Surgical Technique and Efficacy Analysis of Extra-pseudocapsular Transnasal Transsphenoidal Surgery for Pituitary Microprolactinoma

Objective To elucidate the role of transsphenoidal surgery in the treatment of pituitary microprolactinoma.Methods The clinical data of 107 prolactinoma cases treated by extra-pseudocapsular transnasal transsphenoidal surgery(ETTS)for different indications in our department since 2011 was retrospectively analyzed.Results The most common indication was the ineffectiveness of oral medication(41.1%),followed by the personal willingness of the patient(35.5%),and 20.6%of the patients were young women with clear tumor boundaries.The pseudocapsule was not observed in 63 cases(58.9%),incomplete pseudocapsule was observed in 26 cases(24.3%),and complete pseudocapsule in 18 cases(16.8%).A total of 97 patients(90.7%)obtained 1-year post-operation remission.According to the relative location of the adenoma and pituitary gland on the MRI scan,46 patients were classified into a central type,59 a lateral type,and 2 a supra-pituitary type.Two patients developed hypogonadism,one patient developed hypocortisolism,and one patient developed post-operative hypothyroidism.Two patients were administrated with hormone replacement treatment,and the treatment was stopped within one week.There was no permanent hypopituitarism.Further investigation demonstrated that the adenoma types could affect the remission rates of hyperprolactinemia and gross total resection rate in microprolactinoma.Conclusion ETTS was an effective treatment for pituitary microprolactinomas.This could be the first choice for patients who presented enclosed adenoma on the MRI and were potentially curable in a preoperative evaluation.Maximal safe removal of the adenoma by ETTS with the aim to increase the sensitivity of the drugs was also recommended for patients with invasive dopamine agonist resistant prolactinomas and patients with difficulty in childbirth.

From open to laparoscopic adrenalectomy: a review of 16-year experience

Objective To review the experience with adrenal surgery which was associated with significant morbidity and notable mortality in the past, although laparoscopic approach is beginning to be accepted as the procedure of choice Methods The indications and results of adrenalectomy in 104 patients (36 men, 68 women) over the past 16 years were reviewed Any potential improvement of surgical results over time was analyzed Results Ninety three patients (89%) had functional problems while malignancy was present in 11 patients (11%) Anterior approach was employed in 27 patients, posterior in 56, lateral in 10, and laparoscopic in 11 One patient required conversion from laparoscopic to anterior approach No operative mortality was seen, but the morbidity occurred in 16 7% Complication rate decreased significantly in this study period (1981 1990 versus 1991 1996, 22% versus 5%; P =0 02) Laparoscopic adrenalec^tomy was successfully performed for 59% of the patients requiring adrenalectomy recently, compared to 68% of posterior adrenalectomy in the past Conclusions Adrenal surgery is a safe procedure, associated with acceptable morbidity, which has decreased over time Laparoscopic adrenalectomy is becoming the preferred approach for the majority of patients requiring adrenalectomy