Left Ventricular Regional Systolic Function in Patient with Hypertrophic Cardiomyopathy by Quantitative Tissue Velocity Imaging

The left ventricular regional systolic functions in patients with hypertrophic cardiomyopathy （HCM） were assessed by using quantitative tissue velocity imaging （QTVI）. Left ventricular （LV） regional myocardial velocity along long- and short-axis in 31 HCM patients and 20 healthy subjects were analyzed by QTVI, and the regional myocardial systolic peak velocities （MVS） were measured. Mean MVS at each level including mitral annular, basal, middle and apical segments were calculated. The ratio of MVS along long-axis to that along short-axis （Ri） at basal and middle segments of the LV posterior wall and ventricular septum were calculated. The results showed that mean MVS was slower at each level including mitral annular, basal, middle and apical segments in the HCM patients than that in the healthy subjects （P〈0.01）. There were no significant differences in mean MVS between obstructive and non-obstructive groups in HCM patients. MVS of all regional myocardial segments along long-axis in the HCM patients were significantly slower than that in the healthy subjects （P〈0.05）, but there was no significant difference in MVS of all regional myocardial segments along long-axis between hypertrophied and non-hypertrophied group in the HCM patients. Ri was significantly lower in the HCM patients than that in the healthy subjects. The LV regional myocardial contractility along long-axis was impaired not only in the hypertrophied wall but also in the non-hypertrophied one in patients with HCM, suggesting that QTVI can assess accurately LV regional systolic function in patient with HCM and provides a novel means for an early diagnosis before and independent of hypertrophy.

A NUMERICAL MODEL OF LEFT VENTRICLE AND AORTIC VALVE FUNCTION OF ITS AFTERLOAD(Ⅰ)

Due to the study of the function of heart and aoritic valve, we set up a physicalmodel of left ventricle, aortic valve and afterload and derive theoretical equation of each part from the model. Then we calculate the hasic equations within phystology and impair parameters. Bwsed on this, we will discus fully in the next paper the effectofleyt ventricular afterloadon valve opining, ejection and valve Jumction .etc

Left ventricular systolic function assessment in patients with dilated heart failure using cardiovascular magnetic resonance

Cardiovascular magnetic resonance (CMR) has become a reference standard for the measure-ment of cardiac volumes, function, and mass. This study aims to reconstruct three dimen-sional modeling of the left ventricle (LV) in pa-tients with heart failure (HF) using CMRtools and thereby derive the LV functional indices. CMR images were acquired in 41 subjects (6 females) with heart failure (HF) and 12 normal controls (4 females). Five comparisons were made (i) nor-mal and dilated heart failure subjects, (ii) male and female normal heart, (iii) male and female dilated heart, (iv) male normal and dilated heart failure and (v) female normal and dilated heart failure. In HF, a significant higher values of EDV (320 刡 79 vs. 126 刡 22 ml, P<0.0001), ESV (255 刡 68 vs. 54 刡 12 ml, P<0.00001) and lower values of EF (20 刡 7 vs. 58 刡 5 %) were found compared that of normal control. There were significant difference on LV EDV and ESV between sex in both normal and HF subjects.

Evaluation of the Effect of Sigmoid-Shaped Interventricular Septum on Left Ventricular Systolic Function in Patients with Essential Hypertension by Two-Dimensional Speckle Tracking Echocardiography

Objective: To evaluate left ventricular regional and global systolic function by measuring left ventricular longitudinal strain (LS) in hypertensive patients with sigmoid-shaped interventricular septum (SIS) by two-dimensional speckle tracking (2D-STE);in order to explore whether the sigmoid-shaped interventricular septum affects the left ventricular systolic function in patients with hypertension. Methods: Routine echocardiographic parameters were measured in 30 hypertensive patients with SIS (SIS group) and 30 hypertensive patients without SIS (non-SIS group). The left ventricular segments and global LS were measured by 2D-STE, and the two sets of parameters were compared. Results: The value of the thickness of the basal segment of the interventricular septum (IVSBT), the thickness of the middle segment of the interventricular septum (IVSMT) and the ratio of the basal segment of the ventricular septum to the middle segment of the interventricular septum (IVSBT/IVSMT) in SIS group was higher than that in non-SIS group. However, the value of left ventricular outflow tract diameter (LVOTD) in SIS group was lower than that in non-SIS group. There was a significant difference between the two groups (all P Conclusion: SIS affects left ventricular regional systolic function of patients with hypertension. 2D-STE can early evaluate left ventricular longitudinal systolic function in hypertensive patients with SIS.

