Strong ground motion characteristics observed in the February 6,2023 M_(W)7.7 Türkiye earthquake

Türkiye is located in a seismically active region,where the Anatolian,African,and Arabian tectonic plates converge.High seismic hazards cause the region to be struck repeatedly by major earthquakes.On February 06,2023,a devastating M_(W)7.7 earthquake struck Türkiye at 01:17 am local time(01:17 UTC).In this regard,near and far-field ground motion data within the distance of 120 km are compiled and later characterized to identify the key ground motion intensity measures.Additionally,the vertical components of ground motions were examined to capture the complete three-dimensional nature of the seismic event.Moreover,the effect of Pulse-Like(PL)and Non-Pulse-Like(NPL)ground motion on a representative RC frame structure built as per the Türkiye code was investigated.The results indicate that PL behavior was observed in both horizontal and vertical components of ground motions and PL behavior were noted both near the epicenter and at higher distances from the epicenter.Moreover,the ratio of the peak vertical acceleration to peak horizontal acceleration at certain stations was found to be close to 1.Finally,the non-linear time history analysis of the representative reinforced concrete frame structure for ground motions recorded at stations located equidistant from the epicenter,indicated that PL ground motions led to more significant damage compared to NPL ground motions.

Characteristics of Long-term Nonprogressors and Viremia Controllers Infected with HIV-1 via Contaminated Blood Donations or Transfusions Conducted 20 Years Earlier

To characterize long-term nonprogressors （LTNPs） and viremia controllers （VCs）, infected with HIV-1 through contaminated blood donation or transfusion between 1992 and 1996 in Henan, China. LTNPs and VCs were defined by CD4＋T lymphocyte （CD4） count and viral load （VL）. Of 29,294 patients infected with HIV-1 via contaminated blood donation or transfusion that had conducted for more than 20 years, 92 were LTNPs/VCs. There were 70 LTNPs （0.24%）, 43 VCs （0.15%）, and 48 LTNPs＋VCs- （0.16%）.

Current–voltage characteristics of hydrogen DC plasma torches with different sizes in an external axial magnetic field

Current-voltage （l-V） characteristics of hydrogen DC plasma torches with different sizes in an external axial magnetic field under atmospheric pressure are reported. Three anodes with different diameters are adopted in a 50-kW torch： 25 mm, 30 mm, and 35 nun, respectively. Two different diameters of anodes, that is, 100 mm and 130 mm, are adopted in a 1-MW plasma torch. The arc voltage shows a negative trend with the increase of arc current under the operating regimes. On the contrary, arc voltage shows a positive trend as the flow rate of carder gas increases, and a similar trend is found with increasing the external magnetic flux density. A similarity formula is constructed to correlate the experimental data of the torches mentioned above. Linear fitting shows that the Pearson correlation coefficient is 0.9958.

Current-voltage characteristics of an individual helical CdS nanowire rope

This paper studies the electronic transport in an individual helically twisted CdS nanowire rope, on which platinum microleads are attached by focused-ion beam deposition. The current-voltage （I - V） characteristics are nonlinear from 300 down to 60 K. Some step-like structures in the I - V curves and oscillation peaks in the differential conductance （dI/dV - V） curves have been observed even at room temperature. It proposes that the observed behaviour can be attributed to Coulomb-blockade transport in the one-dimensional CdS nanowires with diameters of 6-10 nm.

Analysis of Electrical Characteristics of Photovoltaic Single Crystal Silicon Solar Cells at Outdoor Measurements

The electrical performance of a photovoltaic (PV) silicon solar cell is described by its current–voltage (I–V) character-istic curve, which is in turn determined by device and material properties. In this study, an investigation of the performance and device parameters of photovoltaic single crystalline silicon (Si.) solar cell of the construction n+pp++ PESC(Passivatted Emitter Solar Cell) at different conditions of solar irradiance, title angle and mirror boosting effects had been studied. Also the paper reports on the performance data of the Si. cell, using standard I–V characteristic curves to obtain output parameters and to show that there are possible performance degrading defects presents.

