Suzuki-Miyaura金属偶联反应是在零价钯配合物的催化下,芳基硼酸或硼酸酯与卤代芳烃发生交叉偶联的过程。该反应具有很强的底物适应性和官能团容忍性,广泛应用于众多天然产物与有机材料的合成。鉴于反应的重要性,近年来国外高校逐渐尝试...Suzuki-Miyaura金属偶联反应是在零价钯配合物的催化下,芳基硼酸或硼酸酯与卤代芳烃发生交叉偶联的过程。该反应具有很强的底物适应性和官能团容忍性,广泛应用于众多天然产物与有机材料的合成。鉴于反应的重要性,近年来国外高校逐渐尝试将Suzuki-Miyaura反应引入到本科生的有机实验教学中。本文针对2000年后Journal of Chemical Education期刊中涉及的Suzuki-Miyaura反应,分别从反应条件、后处理和表征方法、实验拓展等多个方面进行了比较和归纳,并对其设计理念和教学特色进行了综述。展开更多
Palladium nanoparticles supported on cross-linked polyaniline with bulky phosphorus ligands were developed.These catalysts showed high efficiency in the Suzuki-Miyaura reaction of aryl chlorides and bromides with phen...Palladium nanoparticles supported on cross-linked polyaniline with bulky phosphorus ligands were developed.These catalysts showed high efficiency in the Suzuki-Miyaura reaction of aryl chlorides and bromides with phenylboronic acids.Aryl chlorides and bromides with functional groups,such as CN,MeO,CHO,MeCO and NO_2,were converted to the corresponding biphenyls in high yields with catalyst loading.Additionally,the catalysts combined high activity with good reusability;they could be used at least five times for the Suzuki-Miyaura coupling reaction.展开更多
文摘Suzuki-Miyaura金属偶联反应是在零价钯配合物的催化下,芳基硼酸或硼酸酯与卤代芳烃发生交叉偶联的过程。该反应具有很强的底物适应性和官能团容忍性,广泛应用于众多天然产物与有机材料的合成。鉴于反应的重要性,近年来国外高校逐渐尝试将Suzuki-Miyaura反应引入到本科生的有机实验教学中。本文针对2000年后Journal of Chemical Education期刊中涉及的Suzuki-Miyaura反应,分别从反应条件、后处理和表征方法、实验拓展等多个方面进行了比较和归纳,并对其设计理念和教学特色进行了综述。
基金supported by the National Natural Science of Foundation of China(21676140)the fund from the State Key Laboratory of Materials-Oriented Chemical Engineering(ZK201402)the Project of Priority Academic Program Development(PAPD) of Jiangsu Higher Education Institutions~~
文摘Palladium nanoparticles supported on cross-linked polyaniline with bulky phosphorus ligands were developed.These catalysts showed high efficiency in the Suzuki-Miyaura reaction of aryl chlorides and bromides with phenylboronic acids.Aryl chlorides and bromides with functional groups,such as CN,MeO,CHO,MeCO and NO_2,were converted to the corresponding biphenyls in high yields with catalyst loading.Additionally,the catalysts combined high activity with good reusability;they could be used at least five times for the Suzuki-Miyaura coupling reaction.
