THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to pos...THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].展开更多
BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induce...BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.展开更多
Based on interpretation of Dao De Jing(a book written by LAO Zi),the connotation of "Tao" had been analyzed and it emphasized that Taoism is the most basic and eternal universal law transcending physical exi...Based on interpretation of Dao De Jing(a book written by LAO Zi),the connotation of "Tao" had been analyzed and it emphasized that Taoism is the most basic and eternal universal law transcending physical existence and the origin of all changes.It pointed out that garden art was integrated art of time and space,Taoism had made profound effect on Chinese landscape art,and its philosophical thought was the important theoretical support for garden artistic creation.On this basis,it laid stress on great influence on artistic creation of Chinese garden produced by Taoist dialectical thoughts and Taoist thoughts such as "Taoism following nature","unity between heaven and human",and "immortal belief";and found ideological source for Chinese landscape art to pursue artistic spirit of natural beauty,uphold designing principle of harmonious coexistence between human and nature,and take supernatural being and fairyland legend as the design version.It also analyzed that Taoist philosophical thought happened to coincide with contrast methods of garden art involving tangibility and intangibility,falsehood and reality,internality and externality,bigness and smallness,highness and lowness,rising and falling,sparseness and denseness,exposedness and unexposedness,and so on.It highlighted artistic charm of "prospect generating beyond images" as the core connotation of Chinese classical garden art;emphasized frequently-used me-thods for garden spatial organization,spatial guidance and indication,layout pattern,arrangement of scenic spots and disposition of landscaping plants which were produced under the influence of Taoism,making Chinese garden be of more implicitness,interestingness and orient glamour.展开更多
Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideol...Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideologies contained in his poetries.On this basis,it had discussed the influence of aesthetic ideology of TAO Yuan-ming on the style of classical gardens in South China,which were quiet and natural,elegant and fresh,simple and plain,and far-reaching in artistic conception.By combining with cases,it pointed out that the poetic prose had been directly quoted as the names of gardens or scenic spots of classical gardens in South China,and showed that the aesthetic ideology of TAO Yuan-ming had set up a successful ideal model for cultural landscapes,producing far-reaching influence on the aesthetic state of mind of gardeners or owners of gardens,further instilling humanistic spirit into classical gardens in South China.展开更多
基金supported by the National Natural Science Foundation of China(62302047,62203250)the Science and Technology Development Fund of Macao SAR(0093/2023/RIA2,0050/2020/A1).
文摘THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].
基金Supported by Liaoning Province“Xingliao Talent Program”Project,No.XLYC2007019.
文摘BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.
基金National Natural Science Foundation of China under Grants(50772112,90922003,50872135)the Director Foundation of Anhui Institute of Optics and Fine Mechanics
文摘Based on interpretation of Dao De Jing(a book written by LAO Zi),the connotation of "Tao" had been analyzed and it emphasized that Taoism is the most basic and eternal universal law transcending physical existence and the origin of all changes.It pointed out that garden art was integrated art of time and space,Taoism had made profound effect on Chinese landscape art,and its philosophical thought was the important theoretical support for garden artistic creation.On this basis,it laid stress on great influence on artistic creation of Chinese garden produced by Taoist dialectical thoughts and Taoist thoughts such as "Taoism following nature","unity between heaven and human",and "immortal belief";and found ideological source for Chinese landscape art to pursue artistic spirit of natural beauty,uphold designing principle of harmonious coexistence between human and nature,and take supernatural being and fairyland legend as the design version.It also analyzed that Taoist philosophical thought happened to coincide with contrast methods of garden art involving tangibility and intangibility,falsehood and reality,internality and externality,bigness and smallness,highness and lowness,rising and falling,sparseness and denseness,exposedness and unexposedness,and so on.It highlighted artistic charm of "prospect generating beyond images" as the core connotation of Chinese classical garden art;emphasized frequently-used me-thods for garden spatial organization,spatial guidance and indication,layout pattern,arrangement of scenic spots and disposition of landscaping plants which were produced under the influence of Taoism,making Chinese garden be of more implicitness,interestingness and orient glamour.
基金Supported by Fund for Scientific Research of Nanjing University of Finance and Economics (B2010017)~~
文摘Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideologies contained in his poetries.On this basis,it had discussed the influence of aesthetic ideology of TAO Yuan-ming on the style of classical gardens in South China,which were quiet and natural,elegant and fresh,simple and plain,and far-reaching in artistic conception.By combining with cases,it pointed out that the poetic prose had been directly quoted as the names of gardens or scenic spots of classical gardens in South China,and showed that the aesthetic ideology of TAO Yuan-ming had set up a successful ideal model for cultural landscapes,producing far-reaching influence on the aesthetic state of mind of gardeners or owners of gardens,further instilling humanistic spirit into classical gardens in South China.
