Hormonal crosstalk is central for tailoring plant responses to the nature of challenges encountered. The role of antagonism between the two major defense hormones, salicylic acid (SA) and jasmonic acid (JA), and m...Hormonal crosstalk is central for tailoring plant responses to the nature of challenges encountered. The role of antagonism between the two major defense hormones, salicylic acid (SA) and jasmonic acid (JA), and modulation of this interplay by ethylene (ET) in favor of JA signaling pathway in plant stress responses is well recognized, but the underlying mechanism is not fully understood. Here, we show the opposing function of two transcription factors, ethylene insensitive3 (EIN3) and EIN3-Like1 (EIL1), in SA-mediated suppression and JA- mediated activation of PLANT DEFENSINI.2 (PDFI.2). This functional duality is mediated via their effect on protein, not transcript levels of the PDF1.2 transcriptional activator octadecanoid-responsive Arabidopsis59 (ORA59). Specifically, JA induces ORA59 protein levels independently of EIN3/EIL1, whereas SA reduces the protein levels dependently of EIN3/EIL1. Co-infiltration assays revealed nuclear co-localization of ORA59 and EIN3, and split- luciferase together with yeast-two-hybrid assays established their physical interaction. The functional ramification of the physical interaction is EIN3-dependent degradation of ORA59 by the 26S proteasome. These findings allude to SA-responsive reduction of ORA59 levels mediated by EIN3 binding to and targeting of ORA59 for degrada4tion, thus nominating ORA59 pool as a coordination node for the antagonistic function of ET/JA and SA.展开更多
This paper reports that an atmospheric pressure dielectric barrier discharge plasma jet, which uses argon or argon + hydrogen peroxide vapour as the working gas, is designed to sterilize the bacillus subtilis. Compar...This paper reports that an atmospheric pressure dielectric barrier discharge plasma jet, which uses argon or argon + hydrogen peroxide vapour as the working gas, is designed to sterilize the bacillus subtilis. Compared with the pure argon plasma, the bacterial inactivation efficacy has a significant improvement when hydrogen peroxide vapour is added into the plasma jet. In order to determine which factors play the main role in inactivation, several methods are used, such as determination of optical emission spectra, high temperature dry air treatment, protein leakage quantification, and scanning electron microscope. These results indicate that the possible inactivation mechanisms are the synergistic actions of chemically active species and charged species.展开更多
The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysacc...The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota.This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.展开更多
In recent years,magnetic nanoparticles(MNPs)have received great attention within the field of biomedicine,especially for cancer therapy.This is because MNPs have many excellent physical and chemical properties to prov...In recent years,magnetic nanoparticles(MNPs)have received great attention within the field of biomedicine,especially for cancer therapy.This is because MNPs have many excellent physical and chemical properties to provide sufficient imaging information along with satisfactory therapeutic efficacy.Moreover,by virtue of various modification strategies,the obtained multifunctional MNPs can further achieve synergized multimodal cancer theranostic,which is worthy of further study.In this review,we summarize the recent developments in imaging-guided strategies and synergistic cancer therapy based on multifunctional MNPs.Then,we discuss the challenge and perspective of the next generation of MNPs-based imaging-guided cancer therapy,hoping to provide guidance in potential applications.展开更多
Marine resources and industry have become one of the most important pillars in economic development all over the world.However,corrosion of materials is always the most serious problem to the infrastructure and equipm...Marine resources and industry have become one of the most important pillars in economic development all over the world.However,corrosion of materials is always the most serious problem to the infrastructure and equipment served in marine environment.Researchers have found that microbiologically influenced corrosion(MIC)and marine bio-fouling are two main mechanisms of marine corrosions due to the complicated marine environment and marine organisms.This article summarized the latest research progress about these two mechanisms and indicated that both MIC and marine bio-fouling are closely related to the biofilms on material surfaces formed by the marine microorganisms and their metabolites.As a result,to prevent the occurrence of MIC and bio-fouling,it is important to control the microorganisms in biofilms or prevent the adhesion and formation of biofilms.The traditional method of using chemical bactericide or antifoulant faces the problems of pollution and microorganism resistance.This article introduced four research approaches about the new tendency of applying new materials and technologies to cooperate with traditional chemicals to achieve better and longer effects with lower environment pollution through synergistic actions.Finally,some future research tendencies were proposed for whole marine anti-corrosion and anti-fouling areas.展开更多
基金supported by National Institutes of Health(R01GM107311)National Science Foundation(IOS-1036491and IOS1352478) grants awarded to K.D.
