Irritable intestinal tract syndrome was classified and treated with acupuncture according to differentiation of symptoms and signs.Of the 40 cases treated,28 were cured,11 improved,and 6 ineffective.The total effectiv...Irritable intestinal tract syndrome was classified and treated with acupuncture according to differentiation of symptoms and signs.Of the 40 cases treated,28 were cured,11 improved,and 6 ineffective.The total effective rate was 85％.The syndrome was classified into fourtypes:weakness of the spleen and stomach,disharmony of the liver spleen,Yang deficiency ofthe spleen and kidney,and retention of dampness and heat.There was no statistically significant difference in therapeutic effects among the four types of syndromes.However,the curative effect in theacupuncture group was better than that in the medication group,and the difference was of statisticalsignificance.展开更多
The pathogenesis of myelodysplastic syndrome(MDS)may be related to the abnormal expression of microRNAs(miRNAs),which could influence the differentiation capacity of mesenchymal stem cells(MSCs)towards adipogenic and ...The pathogenesis of myelodysplastic syndrome(MDS)may be related to the abnormal expression of microRNAs(miRNAs),which could influence the differentiation capacity of mesenchymal stem cells(MSCs)towards adipogenic and osteogenic lineages.In this study,exosomes from bone marrow plasma were successfully extracted and identified.Assessment of miR-103-3p expression in exosomes isolated from BM in 34 MDS patients and 10 controls revealed its 0.52-fold downregulation in patients with MDS compared with controls(NOR)and was downregulated 0.55-fold in MDS-MSCs compared with NOR-MSCs.Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro,while inhibition of miR-103-3p showed the opposite results in NOR-MSCs.Thus,the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs,significantly impacting MDS-MSCs differentiation.The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation,thereby providing possible target for the treatment of MDS pathogenesis.展开更多
Because of no exact name about obesity in traditional Chinese medicine, clinically there have no unified syndrome types about obesity. The present paper uses the original syndrome differentiation of body fluid and sel...Because of no exact name about obesity in traditional Chinese medicine, clinically there have no unified syndrome types about obesity. The present paper uses the original syndrome differentiation of body fluid and selects classical acupuncture and moxibustion prescriptions to treat obesity, which is conducive to further systematizing classical acupuncture and moxibustion prescriptions and providing sufficient basis for clinical popularization.展开更多
BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AI...BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AIM To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.METHODS Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled.Patients were divided into two groups using the random throwing method:Observation(250 cases,fluoxetine hydrochloride+acupuncture treatment)and control(250 cases,fluoxetine hydrochloride treatment).Changes in negative emotions Hamilton Depression Scale 24,serum inflammatory factors[tumor necrosis factorα,interleukin(IL)-1β,IL-6],miR-155 expression levels,and BDNF levels were assessed.RESULTS Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks(P<0.05).This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.CONCLUSION Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment.In addition,it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.展开更多
