Many paramyxoviruses are responsible for a variety of mild to severe human and animal diseases.Based on the novel discoveries over the past several decades,the family Paramyxoviridae infecting various hosts across the...Many paramyxoviruses are responsible for a variety of mild to severe human and animal diseases.Based on the novel discoveries over the past several decades,the family Paramyxoviridae infecting various hosts across the world includes 4 subfamilies,17 classified genera and 78 species now.However,no systematic surveys of bat paramyxoviruses are available from the Chinese mainland.In this study,13,064 samples from 54 bat species were collected and a comprehensive paramyxovirus survey was conducted.We obtained 94 new genome sequences distributed across paramyxoviruses from 22 bat species in seven provinces.Bayesian phylodynamic and phylogenetic analyses showed that there were four different lineages in the Jeilongvirus genus.Based on available data,results of host and region switches showed that the bat colony was partial to interior,whereas the rodent colony was exported,and the felines and hedgehogs were most likely the intermediate hosts from Scotophilus spp.rather than rodents.Based on the evolutionary trend,genus Jeilongvirus may have originated from Mus spp.in Australia,then transmitted to bats and rodents in Africa,Asia and Europe,and finally to bats and rodents in America.展开更多
基金supported by Beijing Natural Science Foundation(Grant No.M21002)the National Key R&D Program of China(Grant No.2021YFC2300902 and 2022YFE0210300)+3 种基金the CAMS Innovation Fund for Medical Sciences(Grant No.2021-I2M-1-038 and 2022-I2M-CoV19-002)Science&Technology Fundamental Resources Investigation Program(Grant No.2022FY100901)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT310029)the Fundamental Research Funds for the Central Universities(Grant No.3332021092).
文摘Many paramyxoviruses are responsible for a variety of mild to severe human and animal diseases.Based on the novel discoveries over the past several decades,the family Paramyxoviridae infecting various hosts across the world includes 4 subfamilies,17 classified genera and 78 species now.However,no systematic surveys of bat paramyxoviruses are available from the Chinese mainland.In this study,13,064 samples from 54 bat species were collected and a comprehensive paramyxovirus survey was conducted.We obtained 94 new genome sequences distributed across paramyxoviruses from 22 bat species in seven provinces.Bayesian phylodynamic and phylogenetic analyses showed that there were four different lineages in the Jeilongvirus genus.Based on available data,results of host and region switches showed that the bat colony was partial to interior,whereas the rodent colony was exported,and the felines and hedgehogs were most likely the intermediate hosts from Scotophilus spp.rather than rodents.Based on the evolutionary trend,genus Jeilongvirus may have originated from Mus spp.in Australia,then transmitted to bats and rodents in Africa,Asia and Europe,and finally to bats and rodents in America.
