Give Full Play the Role of Traditional Chinese Medicine to Prevent and Treat Severe Acute Respiratory Syndrome with Integrative Chinese and Western Medicine Approach

Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Headquarters Vice premier WU Yi cordially met the well-known TCM specialists, and held a symposium with them. Sixteen specialists including WANG Yong-yan, CHEN Ke-ji, LI Fu-ren, JIAO Shu-de, HE Pu-ren, LIU

Tong xie yao fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P

AIM: To investigate whether the Chinese medicine Tong Xie Yao Fang(TXYF) improves dysfunction in an irritable bowel syndrome(IBS) rat model. METHODS: Thirty baby rats for IBS modeling were separated from mother rats(1 h per day) from days 8 to 21, and the rectum was expanded by angioplasty from days 8 to 12. Ten normal rats were used as normal controls. We examined the effects of TXYF on defection frequency, colonic transit function and smooth muscle contraction, and the expression of 5-hydroxytryptamine(5-HT) and substance P(SP) in colonic and hypothalamus tissues by Western blot and RT-PCT techniques in both normal rats and IBS model rats with characterized visceral hypersensitivity.in normal rats and 4.5 ± 1.58 in IBS model rats(P < 0.001). However, the defecation frequency was significantly decreased(3.0 ± 1.25 vs 4.5 ± 1.58, P < 0.05), while the time(in seconds) of colon transit function was significantly increased(256.88 ± 20.32 vs 93.36 ± 17.28, P < 0.001) in IBS + TXYF group rats than in IBS group rats. Increased colonic smooth muscle tension and contract frequency in IBS model rats were significantly decreased by administration of TXYF. Exogenous agonist stimulants increased spontaneous activity and elicited contractions of colon smooth muscle in IBS model rats, and all of these actions were significantly reduced by TXYF involving 5-HT and SP down-regulation. CONCLUSION: TXYF can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of IBS.

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Traditional Chinese medicine(TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency and other TCM syndromes(Zheng). Modern treatments such as surgery, transarterial chemoembolization(TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma.

The Psychosomatic Traits of“People with the Five Elements in Traditional Chinese Medicine”:A Qualitative Study

Objective To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of“people with the five elements in traditional Chinese medicine(TCM).”Methods Data collected from the literature review,two sessions of brainstorming of experts with related experience in“people with the five elements in TCM”from October 2020 to December 2020,and six rounds of in-depth interviews with 30 participants who had various attributes of the five elements from March 2021 to October 2021 were analyzed.Triangulation was used in this study,and theming and synthesizing were used to analyze the data.Results A total of 31 experts and 30 interviewees participated in this study.The median age of the experts and interviewees were 48.0 and 38.5 years,respectively;51.66%and 54.8%of experts and interviewees,respectively,were men.The descriptors of facial diagrams of“people with the five elements in TCM”were complexion,shape,distribution state of facial bones,convergence trend of facial muscles,and facial expression.A theoretical model of“people with the five elements in TCM”was shaped based on these findings.Conclusion The study suggests a possibility for bridging the gap between personality and bodily state,identifying an avenue for personality research from the perspective of TCM.

Traditional Chinese Medicine Nursing Protocols for Wheezing Disease(Bronchial Asthma)

Wheezing disease( bronchial asthma) is a common but refractory disease among pulmonary diseases. It tends to attack repeatedly,and is difficult to be cured. In recent years,some studies have shown that effective traditional Chinese medicine( TCM) nursing interventions on the wheezing disease can significantly ameliorate the treatment compliance of patients,reduce the attack and improve the quality of life. Therefore,it is important for patients with different patterns of syndrome to receive effective and reasonable TCMnursing intervention. This article mainly explored the key points of common syndromes,TCMnursing methods and health guidance of wheezing disease in order to further develop the advantages of TCM,improve its efficacy and standardized its nursing behavior.