BENEFICIAL EFFECTS OF NTG ON LEFT VENTRICULAR VOLUMES AND SYSTOLIC FUNCTION IN PATIENTS WITH MYOCARDIAL INFARCTION

The effect of sublingual administration and intravenous drip of nitroglycerin (SLNTG and IVNTG) on left ventricular volumes (LVVs) were studied and systolic function was quantitatively assessed with two-dimensional echocardiography (2DE) in 28 patients with myocardial infarction (MI), including 13 cases without heart failure (MI-NHF) in one group and 15 with heart failure (MI-HF) in another. The results showed that after SLNTG and IVNTG in both groups the heart rate (HR) increased significantly (P< 0.05-0.001); the systolic blood pressure (SBP) decreased significantly (P< 0.05-0.001); the diastolic blood pressure (DBP) was not significantly changed (all P>0.05); the left ventricular end-diastolic and end-systolic volumes (EDV and ESV) both significantly reduced [EDV: decreased by 5.8-11.6% (-13.2-19.0 ml), P< 0.05-0.001; ESV: decreased by 9.6-16.6% (-8.6-17.3 ml), P< 0.05-0.001)1; the left ventricular ejection fraction (LVEF) all significantly elevated (increased by 6.6%-9.4% (3.2%-3.4%), P < 0.05-0.001] except in MI-NHF group after IVNTG; the segmental EF of normal and hypokinetic segments also significantly increased (P<0.05-0.001). The results suggest that NTG could beneficially reduce left ventricular EDV and ESV; and improve or strengthen its global and segmental systolic function in MI patients, particularly noticeable in patients with heart failure.

Quantification of Regional Left Ventricular Systolic Dysfunction in Patients With Coronary Artery Disease by Strain Rate Imaging

Objectives To detect and compare the systolic strain rate (SR) and strain in the infarct and ischemic myocardium by strain rate imaging (SRI), in order to explore the clinical value of SRI in evaluating regional left ventricular systolic dysfunction. Methods Patients with coronary artery disease were divided into angina pectoris (11 cases) and myocardial infarction (21 cases) groups. Twenty age-matched normal subjects served as the control group. Septal, lateral, anterior, inferior, anteroseptal and posterior walls of the left ventricle were respectively scanned using color tissue Doppler imaging (TDI). Then SR and strain curves were derived from TDI for basal, middle and apical segments of each wall. SRI parameters were: Systolic SR (SRsys), systolic strain (εsys) and maximum strain (εmax). Results Compared with normal segments, SRsys, εsys and εmax decreased significantly in the infarct and ischemic segments (P<0.01). Compared with ischemic segments, SRsys, εsys and εmax decreased significantly in the infarct segments (P<0.05). Conclusions SRsys, εsys and εmax measured by SRI can be used to quantitatively analyze regional left ventricular systolic dysfunction in patients with coronary artery disease, and aid in differentiating infarct from ischemic myocardium.

Left Ventricle Postinfarction Pseudoaneurysm: Anatomical Forms and Surgical Management

Introduction: Left Ventricle Postinfarction Pseudoaneurysm (LVPS)—false aneurysm occurs after a free-wall rupture contained by the adjacent pericardium. LVPS lacks the normal structure of the ventricular wall and disrupts the normal chamber anatomy. However, the natural history, clinical presentation and surgical outcome are still unclear. For that reason, it is necessary to describe the most relevant anatomical characteristics of LVPS and the appropriate surgical strategies currently applied. Methods: We reviewed the anatomical characteristics of several patients diagnosed of LVPS and the surgical technique performed. In this work two different anatomical types of LVPS are described in detail, with the surgical and structural implications for left ventricle reconstruction. Results: There are two different anatomical forms of LVPS: 1) Typical pseudoaneurysm, with a small gateway neck between the Left Ventricle and the false aneurysm chamber (Figure 1(A));2) Atypical pseudoaneurysm, in which the anatomical defect is bigger, without well-defined edges, extends over a large segment of infarcted and thinned myocardial tissue. In both cases, the therapeutics targets and the surgical techniques used were directed to restore the normal geometry of Left Ventricle, keeping the optimal mitral valve function. Conclusions: The surgical key-step is to preserve or to remodel the ventricular chamber anatomy. This fact restores the ventricular geometry, not only removing the wall discontinuity that generated the pseudoaneurysm. Nevertheless, final prognosis depends on the underlying ischemic cardiomyopathy and mechanical complications, such us mitral regurgitation or ventricular septal defect.