A simulating investigation into the characteristics of the mass transfer between molten steel and particles in the 150 t RH-IJ refining

The characteristics of the mass transfer between powder particles and liquid steel in the Ruhrstahl Heraeus process injection （RH-IJ） refining were simulatively investigated by the use of a 1/4 scale water model of a 150 t Ruhrstahl Heraeus（RH） degasser. The influences of the lifting gas flow rate, the up-snorkel and down-snorkel inner diameters and the size of powder particles on the characteristics of the mass transfer were examined. The results show that under the condition that the inner diameters of both the up-snorkel and the down-snorkel are the same, the mass transfer coefficient in the liquid,k increases with the increase of the inner diameter of the up-snorkel,the particle size and the lifting gas flow rate （Q1）. However, the increase of Q~ should not result in a saturated circulation rate. Under the current working condition,k ranges from 3. 392 × 10 -5 m/s to 2. 661 × 10-4 m/s. On the other hand,with a given lifting gas flow rate and up-snorkel inner diameters ,the mass transfer weakens with the increase of the down-snorkel inner diameter. An inherently nonlinear relationship between the circulation rate （Q~） of molten steel in the RH degasser and k,which increases with the increase of Q1,was found. Under the condition of other parameters being the same,k increases with the increase of the powder particle size. In order to enhance the mass transfer,it is better not to use extremely fine powder.

Fifty-Six Big Data V’s Characteristics and Proposed Strategies to Overcome Security and Privacy Challenges (BD2)

The amount of data that is traveling across the internet today, including very large and complex set of raw facts that are not only large, but also, complex, noisy, heterogeneous, and longitudinal data as well. Companies, institutions, healthcare system, mobile application capturing devices and sensors, traffic management, banking, retail, education etc., use piles of data which are further used for creating reports in order to ensure continuity regarding the services that they have to offer. Recently, Big data is one of the most important topics in IT industry. Managing Big data needs new techniques because traditional security and privacy mechanisms are inadequate and unable to manage complex distributed computing for different types of data. New types of data have different and new challenges also. A lot of researches treat with big data challenges starting from Doug Laney’s landmark paper, during the previous two decades;the big challenge is how to operate a huge volume of data that has to be securely delivered through the internet and reach its destination intact. The present paper highlights important concepts of Fifty-six Big Data V’s characteristics. This paper also highlights the security and privacy Challenges that Big Data faces and solving this problem by proposed technological solutions that help us avoiding these challenging problems.

NEW HETEROCYCLIC SYSTEMATIC SYNTHESIS V.THE SYNTHESIS AND CHARACTERISTICS OF 1,3a,5-TRISUBSTITUTED-3a,4,5,11-TETRAHYDRO-1,2,4-OXADIAZOLINO[5,4-d][1,5]BENZODIHETEROPINES

Twenty-seven oxadiazolino[5,4-d][1,5]benzodiheteropine derivatives have been synthesized by the 1,3-dipolar cycloaddition of benzodiheteropines with nitrile oxide 1,3-dipoles,their conformations and the characteristics of the newly formed oxadiazoline fused on them have been studied.It has also been found that the mass spectra show characteristic fragmentation patterns.

TIME-DOMAIN RADIATION CHARACTERISTICS OF V-DIPOLE ARRAYS

The time-domain radiation characteristics of a three V-dipole array have been stud-ied by direct time-domain method.Some valuable results are obtained.

F4-TCNQ concentration dependence of the current voltage characteristics in the Au/P3HT:PCBM:F4-TCNQ/n-Si(MPS) Schottky barrier diode