Acupuncture treatment of empty nose syndrome:A case report

Background:Empty nose syndrome(ENS)is an iatrogenic disorder that most commonly presents with paradoxical nasal obstruction.Diagnosis of ENS is based mainly on symptomatology and surgical history.Symptomatic or surgical treatment is typically offered to patients.Case presentation:A 17-year-old Chinese male presented with ENS following inferior turbinate resection.His main symptoms were dizziness and nasal congestion.He was diagnosed with a traditional Chinese medicine syndrome pattern of liver yang ascending.Acupuncture treatment involved needling ST 36(Zusanli)GB 20(Fengchi),PC 6(Neiguan),LI 4(Hegu),LR 3(Taichong),LR 2(Xingjian),GB 43(Xiaxi),DU 20(Baihui),EX-HN3(Yintang),ST 2(Sibai),and LI 20(Yingxiang).Near complete resolution of dizziness and nasal congestion were achieved after 2 treatments.Conclusion:Acupuncture may be used to resolve symptoms of ENS.Acupoint selection and needle manipulation should be based on TCM pattern diagnosis.

Research progress of Traditional Chinese Medicine in the treatment of tumor-related depression

Cancer related depression(CRD)refers to the significant and lasting depression of the patient due to tumor diagnosis,treatment and comorbidities.It can be attributed to the category of“stagnation syndrome”in traditional Chinese medicine(TCM).Clinically,cancer-related depression can be divided into three stages,namely primary,middle and final stages by analogy with depression syndrome.The location of the initial disease is in the liver.The main syndrome was excess,while the basic pathogenesis is mainly due to liver-qi stagnation syndrome and the principle of treatment is dispersing stagnated liver qi for relieving qi stagnation by using modified Xiaoyao Powder and Chaihu Shugan Powder.In the middle stage of the disease,the location is in the spleen and stomach.The main syndrome was intermingled deficiency and excess.The principle of treatment is relaxing bowels,dissipating phlegm and eliminating dampness,regulating qi-flowing and promoting blood,invigorating spleen and heart,nourishing qi and blood.Xuefuzhuyu tang,Guipi decotion,Bailongjieyu granules can be used as treatment for this period.At the final stage of the disease,the main syndrome was deficiency,the principle of treatment is replenishing lung and heart,benefiting qi and regulating spleen,nourishing lung and kidney.Baihe formulas,Kai-Xin-San are chosed at this stage.

Research advances in traditional Chinese medicine syndromes in cancer patients

Traditional Chinese medicine （TCM） syndrome, also known as TCM ZHENG or TCM pattern, is an integral and essential part of TCM theory that helps to guide the design of individualized treatments. ATCM syndrome, in essence, is a characteristic profile of all clinical manifestations in one patient that can be readily identified by a TCM practitioner. In this article, the authors reviewed the presentations of TCM syndromes in seven common malignancies （liver, lung, gastric, breast, colorectal, pancreatic and esophageal cancers）, the objectivity and the standardization of TCM syndrome differentiation, the evaluation of TCM syndrome modeling in cancer research, and syndrome differentiation-guided TCM treatment of cancers. A better understanding of TCM syndrome theory, as well as its potential biologica basis, may contribute greatly to the clinical TCM diagnosis and the treatment of cancer.