Assessment of Left Ventricular Mechanical Function in Cardiac Syndrome X: Speckle Tracking Imaging Study

Objective: Early detection of LV mechanical abnormalities in patients with cardiac syndrome X (CSX) by speckle tracking echocardiography (STE). Background: Cardiac syndrome X is a triad of angina pectoris, positive stress test for myocardial ischemia and angiographically free coronary arteries. Two dimensional speckle tracking?echocardiography (2D-STE) provides a more sensitive method for evaluation of global and segmental LV function than conventional two dimensional echocardiographic parameters. Subjects and Methods: Seventy patients proved to have CSX and 20 healthy control volunteers were included with a mean age of 49.43 ± 5.92 vs. 49.40 ±6.27 years respectively with no difference regarding sex for both patients and controls. Patients with hypertension, diabetes mellitus, valvular heart disease, cardiomyopathies, inflammatory diseases, myocarditis and arrhythmias were excluded. All included individuals were subjected to complete conventional echocardiographic assessment and left ventricular global and segmental mechanical function was assessed using 2D based strain and strain rate (longitudinal, radial and circumferential) imaging. Results: There was no statistically significant difference in LV conventional echo parameters between patients and controls. However, global mean longitudinal strain was significantly lower in patients than controls (-15.05 ± 3.28 vs. -20.22 ± 2.49;p 0.001). For radial and circumferential strain stain, there was no significant changes between patients vs. controls (29.75 ± 18.26 vs. 28.09 ± 15.48;p = 0.74) and (-19.88 ± 8.63 vs. -21.93 ± 5.69;p 0.05) respectively. Conclusion: In spite of normal conventional echo parameters among patients and controls, LV longitudinal strain and strain rate by 2D speckle tracking imaging were lower in the patients denoting subclinical left ventricular mechanical dysfunction in patients with CSX.

Evaluation of Sub Clinical Myocardial Systolic Dysfunction Using 2D Global Longitudinal Strain Assessment in Type 2 Diabetes Patients in Sub-Saharan Africa

Background: Heart failure is the commonest cardiovascular complication in type 2 diabetes mellitus. However, subclinical left ventricular dysfunction can’t be detected using 2D echocardiography which is routinely used for cardiac evaluation of diabetic patients. We aimed to determine the prevalence and factors associated to left ventricular global longitudinal strain (LV GLS) impairment in type 2 diabetes Cameroonians patients. Methods: We conducted a cross-sectional study from January 2019 to June 2019, including type 2 diabetes patients with preserved left ventricle ejection fraction. Clinical and echocardiographic data were collected, and LV GLS was assessed using speckle tracking technique, a value ≤ -16% been considered as normal value. Results: We recruited 95 patients, with a mean age of 57.4 ± 11.8 years old and median diabetes duration of 5 [2 - 12] years. Echocardiographic evaluation found 56.3% of left ventricle remodelling, 51.6% of left ventricle diastolic dysfunction and mean left ventricle ejection of 63.3% ± 6.6%. LV GLS impairment was present in 43.2% (95% CI: 32.6 - 53.7) of the participants. After adjustment to all significantly associated factors, Obesity (aOR: 4;95% CI: 1.5 - 10.6) and diastolic dysfunction (aOR: 3.1;95% CI: 1.2 - 8.2) were independent factors associated with LV GLS. Conclusions: Subclinical systolic dysfunction assessed by LV GLS impairment is frequent in diabetic patients. Further research should be carried out more extensively to integrate LV GLS in the type 2 diabetes patients’ routine follow up for a better prognostic outcome, especially in low-incomes countries.

Effect of remimazolam vs. propofol on hemodynamics during general anesthesia induction in elderly patients: Single-center, randomized controlled trial

The current study aimed to compare the effects between remimazolam and propofol on hemodynamic stability during the induction of general anesthesia in elderly patients.We used propofol at a rate of 60 mg/(kg·h)in the propofol group(group P)or remimazolam at a rate of 6 mg/(kg·h)in the remimazolam group(group R)for the induction.A processed electroencephalogram was used to determine whether the induction was successful and when to stop the infusion of the study drug.We measured when patients entered the operating room(T_(0)),when the induction was successful(T_(1)),and when before(T_(2))and 5 min after successful endotracheal intubation(T_(3)).We found that mean arterial pressure(MAP)was lower at T_(1–3),compared with T_(0) in both groups,but higher at T_(2) in the group R,whileΔMAP_(T0–T2) andΔMAP_(max) were smaller in the group R(ΔMAP_(T0–T2):the difference between MAP at time point T_(0) and T_(2),ΔMAP_(max):the difference between MAP at time point T_(0) and the lowest value from T_(0) to T_(3)).Cardiac index and stroke volume index did not differ between groups,whereas systemic vascular resistance index was higher at T_(1–3) in the group R.These findings show that remimazolam,compared with propofol,better maintains hemodynamic stability during the induction,which may be attributed to its ability to better maintain systemic vascular resistance levels.

