Target Controllability of Multi-Layer Networks With High-Dimensional Nodes

This paper studies the target controllability of multilayer complex networked systems,in which the nodes are highdimensional linear time invariant(LTI)dynamical systems,and the network topology is directed and weighted.The influence of inter-layer couplings on the target controllability of multi-layer networks is discussed.It is found that even if there exists a layer which is not target controllable,the entire multi-layer network can still be target controllable due to the inter-layer couplings.For the multi-layer networks with general structure,a necessary and sufficient condition for target controllability is given by establishing the relationship between uncontrollable subspace and output matrix.By the derived condition,it can be found that the system may be target controllable even if it is not state controllable.On this basis,two corollaries are derived,which clarify the relationship between target controllability,state controllability and output controllability.For the multi-layer networks where the inter-layer couplings are directed chains and directed stars,sufficient conditions for target controllability of networked systems are given,respectively.These conditions are easier to verify than the classic criterion.

Propofol sedation in routine endoscopy:A case series comparing target controlled infusion vs manually controlled bolus concept

BACKGROUND Many studies have addressed safety and effectiveness of non-anaesthesiologist propofol sedation(NAPS)for gastrointestinal(GI)endoscopy Target controlled infusion(TCI)is claimed to provide an optimal sedation regimen by avoiding under-or oversedation.AIM To assess safety and performance of propofol TCI sedation in comparison with nurse-administered bolus-sedation.METHODS Fouty-five patients undergoing endoscopy under TCI propofol sedation were prospectively included from November 2016 to May 2017 and compared to 87 patients retrospectively included that underwent endoscopy with NAPS.Patients were matched for age and endoscopic procedure.We recorded time of sedation and endoscopy,dosage of medication and adverse events.RESULTS There was a significant reduction in dose per time of propofol administered in the TCI group,compared to the NAPS group(8.2±2.7 mg/min vs 9.3±3.4 mg/min;P=0.046).The time needed to provide adequate sedation levels was slightly but significantly lower in the control group(5.3±2.7 min vs 7.7±3.3 min;P<0.001),nonetheless the total endoscopy time was similar in both groups.No differences between TCI and bolus-sedation was observed for mean total-dosage of propofol rate as well as adverse events.CONCLUSION This study indicates that sedation using TCI for GI endoscopy reduces the dose of propofol necessary per minute of endoscopy.This may translate into less adverse events.However,further and randomized trials need to confirm this trend.

Multi-rate tracking controller analysis and design for target tracking systems

As the sampling rates of the inner loop and the outer loop of the target tracking control system are different,a typical digital multi-rate control system was formed.If the traditional single-rate design method was applied,the low sampling rate loop will seriously impact the dynamical characteristic of the system.After analyzing and calculating the impact law of the low sampling rate loop to the bandwidth and the stability of the tracking system,a kind of multi-rate control system design method was introduced.Corresponding to the different sampling rates of the inner loop and the outer loop,the multi-rate control strategy was constituted by a high sampling rate sub-controller and a low sampling rate sub-controller.The two sub-controllers were designed separately and connected by means of the sampling rate converter.The low sampling rate controller determined the response rapidity of the system,while the high sampling rate controller applied additionally effective control outputs to the system during a sampling interval of the low sampling rate controller.With the introduced high and low sampling rates sub-controllers,the tracking control system can achieve the same performance as a single-rate controller with high sampling rate,yet it works under a much lower sampling rate.The simulation and experimental results show the effectiveness of the introduced multi-rate control design method.It reduces the settling time by 5 times and the over shoot by 4 times compared with the PID control.

Self-assembled Nanoparticles based on Folic Acid Modifi ed Carboxymethyl Chitosan Conjugated with Targeting Antibody

Nanoparticles conjugated with antibody were designed as active drug delivery system to reduce the toxicity and side effects of drugs for acute myeloid leukemia（AML）.Moreover,methotrexate（MTX）was chosen as modeldrug and encapsulate within folic acid modified carboxymethylchitosan（FACMCS）nanoparticles through self-assembling.The chemicalstructure,morphology,release and targeting of nanoparticles were characterized by routine detection.It is demonstrated that the mean diameter is about 150 nm,the release rate increases with the decreasing of p H,the binding rate of CD33 antibody and FA-CMCS nanoparticles is about 5：2,and nanoparticles can effectively bind onto HL60 cells in vitro.The experimentalresults indicate that the FA-CMCS nanoparticles conjugated with antibody may be used as a potentialp Hsensitive drug delivery system with leukemic targeting properties.

