Heart abnormality associates with a wide spectrum of psychiatric disorders:Evidence from Mendelian randomization analyses

Psychiatric disorders and heart abnormality are closely interconnected.Previous knowledge has been well-established that psychiatric disorders can lead to increased cardiovascular morbidity and even sudden cardiac death.Conversely,whether heart abnormality contributes to psychiatric disorders remains rarely studied.The work by Zhang et al pointed out that chronic heart failure had effects on the anxiety and depression(AD)severity,and indices including left ventricular ejection fraction,N-terminal pro-brain natriuretic peptide and interleukin-6 were independent risk factors for AD severity.In addition to the aforementioned AD,we herein find that heart failure might additionally impact the development of autism spectrum disorder and post-traumatic stress disorder(albeit P>0.05),and significantly protects against the presence of attention deficit hyperactivity disorder(ADHD),[odds ratio(OR)=0.61,P=0.0071]by using a Mendelian randomization analysis.Bradycardia is also a protective factor for ADHD(OR=0.61,P=0.0095),whereas hypertrophic cardiomyopathy is a mild risk factor for schizophrenia(OR=1.02,P=0.032).These data suggest a wide spectrum of psychiatric disorders secondary to heart abnormality,and we highlight more psychiatric care that should be paid to patients with heart abnormality.

High-grade serous carcinoma of the fallopian tube in a young woman with chromosomal 4q abnormality:A case report

BACKGROUND Few studies have reported an association between an increased risk of acquiring cancers and survival in patients with 4q deletion syndrome.This study presents a rare association between chromosome 4q abnormalities and fallopian tube highgrade serous carcinoma(HGSC)in a young woman.CASE SUMMARY A 35-year-old woman presented with acute dull abdominal pain and a known chromosomal abnormality involving 4q13.3 duplication and 4q23q24 deletion.Upon arrival at the emergency room,her abdomen appeared ovoid and distended with palpable shifting dullness.Ascites were identified through abdominal ultrasound,and computed tomography revealed an omentum cake and an enlarged bilateral adnexa.Blood tests showed elevated CA-125 levels.Paracentesis was conducted,and immunohistochemistry indicated that the cancer cells favored an ovarian origin,making us suspect ovarian cancer.The patient underwent debulking surgery,which led to a diagnosis of stage IIIC HGSC of the fallopian tube.Subsequently,the patient received adjuvant chemotherapy with carboplatin and paclitaxel,resulting in stable current condition.CONCLUSION This study demonstrates a rare correlation between a chromosome 4q abnormality and HGSC.UBE2D3 may affect crucial cancer-related pathways,including P53,BRCA,cyclin D,and tyrosine kinase receptors,thereby possibly contributing to cancer development.In addition,ADH1 and DDIT4 may be potential influencers of both carcinogenic and therapeutic responses.

外科手术治疗完全型大动脉转位合并非限制性室间隔缺损或Taussig-Bing畸形超龄患儿的疗效及预后分析

目的:探讨6个月以上的完全型大动脉转位(TGA)合并非限制性室间隔缺损(VSD)或Taussig-Bing畸形(TBA)患儿在合并肺动脉高压时,行大动脉调转手术(ASO)或心房调转术的效果及其影响因素。方法:回顾性分析2009年1月至2018年12月期间于我院行ASO或心房调转手术的48例6个月以上的TGA合并非限制性VSD或TBA患儿的临床资料,并对所有患儿进行随访及院内随诊复查。结果:48例患儿中,37例(77.1%)合并重度或极重度肺动脉高压[肺动脉收缩压≥70 mmHg(1 mmHg=0.133 kPa)或肺/体循环压力比值(P/S PR)≥0.75]。本组患儿术后30 d内死亡3例(6.25%),3个月总体死亡率10.4%(5/48)。43例存活患儿均完成了随访,随访时间(4.8±2.4)年(范围:0.5~10.0年),随访期间无患儿死亡。多因素Logistic回归分析显示,术前P/S PR(OR=2.118,95%CI:1.042~4.306,P=0.038)、动脉血氧饱和度(SpO2)(OR=0.894,95%CI:0.803~0.995,P=0.018)及术后P/S PR与术前P/S PR的比值(OR=1.746,95%CI:1.159~2.630,P=0.008)均是患儿术后死亡的危险因素。结论:TGA合并非限制性VSD或TBA的6个月以上患儿多合并重度或极重度肺动脉高压,手术治疗结果满意。术前肺动脉高压及术后肺/体压力比值下降不明显甚至升高是术后死亡的危险因素。

