OBJECTIVE: To explore the effects of Tanshinone combined with western medicine on clinical symptoms and cardiac function in patients with acute heart failure. METHODS: The medical records of 96 patients with acute hea...OBJECTIVE: To explore the effects of Tanshinone combined with western medicine on clinical symptoms and cardiac function in patients with acute heart failure. METHODS: The medical records of 96 patients with acute heart failure were randomly divided into 2 groups(48 cases in observation group and 48 cases in control group). The control group was treated with conventional western medicine, and the observation group was treated with Tanshinone IIA sulfonic acid natrium on the basis of western medicine. The traditional Chinese medicine(TCM) syndromes scores before and after treatment(after 28 d of treatment), clinical efficacy, and cardiac echocardiographic indexes and serum biochemical indicators before and after treatment were observed in the 2 groups. RESULTS: After treatment, the scores of TCM syndromes in the 2 groups were significantly decreased(P < 0.05), and the change in observation group was significantly greater than that in control group(P < 0.05). The total clinical effective rate in observation group was significantly higher than that in control group(91.67% vs 75.00%)(P < 0.05). After treatment, the echocardiographic indexes of left ventricular end-diastolic diameter(LVEDD) and left ventricular end-systolic diameter(LVESD) values were significantly reduced in the 2 groups while the left ventricular ejection fraction(LVEF) and stroke volume(SV) value were significantly increased, and the changes in observation group were significantly larger than those in control group(P < 0.05). After treatment, the levels of serum nuclear factor-kappaB(NF-KB), interleukin-1β(IL-1β) and N-terminal pro-brain natriuretic peptide(NT-proBNP) were significantly decreased in the 2 groups(P < 0.05), while the 6-keto-prostaglandin F1α(6-ketoPGF1α) level was significantly increased. And the changes in observation group were significantly greater than those in control group(P < 0.05). CONCLUSION: Tanshinone combined with western medicine can significantly improve the clinical symptoms of patients with acute heart failure, improve cardiac function, reduce the myocardial damage degree, and effectively reduce the risk of short-term recurrence and death, and it has exact clinical efficacy.展开更多
目的探讨丹参酮ⅡA磺酸钠注射液不良反应的临床特点及其原因,为临床合理用药提供参考。方法检索丹参酮ⅡA磺酸钠注射液不良反应和配伍禁忌的文献报道(2000年1月—2011年12月国内医药学期刊),进行统计分析。结果 18例药品不良反应(advers...目的探讨丹参酮ⅡA磺酸钠注射液不良反应的临床特点及其原因,为临床合理用药提供参考。方法检索丹参酮ⅡA磺酸钠注射液不良反应和配伍禁忌的文献报道(2000年1月—2011年12月国内医药学期刊),进行统计分析。结果 18例药品不良反应(adverse drug reaction,ADR)报告中,丹参酮ⅡA磺酸钠注射液不良反应的临床表现多样,皮肤及附件反应和神经肌肉系统反应各占50%,以老年人及女性为主,涉及器官系统多,存在诸多配伍禁忌。结论临床医务工作者应对丹参酮ⅡA磺酸钠注射液的不良反应引起高度重视,以避免不良反应的重复发生,规避风险,确保安全合理用药。展开更多
目的探讨丹参酮ⅡA磺酸钠注射液对轻、中度脑外伤脑出血患者CT下血肿体积影响。方法选取我院神经外科收治的轻、中度脑外伤脑出血患者102例,随机数字表达法分为2组,其中对照组51例,予肠外营养支持、抗感染、降颅内压、止血及对症处理等...目的探讨丹参酮ⅡA磺酸钠注射液对轻、中度脑外伤脑出血患者CT下血肿体积影响。方法选取我院神经外科收治的轻、中度脑外伤脑出血患者102例,随机数字表达法分为2组,其中对照组51例,予肠外营养支持、抗感染、降颅内压、止血及对症处理等常规治疗,7日为1个疗程,治疗2个疗程;实验组51例,在常规治疗的基础上加用丹参酮ⅡA磺酸钠注射液,80 mg注入150 m L 0.9%氯化钠注射液中,1次/d静脉滴注,7日为1个疗程,治疗2个疗程。治疗结束后,对比治疗前后患者凝血功能,CT下血肿体积、周围水肿体积以及神经功能缺损状况。结果 1治疗后2组患者凝血功能均明显改善,且实验组凝血功能各项指标较对照组明显好转,差异有统计学意义(P<0.05);2治疗后2组患者CT下血肿体积、NIHSS评分较治疗前显著降低,而周围水肿体积较对照组明显升高,差异有统计学意义(P<0.05);3治疗后实验组患者CT下血肿体积、周围水肿体积、NIHSS评分较对照组明显降低,差异有统计学意义(P<0.01)。结论丹参酮ⅡA磺酸钠注射液能够明显改善轻、中度脑外伤脑出血患者凝血功能,降低颅内血肿、水肿体积,降低神经功能损伤,提高患者生活质量。展开更多