In this study, we investigate some main electrical parameters of the gold/poly（3-hexylthiophene）：[6,6]-phenyl C61 bu- tyric acid methyl ester：2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane/n-type silicon （Au/P3HT：PCBM：F4-TCNQ/n- Si） metal-polymer-semiconductor （MPS） Schottky barrier diode （SBD） in terms of the effects of F4-TCNQ concentration （0%, 1%, and 2%）. F4-TCNQ-doped P3HT：PCBM is fabricated to figure out the p-type doping effect on the device per- formance. The main electrical parameters, such as ideality factor （n）, barrier height （ФB0）, series resistance （Rs）, shunt resistance （Rsh）, and density of interface states （Nss） are determined from the forward and reverse bias current-voltage （l-V） characteristics in the dark and at room temperature. The values of n, Rs, ФB0, and Nss are significantly reduced by using the 1% F4-TCNQ doping in P3HT：PCBM：F4-TCNQ organic blend layer, additionally, the carrier mobility and current are increased by the soft （1%） doping. The most ideal values of electrical parameters are obtained for 1% F4-TCNQ used diode. On the other hand, the carrier mobility and current for the hard doping （2%） become far away from the ideal diode values due to the unbalanced generation of holes/electrons and doping-induced disproportion when compared with 1% F4-TCNQ doping. These results show that the electrical properties of MPS SBDs strongly depend on the F4-TCNQ doping and doping concentration of interfacial P3HT：PCBM：F4-TCNQ organic layer. Moreover, the soft F4-TCNQ dop- ing concentration （1%） in P3HT：PCBM：F4-TCNQ organic layer significantly improves the electrical characteristics of the Au/P3HT：PCBM：F4-TCNQ/n-Si （MPS） SBDs which enables the fabricating of high-quality electronic and optoelectronic devices.

Non Ideal Schottky Barrier Diode’s Parameters Extraction and Materials Identification from Dark I-V-T Characteristics

Several parameters of a commercial Si-based Schottky barrier diode (SBD) with unknown metal material and semiconductor-type have been investigated in this work from dark forward and reverse I-V characteristics in the temperature (T) range of [274.5 K - 366.5 K]. Those parameters include the reverse saturation current (Is), the ideality factor (n), the series and the shunt resistances (Rs and Rsh), the effective and the zero bias barrier heights (ΦB and ΦB0), the product of the electrical active area (A) and the effective Richardson constant (A**), the built-in potential (Vbi), together with the semiconductor doping concentration (NA or ND). Some of them have been extracted by using two or three different methods. The main features of each approach have been clearly stated. From one parameter to another, results have been discussed in terms of structure performance, comparison on one another when extracted from different methods, accordance or discordance with data from other works, and parameter’s temperature or voltage dependence. A comparison of results on ΦB, ΦB0, n and NA or ND parameters with some available data in literature for the same parameters, has especially led to clear propositions on the identity of the analyzed SBD’s metal and semiconductor-type.

血管免疫母细胞性T细胞淋巴瘤临床特征及预后分析

目的:探讨血管免疫母细胞性T细胞淋巴瘤(AITL)患者的临床特征及预后影响因素。方法:回顾性分析2011至2021年在新疆医科大学第一附属医院血液病中心诊治的42例AITL患者临床资料,使用Kaplan-Meier方法计算患者生存率及无进展生存率,log-rank方法进行组间比较。结果:42例患者以老年人为主,中位发病年龄66(22-80)岁,其中25例为男性。38例Ann Arbor分期III-IV期,23例伴有B组症状,34例IPI中高危及高危。起病临床表现以无痛性淋巴结肿大为主(31例),可伴多浆膜腔积液(24例)、发热(17例)、皮疹(11例)和贫血(15例)。18例病理组织活检显示EBV阳性,28例Ki-67≥40%,6例伴发EBV血症。42例患者中位生存时间为12(1-121)个月,3年预估生存率为37.6%,无进展生存率为26.1%。单因素分析结果显示,白介素-6升高、合并多浆膜腔积液的患者生存率更低。结论:AITL起病时临床表现多样,侵袭性高,预后差,常规化疗远期预后不佳。高白介素-6水平、伴有多浆膜腔积液是影响患者预后的不良因素。

IGBT模块V-I特性曲线簇建模及其结温提取应用

绝缘栅双极型晶体管(Insulated gate bipolar transistor,IGBT)以其高效率、大容量和低成本等特点在新能源发电及储能、高压直流输电、电力牵引和电气化交通等领域应用非常广泛。然而一旦IGBT模块发生故障,将打破相关装置和设备的正常运行状态,引发一系列连锁事故,造成人员伤害和严重的经济损失。根据一项调查统计结果,光伏电站大约34%的可靠性问题是由IGBT模块故障所引发的,因此,IGBT模块可靠性问题愈发受到关注。相关研究成果表明,IGBT模块的结温与模块可靠性问题之间存在密切的关系,如何能够快速准确地获取当前IGBT模块的实时结温是IGBT模块可靠性研究的关键。通过对IGBT模块的V-I输出特性曲线进行深入分析和研究,提出一种表征IGBT模块导通压降、结温和集电极电流关系的建模方法。利用该方法建立的表征模型可以方便快捷地提取IGBT模块结温,并通过试验验证了基于该建模方法的IGBT模块结温提取策略的有效性。除此之外,该建模方法考虑到了模块键合线老化的影响,并给出了相应的模型校正方法和结温提取策略。