The law of anti-VCAM-1 targeted microbubbles adhesion to activated endothelial cells under controlled shear flow

Microbubbles can enhance the detection in noninvasive ultrasound imaging.Recently,targeted microbubbles have been developed to selectively adhere to specific and overexpressed p molecules in endothelial cells in some pathologic conditions.However,the law of

EQUIVALENCE OF THREE DIFFERENT KINDS OF OPTIMAL CONTROL PROBLEMS FOR STOKES EQUATIONS

This article presents an equivalence theorem for three different kinds of optimal control problems, which are optimal target control problems, optimal norm control problems, and optimal time control problems. Controlled systems in this study are internally controlled Stokes equations.

Evaluation of cloud seeding project in Yazd Province of Iran using historical regression method(case study:Yazd 1 cloud seeding project,1999)

In this research, the result of the cloud seeding over Yazd province during three months of February, March and April in 1999 has been evaluated using the historical regression method. Hereupon, the rain-gages in Yazd province as the target stations and the rain-gages of the neighboring provinces as the control stations have been selected. The rainfall averages for the three aforementioned months through 25 years (1973-1997) in all control and target stations have been calculated. In the next step, the correlations between the rainfalls of control and target stations have been estimated about 75%, which indicates a good consistency in order to use the historical regression. Then, through the obtained liner correlation equation between the control and target stations the precipitation amount for February, March and April in 1999, over the target region (Yazd province) was estimated about 27.57 mm, whiles the observed amount was 34.23 mm. In fact the precipitation increasing around 19.5% over Yazd province confirmed the success of this cloud seeding project.

Developing an intermediate-complexity projection model for China's fisheries:A case study of small yellow croaker(Larimichthys polyactis)in the Haizhou Bay,China

Projection models are commonly used to evaluate the impacts of fishing.However,previously developed projection tools were not suitable for China’s fisheries as they are either overly complex and data-demanding or too simple to reflect the realistic management measures.Herein,an intermediate-complexity projection model was developed that could adequately describe fish population dynamics and account for management measures including mesh size limits,summer closure,and spatial closure.A two-patch operating model was outlined for the projection model and applied to the heavily depleted but commercially important small yellow croaker(Larimichthys polyactis)fishery in the Haizhou Bay,China,as a case study.The model was calibrated to realistically capture the fisheries dynamics with hindcasting.Three simulation scenarios featuring different fishing intensities based on status quo and maximum sustainable yield(MSY)were proposed and evaluated with projections.Stochastic projections were additionally performed to investigate the influence of uncertainty associated with recruitment strengths and the implementation of control targets.It was found that fishing at FMSY level could effectively rebuild the depleted stock biomass,while the stock collapsed rapidly in the status quo scenario.Uncertainty in recruitment and implementation could result in variabilities in management effects;but they did not much alter the management effects of the FMSY scenario.These results indicate that the lack of science-based control targets in fishing mortality or catch limits has hindered the achievement of sustainable fisheries in China.Overall,the presented work highlights that the developed projection model can promote the understanding of the possible consequences of fishing under uncertainty and is applicable to other fisheries in China.

Effect of short neuropeptide F signaling on larval feeding in Mythimna separata

Mythimna separata is a notorious phytophagous pest which poses serious threats to cereal crops owing to the gluttony of the larvae.Because short neuropeptide F(sNPF)and its receptor sNPFR are involved in a diversity of physiological functions,especially in functions related to feeding in insects,it is a molecular target for pest control.Herein,an sNPF and 2 sNPFRs were identified and cloned from M.separata.Bioinformatics analysis revealed that the sNPF and its receptors had a highly conserved RLRFamide C-terminus and 7 transmembrane domains,respectively.The sNPF and its receptor genes were distributed across larval periods and tissues,but 2 receptors had distinct expression patterns.The starvation-induced assay elucidated that sNPF and sNPFR expression levels were downregulated under food deprivation and recovered with subsequent re-feeding.RNA interference knockdown of sNPF,sNPFR1,and sNPFR2 by injection of double-stranded RNA into larvae not only suppressed food consumption and increased body size and weight,but also led to decrease of glycogen and total lipid contents,and increase of trehalose compared with double-stranded green fluorescent protein injection.Furthermore,molecular docking was performed on the interaction mode between sNPFR protein and its ligand sNPF based on the 3-dimensional models constructed by AlphaFold;the results indicated that both receptors were presumably activated by the mature peptide sNPF-2.These results revealed that sNPF signaling played a considerably vital role in the feeding regulation of M.separata and represents a potential control target for this pest.

Light controlled imaging probes for intracellular target recognition： photochromism as a tool to enhance sensing precision

Chemosensors and imaging probes have been the focus of significant research interest over the past few decades. In part due to ease of preparation and simplicity in manipulation, fluorescent probes have been extensively used for biomedical applications. When used for #7 vitro cell imaging [1,2],