左室收缩功能评估的超声新方法:心肌做功

心肌做功是一种无创评估左室收缩功能的超声新方法,其通过整合左室整体长轴应变和无创左室收缩压来评估心肌收缩功能。心肌做功能在心血管疾病的早期阶段评估左室整体和局部收缩功能,随访患者病情进展情况以及预后。为了让超声医师更好地理解和应用这一超声新方法,本文就心肌做功的概念、参数、正常参考值及临床应用做一评述。

超声左心室自动功能成像评估胰岛素泵输注治疗2型糖尿病合并肺结核左心室功能

目的:探索超声左心室自动功能成像(AFI)评估胰岛素泵输注治疗2型糖尿病(T2DM)合并肺结核左心室功能的效果。方法:选取2020年12月至2022年10月新疆医科大学第一附属医院收治的108例T2DM合并肺结核老年患者纳入观察组,选取同期在本院接受体检的90名健康体检者纳入健康对照组。观察组接受胰岛素泵的输注治疗,并于治疗前后采用超声左心室AFI评估左心室功能参数;健康对照组检查左心室指标及血糖指标。对比两组的临床指标以及超声参数上的差异性。结果:观察组治疗后与治疗前比较收缩压与空腹血糖水平均较低;观察组治疗后与治疗前分别与健康对照组相比长轴方向的全球纵向应变(GLPS-LAX)、四腔心切面的全球纵向应变(GLPS-A4C)及平均全球纵向应变(GLPS-AVG)比较均有所降低;观察组治疗后与治疗前相比GLPS-LAX、GLPS-AVG较高,差异有统计学意义(t=2.846、4.926,P<0.05)。结论:T2DM合并肺结核患者在经过胰岛素泵注射治疗后,通过采用超声左心室AFI对患者的左心室功能进行评估时发现,其左心室功能获得有效改善,采用超声左心室AFI评估T2DM合并肺结核左心室功能具有重要的临床意义。

TMAD评价保留射血分数无症状SAS病人左室功能受损及预后

目的:探讨组织追踪二尖瓣环位移(TMAD)技术评价保留射血分数无症状重度主动脉瓣狭窄(SAS)病人左室纵向运动功能及其对预后的预测价值。方法:入选60例保留射血分数无症状SAS病人,依据随访结果分成2组,其中有心血管相关事件定义为A组(21例),未发生心血管相关事件定义为B组(39例)。收集研究对象临床资料,所有入选病人检查后进行24个月随访。采集病人连续4个心动周期心尖四腔、三腔及两腔切面动态图像,双平面辛普森法测量左室射血分数(LVEF)。利用二维斑点追踪超声心动图技术获取左室整体纵向应变(LVGLS),四腔心获取间隔与侧壁瓣环连线中点的纵向平均位移(TMAD Midpt),设备并可自动获取TMAD占舒张末期左室长径的百分比(TMAD Midpt%)。比较2组上述各参数的差异,并分析TMAD Midpt%预测SAS病人发生心脏相关事件的价值。结果:60例病人中A组TMAD Midpt%及LVGLS低于B组(P<0.01),2组LVEF差异无统计学意义(P>0.05);A组病人心肌质量指数(MI)与B型脑钠肽(BNP)明显高于B组(P<0.01),2组其他临床资料及超声心动图参数比较差异均无统计学意义(P>0.05)。60例病人TMAD Midpt%随着LVGLS的降低而降低,两者呈正相关关系(r=0.696,P<0.01)。ROC曲线分析显示,TMAD Midpt%预测心脏事件与LVGLS具有相当的价值,曲线下面积分别为0.897、0.901(P<0.01)。结论:TMAD Midpt%在预测心脏事件发生方面与LVGLS具有相同的价值,而技术简便,可以快速地评估左室射血分数保留的无症状SAS病人左室功能损害及预测心脏事件的发生,值得临床推广应用。