Objective:To observe the difference in clinical efficacy between acupuncture with point selection based on syndrome differentiation along the meridians and acupuncture at non-meridian and non-acupoint points for funct...Objective:To observe the difference in clinical efficacy between acupuncture with point selection based on syndrome differentiation along the meridians and acupuncture at non-meridian and non-acupoint points for functional dyspepsia(FD).Methods:A total of 74 FD patients were randomized into an observation group and a control group,with 37 cases in each group.Both groups received acupuncture treatment.Zusanli(ST 36)and Neiguan(PC 6)were selected in the observation group,with Taichong(LR 3)and Neiting(ST 44)added for excess syndrome,and Gongsun(SP 4)and Yinlingquan(SP 9)added for deficiency syndrome.Four non-meridian and non-acupoint points were selected in the control group.The treatments in both groups were performed once a day with a 2-day break after 5 consecutive treatments,which constituted one treatment course.A total of 4 courses were performed.The scores of Nepean dyspepsia index(NDI)and Leeds dyspepsia questionnaire(LDQ)were recorded before and after treatment,and during follow-up(8,12,16,20 and 24 weeks after recruitment)to assess the clinical efficacy.Results:The NDI scores in the two groups after treatment and at each time point during follow-up were higher than those before treatment(all P<0.05),and the LDQ scores were lower than those before treatment(all P<0.05).The NDI scores after treatment and at each time point during follow-up in the observation group were higher than those in the control group(all P<0.01);the total LDQ score and scores of upper abdominal pain,postprandial satiety and upper abdominal burning sensation after treatment and at each time point during follow-up in the observation group were significantly lower than those in the control group(P<0.01 or P<0.05)..Conclusion:Acupuncture with point selection based on syndrome differentiation along the meridians has a better curative effect than acupuncture at non meridian and non-acupoint points in the treatment of FD.展开更多
Knee osteoarthritis(KOA)is a chronic derivative joint issue that mainly damages the artistic cartilage and leads to pain,swelling,and stiffness around the joint,which is commomly worldwide.With the aging of society an...Knee osteoarthritis(KOA)is a chronic derivative joint issue that mainly damages the artistic cartilage and leads to pain,swelling,and stiffness around the joint,which is commomly worldwide.With the aging of society and the increment in obesity rate,the incidence of KOA increases sharply,which seriously effects the quality of human life.Before,how to take effective treatment methods is very important.Severe ways to treat the disease include non-steroidal drugs,local injections,surgery,and cell and gene therapies.However,each therapy has certain defections,such as gastrotestinal tract irritation,cardiovascular safety,or high medical costs for patients.Traditional Chinese medicine has a long history in treating KOA,reported by acupuncture,massage,internal administration of traditional Chinese medicine,and external use of traditional Chinese medicine.In clinical practice,patients can be treated from the root agreement to different etiology,and patients can be treated agreement to different syndrome types by syndrome difference to achieve effect.Studies have shown that warm acupuncture is effect in treating KOA.It has two kinds of treatment methods:acupuncture and moxibustion at the same time.It has fewer side effects and is more acceptable to patients.However,there are still some problems in the basic research and clinical application of warm acupuncture and moxibustion in treating KOA.This paper discussed the existing problems from the followingfive aspects:lack of unified synthesis difference and treatment system,problems in clinical research,weak basic research,problems in the study of moxibustion,and lack of the best treatment program recognized by the academic community.Meanwhile,the selection of acupoints,the relationship between acupuncture depth and anatomy should be further studied in order to offer research ideas for the healthy development of the treatment of KOA with warming acupuncture and moxibustion in the future.展开更多