新型免疫检查点分子VISTA的研究进展

T细胞活化V结构域免疫球蛋白抑制因子(VISTA)是一种新型免疫检查点蛋白,具有与B7家族相似但独特的结构。VISTA在多种细胞中表达,包括髓系细胞和肿瘤细胞。在肿瘤中,VISTA可能通过调节髓系细胞和T细胞起到免疫抑制的作用。临床研究发现,VISTA在多种癌症中表达并与患者预后相关,可能是癌症治疗的潜在靶点,已有多种VISTA拮抗剂正在研发中。然而对VISTA分子机制和在免疫治疗中的确切作用仍需进一步研究。VISTA最新研究进展包括其与配体的相互作用以及其在肿瘤免疫治疗中的应用可能是免疫检查点抑制剂治疗实体肿瘤的新理论依据。

鼻外NK/T细胞淋巴瘤患者临床特征和预后分析——淮海淋巴瘤协作组多中心回顾性研究

目的:探索鼻外NK/T细胞淋巴瘤(NKTCL)患者的临床特征和预后影响因素。方法:回顾性收集2015年6月-2021年4月在淮海淋巴瘤协作组10家医疗中心确诊的138例鼻外NKTCL患者的临床资料,比较不同受累患者临床病理特征差异、培门冬酶方案疗效,并进行生存分析。结果:共纳入138例鼻外NKTCL患者,中位年龄46岁,男女比例约2∶1。胃肠受累39例,口咽受累患者32例,皮肤受累患者17例,淋巴结受累11例,眼眶受累11例,其他部位受累28例。皮肤受累患者较口咽受累患者伴有更高比例的晚期疾病和更低比例的CD56阳性率。胃肠受累患者中使用培门冬酶治疗方案的患者生存率明显高于未使用的患者(P<0.01)。多因素分析结果表明,血肌酐是皮肤受累患者预后的独立影响因素(HR=1.027,95%CI:1.001-1.054,P=0.040),ECOG PS评分和EBV DNA是胃肠受累患者预后的独立影响因素(HR=2.635,95%CI:1.096-6.338,P=0.030;HR=4.772,95%CI:1.092-20.854,P=0.038),ECOG PS评分和CA分期是口咽受累患者预后的独立影响因素(HR=13.875,95%CI:2.517-76.496,P=0.002;HR=20.261,95%CI:2.466-166.470,P=0.005)。结论:受累部位不同的鼻外NKTCL患者的临床病理特征表现不同,需要进一步探索个体化治疗方案。