TMAD技术在无症状重度主动脉瓣狭窄患者预后评估中的价值

目的 探讨组织追踪二尖瓣环位移(tissue-tracking mitral annular displacement,TMAD)技术对保留射血分数(LVEF)无症状重度主动脉瓣狭窄(severe aortic stenosis,SAS)患者预后评估中的预测价值。方法 选取60例保留LVEF≥50%无症状SAS患者,依据随访有无发生主要心血管不良事件(MACE)分成A、B两组。采集患者连续4个心动周期心尖四腔、三腔及两腔切面动态图像,双平面辛普森法测量左心室LVEF。利用二维斑点追踪超声心动图技术获取左心室整体纵向应变(left ventricular globe Longitudinal straing,LVGLS),四腔心获取间隔与侧壁瓣环连线中点的纵向平均位移(TMAD),设备并可自动获取TMAD占舒张末期左心室长径的百分比(TMAD Midpt),检查后进行24个月的随访。比较两组上述各参数的差异,并分析TMAD Midpt预测SAS患者发生心脏相关事件的价值。结果 60例患者中A组21例,占35.0%,B组39例,占65.0%。A组TMAD Midpt及LVGLS显著低于B组,差异有统计学意义(P<0.01),两组间LVEF差异无统计学意义(P>0.05);A组患者心肌质量指数(myocardial mass index,MI)与B型脑钠肽(BNP)高于B组,差异有统计学意义(P<0.01),其他临床资料及超声心动图参数比较差异无统计学意义(P>0.05)。60例患者TMAD Midpt随着LVGLS的降低而降低,两者呈显著正相关(r=0.696,P<0.01)。ROC曲线分析,TMAD Midpt预测心脏事件与LVGLS具有相当的价值,曲线下面积分别为0.897、0.901(P<0.01)。结论 TMAD技术可以简便、快速地评估左心室射血分数保留的无症状SAS患者左心室功能损害,评估该类患者预后具有重要价值,值得临床推广应用。

组织瓣环运动位移评价心室肥厚患者左室收缩功能

目的探讨组织瓣环运动位移(TMAD)自动追踪技术定量评价心室肥厚患者左室收缩功能的应用价值。方法纳入60例心室肥厚患者,原发性高血压亚组30例,尿毒症亚组30例,纳入35例健康体检者作为对照组。应用二维斑点追踪技术自动获取心尖四腔心切面、心尖两腔心切面二尖瓣环四个位点TMAD值、左心室整体纵向应变(LVGLS)及左室整体圆周应变(LVGCS),应用Bland-Altman法检验TMAD参数一致性及绘制受试者工作特性(ROC)曲线评价TMAD参数的诊断效能。结果原发性高血压亚组和尿毒症亚组的收缩压(SBP)、舒张压(DBP)明显高于对照组(P<0.05);尿毒症亚组的心率(HR)高于原发性高血压亚组及对照组(P<0.05)。尿毒症亚组的TMAD参数及应变参数均明显低于对照组(P<0.05)。原发性高血压亚组的LVGLS、T-AP4sep、T-AP4mid%、T-AP2int、T-AP2ant及T-AP2mid%低于对照组(P<0.05)。ROC曲线结果显示,TMAD各参数对心室肥厚患者左室收缩功能降低具有中等预测价值。结论TMAD可以定量评价心室肥厚患者的左室收缩功能,且可重复性好。

离心抗阻训练在治疗慢性心力衰竭中的临床研究

目的探讨离心抗阻训练在慢性心力衰竭中的疗效。方法将120例慢性心力衰竭患者分为观察组和对照组,观察组接受离心抗阻训练,对照组接受传统的康复训练。比较分析2组患者治疗后在运动耐受性、左心室收缩功能、生活质量等方面的差异。结果治疗后观察组的运动耐受性、左心室收缩功能、生活质量等指标均优于对照组,差异均具有统计学意义(P<0.05)。结论离心抗阻训练可以有效治疗慢性心力衰竭,可显著提高患者的运动耐力、左心室收缩功能和生活质量。

超声心动图评价肝硬化心肌病的研究进展评述

肝硬化心肌病(CCM)是肝硬化患者的常见并发症,主要表现为机体在应激状态的心肌收缩功能不全和/或舒张功能降低伴电生理异常。超声心动图作为一种临床心脏影像学技术具有可及性强和系统性一站式心血管解剖结构和功能评估等诸多优势,已广泛应用于CCM的诊断。CCM发病机制复杂、血流动力学多变,超声心动图单一技术和/或参数很难全面和准确的监测CCM相关的隐匿性心血管结构和功能异常。本文就超声心动图对CCM心脏结构、功能评估的研究进展作一述评,以期能够推动这项技术的广泛临床应用。