目的探讨增液白虎汤配合切脉针灸辅助治疗鼻咽癌(Nasopharyngeal carcinoma,NPC)对患者放疗后吞咽障碍(Swallowing disorders,SD)临床疗效和EB病毒壳抗原免疫球蛋白A(VCA-IgA)、EB病毒Rta蛋白抗体免疫球蛋白G(Rta-lgG)、唾液酸(SA)抗体...目的探讨增液白虎汤配合切脉针灸辅助治疗鼻咽癌(Nasopharyngeal carcinoma,NPC)对患者放疗后吞咽障碍(Swallowing disorders,SD)临床疗效和EB病毒壳抗原免疫球蛋白A(VCA-IgA)、EB病毒Rta蛋白抗体免疫球蛋白G(Rta-lgG)、唾液酸(SA)抗体水平影响。方法选择2015年6月-2017年4月于我院确诊并行治疗的鼻咽癌放疗后SD患者83例,按照随机数字表法将患者分为联合组(n=41)和对照组(n=42)。两组患者均使用增液白虎汤,而联合组在对照组基础上加行切脉针灸治疗,完成全部治疗后对患者进行为期2年的随访。观察两组患者末次随访时吞咽困难症状的疗效,治疗前及末次随访时吞咽功能评价,生活质量评分,血清EB病毒抗体水平及治疗不良反应情况之间的差异。结果联合组患者治疗总有效率90.24%与对照组总有效率71.42%相比显著较高(P<0.05)。联合组末次随访时患者饮水试验平均等级,流质、半流质及固态形态食物吞咽功能评价量表(vadeofluroscopic dysphagia scale,VDS)评分及世界卫生组织生存质量测定量表(World Health Organization Quality of Life instrument-brief,WHOQOLBREF)评分同对照组比较差异显著(P<0.05)。联合组末次随访时VCA-IgA滴度为1∶20及以下人数较对照组显著较高,而血清Rta-lgG及SA含量则显著较低(P<0.05)。两组患者不良反应人数比较无显著差异(P=0.223)。结论在增液汤基础上加用切脉针灸能有效治疗NPC患者放疗后SD,其效果优于单纯使用增液白虎汤治疗。展开更多
Primary hypertension is the most common cardiovascular disease. Some relevant research indicates that puncturing Fengchi （GB 20） can effectively reduce the elevated blood pressure of patient with hypertension. Howev...Primary hypertension is the most common cardiovascular disease. Some relevant research indicates that puncturing Fengchi （GB 20） can effectively reduce the elevated blood pressure of patient with hypertension. However, is this method effective for all the patients with hypertension？ With regards to this, the author conducted a therapeutic observation in clinic, puncturing Fengchi （GB 20） according to different syndrome of patient with hypertension. Now the conclusion is as follows.展开更多
慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)是鼻腔及鼻窦黏膜的慢性炎症,包括慢性鼻-鼻窦炎不伴鼻息肉(chronic rhinosinusitis without nasal polyps,CRSsNP)和慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSw...慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)是鼻腔及鼻窦黏膜的慢性炎症,包括慢性鼻-鼻窦炎不伴鼻息肉(chronic rhinosinusitis without nasal polyps,CRSsNP)和慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)。中医治疗CRS主要包括:辨证论治、专方验方、中成药、针灸、耳穴贴压、中药鼻腔雾化和中药鼻腔冲洗、穴位按摩等;西医治疗主要包括糖皮质激素、抗生素、抗过敏药物、黏液溶解促排剂、手术治疗等。中西医结合治疗是目前治疗CRS的重要手段,但存在以下问题:相关临床文献较少,尚无临床指南,且中医药治疗CRS的作用机制还不明确。今后,需要行多中心、大样本的临床研究,进一步深入探讨中医药治疗CRS的作用机制,为中西医结合治疗CRS提供科学依据。展开更多
文摘Irritable intestinal tract syndrome was classified and treated with acupuncture according to differentiation of symptoms and signs.Of the 40 cases treated,28 were cured,11 improved,and 6 ineffective.The total effective rate was 85％.The syndrome was classified into fourtypes:weakness of the spleen and stomach,disharmony of the liver spleen,Yang deficiency ofthe spleen and kidney,and retention of dampness and heat.There was no statistically significant difference in therapeutic effects among the four types of syndromes.However,the curative effect in theacupuncture group was better than that in the medication group,and the difference was of statisticalsignificance.
基金This work was supported by The Nature Science Foundation of China(Nos.82070176,82070128,81900132)the Medical Science and Technology Research Fund of Guangdong Province(No.A2020585).
文摘The pathogenesis of myelodysplastic syndrome(MDS)may be related to the abnormal expression of microRNAs(miRNAs),which could influence the differentiation capacity of mesenchymal stem cells(MSCs)towards adipogenic and osteogenic lineages.In this study,exosomes from bone marrow plasma were successfully extracted and identified.Assessment of miR-103-3p expression in exosomes isolated from BM in 34 MDS patients and 10 controls revealed its 0.52-fold downregulation in patients with MDS compared with controls(NOR)and was downregulated 0.55-fold in MDS-MSCs compared with NOR-MSCs.Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro,while inhibition of miR-103-3p showed the opposite results in NOR-MSCs.Thus,the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs,significantly impacting MDS-MSCs differentiation.The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation,thereby providing possible target for the treatment of MDS pathogenesis.
