[Objective] The aim was to build an evaluation method rapidly identifying wheat drought tolerance with near infrared diffuse reflectance spectroscopy. [Method] In the research, 36 wheat varieties in 2007-2009 were cho...[Objective] The aim was to build an evaluation method rapidly identifying wheat drought tolerance with near infrared diffuse reflectance spectroscopy. [Method] In the research, 36 wheat varieties in 2007-2009 were chosen and drought-tolerance degrees of wheat were graded and identified according to Winter-wheat Drought Tol- erance Evaluation Technical Standards （GB/T 21127-2007）, and harvest wheat grains underwent spectrum collection, with a full-spectrum analyzer, to establish a database. [Result] Based on qualitative analysis and full-spectrum correlation research, the coef- ficient of determination （RSQ） and cross-validation coefficient of determination （1-VR） were concluded at 0.697 5 and 0.600 2, showing near-infrared diffuse reflectance spectroscopy is of significant differences among wheat varieties and of significant or extremely significant correlation with drought-tolerance indices. [Conclusion] The re- search indicates that to evaluate drought-tolerance of wheat with near-infrared diffuse reflectance spectroscopy is a rapid and feasible way, which is simple, convenient without damages on grains, and of practical values for construction wheat drought-tol- erance evaluation index system and identification of breeding materials.展开更多
目的探讨2例TANC2基因变异所致神经发育障碍性疾病(NDDs)患儿的临床及遗传学特征。方法回顾性分析于2020年4月和2021年4月就诊于郑州大学第三附属医院小儿神经内科的2例NDDs患儿的临床资料。采集患儿及其父母的外周血样,进行全外显子组...目的探讨2例TANC2基因变异所致神经发育障碍性疾病(NDDs)患儿的临床及遗传学特征。方法回顾性分析于2020年4月和2021年4月就诊于郑州大学第三附属医院小儿神经内科的2例NDDs患儿的临床资料。采集患儿及其父母的外周血样,进行全外显子组测序,对候选变异进行Sanger测序家系验证。以"TANC2基因""神经发育障碍性疾病"为中文关键词,以"Neurodevelopmental disorders""Nervous system development disorders""TANC2"为英文关键词,检索时间为建库至2023年12月,在中国知网、万方数据知识服务平台、PubMed数据库检索相关病例进行回顾性分析。本研究通过郑州大学附属第三医院医学伦理委员会的审查[伦理号:(2020)医伦审第57号]。结果例1为1岁3月龄女性,1岁时出现抽搐发作,共3次,口服奥卡西平治疗后抽搐缓解,2岁7个月时停用奥卡西平,语言、运动及智力发育基本正常。例2为1岁10月龄男性,1岁时出现抽搐发作,表现为肌阵挛发作,发作频繁,加用丙戊酸钠治疗后抽搐得到控制。患儿语言、运动及智力均落后约半年。基因测序显示例1和例2分别存在TANC2基因(NM_025185.4)c.3398G>A(p.Gly1133Glu)和c.2829+1G>A新发变异。根据美国医学遗传学与基因组学学会(ACMG)相关变异指南,前者评级为可能致病性变异(PS2+PM2_Supporting+PP3),后者评级为致病性变异(PVS1+PS2+PM2_Supporting)。共检索到国外文献2篇,共17个病例,16种TANC2基因变异位点,包括剪接变异4种(25.0%)、移码变异8种(50.0%)、无义变异4种(25.0%)。常见表现包括自闭症谱系障碍(70.6%,12/17)、智力障碍(94.1%,16/17)、语言发育迟缓(88.2%,15/17)、运动发育迟缓(58.8%,10/17)、特殊面容、癫痫、共济失调、胸廓以及脊柱畸形等。结论TANC2基因变异考虑为2例NDDs患儿癫痫及发育迟缓的遗传学病因。展开更多
Developing the new quality productive forces is an inherent requirement and an important focus for promoting high-quality development. However, it is not enough to understand the whole picture merely from a domestic p...Developing the new quality productive forces is an inherent requirement and an important focus for promoting high-quality development. However, it is not enough to understand the whole picture merely from a domestic perspective. The concept of new quality productive forces was put forward due to the changes in the international environment, including the emergence of anti-globalization trends and the economic policies of some major economies that are less open than before. With the changes in the global economic concept, China's economic development needs its innovative theory. As the world's second-largest economy, China is committed to the development of new quality productive forces and will make significant contributions to global development. In theory, it shows direction for the development of new quality productive forces on a global scale. In practice, it provides experiences for other economies to develop new quality productive forces. It also helps address the common challenges facing global development. The competition between major countries in traditional fields will continue, but in the case of the development of new quality productive forces, it will show some new characteristics. It will be more reflected in the field of strategic emerging industries, the confrontation risk in major country rivalry will be reduced, and strategic planning and design will become more important.展开更多
