. Methods：The Sprague-Dawley （SD） rats were randomly allocated into a model group, a confinement group, an electroacupuncture （EA） group, and a control group. Rats with morphine addiction were made by intraperitoneal injection of naloxone （same dose injection of saline for rats in the control group）, followed by a 2-week morphine withdrawal. Acupuncture and confinement were completed during the morphine withdrawal period. Upon withdrawal, the rats received conditioned place preference （CPP） training and open field test. The multi-channel neural signal processor was used in the electrophysiological experiment to measure the neuronal discharges in different subareas of prefrontal cortex in CPP box and aversion box. Results：Rats in the model group and the confinement group spent longer period of time in CPP box than those in the EA group and the control group （allP〈0.01）; there was no statistically significant difference between the EA group and the control group. The total distances of movement by rats in the model group and the confinement group were longer than those in the EA group and the control group （allP〈0.01）. The mPFC neuronal discharge frequencies were compared between morphine preference box and aversion box. The mPFC neuronal discharge frequencies in the model group and the confinement group were higher than those in the EA group and the control group （allP〈0.05）; there was no statistically significant difference between the EA group and the control group. Conclusion：Acupuncture can effectively interfere with the reward alteration following morphine withdrawal, possibly because of its involvement with the mPFC neuronal discharges.展开更多
文摘435 heroin addicts were treated for 10 days to evaluate the therapeutic effectiveness ofabstinence capsule on heroin withdrawal symptoms and its main adverse actions.Lofexidine was applied in a control group of 48 addicts.The single blind method and somedetermination methods used internationally were employed to evaluate the therapeuticeffectiveness and adverse actions of the drugs.The results showed that the abstinence capsulehas better therapeutic effectiveness,with less adverse actions,wider safety range,longer timeof action and less cost than lofexidine.
文摘Adrenocortical hormone (ACH) has antiinflammatory and antiallergic actions, changes stress state and controls the attack of some severe and obstinate diseases. The treatment of chronic diseases with ACH often leads to its dependence; especially oral administration of ACH for a long time is liable to inhibit the function of hypothalamus-pituitary-adrenocortical-thymic axis (HPAT), and results in the hypo-reservation of adrenal cortex. Hence, sudden ACH withdrawal or decrease often causes the disease recurrence, even adrenocortical crisis. Academician Shen Ziyin has a wealth of clinical experience in both the withdrawal and reduction of ACH and the keeping of therapeutical effectiveness to form his unique remedy in the application of drugs. Shen's rich experience is described as follows.
文摘目的观察电针治疗尼古丁依赖的临床疗效。方法将60例尼古丁依赖者用随机数字表法分为电针组和对照组,每组30例。对照组采用口服酒石酸伐尼克兰片治疗,电针组予电针治疗。分别于治疗前以及治疗第3天、治疗第1周、治疗第2周、治疗第3周、治疗第4周和第16周随访时,观察两组吸烟量、烟草依赖评估量表(fagerstorm test for nicotine dependence,FTND)、吸烟严重度指数(heaviness of smoking index,HSI)、吸烟渴求简短问卷(brief questionnaire of smoking urges,QSU-Brief)和明尼苏达尼古丁戒断症状量表(Minnesota nicotine withdrawal scale,MNWS)评分的变化。结果治疗第4周及第16周随访时,两组吸烟量、FTND、HSI、QSU-Brief和MNWS的评分均较治疗前降低(P<0.05)。治疗第3天以及治疗第1、第2和第3周,电针组吸烟量评分低于对照组(P<0.05);治疗第4周,两组吸烟量评分比较,差异无统计学意义(P>0.05)。治疗第3天以及治疗第1、第2和第3周,电针组QSU-Brief评分低于对照组(P<0.05);治疗第4周及第16周随访时,两组QSU-Brief评分比较,差异无统计学意义(P>0.05)。结论电针可改善尼古丁依赖者的戒断症状,临床疗效优于口服酒石酸伐尼克兰片,电针疗效的累积效应与时间呈正相关。
文摘Objective： To assess the efficacy of acupuncture plus Methadone in treating heroin withdrawal syndrome. Methods： According to the requirements of evidence-based medicine, the inclusion criteria, exclusion criteria and retrieval strategy were set for original documents. Randomized controlled trials（RCTs） involving acupuncture plus Methadone in treating heroin withdrawal syndrome were retrieved from China National Knowledge Infrastructure Database（CNKI）,Wanfang Academic Journal Full-text Database（Wanfang）, Chinese Biomedical Literature Database（CBM）, Chongqing VIP Database（CQVIP）, PubM ed, Cochrane Library and EMBASE. According to the Cochrane Handbook for Systematic Reviews of Interventions, each included trial was assessed strictly including risk of bias and quality evaluation. Meta-analysis and descriptive-analysis were conducted using the RevM an 5.3 software. Results： A total of 8 trials involving 931 patients were included. Meta-analysis showed that there was no statistical significance [RR=1.05; 95%CI（0.99, 1.11）; P=0.11] in comparing total effective rate between the acupuncture plus Methadone and Methadone alone; the cure rate of acupuncture plus Methadone was higher than that of Methadone alone[RR=1.45; 95%CI（1.19, 1.78）; P=0.0003]; the relapse rate of the acupuncture plus Methadone was lower [RR=0.691;95%CI（0.60, 0.80）; P〈0.00001]. On the basis of these results, the method recommended by the Grading of Recommendations Assessment, Development and Evaluation（GRADE） was taken to evaluate the quality of the evidence. It showed that the level of the evidence was low and it was weakly recommended. Conclusion： According to the included trials, acupuncture plus Methadone in treating heroin withdrawal syndrome is more effective and better than Methadone alone, but it still needs more high-quality, large sample, and polycentric researches to confirm it.
