We spotlight recent findings from a Nature paper unveiling captivating insights into how substrates such as NADþand ATP stimulate the condensation of TIR domain proteins.This process culminates in the formation o...We spotlight recent findings from a Nature paper unveiling captivating insights into how substrates such as NADþand ATP stimulate the condensation of TIR domain proteins.This process culminates in the formation of a quaternary structural pattern akin to the catalytic arrangement observed in conventional TNL proteins.Consequently,this mechanism enables the production of pivotal signaling molecules crucial for fortifying plant immunity.Expanding on these revelations,we propose the prospect of creating modulatory compounds capable of initiating the phase separation of TIR domain proteins as an innovative approach to enhance plant immunity against pathogenic challenges.展开更多
基金support from the National Key Research and Development Program of China(no.2022YFE0108400)the National Natural Science Foundation of China(no.32372580)the Haihe Laboratory of Sustainable Chemical Transformations.
文摘We spotlight recent findings from a Nature paper unveiling captivating insights into how substrates such as NADþand ATP stimulate the condensation of TIR domain proteins.This process culminates in the formation of a quaternary structural pattern akin to the catalytic arrangement observed in conventional TNL proteins.Consequently,this mechanism enables the production of pivotal signaling molecules crucial for fortifying plant immunity.Expanding on these revelations,we propose the prospect of creating modulatory compounds capable of initiating the phase separation of TIR domain proteins as an innovative approach to enhance plant immunity against pathogenic challenges.