文摘Hormonal crosstalk is central for tailoring plant responses to the nature of challenges encountered. The role of antagonism between the two major defense hormones, salicylic acid (SA) and jasmonic acid (JA), and modulation of this interplay by ethylene (ET) in favor of JA signaling pathway in plant stress responses is well recognized, but the underlying mechanism is not fully understood. Here, we show the opposing function of two transcription factors, ethylene insensitive3 (EIN3) and EIN3-Like1 (EIL1), in SA-mediated suppression and JA- mediated activation of PLANT DEFENSINI.2 (PDFI.2). This functional duality is mediated via their effect on protein, not transcript levels of the PDF1.2 transcriptional activator octadecanoid-responsive Arabidopsis59 (ORA59). Specifically, JA induces ORA59 protein levels independently of EIN3/EIL1, whereas SA reduces the protein levels dependently of EIN3/EIL1. Co-infiltration assays revealed nuclear co-localization of ORA59 and EIN3, and split- luciferase together with yeast-two-hybrid assays established their physical interaction. The functional ramification of the physical interaction is EIN3-dependent degradation of ORA59 by the 26S proteasome. These findings allude to SA-responsive reduction of ORA59 levels mediated by EIN3 binding to and targeting of ORA59 for degrada4tion, thus nominating ORA59 pool as a coordination node for the antagonistic function of ET/JA and SA.
基金Project supported by the Science Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences (Grant No. 085FZ10134)
文摘This paper reports that an atmospheric pressure dielectric barrier discharge plasma jet, which uses argon or argon + hydrogen peroxide vapour as the working gas, is designed to sterilize the bacillus subtilis. Compared with the pure argon plasma, the bacterial inactivation efficacy has a significant improvement when hydrogen peroxide vapour is added into the plasma jet. In order to determine which factors play the main role in inactivation, several methods are used, such as determination of optical emission spectra, high temperature dry air treatment, protein leakage quantification, and scanning electron microscope. These results indicate that the possible inactivation mechanisms are the synergistic actions of chemically active species and charged species.
基金Supported by the National Natural Science Foundation of China(No.81903947)the Key Research and Development Project of Shandong Province,China(No.2019GSF108209)+1 种基金Key Basic Research of the Natural Science Foundation of Shandong Province,China(No.ZR2019ZD23)Shandong University Youth Innovative Talent Introduction Project(LJRZ 2019,No.9-201)。
文摘The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver disease.Polysaccharides extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and anti-oxidation.The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment.In addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota.This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.
基金support from the National Natural Science Foundation of China(52201198,52027801,and 51631001)the National Key R&D Program of China(2017YFA0206301)the China-Germany Collaboration Project(M-0199).
文摘In recent years,magnetic nanoparticles(MNPs)have received great attention within the field of biomedicine,especially for cancer therapy.This is because MNPs have many excellent physical and chemical properties to provide sufficient imaging information along with satisfactory therapeutic efficacy.Moreover,by virtue of various modification strategies,the obtained multifunctional MNPs can further achieve synergized multimodal cancer theranostic,which is worthy of further study.In this review,we summarize the recent developments in imaging-guided strategies and synergistic cancer therapy based on multifunctional MNPs.Then,we discuss the challenge and perspective of the next generation of MNPs-based imaging-guided cancer therapy,hoping to provide guidance in potential applications.
基金supported by the National Key R&D Program of China(2018YFC1105304)the National Natural Science Foundation of China(Grant Nos.51702106)+1 种基金the Natural Science Foundation of Guangdong Province(2016A030308014)China Postdoctoral Science Foundation(Grant Nos.2017M622686,2018T110865).
文摘Marine resources and industry have become one of the most important pillars in economic development all over the world.However,corrosion of materials is always the most serious problem to the infrastructure and equipment served in marine environment.Researchers have found that microbiologically influenced corrosion(MIC)and marine bio-fouling are two main mechanisms of marine corrosions due to the complicated marine environment and marine organisms.This article summarized the latest research progress about these two mechanisms and indicated that both MIC and marine bio-fouling are closely related to the biofilms on material surfaces formed by the marine microorganisms and their metabolites.As a result,to prevent the occurrence of MIC and bio-fouling,it is important to control the microorganisms in biofilms or prevent the adhesion and formation of biofilms.The traditional method of using chemical bactericide or antifoulant faces the problems of pollution and microorganism resistance.This article introduced four research approaches about the new tendency of applying new materials and technologies to cooperate with traditional chemicals to achieve better and longer effects with lower environment pollution through synergistic actions.Finally,some future research tendencies were proposed for whole marine anti-corrosion and anti-fouling areas.