基金supported by Shanghai Leading Academic Discipline Project(S30304)Youth Foundation of Shanghai Municipal Health Bureau(2008Y124)Innovation Project of Shanghai Municipal Education Commission(12YZ070)
文摘Obj ective： To observe and analyze the intervention effects of needling different points for post- withdrawal syndrome of heroin dependence, and thus provide clinical basis for screening specific points. Methods： A total of 60 males with heroin dependence were randomly allocated into 3 groups, the Neiguan （PC 6） group, the Shenmen （HT 7） group and the control group. The results were observed and evaluated before, during, and 3 weeks after treatment using the rating scale for post-withdrawal syndrome and Hamilton anxiety scale （HAMA）. Results： In regards to the control of post-withdrawal symptoms, the groups of Neiguan （PC 6） and Shenmen （HT 7） showed statistical difference when compared with the control group （P〈0.05, P〈0.01）; however, there was no statistical difference between the Neiguan （PC 6） group and Shenmen （HT 7） group （P〉0.05）. Conclusion： Acupuncture can alleviate the post-withdrawal syndrome and anxiety of heroin dependence. Although both Neiguan （PC 6） and Shenmen （HT 7） have equally remarkable effects, Shenmen （HT 7） have a better tendency for marked effect for heart-mind related symptoms.
基金Shanghai Municipal Education Commission(CZ0523)Shanghai Leading Academic Discipline Project(T0302)
文摘Objective： To observe the effects of electroacupuncture on withdrawal anxiety in heroin-dependent patients. Methods： Sixty heroin-withdrawal subjects with negative urine morphine were digitally randomized into two groups： acupuncture group in which 30 cases were treated by electroacupuncture and control group in which 30 cases were given no treatment. The patients were assessed by Hamilton anxiety scale before treatment and one week, two weeks and three weeks after treatment. Results： After treatment, the anxiety symptoms of heroin-dependent patients were improved more significantly in the acupuncture group than in the control group （P〈0.01）. Conclusion： Electroacupuncture has good effects on anxiety symptoms and emotions of heroin-dependent patients.
基金supported by National Natural Science Foundation of China No.81373753Natural Science Foundation of Shanghai No.13ZR1441900the Budgeted Scientific Research Project of Shanghai University of Traditional Chinese Medicine No.2013JW16~~
文摘Objective：To observe the effect of reward alteration following acupuncture for morphine withdrawal rats on the behavior and neuronal discharges in the medial prefrontal cortex （mPFC）. Methods：The Sprague-Dawley （SD） rats were randomly allocated into a model group, a confinement group, an electroacupuncture （EA） group, and a control group. Rats with morphine addiction were made by intraperitoneal injection of naloxone （same dose injection of saline for rats in the control group）, followed by a 2-week morphine withdrawal. Acupuncture and confinement were completed during the morphine withdrawal period. Upon withdrawal, the rats received conditioned place preference （CPP） training and open field test. The multi-channel neural signal processor was used in the electrophysiological experiment to measure the neuronal discharges in different subareas of prefrontal cortex in CPP box and aversion box. Results：Rats in the model group and the confinement group spent longer period of time in CPP box than those in the EA group and the control group （allP〈0.01）; there was no statistically significant difference between the EA group and the control group. The total distances of movement by rats in the model group and the confinement group were longer than those in the EA group and the control group （allP〈0.01）. The mPFC neuronal discharge frequencies were compared between morphine preference box and aversion box. The mPFC neuronal discharge frequencies in the model group and the confinement group were higher than those in the EA group and the control group （allP〈0.05）; there was no statistically significant difference between the EA group and the control group. Conclusion：Acupuncture can effectively interfere with the reward alteration following morphine withdrawal, possibly because of its involvement with the mPFC neuronal discharges.