2型糖尿病视网膜病变患者中医证型分布及其与血清炎症因子及脂联素水平的相关性研究

【目的】探讨2型糖尿病视网膜病变(type 2 diabetic retinopathy,T2DR)的中医证型分布及其与血清炎症因子、脂联素(APN)水平的相关性,为T2DR的中医辨证分型提供客观依据。【方法】采用横断面病例对照研究方法,选择2022年9月至2023年3月在江西省赣州市人民医院眼科诊断为T2DR的患者共42例84眼,观察T2DR患者眼底荧光血管造影(FFA)分期与中医辨证分型的关系,分析不同中医证型与血清炎症因子及APN水平的关系以及不同FFA分期的血清炎症因子及APN水平差异,探讨T2DR患者各变量与不同中医证型之间的相关性。【结果】(1)42例T2DR患者中,男性27例,女性15例,平均年龄为(54.0±12.0)岁;其中,肝肾亏虚、目络失养证14例(33.3%),阴精不足、燥热内生证15例(35.7%),气阴两虚、络脉瘀阻证9例(21.4%),阴阳两虚、血瘀痰凝证4例(9.5%),脾失健运、水湿阻滞证0例(0.0%)。(2)肝肾亏虚、目络失养证患者中双眼眼底FFA分期≥4期[增殖期糖尿病视网膜病变(PDR)]者占78.6%(11/14),阴精不足、燥热内生证患者占73.3%(11/15),气阴两虚、络脉瘀阻证患者和阴阳两虚、血瘀痰凝证患者均占100%(9/9;4/4),但组间比较,差异无统计学意义(P=0.272)。(3)42例T2DR患者中,有35例(83.3%)患者的肿瘤坏死因子α(TNF-α)、28例(68.3%)患者的C反应蛋白(CRP)、38例(90.5%)患者的糖化血红蛋白(HbA1c)水平均高于正常值;但不同FFA分期患者的血清炎症因子TNF-α、CRP、白细胞介素6(IL-6)、血管内皮生长因子(VEGF)及APN、HbA1c水平比较,差异均无统计学意义(P>0.05);同时,不同中医证型的血清APN、TNF-α、CRP、IL-6、VEGF水平比较,差异也均无统计学意义(P>0.05)。(4)相比肝肾亏虚、目络失养证患者,阴阳两虚、血瘀痰凝证患者的眼部病程较短,两者的相关性接近差异有统计学意义(r=-0.467,P=0.051);相比阴精不足、燥热内生证患者,阴阳两虚、血瘀痰凝证患者的CRP水平较高(r=0.592,P=0.010);相比气阴两虚、络脉瘀阻证患者,阴阳两虚、血瘀痰凝证患者的CRP水平较高(r=0.668,P=0.013)和糖尿病病程更长(r=0.629,P=0.021)。【结论】血清TNF-α及CRP在T2DR中有更高的表达;肝肾亏虚、目络失养证和阴精不足、燥热内生证为T2DR的常见证型;阴阳两虚、血瘀痰凝证与CRP密切相关,同时阴阳两虚、血瘀痰凝证型患者有更长的糖尿病病程。

95例真菌性脓毒症的中医证候特征、中药组方规律及临床疗效研究

目的总结真菌性脓毒症患者的中医证候学特征,通过数据挖掘分析中药组方规律并评估临床疗效,为中医药治疗真菌性脓毒症提供依据。方法回顾性收集首都医科大学附属北京中医医院重症医学科2007年7月1日至2022年7月31日入院的脓毒症患者的临床资料,病原学检验显示真菌感染。采集患者一般情况、中医四诊信息、辨证分型、中药使用情况,采用频数、频率进行描述性统计。中药方面采用R语言进行中药频数统计、高频中药关联分析,通过SPSS进行聚类分析。分析患有不同基础疾病的真菌性脓毒症患者的中药应用情况。临床疗效通过好转率和APACHEⅡ评分进行评估。结果本研究共纳入患者95名,主要为白念珠菌感染患者,男性51例,女性44例,年龄(84.9±11.2)岁。感染部位方面以肺部真菌感染为主。预后方面,真菌性脓毒症患者28 d病死率为11.6%。患者伴有多种基础疾病,临床以发热、咳嗽、喘憋、意识障碍为主要症状,舌象以舌红或舌淡白、苔白腻多见,脉象以细、弦、滑、沉为主。证候方面,痰热壅肺证、气阴两虚证为主要的临床证候。中药的应用以苦寒、甘温药为主,主要归肺经、脾经、胃经,发挥补益虚损、清热解毒、利湿化痰、活血祛瘀等作用。关联规则分析得出核心药物组合为黄芪-当归-金银花-甘草,蛇床子-苦参-干姜,红花-白术-陈皮,枳壳-陈皮-柴胡等。聚类分析将高频中药分为2个有效类方群,分别侧重祛除病邪和补益虚损。基础疾病对患者的用药亦有影响,根据基础疾病的不同,在治疗上有侧重地施以通利心脉、清肺平喘、疏肝解毒、补益肾阳、健脾燥湿之法。临床好转率为86.3%,出院时APACHEⅡ评分较入院时明显降低(P<0.05)。结论真菌性脓毒症患者的中医证候以正虚邪盛为主要特征,中药治疗时注重补虚祛邪,临床疗效值得肯定。