THE GEOCHEMISTRY CHARACTERISTICS OF BLUESCHIST IN THE GANGMAR AREA, QIANGTANG BLOCK, TIBET

The Qinghai—Xizang (Tibet) Plateau was assembled by the successive accretion of continental and arc terranes to Asia during the Palaeozoic, Mesozoic and early Tertiary. From north to south, the Plateau was divided into four terranes (from north to south): Songpan\|Garze, Qingtang, Lhasa and India terranes. The Qiangtang terrane was divided into two parts by Chabu\|Shuanghu suture: Northern Qiangtang and Southern Qiangtang blocks. It was believed that there is a suture as Palaeotethyan suture between the two blocks from Lungmu lake to Chabu, to Shuanghu, to Langcangjiang, but some geologists opposited this opinion, such as Wang Chengshan et al.(1987) and Deng Wanming et al.(1996). The blueschists that bear the typical glaucophane were found in the Gangmar Area in summer of 1997. The blueschists consist of glaucophane, crossite, phengite, actinolite, epidote, sphene ,rutile, and so on. Blueschists show nappe structures in enclosing rocks, and thrust over Tertiary from north to south.The age of blueschist is 275～285Ma which stand for the metamorphic age of blueschist. The geochemical contents of blueschists are the following: SiO\-2 is 45 37%～53 82%, Na 2O>K 2O, K 2O+Na 2O are 3 72%～7 61%, Na 2O/K 2O is 1 70～19 67, MnO is 0 16%～0 22%, FeO+Fe 2O 3 are 11 12%～14 27%, TiO 2 is 2 34%～4 28%, P 2O 5 is 0 34%～1 03%. From the contents, SiO 2 is inverse relation with K 2O+Na 2O, K 2O and FeO+Fe 2O 3. In the SiO 2\|K 2O+Na 2O diagram, the blueschists fall in the field of Alkali basalt; in the TiO 2\|MnO(10\|P 2O 5×10 triangular diagram, these plot within the Ocean Island Basalts(OIB) field. The whole REE content is (117 03～390 97)×10 -6 , LREE/HREE is 5 05～9 80, the REE diagram shows the feature that LREE is rich and HREE is depleted, this is similar to the OIB. In the spidergram of trace elements show the same characterristics as the OIB. Meanwhile, the trace elements ratios, such as Ba/Nb, La/Nb, Nb/Th, Nb/Y, Zr/Y, Zr/Nb, Hf/Sm, Ta/Hf, Nb/Ta, Nb/U, suggest the tectonic setting is OIB. On the basis of these materials, the blueschists are akin to within\|plate ocean island basalts. This shows that there is a ocean or oceanic basin in the Chabu\|Shuanghu belts and the formation of blueschists is the quicky subduction of the Ocean Island Basalts in Early Permian between the Gondwana and Eurasia continents. It demonstrated, therefore, that the Chabu\|Suanghu suture exists and may extend to the east to Lnagchangjiang, and may extend into Thailand\|Malaysia Peninsula.

Clinical characteristics and current management of hepatitis B and C in China

AIM: To describe a population of outpatients in China infected by hepatitis B virus (HBV) and/or hepatitis C virus (HCV), and assess their current management status. METHODS: A multicenter, cross-sectional study of HBV- and/or HCV-infected patients was conducted from August to November, 2011 in western China. Patients >= 18 years of age with HBV and/or HCV infections who visited outpatient departments at 10 hospitals were evaluated, whether treated or not. Data were collected on the day of visit from medical records and patient interviews. RESULTS: A total 4010 outpatients were analyzed, including 2562 HBV- infected and 1406 HCV-infected and 42 HBV/HCV co-infected patients. The median duration of documented infection was 7.5 years in HBV- infected and 1.8 years in HCV-infected patients. Cirrhosis was the most frequent hepatic complication (12.2%), appearing in one-third of patients within 3 years prior to or at diagnosis. The HCV genotype was determined in only 10% of HCV-infected patients. Biopsy data were only available for 54 patients (1.3%). Antiviral medications had been received by 58.2% of patients with HBV infection and 66.6% with HCV infection. Nucleos(t) ide analogs were the major antiviral medications prescribed for HBV- infected patients (most commonly adefovir dipivoxil and lamivudine). Ribavirin + pegylated interferon was prescribed for two-thirds of HCV-infected patients. In the previous 12 mo, around one-fifth patients had been hospitalized due to HBV or HCV infection. CONCLUSION: This observational, real-life study has identified some gaps between clinical practice and guideline recommendations in China. To achieve better health outcomes, several improvements, such as disease monitoring and optimizing antiviral regimens, should be made to improve disease management. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

The influences of model parameters on the characteristics of memristors

As the fourth passive circuit component, a memristor is a nonlinear resistor that can ＂remember＂ the amount of charge passing through it. The characteristic of ＂remembering＂ the charge and non-volatility makes memristors great potential candidates in many fields. Nowadays, only a few groups have the ability to fabricate memristors, and most researchers study them by theoretic analysis and simulation. In this paper, we first analyse the theoretical base and characteristics of memristors, then use a simulation program with integrated circuit emphasis as our tool to simulate the theoretical model of memristors and change the parameters in the model to see the influence of each parameter on the characteristics. Our work supplies researchers engaged in memristor-based circuits with advice on how to choose the proper parameters.

