In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity,a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antib...In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity,a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity.The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity,and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.展开更多
To evaluate the contribution of hematologic factors and longterm inflammation to the development of myocardial infarction at a young age, we measured hematolo gic variables, including soluble fibrin and high-sensitivi...To evaluate the contribution of hematologic factors and longterm inflammation to the development of myocardial infarction at a young age, we measured hematolo gic variables, including soluble fibrin and high-sensitivity C-reactive protei n, in 90 patients who had myocardial infarction and 138 controls ≤45 years of a ge. Plasma levels of soluble fibrin and C-reactive protein were significantly h igher in patients than in controls. On multivariate regression analysis, soluble fibrin was the strongest predictor of myocardial infarction at a young age.展开更多
文摘In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity,a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for their in vitro antibacterial activity.The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity,and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b.
文摘To evaluate the contribution of hematologic factors and longterm inflammation to the development of myocardial infarction at a young age, we measured hematolo gic variables, including soluble fibrin and high-sensitivity C-reactive protei n, in 90 patients who had myocardial infarction and 138 controls ≤45 years of a ge. Plasma levels of soluble fibrin and C-reactive protein were significantly h igher in patients than in controls. On multivariate regression analysis, soluble fibrin was the strongest predictor of myocardial infarction at a young age.