肿瘤患者呼吸道多重耐药菌感染中医证型及易感因素研究

【目的】探讨呼吸道多重耐药菌感染肿瘤患者的中医证候分布特点及易感因素。【方法】采用病例对照研究方法,以痰细菌培养阳性的250例呼吸道多重耐药菌感染肿瘤患者为多耐组,以痰细菌培养阳性的250例呼吸道非多重耐药菌感染肿瘤患者为对照组,收集2组患者的年龄、性别、临床相关检查结果及既往抗菌药物使用状况等临床资料,分析呼吸道多重耐药菌感染肿瘤患者的中医证候分布特点和易感因素。【结果】(1)易感因素方面:单因素分析结果提示,2组间的高血压史、糖尿病史、冠心病史、化疗周期、抗菌药物使用时间、白蛋白、血红蛋白比较,差异均有统计学意义(P<0.05或P<0.01);多因素Logistic回归分析结果提示,以上变量均是肿瘤患者呼吸道多重耐药菌感染的危险因素,差异均有统计学意义(P<0.05或P<0.01)。(2)病原菌分布方面:肿瘤患者呼吸道多重耐药菌感染最常见致病菌排前3位的依次为鲍曼不动杆菌、铜绿假单胞菌、大肠埃希菌。(3)中医证候分布方面:实证方面,多耐组痰浊阻肺、热陷心包、痰热蕴肺的证型表现均较对照组严重,差异均有统计学意义(P<0.05或P<0.01);虚证方面,多耐组脾肾两虚、肺肾两虚、肝肾阴虚及心肾阳虚的证型表现均较对照组严重,差异均有统计学意义(P<0.05或P<0.01)。【结论】合并基础病、化疗周期长、抗菌药物使用时间长、低水平白蛋白及低血红蛋白为肿瘤患者发生呼吸道多重耐药菌感染的危险因素;相对于非多重耐药菌感染肿瘤患者,多重耐药菌感染肿瘤患者病情较重,中医证型以虚实夹杂型为主,而非多重耐药菌感染肿瘤患者以实证居多。

辨证施护联合热敏灸治疗肝硬化腹水临床观察

目的探究中医辨证施护联合热敏灸治疗肝硬化腹水的临床效果。方法选择肝硬化腹水患者60例,分为对照组(予常规治疗)和试验组(予热敏灸联合中药治疗),对比两组临床疗效及不良反应发生率。结果试验组治疗总有效率为96.67%(29/30),高于对照组的83.33%(25/30),差异有统计学意义(P<0.05)。对照组不良反应发生率为6.67%(2/30),而试验组患者未出现不良反应,差异有统计学意义(P<0.05)。结论中医辨证施护联合热敏灸治疗肝硬化腹水效果显著、安全高,值得临床推广应用。

穴位贴敷联合中药雾化吸入护理在老年慢性阻塞性肺疾病急性加重期患者中的应用效果

目的:探讨穴位贴敷联合中药雾化吸入护理在老年慢性阻塞性肺疾病急性加重期患者中的应用效果。方法:选取2021年6月~2023年6月北京朝阳医院收治的老年慢性阻塞性肺疾病急性加重期患者100例为研究对象,根据随机数表法分为研究组和对照组,各50例。研究采用穴位贴敷联合中药雾化吸入护理,对照组采用常规护理,比较两组中医症候积分、肺功能指标、炎症反应、免疫功能及生存质量。结果:研究组干预后咳嗽、喘息气短、咳痰、肺湿啰音中医症候积分低于对照组(P<0.05);研究组治疗有效率高于对照组(P<0.05);研究组干预后呼气峰值体积流量(PEF)、用力呼气容积/用力肺活量(FEV1/FVC)、用力呼气容积占预计值百分比(FEV1%pred)、用力肺活量占预计值百分比(FVC%pre)高于对照组(P<0.05);研究组干预后基质金属蛋白酶-9(MMP-9)、白介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)低于对照组,CD4+/CD8+高于对照组(P<0.05)。结论:穴位贴敷联合中药雾化吸入护理可以改善患者临床症状,降低炎症反应,提高患者免疫功能及肺功能,提高临床治疗效果。

芒针联合中医辨证干预肝郁脾虚型溃疡性结肠炎临床疗效观察

目的评价芒针疗法联合中医辨证干预肝郁脾虚型溃疡性结肠炎的有效性和安全性。方法选择肝郁脾虚型溃疡性结肠炎患者64例,按照随机数字表法将其分为两组,分别为治疗组和对照组,治疗组根据中医辨证,给予芒针治疗,配合培土疏郁汤口服;对照组口服美沙拉嗪缓释颗粒。比较两组治疗前后的中医证候积分及治疗后临床有效率。结果治疗后,治疗组中医证候积分低于对照组,差异有统计学意义(P<0.01);治疗组的临床总有效率高于对照组,差异有统计学意义(P<0.05)。结论芒针疗法联合中医辨证干预肝郁脾虚型溃疡性结肠炎较单纯西药口服更具有优势,值得临床推广。