大动脉调转术治疗完全性大动脉转位和Taussig-Bing心脏畸形

为总结大动脉调转术治疗完全性大动脉转位和Taussig-Bing心脏畸形的经验,回顾性总结4例生后13天内的完全性大动脉转位和2例2个月和4个月Taussig-Bing心脏畸形的手术情况。手术均在全麻、深低温、体外循环下施行,采用温血诱导、间断冷血灌注、终末温血复苏的心肌保护方法。本文主要经验:①正确掌握手术时机;②明确冠状动脉解剖特征,正确处理冠状动脉,防止术后阻塞;③妥善处理肺动脉,防止肺动脉瓣上狭窄;④加强术后监护,防治并发症。

Abnormality of Magnetic Behavior and Resistivity of La_(0.7-x)Dy_x Sr_(0.3)MnO_3 (0.00≤x≤0.30)System at Low Temperature

By measuring M-T curves, ρ-T curves and MR-T curves of the samples under different temperatures, the influence of Dy doping （0.00 ≤ x ≤0.30） on the magnetic and electric properties of La0.7-xDyxSr0.3MnO3 has been studied. The experimental results show that, with the increase of the Dy content, the system undergoes a transition from long range ferromagnetic order to the cluster-spin glass state and further to antiferromagnetic order. For the samples with x=0.20 and 0.30, their magnetic behaviors are abnormal at low temperature, and their resistivities at low temperature have a minimum value. These peculiar phenomena not only come from the lattice effect induced by doping, but also from extra magnetic coupling induced by doping.

改良Nikaidoh在合并肺动脉瓣狭窄的Taussig-Bing畸形中的应用

目的探讨改良Nikaidoh在合并肺动脉瓣狭窄的Taussig-Bing畸形中的应用。方法采用改良Nikaidoh手术将主动脉和肺动脉根部互换移植,重建左、右心室流出道。观察心脏各部位结构变化,术后恢复及生长发育情况。结果改良Nikaidoh术后心室与大动脉关系恢复正常,无严重进展性主动脉瓣关闭不全,无中度以上肺动脉瓣反流,无左、右心室流出道梗阻。术后存活5例,1例死于严重心力衰竭及多器官功能不全。随访4个月~7年,患者生长发育改善,血氧饱和度明显上升,发绀消失。结论改良Nikaidoh在合并肺动脉瓣狭窄的Taussig-Bing畸形中应用可获得解剖根治,并取得良好的手术效果。

Tooth number abnormality:from bench to bedside

Tooth number abnormality is one of the most common dental developmental diseases,which includes both tooth agenesis and supernumerary teeth.Tooth development is regulated by numerous developmental signals,such as the well-known Wnt,BMP,FGF,Shh and Eda pathways,which mediate the ongoing complex interactions between epithelium and mesenchyme.Abnormal expression of these crutial signalling during this process may eventually lead to the development of anomalies in tooth number;however,the underlying mechanisms remain elusive.In this review,we summarized the major process of tooth development,the latest progress of mechanism studies and newly reported clinical investigations of tooth number abnormality.In addition,potential treatment approaches for tooth number abnormality based on developmental biology are also discussed.This review not only provides a reference for the diagnosis and treatment of tooth number abnormality in clinical practice but also facilitates the translation of basic research to the clinical application.

A Diagnostic Study on the Relationship between the Assembling of Low Frequency Waves in the Pacific Ocean and the Abnormality of the Subtropical High

By use of the filter analysis technique, the Complex Empirical Othogonal Function (CEOF) method and the ECMWF/WMO 2.5°×2.5°grid data of the geopotential heights during the summer months in 1988, an interseasonal process that the western Pacific subtropical high (WPSH) was anomalously far to the north in the first and second ten days of July is studied. It has been found that in the western Pacific subtropical region in the first and second ten days of July,it is the continuous assembly of low frequency geopotential waves (LFGWs) that leads to the abnormality of WPSH. This abnormality emerges with the enhancement of wave assembling and ceases while the wave assembling situation disappears. The structure of the low frequency assembling waves corresponds to the structure of subtropical high in its abnormal period. The effect of the assembling waves on the abnormality of subtropical high can be considered as the accumulation of disturbance energy carried by the low frequency waves from different directions in the western Pacific region.

Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain

Objective This study aimed to investigate the expression pattern and function of Nuclear receptor subfamily 2 group E member 1 （Nr2e1） in retinoic acid （RA）-induced brain abnormality. Methods The mouse model of brain abnormality was established by administering 28 mg/kg RA, and neural stem cells （NSCs） were isolated from the mouse embryo and cultured in vitro. Nr2e1 expression was detected by whole mount in situ hybridization, RT-PCR, and Western blotting. Nr2e1 function was determined by transducing Nr2e1 sh RNA into NSCs, and the effect on the sonic hedgehog （Shh） signaling pathway was assessed in the cells. In addition, the regulation of Nr2e1 expression by RA was also determined in vitro. Results Nr2e1 expression was significantly downregulated in the brain and NSCs of RA-treated mouse embryos, and knockdown of Nr2e1 affected the proliferation of NSCs in vitro. In addition, a similar expression pattern of Nr2e1 and RA receptor （RAR） α was observed after treatment of NSCs with different concentrations of RA. Conclusion Our study demonstrated that Nr2e1 could be regulated by RA, which would aid a better understanding of the mechanism underlying RA-induced brain abnormality.

DISTRIBUTION OF LOW FREQUENCY WAVES IN NORTH PACIFIC AND INTRASEASONAL ABNORMALITY OF THE WESTERN PACIFIC SUBTROPICAL HIGH

By using ECMWF (2. 5°×2. 5°) grid data, analyzing correlation for the summer (June-August) of 1980 (the West Pacific Subtropical High (WPSH) anomalously more to the south), 1988 (the WPSH anomalously more to the north), 1981 (normal) in the west Pacific area, distribution characteristics of the low frequency waves are discussed. The relationship between distribution of the low frequency waves and intraseasonal abnormality of the west subtropical high is also analyzed. There is some discussions:(1)If the WPSH acts anomalously in summer, there is a distinct zonal wave series in the subtropical zone of the north Pacific.(2) One of the important characteristics of the WPSH abnormality is that there are low frequency geopotential high centres from east Pacific and northeast Asia, being combined in the west Pacific area.For different circulation, the combination areas are different, which define the WSPH anomalously more to the north or south.

The Yearly Most Wind Direction Abnormality and Meteorological Disaster in Yumen in Recent 57 Years

By using the historical data during 1953-2009,the yearly most wind direction change in Yumen and the meteorological disasters of 4 times yearly most wind direction abnormality in recent 57 years were analyzed. The results showed that there were 51 years which the yearly most wind direction was the easterlies in Yumen,and the westerly had 4 years. There were 2 years which the occurrence frequencies of westerly and easterlies were same. 4 years which the yearly wind direction abnormality was the most were in 1961,1979,1987 and 1998. When the yearly wind direction abnormality was the most,the meteorological disaster was serious. The total output of grain in Gansu Province in 1961 was the least in the history in recent 60 years. The serious drought disaster in 1961 caused that half agricultural population in Gansu seriously lacked of the grain,and the dead population sharply increased. In the end of 1961,the population in Gansu decreased nearly million than in 1958. The annual precipitation in 1979 was the most in recent 57 years. The daily precipitation on June 11,1987 was the most in June of recent 57 years in Yumen. The annual average temperature in 1998 was the highest in Yumen in recent 57 years.

Regional brain structural abnormality in ischemic stroke patients:a voxel-based morphometry study

Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clin- ical rating scales of the Fugl-Meyer Motor Assessment （r = -0.609, P = 0.047） and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale （r = -0.737, P = 0.010）. Our findings call objectively identify the functional abnormality in some brain regions of ischemic stroke patients.

Abnormality Degree Detection Method Using Negative Potential Field Group Detectors

Online monitoring methods have been widely used in many major devices, however the normal and abnormal states of equipment are estimated mainly based on the monitoring results whether monitored parameters exceed the setting thresholds. Using these monitoring methods may cause serious false positive or false negative results. In order to precisely monitor the state of equipment, the problem of abnormality degree detection without fault sample is studied with a new detection method called negative potential field group detectors（NPFG-detectors）. This method achieves the quantitative expression of abnormality degree and provides the better detection results compared with other methods. In the process of Iris data set simulation, the new algorithm obtains the successful results in abnormal detection. The detection rates for 3 types of Iris data set respectively reach 100%, 91.6%, and 95.24% with 50% training samples. The problem of Bearing abnormality degree detection via an abnormality degree curve is successfully solved.