文摘OBJECTIVE: To explore the effects of Tanshinone combined with western medicine on clinical symptoms and cardiac function in patients with acute heart failure. METHODS: The medical records of 96 patients with acute heart failure were randomly divided into 2 groups(48 cases in observation group and 48 cases in control group). The control group was treated with conventional western medicine, and the observation group was treated with Tanshinone IIA sulfonic acid natrium on the basis of western medicine. The traditional Chinese medicine(TCM) syndromes scores before and after treatment(after 28 d of treatment), clinical efficacy, and cardiac echocardiographic indexes and serum biochemical indicators before and after treatment were observed in the 2 groups. RESULTS: After treatment, the scores of TCM syndromes in the 2 groups were significantly decreased(P < 0.05), and the change in observation group was significantly greater than that in control group(P < 0.05). The total clinical effective rate in observation group was significantly higher than that in control group(91.67% vs 75.00%)(P < 0.05). After treatment, the echocardiographic indexes of left ventricular end-diastolic diameter(LVEDD) and left ventricular end-systolic diameter(LVESD) values were significantly reduced in the 2 groups while the left ventricular ejection fraction(LVEF) and stroke volume(SV) value were significantly increased, and the changes in observation group were significantly larger than those in control group(P < 0.05). After treatment, the levels of serum nuclear factor-kappaB(NF-KB), interleukin-1β(IL-1β) and N-terminal pro-brain natriuretic peptide(NT-proBNP) were significantly decreased in the 2 groups(P < 0.05), while the 6-keto-prostaglandin F1α(6-ketoPGF1α) level was significantly increased. And the changes in observation group were significantly greater than those in control group(P < 0.05). CONCLUSION: Tanshinone combined with western medicine can significantly improve the clinical symptoms of patients with acute heart failure, improve cardiac function, reduce the myocardial damage degree, and effectively reduce the risk of short-term recurrence and death, and it has exact clinical efficacy.
文摘目的探讨丹参酮ⅡA磺酸钠注射液不良反应的临床特点及其原因,为临床合理用药提供参考。方法检索丹参酮ⅡA磺酸钠注射液不良反应和配伍禁忌的文献报道(2000年1月—2011年12月国内医药学期刊),进行统计分析。结果 18例药品不良反应(adverse drug reaction,ADR)报告中,丹参酮ⅡA磺酸钠注射液不良反应的临床表现多样,皮肤及附件反应和神经肌肉系统反应各占50%,以老年人及女性为主,涉及器官系统多,存在诸多配伍禁忌。结论临床医务工作者应对丹参酮ⅡA磺酸钠注射液的不良反应引起高度重视,以避免不良反应的重复发生,规避风险,确保安全合理用药。
文摘目的探讨丹参酮ⅡA磺酸钠注射液对轻、中度脑外伤脑出血患者CT下血肿体积影响。方法选取我院神经外科收治的轻、中度脑外伤脑出血患者102例,随机数字表达法分为2组,其中对照组51例,予肠外营养支持、抗感染、降颅内压、止血及对症处理等常规治疗,7日为1个疗程,治疗2个疗程;实验组51例,在常规治疗的基础上加用丹参酮ⅡA磺酸钠注射液,80 mg注入150 m L 0.9%氯化钠注射液中,1次/d静脉滴注,7日为1个疗程,治疗2个疗程。治疗结束后,对比治疗前后患者凝血功能,CT下血肿体积、周围水肿体积以及神经功能缺损状况。结果 1治疗后2组患者凝血功能均明显改善,且实验组凝血功能各项指标较对照组明显好转,差异有统计学意义(P<0.05);2治疗后2组患者CT下血肿体积、NIHSS评分较治疗前显著降低,而周围水肿体积较对照组明显升高,差异有统计学意义(P<0.05);3治疗后实验组患者CT下血肿体积、周围水肿体积、NIHSS评分较对照组明显降低,差异有统计学意义(P<0.01)。结论丹参酮ⅡA磺酸钠注射液能够明显改善轻、中度脑外伤脑出血患者凝血功能,降低颅内血肿、水肿体积,降低神经功能损伤,提高患者生活质量。