文摘Because of no exact name about obesity in traditional Chinese medicine, clinically there have no unified syndrome types about obesity. The present paper uses the original syndrome differentiation of body fluid and selects classical acupuncture and moxibustion prescriptions to treat obesity, which is conducive to further systematizing classical acupuncture and moxibustion prescriptions and providing sufficient basis for clinical popularization.
文摘BACKGROUND Abdominal postoperative patients are susceptible to postoperative depression resulting from pain and stress,which can hinder their rehabilitation.Acupuncture has shown potential to relieve this condition.AIM To analyze the mechanism by which acupuncture relieves postoperative depression in patients post-abdominal surgery.METHODS Abdominal postoperative patients with depression between January 2015 and December 2023 at the First Affiliated Hospital of Heilongjiang University of Chinese Medicine were enrolled.Patients were divided into two groups using the random throwing method:Observation(250 cases,fluoxetine hydrochloride+acupuncture treatment)and control(250 cases,fluoxetine hydrochloride treatment).Changes in negative emotions Hamilton Depression Scale 24,serum inflammatory factors[tumor necrosis factorα,interleukin(IL)-1β,IL-6],miR-155 expression levels,and BDNF levels were assessed.RESULTS Significant improvements were observed in the observation group compared to the control group in all assessed parameters after six weeks(P<0.05).This suggests that the combination of fluoxetine hydrochloride and acupuncture may be more effective in managing postoperative depression than medication alone.CONCLUSION Acupuncture complies with the principle of traditional Chinese medicine syndrome differentiation and ensures the pertinence and effectiveness of treatment.In addition,it not only actively improves depressive symptoms but also effectively regulates the serum level of inflammatory factors.
文摘Objective:To observe the difference in clinical efficacy between acupuncture with point selection based on syndrome differentiation along the meridians and acupuncture at non-meridian and non-acupoint points for functional dyspepsia(FD).Methods:A total of 74 FD patients were randomized into an observation group and a control group,with 37 cases in each group.Both groups received acupuncture treatment.Zusanli(ST 36)and Neiguan(PC 6)were selected in the observation group,with Taichong(LR 3)and Neiting(ST 44)added for excess syndrome,and Gongsun(SP 4)and Yinlingquan(SP 9)added for deficiency syndrome.Four non-meridian and non-acupoint points were selected in the control group.The treatments in both groups were performed once a day with a 2-day break after 5 consecutive treatments,which constituted one treatment course.A total of 4 courses were performed.The scores of Nepean dyspepsia index(NDI)and Leeds dyspepsia questionnaire(LDQ)were recorded before and after treatment,and during follow-up(8,12,16,20 and 24 weeks after recruitment)to assess the clinical efficacy.Results:The NDI scores in the two groups after treatment and at each time point during follow-up were higher than those before treatment(all P<0.05),and the LDQ scores were lower than those before treatment(all P<0.05).The NDI scores after treatment and at each time point during follow-up in the observation group were higher than those in the control group(all P<0.01);the total LDQ score and scores of upper abdominal pain,postprandial satiety and upper abdominal burning sensation after treatment and at each time point during follow-up in the observation group were significantly lower than those in the control group(P<0.01 or P<0.05)..Conclusion:Acupuncture with point selection based on syndrome differentiation along the meridians has a better curative effect than acupuncture at non meridian and non-acupoint points in the treatment of FD.