The role of immune abnormality in depression and cardiovascular disease

Depression and cardiovascular disease （CVD） are both highly prevalent disorders, and some evidence shows that there is a ＇vicious cy- cle＇ linking major depression and CVD. There is also growing evidence that immune abnormalities underpin the common pathophysiology of both CVD and major depression. The abnormalities include the following： abnormal levels of inflammatory markers, such as interleukin-6 （IL-6）, interleukin-1β （IL-1β）, minor necrosis factor α （TNF-α） and interleukin-12 （IL-12）; increased acute phase proteins, such as C-reactive protein, fibrinogen and haptoglobin; and abnormal complement factors. The findings show that major depression and CVD patients have greater immune abnormalities, which may increase depressive symptoms and cardiovascular pathological changes, and that there may be a bidirectional relationship, therefore more prospective studies are needed to draw conclusions.

A Method for Detecting Abnormality of CAN Bus in Vehicle

With the development of intelligent and netw orking technology in automobile,the malicious attacks against in-vehicle CAN netw orks are increasing day by day,and the problem of information safety in automobile is aggravated. In this regard,this paper analyzes the security loopholes and threats w hich the CAN bus faced,put forw ard a kind of anomaly detection algorithm for vehicle CAN bus. The method uses support vector machine algorithm to distinguish betw een normal message and abnormal message,so as to realize the CAN bus anomaly detection. Theoretical and experimental studies show that this method can effectively detect abnormal packets in the CAN bus w ith a detection rate of over 90%,w hich can effectively resist malicious attacks such as tampering and cheating on the vehicle CAN bus.

Identification of embryonic chromosomal abnormality using FISH-based preimplantaion genetic diagnosis

Objective: Embryonic chromosomal abnormality is one of the main reasons for in vitro fertilization (IVF) failure. This study aimed at evaluating the value of Fluorescence in-situ Hybridization (FISH)-based Preimplantation Genetic Diagnosis (PGD) in screening for embryonic chromosomal abnormality to increase the successful rate of IVF. Method: Ten couples, four with high risk of chromosomal abnormality and six infertile couples, underwent FISH-based PGD during IVF procedure. At day 3, one or two blastomeres were aspirated from each embryo. Biopsied blastomeres were examined using FISH analysis to screen out embryos with chromosomal abnormalities. At day 4, embryos without detectable chromosomal abnormality were transferred to the mother bodies as in regular IVF. Results: Among 54 embryos screened using FISH-based PGD, 30 embryos were detected to have chromosomal abnormalities. The 24 healthy embryos were implanted, resulting in four clinical pregnancies, two of which led to successful normal birth of two healthy babies; one to ongoing pregnancy during the writing of this article; and one to ectopic pregnancy. Conclusion: FISH-based PGD is an effective method for detecting embryonic chromosomal abnormality, which is one of the common causes of spontaneous miscarriages and chromosomally unbalanced offsprings.

动脉调转术治疗Taussig-Bing畸形

动脉调转术目前已成为治疗Taussig-Bing畸形的主流术式。随着手术经验的积累,在患儿2~3月龄时行一期动脉调转术已成为临床首选矫治方案。由于术式复杂,诸多手术细节值得注意。术中须保证移植后的冠状动脉无张力且血流通畅,修补室间隔缺损时注意保护新主动脉瓣,重建后的肺动脉无张力且对冠状动脉无压迫。动脉调转术后患者中远期生存率较为满意,但中远期再干预比例较高,原因主要包括主动脉及肺动脉吻合口再梗阻、新主动脉瓣反流,再干预一般能取得满意疗效。

Atresia of the appendix vermiformis:A rare case of developmental abnormality

Acute appendicitis,which requires immediate surgical intervention,is an important diagnosis in patients with acute abdomen.However,developmental abnormalities may interfere with the preoperative diagnosis and surgical treatment in some cases.Agenesis and atresia of the cecal vermiform appendix is an extremely rare clinical diagnosis.In addition,preoperative diagnosis may be difficult in some cases.Thus,diagnosis of the congenital absence of the vermiform appendix requires a thorough exploration of the retrocecal and ileocecal regions.A 59-year-old male was admitted from the emergency services with right lower abdominal pain.A celiotomy was performed with the suspicion of acute appendicitis.However,an atresia of the vermiform appendix was observed.The patient's appendix was thus removed.Pathological examination confirmed suppurative appendicitis.This case underlines the importance of the clinical entity for surgeons who may deal with a similar case.