To identify the roles of serum IL-18, IL- 10, TNF-α and sIL-2R in the pathogenisis of chronic hepatitis C and the effects of interferon on the men- tioned serum cytokines. Methods: The levels of IL-18, IL-10, TNF-α ...To identify the roles of serum IL-18, IL- 10, TNF-α and sIL-2R in the pathogenisis of chronic hepatitis C and the effects of interferon on the men- tioned serum cytokines. Methods: The levels of IL-18, IL-10, TNF-α and sIL-2R were detected in 10 healthy controls, 24 a- symptomatic HCV carriers, and 27 patients with chronic hepatitis C (before and after IFN treatment) by enzyme linked immunosorbent assay (ELISA). Results: The levels of IL-18, IL-10, TNF-α and sIL- 2R in the patients of chronic hepatitis C were higher than those in the healthy controls (P<0.05) and in asymptomatic HCV carriers (P<0. 05). The values of the mentioned cytokines showed a significant posi- tive correlation to GPT. The levels of the mentioned cytokines decreased obviously after IFN treatment (P <0. 05), while the serum levels of IL-10 and sIL-2R reduced in sequence in no-response group, partial- response group and complete-response group. Conclusions: IL-18, IL-10, TNF-α and sIL-2R co- participate in the pathogenisis of chronic hepatitis C, and are used to evaluate the effect of IFN on the im- mune state of organisms, and IL-10 and sIL-2R are important for predicting the anti-viral efficacy of IFN.展开更多
目的探讨创伤性脓毒症患者IL-1β、IL-6、IL-18、TNF-α因子变化分析。方法选择就诊的120例创伤患者作为本次的研究对象,参加试验的患者入院时间2018年1月至2019年1月,依据患者病症程度分为对照组、创伤组、创伤性脓毒症组,对3组患者血...目的探讨创伤性脓毒症患者IL-1β、IL-6、IL-18、TNF-α因子变化分析。方法选择就诊的120例创伤患者作为本次的研究对象,参加试验的患者入院时间2018年1月至2019年1月,依据患者病症程度分为对照组、创伤组、创伤性脓毒症组,对3组患者血清IL-1β、IL-6、IL-18、TNF-α因子变化趋势、免疫功能状态的细胞因子以及外周血Th17/Treg平衡相关细胞因子含量进行分析。结果发病后创伤性脓毒症组炎性因子水平高于对照组和创伤组(P<0.05);确诊后1 d IL-6和IL-18水平为上升趋势,确诊后3~7 d为下降趋势;确诊后第3天,TNF-α和IL-1β水平为上升趋势,确诊后5~7 d为下降趋势;创伤后发生脓毒症的患者比未发生脓毒症的患者IL-18水平高,且脓毒症的严重程度与循环IL-18水平相关。结论对患者的IL-1β、IL-6、IL-18、TNF-α因子变化进行检测,对脓毒症进行早期合理治疗,提高患者治疗效果。展开更多
目的研究复方α酮酸片联合尿毒清颗粒对糖尿病肾病患者肾功能及血清中TNF-α、IL-18水平的影响。方法糖尿病肾病患者126例为研究对象,随即分为对照组30例,观察组96例。所有患者入院后测定肌酐(Scr)、内生肌酐清除率(Ccr)、24 h尿蛋白定...目的研究复方α酮酸片联合尿毒清颗粒对糖尿病肾病患者肾功能及血清中TNF-α、IL-18水平的影响。方法糖尿病肾病患者126例为研究对象,随即分为对照组30例,观察组96例。所有患者入院后测定肌酐(Scr)、内生肌酐清除率(Ccr)、24 h尿蛋白定量(UPr);用ELISA方法测定血清中IL-18、放免法测定血中TNF-α的水平;治疗组在观察组治疗的基础上给予复方α酮酸片联合尿毒清颗粒,治疗半年后再次复查以上指标。结果治疗后,观察组在Scr、Ccr、24 h UPr、IL-18、TNF-α等方面均较观察组好转,差异有统计学意义(P<0.05);自身对比研究发现,治疗前、后患者Scr、Ccr、24 h UPr、血清中IL-18、TNF-α差异有统计学意义(P<0.05)。结论复方α酮酸片联合尿毒清可以降低糖尿病肾病患者血清中TNF-α、IL-18水平,保护肾功能。展开更多
文摘To identify the roles of serum IL-18, IL- 10, TNF-α and sIL-2R in the pathogenisis of chronic hepatitis C and the effects of interferon on the men- tioned serum cytokines. Methods: The levels of IL-18, IL-10, TNF-α and sIL-2R were detected in 10 healthy controls, 24 a- symptomatic HCV carriers, and 27 patients with chronic hepatitis C (before and after IFN treatment) by enzyme linked immunosorbent assay (ELISA). Results: The levels of IL-18, IL-10, TNF-α and sIL- 2R in the patients of chronic hepatitis C were higher than those in the healthy controls (P<0.05) and in asymptomatic HCV carriers (P<0. 05). The values of the mentioned cytokines showed a significant posi- tive correlation to GPT. The levels of the mentioned cytokines decreased obviously after IFN treatment (P <0. 05), while the serum levels of IL-10 and sIL-2R reduced in sequence in no-response group, partial- response group and complete-response group. Conclusions: IL-18, IL-10, TNF-α and sIL-2R co- participate in the pathogenisis of chronic hepatitis C, and are used to evaluate the effect of IFN on the im- mune state of organisms, and IL-10 and sIL-2R are important for predicting the anti-viral efficacy of IFN.
文摘目的探讨创伤性脓毒症患者IL-1β、IL-6、IL-18、TNF-α因子变化分析。方法选择就诊的120例创伤患者作为本次的研究对象,参加试验的患者入院时间2018年1月至2019年1月,依据患者病症程度分为对照组、创伤组、创伤性脓毒症组,对3组患者血清IL-1β、IL-6、IL-18、TNF-α因子变化趋势、免疫功能状态的细胞因子以及外周血Th17/Treg平衡相关细胞因子含量进行分析。结果发病后创伤性脓毒症组炎性因子水平高于对照组和创伤组(P<0.05);确诊后1 d IL-6和IL-18水平为上升趋势,确诊后3~7 d为下降趋势;确诊后第3天,TNF-α和IL-1β水平为上升趋势,确诊后5~7 d为下降趋势;创伤后发生脓毒症的患者比未发生脓毒症的患者IL-18水平高,且脓毒症的严重程度与循环IL-18水平相关。结论对患者的IL-1β、IL-6、IL-18、TNF-α因子变化进行检测,对脓毒症进行早期合理治疗,提高患者治疗效果。
文摘目的研究复方α酮酸片联合尿毒清颗粒对糖尿病肾病患者肾功能及血清中TNF-α、IL-18水平的影响。方法糖尿病肾病患者126例为研究对象,随即分为对照组30例,观察组96例。所有患者入院后测定肌酐(Scr)、内生肌酐清除率(Ccr)、24 h尿蛋白定量(UPr);用ELISA方法测定血清中IL-18、放免法测定血中TNF-α的水平;治疗组在观察组治疗的基础上给予复方α酮酸片联合尿毒清颗粒,治疗半年后再次复查以上指标。结果治疗后,观察组在Scr、Ccr、24 h UPr、IL-18、TNF-α等方面均较观察组好转,差异有统计学意义(P<0.05);自身对比研究发现,治疗前、后患者Scr、Ccr、24 h UPr、血清中IL-18、TNF-α差异有统计学意义(P<0.05)。结论复方α酮酸片联合尿毒清可以降低糖尿病肾病患者血清中TNF-α、IL-18水平,保护肾功能。