慢性萎缩性胃炎肝胃气滞证和脾胃虚弱证患者血清代谢组学特征研究

【目的】基于非靶向代谢组学技术,分析慢性萎缩性胃炎(chronic atrophic gastritis,CAG)肝胃气滞证和脾胃虚弱证患者的代谢组学特征,发现与CAG患者中医证型相关的血清代谢差异物,为中医辨证客观化提供参考依据。【方法】纳入60例CAG患者,其中肝胃气滞证及脾胃虚弱证各30例。收集2组患者空腹肘静脉血5 mL,采用超高效液相色谱-质谱技术检测血清代谢物含量,采用主成分分析(PCA)、正交偏最小二乘法判别分析(OPLS-DA)和聚类分析等多元统计方法筛选CAG肝胃气滞证和脾胃虚弱证患者之间的差异代谢物,最后利用KEGG数据库对筛选的差异代谢物进行代谢物通路分析。【结果】通过比较CAG肝胃气滞证和脾胃虚弱证患者血清代谢物,发现CAG肝胃气滞证和脾胃虚弱证之间N-乙酰基甘氨酸、组胺、O-磷酸丝氨酸、硒甲基硒代半胱氨酸、甲基间酪氨酸等氨基酸衍生物和酪氨酸-亮氨酸-苯丙氨酸、组氨酸-丙氨酸-谷酰胺-赖氨酸、L-天冬酰胺基-L-脯氨酰-L-丝氨酸、L-异亮氨酸-L-异亮氨酸等小肽类物质代谢具有显著性差异。【结论】CAG肝胃气滞证和脾胃虚弱证患者之间存在氨基酸代谢差异,N-乙酰基甘氨酸、甲基间酪氨酸、O-磷酸丝氨酸等代谢物可能是区别CAG肝胃气滞证和脾胃虚弱证的潜在生物标志物。

1327例突发性聋的中医证型分布特点

【目的】通过大样本分析探讨突发性聋的证型分布规律,为突发性聋的中医辨证提供参考。【方法】对广州中医药大学第一附属医院收治的1 327例突发性聋住院患者的临床资料进行回顾性分析,统计各证型分布比例,并分析不同证型患者的性别、年龄、伴随症状、听力曲线类型及耳聋程度等有无差异,总结其证型分布规律及临床特点。【结果】(1)按中医辨证分型标准,1 327例突发性聋患者的证型分布频次由高到低依次为气血亏虚证(75.4%)、痰火郁结证(13.8%)、气滞血瘀证(5.3%)、肝火上扰证(2.8%)、风热侵袭证(1.5%)、肾精亏损证(1.3%)。(2)气血亏虚证女性占比多于男性(P<0.05),而痰火郁结证及其他证型则男性占比多于女性(P<0.05)。(3)痰火郁结证伴眩晕比例较高(P<0.05),而其他伴随症状及年龄、听力曲线类型、耳聋程度等方面,不同证型间比较差异均无统计学意义(P>0.05)。【结论】突发性聋以气血亏虚证最为常见,其次为痰火郁结证,其他证型相对少见,性别及是否伴眩晕对于辨证可能有一定参考意义。

高彦彬教授从络病论治慢性肾衰经验

慢性肾衰是各类进展性肾脏疾病的最终结局,病机错综复杂,中医对其治疗具有较好疗效。高彦彬教授学术思想师承国医大师吕仁和教授,临证四十载,认为此病属于“络病”范畴,并针对慢性肾衰提出肾元虚衰、肾络瘀结、浊毒内停的基本病机和益气固肾、解毒通络的基本治法。临床上以虚定型,以实定候进行辨证论治,并基于治未病理论,提出慢性肾病三级预防策略。

