Objective: To explore the correlation of TI-RADS grading with oncogene and invasion molecule expression in thyroid cancer lesions. Methods: Patients who were diagnosed with thyroid cancer in this hospital between Janu...Objective: To explore the correlation of TI-RADS grading with oncogene and invasion molecule expression in thyroid cancer lesions. Methods: Patients who were diagnosed with thyroid cancer in this hospital between January 2017 and January 2018 were divided into TI-RADS grade 4 group (n=54) and TI-RADS grade 5 group (n=56) according to TI-RADS grading. 50 patients who underwent surgery and were diagnosed with thyroid adenoma in this hospital during the same period were chosen as benign thyroid group. The differences in the expression of oncogenes and invasion molecules in lesion tissues were compared among the three groups. Results: Proto-oncogenes c-myc, c-erbB-2, RET and TRK mRNA expression in lesions of TI-RADS grade 4 group and TI-RADS grade 5 group were higher than those of benign thyroid group whereas tumor suppressor genes DPC4, p53, PTEN and HBB mRNA expression were lower than those of benign thyroid group;invasion molecules BCORL1, BRD4, STAT3, CD151, SATB1 and CXCR4 mRNA expression were higher than those of benign thyroid group whereas ST7L mRNA expression were lower than that of thyroid benign group. With the increase of TI-RADS grading, the changes in the expression of oncogenes and invasion molecules were aggravated. Conclusion: The changes in oncogene and invasion molecule expression were aggravated with the increase of TI-RADS grading of thyroid cancer, and the specific TI-RADS grading was positively correlated with tumor malignancy.展开更多
目的研究甲状腺结节(thyroid imaging reporting and data system,TI-RADS)分级与代谢相关指标的关系。方法非随机选取伊犁哈萨克自治州中医医院于2022年1月—2023年1月期间收治的150例甲状腺结节检出患者为研究对象,经TI-RADS分级分为T...目的研究甲状腺结节(thyroid imaging reporting and data system,TI-RADS)分级与代谢相关指标的关系。方法非随机选取伊犁哈萨克自治州中医医院于2022年1月—2023年1月期间收治的150例甲状腺结节检出患者为研究对象,经TI-RADS分级分为TI-RADS 3类及以下者(良性组)51例、TI-RADS 4a类(低度恶性组)50例、TI-RADS 4b类及以上组(恶性组)49例,对比3组患者代谢相关指标水平差异,并分析相关性。结果3组患者总胆固醇、甘油三酯、高密度脂蛋白、HOMA胰岛素抵抗指数、餐后2 h血糖比较,差异无统计学意义(P均>0.05);3组患者低密度脂蛋白(low-density lipoprotein,LDL-C)、糖化血红蛋白(glycosylatedhemoglobin,HbA1c)、空腹血糖(fastingplasmaglucose,FPG)、抗甲状腺球蛋白抗体(antithyroglobulin anti-bodies,TGAb)、体重指数(body mass index,BMI)水平比较,差异有统计学意义(P均<0.05)。Pearson相关分析结果显示,甲状腺结节TI-RADS分级与LDL-C、HbA1c、FPG、TGAb水平之间呈现正相关(r=1.334、0.092、0.193、1.294,P均<0.05),甲状腺结节TI-RADS分级BMI水平之间呈现负相关(r=-0.092,P<0.05)。结论代谢相关指标与甲状腺结节的TI-RADS分级之间存在联系,高级别结节患者在BMI、LDL-C、HbA1c、FPG、TGAb指标方面表现出异常。展开更多
Introduction: A thyroid nodule is a localized hypertrophy within the thyroid parenchyma. The aim of our study was to study the benefit of ultrasound in the Ti-rads classification of thyroid nodules. Methodology: This ...Introduction: A thyroid nodule is a localized hypertrophy within the thyroid parenchyma. The aim of our study was to study the benefit of ultrasound in the Ti-rads classification of thyroid nodules. Methodology: This was a prospective study with a descriptive aim, with prospective collection, which took place over a period of 17 months at the “Marie Curie” medical clinic. The ultrasound machine used was a Voluson E8 from 2011 and the examinations were carried out by two radiologists and two experienced sonographers. The parameters studied were sociodemographic data;clinical data and ultrasound aspects of the Ti-rads classification in the management of nodules. Results: We collected 235 patients out of 738 patients referred to the service for a cervical ultrasound, i.e. a frequency of 31.84% of cases. There was a female predominance with 95.7% of cases and a sex ratio of 0.04. The average age of our patients was 50 years. We found on cervical ultrasound: Isthmo-lobar glandular hyperplasia in 99 patients, i.e. a frequency of 42.1%. The Ti-rads 3 classification was the most represented in 69.4% of cases. The benignity criterion represented 85.6% of cases in our patients and the malignancy criterion represented 14.4% of cases. Conclusion: The precise description of a thyroid nodule provided by ultrasound (Ti-rads) is essential in the management of nodules.展开更多
