Acute fatal poisoning due to the inhalation of toxic gas frequently occurs in China.Volatile sulphur compounds(VSCs)are toxic to humans.In fatal poisoning investigations,such as those in industrial settings,a number o...Acute fatal poisoning due to the inhalation of toxic gas frequently occurs in China.Volatile sulphur compounds(VSCs)are toxic to humans.In fatal poisoning investigations,such as those in industrial settings,a number of VSCs,including methanethiol(MT),dimethyl sulphide(DMS),dimethyl disulphide(DMDS)and dimethyl trisulphide(DMTS),can coexist.To date,there is limited data regarding these compounds in post-mortem cases.In the present study,we report toxicological findings in a fatal accident case with two victims.Headspace gas chromatography/flame ionization detector with two columns of different polarities was utilized to screen MT,DMS,DMDS and DMTS in blood.The limits of detection in both methods were 0.05 mg/mL.No sulphur compounds were detected in the blood samples of the two victims.DMS and DMDS were detected in the lungs at concentrations of 0.5 and 1.3 mg/g and 2.2 and 4.1 mg/g,respectively.DMDS liver concentrations were 2.5 and 6.5 mg/g.In addition to hydrogen sulphide,screening for additional VSCs could help establish the cause of death.展开更多
In this study, a novel approach by combining base-catalyzed epoxide ring-opening and thiol-ene click chemistry is presented for the side-chain modification of dextran. The vinyl-modified dextran is prepared by a basic...In this study, a novel approach by combining base-catalyzed epoxide ring-opening and thiol-ene click chemistry is presented for the side-chain modification of dextran. The vinyl-modified dextran is prepared by a basic epoxide ring opening reaction of allyl glycidyl ether in 0.1 mol/L NaOH, followed by thiol-addition click reaction of three model sulfhydryl compounds using water-soluble Irgacure 2959 as the photoinitiator, leading to side-chain functionalized dextran modified with carboxyl, bidentate dicarboxyl or amino groups. This is the first example of combining epoxide ring-opening and thiol- ene click chemistry for side-chain modification of dextran in aqueous media. Importantly, it may also be extended as a convenient and efficient method for the side-chain modification of other polysaccharides.展开更多
基金supported by the National,Shanghai Scientific ProgramTechnology Committee of Shanghai Municipality for their financial support[grant number 2016YFC0800704/15DZ1207500/14DZ2270800/16DZ2290900]of this study.
文摘Acute fatal poisoning due to the inhalation of toxic gas frequently occurs in China.Volatile sulphur compounds(VSCs)are toxic to humans.In fatal poisoning investigations,such as those in industrial settings,a number of VSCs,including methanethiol(MT),dimethyl sulphide(DMS),dimethyl disulphide(DMDS)and dimethyl trisulphide(DMTS),can coexist.To date,there is limited data regarding these compounds in post-mortem cases.In the present study,we report toxicological findings in a fatal accident case with two victims.Headspace gas chromatography/flame ionization detector with two columns of different polarities was utilized to screen MT,DMS,DMDS and DMTS in blood.The limits of detection in both methods were 0.05 mg/mL.No sulphur compounds were detected in the blood samples of the two victims.DMS and DMDS were detected in the lungs at concentrations of 0.5 and 1.3 mg/g and 2.2 and 4.1 mg/g,respectively.DMDS liver concentrations were 2.5 and 6.5 mg/g.In addition to hydrogen sulphide,screening for additional VSCs could help establish the cause of death.
基金financially supported by the National Natural Science Foundation of China(Nos.51373168,51390484,51233004 and 51321062)
文摘In this study, a novel approach by combining base-catalyzed epoxide ring-opening and thiol-ene click chemistry is presented for the side-chain modification of dextran. The vinyl-modified dextran is prepared by a basic epoxide ring opening reaction of allyl glycidyl ether in 0.1 mol/L NaOH, followed by thiol-addition click reaction of three model sulfhydryl compounds using water-soluble Irgacure 2959 as the photoinitiator, leading to side-chain functionalized dextran modified with carboxyl, bidentate dicarboxyl or amino groups. This is the first example of combining epoxide ring-opening and thiol- ene click chemistry for side-chain modification of dextran in aqueous media. Importantly, it may also be extended as a convenient and efficient method for the side-chain modification of other polysaccharides.
