目的探究综合运用白蛋白和光疗对治疗重度新生儿高胆红素血症的效果及对患儿总胆汁酸(total bile acid,TBA)、总胆红素(total bilirubin,TSB)水平的影响。方法选择2020年1月—2022年12月于淮安市淮阴区妇幼保健院接受临床干预的85例重...目的探究综合运用白蛋白和光疗对治疗重度新生儿高胆红素血症的效果及对患儿总胆汁酸(total bile acid,TBA)、总胆红素(total bilirubin,TSB)水平的影响。方法选择2020年1月—2022年12月于淮安市淮阴区妇幼保健院接受临床干预的85例重度新生儿高胆红素血症的患儿为研究对象,按照其接受干预方式分为研究组(45例)和对照组(40例)。研究组联用白蛋白与光疗治疗,对照组接受单纯光疗治疗。比较两组患儿临床干预效果、干预过程中TBA、TSB等实验室指标的变化情况,并统计两组患儿治疗过程中并发症的发生情况。结果研究组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。干预12~72 h,研究组患儿的TBA和TSB水平均低于对照组,差异有统计学意义(P<0.05)。干预前,两组患儿超敏C反应蛋白(HS-CRP)、游离脂肪酸(FFA)水平比较,差异无统计学意义(P>0.05);干预后,研究组患儿HS-CRP、FFA水平均低于对照组,差异有统计学意义(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论白蛋白联合光疗对重度新生儿高胆红素血症患儿具有较好的干预效果,能够显著降低新生儿TBA及TSB水平,治疗安全性较好,值得临床应用。展开更多
Objective:To study the levels of serum cystatin C(Cys-C),total bile acid(TBA),and other routine blood parameters on patients with decompensated hepatitis B cirrhosis.Methods:Study group 1 consisted of 30 patients with...Objective:To study the levels of serum cystatin C(Cys-C),total bile acid(TBA),and other routine blood parameters on patients with decompensated hepatitis B cirrhosis.Methods:Study group 1 consisted of 30 patients with hepatitis B-related decompensated cirrhosis,and study group 2 consisted of 30 patients with hepatitis B;while the control group consisted of 30 healthy people who underwent physical examination.The blood parameters were used to evaluate the clinical treatment effect of patients.Results:The TBA,Cys-C,alanine transaminase(ALT),total bilirubin(TBIL),aspartate aminotransferase(AST),and international normalized ratio(INR)in study group 1 were significantly higher than those of study group 2 and the control group;while the platelet count(PLT),hemoglobin(Hb),albumin(ALB),and estimated glomerular filtration rate(eGFR)were significantly lower in the study group 1 compared to the control group and study group 2(P<0.05).The Cys-C,PLT,TBA,AST,TBIL,and INR of patients in study group 1 who were successfully treated were significantly lower than the patients who were not successfully treated(P<0.05).Conclusion:Serum Cys-C,TBA,and routine blood parameters are useful in predicting the condition and the prognosis of patients of hepatitis B-related decompensated cirrhosis.展开更多
文摘目的探究综合运用白蛋白和光疗对治疗重度新生儿高胆红素血症的效果及对患儿总胆汁酸(total bile acid,TBA)、总胆红素(total bilirubin,TSB)水平的影响。方法选择2020年1月—2022年12月于淮安市淮阴区妇幼保健院接受临床干预的85例重度新生儿高胆红素血症的患儿为研究对象,按照其接受干预方式分为研究组(45例)和对照组(40例)。研究组联用白蛋白与光疗治疗,对照组接受单纯光疗治疗。比较两组患儿临床干预效果、干预过程中TBA、TSB等实验室指标的变化情况,并统计两组患儿治疗过程中并发症的发生情况。结果研究组患者治疗总有效率高于对照组,差异有统计学意义(P<0.05)。干预12~72 h,研究组患儿的TBA和TSB水平均低于对照组,差异有统计学意义(P<0.05)。干预前,两组患儿超敏C反应蛋白(HS-CRP)、游离脂肪酸(FFA)水平比较,差异无统计学意义(P>0.05);干预后,研究组患儿HS-CRP、FFA水平均低于对照组,差异有统计学意义(P<0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论白蛋白联合光疗对重度新生儿高胆红素血症患儿具有较好的干预效果,能够显著降低新生儿TBA及TSB水平,治疗安全性较好,值得临床应用。
基金SPPH Incubator Fund for Development of Science and Technology(2021YJY-19)SPPH Foundation for Development of Science and Technology(2021BJ-26)International Science and Technology Cooperation Projects of Shaanxi Province(2022KW-14).
文摘Objective:To study the levels of serum cystatin C(Cys-C),total bile acid(TBA),and other routine blood parameters on patients with decompensated hepatitis B cirrhosis.Methods:Study group 1 consisted of 30 patients with hepatitis B-related decompensated cirrhosis,and study group 2 consisted of 30 patients with hepatitis B;while the control group consisted of 30 healthy people who underwent physical examination.The blood parameters were used to evaluate the clinical treatment effect of patients.Results:The TBA,Cys-C,alanine transaminase(ALT),total bilirubin(TBIL),aspartate aminotransferase(AST),and international normalized ratio(INR)in study group 1 were significantly higher than those of study group 2 and the control group;while the platelet count(PLT),hemoglobin(Hb),albumin(ALB),and estimated glomerular filtration rate(eGFR)were significantly lower in the study group 1 compared to the control group and study group 2(P<0.05).The Cys-C,PLT,TBA,AST,TBIL,and INR of patients in study group 1 who were successfully treated were significantly lower than the patients who were not successfully treated(P<0.05).Conclusion:Serum Cys-C,TBA,and routine blood parameters are useful in predicting the condition and the prognosis of patients of hepatitis B-related decompensated cirrhosis.