刘凤斌对慢性萎缩性胃炎“炎-癌”转化的病机探索与辨治思路

慢性萎缩性胃炎(chronic atrophic gastritis,CAG)是临床上常见的难治性胃病,属于胃癌前病变。刘凤斌教授及其团队历经30余年的探索和实践,提出“脾虚为本,气血湿为标,瘀毒为变”是CAG“炎-癌”转化的病机演变特点。脾胃虚弱为CAG发病的始动因素,贯穿疾病始终;气滞、血瘀、湿阻为CAG“炎-癌”转化的触发和加重因素;瘀毒的形成是CAG进展和转变的关键。辨治应遵循“证镜结合,分期论治”的原则,辨病和辨证相结合,宏观和微观辨证相补充;健脾扶正需贯穿始终。CAG早期阶段(胃黏膜以轻中度萎缩伴或不伴轻度肠上皮化生),其病机以脾胃虚弱为本,伴有气滞、湿阻、血瘀病理因素,治疗以健脾清热、理气活血为基本治法;CAG晚期阶段(胃黏膜重度萎缩伴或不伴中重度肠上皮和/或轻中度上皮内瘤变),基本病机为脾胃虚弱、痰瘀互结、胃络瘀毒,治疗以扶正散结、通络解毒为基本治法,从而构筑中医药阻断胃“炎-癌”转化的整体防线。

缺铁性贫血孕妇的中医体质分布及影响因素研究

【目的】分析缺铁性贫血(iron deficiency anemia,IDA)孕妇的中医体质分布规律及相关影响因素,为中医药防治妊娠期IDA提供指导方案。【方法】纳入109例符合条件的妊娠期IDA患者,收集孕妇的一般资料、中医体质鉴别结果和相关实验室指标,包括血清铁蛋白(Fer)、血红蛋白(Hb)及平均红细胞体积(MCV)。对IDA孕妇的中医体质分布规律及相关影响因素、妊娠结局进行统计分析。【结果】(1)109例IDA孕妇中医体质以偏颇质为主,有60例(55.05%),各体质分布人数和比例从高到低依次为:平和质49例(44.95%)>湿热质13例(11.93%)>阳虚质12例(11.01%)>阴虚质11例(10.09%)>气虚质10例(9.17%)>气郁质9例(8.26%)>血瘀质3例(2.75%)>痰湿质2例(1.83%)。(2)不同体质类型IDA孕妇的Hb和MCV水平比较,差异均无统计学意义(P>0.05),但湿热质IDA孕妇的Fer水平显著高于平和质(P<0.01),湿热质IDA孕妇发生羊水混浊的概率显著高于平和质及其他偏颇体质(P<0.05)。【结论】湿热质是IDA孕妇最常见的偏颇体质,其次是阳虚质、阴虚质和气虚质,湿热质可能是IDA孕妇的易感体质,此体质类型IDA孕妇的Fer水平显著高于平和质,而其发生羊水混浊的概率显著高于平和质及其他偏颇体质。

茯苓甘草合剂辅助西药对慢性阻塞性肺疾病合并肌肉衰减患者NF-κB信号通路的影响

目的探讨茯苓甘草合剂辅助西药对慢性阻塞性肺疾病(COPD)合并肌肉衰减NF-κB信号通路的影响及分子机制。方法选取2020年8月至2022年8月COPD合并肌肉衰减患者104例,作为研究对象随机数字表法分为对照组和观察组,每组52例。对照组给予西药治疗,观察组给予西药+茯苓甘草合剂治疗。统计2组中医疗效、不良反应及治疗前后中医证候积分、NF-κB mRNA、蛋白及因子[白细胞介素-8(IL-8)、白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)]、营养状况指标[转铁蛋白(Tf)、血红蛋白(Hb)、白蛋白(ALB)]、肌肉衰减相关指标[握力试验、起立-行走计时测试(TUGT)、5次坐立试验(FTSST)、肌少症筛查问卷(SARC-F)]。结果观察组中医治疗总有效率[86.54%(45/52)]高于对照组[67.31%(35/52)](P<0.05);治疗1个月、3个月后观察组中医证候积分低于对照组(P<0.05);治疗1个月、3个月后观察组NF-κB mRNA、NF-κB蛋白、IL-8、IL-1、TNF-α低于对照组(P<0.05);治疗3个月后观察组握力高于对照组,FTSST、TUGT、SARC-F评分低于对照组(P<0.05);治疗期间,2组均未出现明显不良反应。结论茯苓甘草合剂辅助西药治疗COPD合并肌肉衰减效果确切,可通过抑制NF-κB信号通路,减轻炎性反应,改善患者营养状态,有效改善临床症状,且安全性高。