文摘Objective: To explore the correlation of TI-RADS grading with oncogene and invasion molecule expression in thyroid cancer lesions. Methods: Patients who were diagnosed with thyroid cancer in this hospital between January 2017 and January 2018 were divided into TI-RADS grade 4 group (n=54) and TI-RADS grade 5 group (n=56) according to TI-RADS grading. 50 patients who underwent surgery and were diagnosed with thyroid adenoma in this hospital during the same period were chosen as benign thyroid group. The differences in the expression of oncogenes and invasion molecules in lesion tissues were compared among the three groups. Results: Proto-oncogenes c-myc, c-erbB-2, RET and TRK mRNA expression in lesions of TI-RADS grade 4 group and TI-RADS grade 5 group were higher than those of benign thyroid group whereas tumor suppressor genes DPC4, p53, PTEN and HBB mRNA expression were lower than those of benign thyroid group;invasion molecules BCORL1, BRD4, STAT3, CD151, SATB1 and CXCR4 mRNA expression were higher than those of benign thyroid group whereas ST7L mRNA expression were lower than that of thyroid benign group. With the increase of TI-RADS grading, the changes in the expression of oncogenes and invasion molecules were aggravated. Conclusion: The changes in oncogene and invasion molecule expression were aggravated with the increase of TI-RADS grading of thyroid cancer, and the specific TI-RADS grading was positively correlated with tumor malignancy.
文摘目的研究甲状腺结节(thyroid imaging reporting and data system,TI-RADS)分级与代谢相关指标的关系。方法非随机选取伊犁哈萨克自治州中医医院于2022年1月—2023年1月期间收治的150例甲状腺结节检出患者为研究对象,经TI-RADS分级分为TI-RADS 3类及以下者(良性组)51例、TI-RADS 4a类(低度恶性组)50例、TI-RADS 4b类及以上组(恶性组)49例,对比3组患者代谢相关指标水平差异,并分析相关性。结果3组患者总胆固醇、甘油三酯、高密度脂蛋白、HOMA胰岛素抵抗指数、餐后2 h血糖比较,差异无统计学意义(P均>0.05);3组患者低密度脂蛋白(low-density lipoprotein,LDL-C)、糖化血红蛋白(glycosylatedhemoglobin,HbA1c)、空腹血糖(fastingplasmaglucose,FPG)、抗甲状腺球蛋白抗体(antithyroglobulin anti-bodies,TGAb)、体重指数(body mass index,BMI)水平比较,差异有统计学意义(P均<0.05)。Pearson相关分析结果显示,甲状腺结节TI-RADS分级与LDL-C、HbA1c、FPG、TGAb水平之间呈现正相关(r=1.334、0.092、0.193、1.294,P均<0.05),甲状腺结节TI-RADS分级BMI水平之间呈现负相关(r=-0.092,P<0.05)。结论代谢相关指标与甲状腺结节的TI-RADS分级之间存在联系,高级别结节患者在BMI、LDL-C、HbA1c、FPG、TGAb指标方面表现出异常。
文摘Introduction: A thyroid nodule is a localized hypertrophy within the thyroid parenchyma. The aim of our study was to study the benefit of ultrasound in the Ti-rads classification of thyroid nodules. Methodology: This was a prospective study with a descriptive aim, with prospective collection, which took place over a period of 17 months at the “Marie Curie” medical clinic. The ultrasound machine used was a Voluson E8 from 2011 and the examinations were carried out by two radiologists and two experienced sonographers. The parameters studied were sociodemographic data;clinical data and ultrasound aspects of the Ti-rads classification in the management of nodules. Results: We collected 235 patients out of 738 patients referred to the service for a cervical ultrasound, i.e. a frequency of 31.84% of cases. There was a female predominance with 95.7% of cases and a sex ratio of 0.04. The average age of our patients was 50 years. We found on cervical ultrasound: Isthmo-lobar glandular hyperplasia in 99 patients, i.e. a frequency of 42.1%. The Ti-rads 3 classification was the most represented in 69.4% of cases. The benignity criterion represented 85.6% of cases in our patients and the malignancy criterion represented 14.4% of cases. Conclusion: The precise description of a thyroid nodule provided by ultrasound (Ti-rads) is essential in the management of nodules.