对比机械通气重症肺炎及普通肺炎患者右心功能及右心室-肺动脉耦联的斑点追踪超声评价

目的 对比机械通气重症肺炎及普通肺炎患者的右心功能超声指标及右心室-肺动脉耦联指标的二维斑点追踪成像(2D-STI)评估价值。方法 选取66例肺炎患者,根据重症肺炎临床标准分为重症肺炎组25例和普通肺炎组41例,另纳入20例健康人为对照组进行超声心动图检查。于心尖四腔心切面获取右心室中段内径(RVD)、三尖瓣环收缩期位移(TAPSE)、三尖瓣环收缩期峰速度(S’)、三尖瓣反流峰值流速(TRV);经剑突下获取下腔静脉(IVC)长轴内径(IVCD)并计算呼吸变异率(IVCV)并估测右房压(RAP),并计算肺动脉收缩压(PASP)。右心室-肺动脉耦联指标以三尖瓣环收缩期位移(tricuspid annular plane systolic excursion, TAPSE)和肺动脉收缩压(pulmonary artery systolic pressure, PASP)的比值(TAPSE/PASP)表示。应用二维斑点追踪成像(two-dimensional speckle tracking imaging, 2D-STI)技术获取右心室游离壁整体应变(RVLSfw),基底段应变(RVLSbas)、中段应变(RVLSmid)、心尖段应变(RVLSapi)。将RVLSfw纳入右心室-肺动脉耦联中获取新指标RVLSfw/PASP,比较组间差异并做相关性分析。结果 重症肺炎组RVD、IVCD、TRV、PASP均高于普通肺炎组和对照组,IVCV、TAPSE均低于普通肺炎组和对照组(P<0.05),重症肺炎组S’低于普通肺炎组(P<0.05);普通肺炎组RVD、IVCD高于对照组(P<0.05)。2D-STI指标:重症肺炎组RVLSfw、RVLSbas和RVLSapi均低于普通肺炎组和对照组(P<0.05),普通肺炎组和对照组之间该指标无统计学意义(P>0.05);右心室-肺动脉耦联指标:重症肺炎组TAPSE/PASP、S’/PASP和RVLSfw/PASP均低于普通肺炎组和对照组,普通肺炎组和对照组之间该指标差异无统计学意义(P>0.05)。相关性分析显示:RVLSfw/PASP和TAPSE/PASP呈强相关(r=0.927,P<0.05)。结论 2D-STI指标和右心室-肺动脉耦联均对接受机械通气的重症肺炎患者的右心功能评估有一定价值,RVLSfw/PASP可作为评估右心室-肺动脉耦联的可靠指标。

3D-STI评估2型糖尿病视网膜病变患者左室心肌应变的应用

目的:应用三维斑点追踪成像(three-dimensional speckle tracking imaging,3D-STI)技术评估射血分数保留的2型糖尿病(diabetes mellitus type 2,T2DM)合并糖尿病视网膜病变(diabetic retinopathy,DR)患者的左室心肌损伤情况,探讨3D-STI技术评价此类患者左室收缩功能的临床应用价值。方法:选取2023年2月至2024年2月佳木斯大学附属第一医院内分泌科住院收治的射血分数保留的T2DM患者共50例作为病例组,根据眼底照相结果将患者分为DR组25例和非DR组25例,同期体检的健康志愿者25例作为对照组。采集左室全容积图像,应用3D-STI技术获取射血分数(3D-EF)、整体纵向应变(GLPS)、圆周应变(GCPS)、面积应变(GAPS),并进行比较分析。结果:对照组与非DR组、DR组3D-LVEF、GAPS、GLPS、GCPS指标有统计学差异(P<0.05);进一步两两比较结果显示,非DR组和DR组3D-LVEF、GAPS、GLPS、GCPS绝对值均低于对照组,DR组GLPS绝对值低于非DR组,有统计学差异(P<0.05)。3D-LVEF、GLPS、GCPS、GAPS绝对值与疾病复杂程度均呈现负相关关系。结论:3D-STI能够早于常规超声心动图发现射血分数保留的T2DM患者左室收缩功能的变化;T2DM合并DR者左室心肌损伤更为明显。