Frequency of the C677T Polymorphism of MTHFR, G20210A of Prothrombin and R506Q of Factor V Leiden in Type 2 Diabetics in Abidjan

In Africa, the prevalence of diabetes is escalating and remains a concern due to the numerous complications it causes. Vascular damage associated with diabetes leads to a prothrombotic state observed in diabetic individuals. Diabetes is a complex and multifactorial disease involving genetic components. With the aim of preventing complications and contributing to an efficient management of diabetes, we investigated genes likely to lead to a risk of thrombosis, in particular the C677T of MTHFR, G20210A of prothrombin, and R506Q of factor V Leiden in type 2 diabetics in Abidjan receiving ambulatory care. A descriptive cross-sectional study was carried out on consenting type 2 diabetic patients. Mutation detection was carried out using the PCR-RFLP method employing restriction enzymes. Hemostasis tests (fibrinogen, D-dimers, fibrin monomers, and von Willebrand factor) were performed using citrate tubes on the Stage? Star Max automated system. Plasminogen activator inhibitor was assayed by ELISA method, and biochemical parameters were determined using the COBAS C311. The study population consisted of 45 diabetic patients, 51.1% of whom presented vascular complications, mainly neuropathy. Disturbances in hemostasis parameters were observed, with 15.5% of patients showing an increase in fibrin monomers. Mutation analysis revealed an absence of factor V mutation (factor V Leiden) and of G20210A mutation of the prothrombin gene. However, 15.6% of subjects had a heterozygous C677T mutation of MTHFR, with 57% of them being anemic. The exploration of biological and genetic factors associated with thrombotic risk is of significant interest in the optimal management of African type 2 diabetics.

抗EGFRvⅢCAR-T疗法联合Notch1通路抑制剂对人胶质瘤起始细胞自我更新能力的抑制作用

目的观察抗表皮生长因子受体vⅢ嵌合抗原受体基因修饰T淋巴细胞(抗EGFRvⅢCAR-T)疗法联合Notch1通路抑制剂DAPT对人胶质瘤起始细胞(GICs)自我更新能力的抑制作用。方法将胶质母细胞瘤原代细胞分为DT007和DT008两部分,经干细胞成球培养后采用免疫磁珠法分选,Western blotting法及免疫荧光法鉴定为GICs,分别命名为PA37S和PA38S。取PA37S、PA38S两种细胞,每种细胞随机分为对照组(加入细胞培养液)、DAPT组(加入10µmol/L DAPT)、CAR-T组(加入慢病毒转染获得的抑制EGFRvⅢ表达的抗EGFRvⅢCAR-T淋巴细胞)、CAR-T+DAPT组(加入抗EGFRvⅢCAR-T淋巴细胞和10µmol/L DAPT),均培养24 h。采用Western blotting法检测细胞EGFRvⅢ、Notch1活化相关指标Hes1蛋白相对表达量,成球实验检测细胞球直径和数目,极限稀释实验检测5、10、20、50、100、200、500个/孔细胞密度下的细胞球数目。结果在PA37S、PA38S细胞中,CAR-T组、CAR-T+DAPT组EGFRvⅢ蛋白相对表达量均低于对照组、DAPT组,DAPT组、CAR-T+DAPT组Hes1蛋白相对表达量均低于对照组、CAR-T组(P均<0.05)。成球实验结果显示,在PA37S、PA38S细胞中,DAPT组、CAR-T组、CAR-T+DAPT组细胞球数量和直径均低于对照组,以CAR-T+DAPT组降低更明显(P均<0.05)。极限稀释实验结果显示,在PA37S细胞和PA38S细胞中,5、10个/孔细胞密度下各组细胞球数量比较差异均无统计学意义(P均>0.05);20个/孔细胞密度下CAR-T+DAPT组细胞球数量低于对照组,50、100、200个/孔细胞密度下CAR-T+DAPT组细胞球数量均低于对照组、DAPT组、CAR-T组,500个/孔细胞密度下DAPT组、CAR-T组、CAR-T+DAPT组细胞球数量均低于对照组且CAR-T+DAPT组降低更明显(P均<0.05)。结论抗EGFRvⅢCAR-T疗法联合DAPT可抑制GICs的自我更新能力。