基金Supported by National Wheat Industry System(CARS-E-2-36)Henan Wheat Industry System(S2010-10-02)National Science and Technology Support Plan(2011BAD35B-03)~~
文摘[Objective] The aim was to build an evaluation method rapidly identifying wheat drought tolerance with near infrared diffuse reflectance spectroscopy. [Method] In the research, 36 wheat varieties in 2007-2009 were chosen and drought-tolerance degrees of wheat were graded and identified according to Winter-wheat Drought Tol- erance Evaluation Technical Standards （GB/T 21127-2007）, and harvest wheat grains underwent spectrum collection, with a full-spectrum analyzer, to establish a database. [Result] Based on qualitative analysis and full-spectrum correlation research, the coef- ficient of determination （RSQ） and cross-validation coefficient of determination （1-VR） were concluded at 0.697 5 and 0.600 2, showing near-infrared diffuse reflectance spectroscopy is of significant differences among wheat varieties and of significant or extremely significant correlation with drought-tolerance indices. [Conclusion] The re- search indicates that to evaluate drought-tolerance of wheat with near-infrared diffuse reflectance spectroscopy is a rapid and feasible way, which is simple, convenient without damages on grains, and of practical values for construction wheat drought-tol- erance evaluation index system and identification of breeding materials.
文摘目的探讨2例TANC2基因变异所致神经发育障碍性疾病(NDDs)患儿的临床及遗传学特征。方法回顾性分析于2020年4月和2021年4月就诊于郑州大学第三附属医院小儿神经内科的2例NDDs患儿的临床资料。采集患儿及其父母的外周血样,进行全外显子组测序,对候选变异进行Sanger测序家系验证。以"TANC2基因""神经发育障碍性疾病"为中文关键词,以"Neurodevelopmental disorders""Nervous system development disorders""TANC2"为英文关键词,检索时间为建库至2023年12月,在中国知网、万方数据知识服务平台、PubMed数据库检索相关病例进行回顾性分析。本研究通过郑州大学附属第三医院医学伦理委员会的审查[伦理号:(2020)医伦审第57号]。结果例1为1岁3月龄女性,1岁时出现抽搐发作,共3次,口服奥卡西平治疗后抽搐缓解,2岁7个月时停用奥卡西平,语言、运动及智力发育基本正常。例2为1岁10月龄男性,1岁时出现抽搐发作,表现为肌阵挛发作,发作频繁,加用丙戊酸钠治疗后抽搐得到控制。患儿语言、运动及智力均落后约半年。基因测序显示例1和例2分别存在TANC2基因(NM_025185.4)c.3398G>A(p.Gly1133Glu)和c.2829+1G>A新发变异。根据美国医学遗传学与基因组学学会(ACMG)相关变异指南,前者评级为可能致病性变异(PS2+PM2_Supporting+PP3),后者评级为致病性变异(PVS1+PS2+PM2_Supporting)。共检索到国外文献2篇,共17个病例,16种TANC2基因变异位点,包括剪接变异4种(25.0%)、移码变异8种(50.0%)、无义变异4种(25.0%)。常见表现包括自闭症谱系障碍(70.6%,12/17)、智力障碍(94.1%,16/17)、语言发育迟缓(88.2%,15/17)、运动发育迟缓(58.8%,10/17)、特殊面容、癫痫、共济失调、胸廓以及脊柱畸形等。结论TANC2基因变异考虑为2例NDDs患儿癫痫及发育迟缓的遗传学病因。
文摘Developing the new quality productive forces is an inherent requirement and an important focus for promoting high-quality development. However, it is not enough to understand the whole picture merely from a domestic perspective. The concept of new quality productive forces was put forward due to the changes in the international environment, including the emergence of anti-globalization trends and the economic policies of some major economies that are less open than before. With the changes in the global economic concept, China's economic development needs its innovative theory. As the world's second-largest economy, China is committed to the development of new quality productive forces and will make significant contributions to global development. In theory, it shows direction for the development of new quality productive forces on a global scale. In practice, it provides experiences for other economies to develop new quality productive forces. It also helps address the common challenges facing global development. The competition between major countries in traditional fields will continue, but in the case of the development of new quality productive forces, it will show some new characteristics. It will be more reflected in the field of strategic emerging industries, the confrontation risk in major country rivalry will be reduced, and strategic planning and design will become more important.