文摘Knee osteoarthritis(KOA)is a chronic derivative joint issue that mainly damages the artistic cartilage and leads to pain,swelling,and stiffness around the joint,which is commomly worldwide.With the aging of society and the increment in obesity rate,the incidence of KOA increases sharply,which seriously effects the quality of human life.Before,how to take effective treatment methods is very important.Severe ways to treat the disease include non-steroidal drugs,local injections,surgery,and cell and gene therapies.However,each therapy has certain defections,such as gastrotestinal tract irritation,cardiovascular safety,or high medical costs for patients.Traditional Chinese medicine has a long history in treating KOA,reported by acupuncture,massage,internal administration of traditional Chinese medicine,and external use of traditional Chinese medicine.In clinical practice,patients can be treated from the root agreement to different etiology,and patients can be treated agreement to different syndrome types by syndrome difference to achieve effect.Studies have shown that warm acupuncture is effect in treating KOA.It has two kinds of treatment methods:acupuncture and moxibustion at the same time.It has fewer side effects and is more acceptable to patients.However,there are still some problems in the basic research and clinical application of warm acupuncture and moxibustion in treating KOA.This paper discussed the existing problems from the followingfive aspects:lack of unified synthesis difference and treatment system,problems in clinical research,weak basic research,problems in the study of moxibustion,and lack of the best treatment program recognized by the academic community.Meanwhile,the selection of acupoints,the relationship between acupuncture depth and anatomy should be further studied in order to offer research ideas for the healthy development of the treatment of KOA with warming acupuncture and moxibustion in the future.
文摘目的探讨增液白虎汤配合切脉针灸辅助治疗鼻咽癌(Nasopharyngeal carcinoma,NPC)对患者放疗后吞咽障碍(Swallowing disorders,SD)临床疗效和EB病毒壳抗原免疫球蛋白A(VCA-IgA)、EB病毒Rta蛋白抗体免疫球蛋白G(Rta-lgG)、唾液酸(SA)抗体水平影响。方法选择2015年6月-2017年4月于我院确诊并行治疗的鼻咽癌放疗后SD患者83例,按照随机数字表法将患者分为联合组(n=41)和对照组(n=42)。两组患者均使用增液白虎汤,而联合组在对照组基础上加行切脉针灸治疗,完成全部治疗后对患者进行为期2年的随访。观察两组患者末次随访时吞咽困难症状的疗效,治疗前及末次随访时吞咽功能评价,生活质量评分,血清EB病毒抗体水平及治疗不良反应情况之间的差异。结果联合组患者治疗总有效率90.24%与对照组总有效率71.42%相比显著较高(P<0.05)。联合组末次随访时患者饮水试验平均等级,流质、半流质及固态形态食物吞咽功能评价量表(vadeofluroscopic dysphagia scale,VDS)评分及世界卫生组织生存质量测定量表(World Health Organization Quality of Life instrument-brief,WHOQOLBREF)评分同对照组比较差异显著(P<0.05)。联合组末次随访时VCA-IgA滴度为1∶20及以下人数较对照组显著较高,而血清Rta-lgG及SA含量则显著较低(P<0.05)。两组患者不良反应人数比较无显著差异(P=0.223)。结论在增液汤基础上加用切脉针灸能有效治疗NPC患者放疗后SD,其效果优于单纯使用增液白虎汤治疗。
文摘Primary hypertension is the most common cardiovascular disease. Some relevant research indicates that puncturing Fengchi （GB 20） can effectively reduce the elevated blood pressure of patient with hypertension. However, is this method effective for all the patients with hypertension？ With regards to this, the author conducted a therapeutic observation in clinic, puncturing Fengchi （GB 20） according to different syndrome of patient with hypertension. Now the conclusion is as follows.
文摘慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)是鼻腔及鼻窦黏膜的慢性炎症,包括慢性鼻-鼻窦炎不伴鼻息肉(chronic rhinosinusitis without nasal polyps,CRSsNP)和慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)。中医治疗CRS主要包括:辨证论治、专方验方、中成药、针灸、耳穴贴压、中药鼻腔雾化和中药鼻腔冲洗、穴位按摩等;西医治疗主要包括糖皮质激素、抗生素、抗过敏药物、黏液溶解促排剂、手术治疗等。中西医结合治疗是目前治疗CRS的重要手段,但存在以下问题:相关临床文献较少,尚无临床指南,且中医药治疗CRS的作用机制还不明确。今后,需要行多中心、大样本的临床研究,进一步深入探讨中医药治疗CRS的作用机制,为中西医结合治疗CRS提供科学依据。
