Organelle Structures: Bridging Strategy and Technological Processes

The shifting requirements as imposed on operations ma nagement require adjusting and tailoring the organisational structure to meet ma rket demands. However, translating these requirements directly into hierarchical structure will not ensure the integration of processes across organisational un its and guarantee desirable performance. Therefore, management and management li terature wonders: · How should we connect processes to the external environment within a strategi c framework · Which organisational structures do meet performance requirements · Which choices and freedom do we have within organisational structures · How and when do we implement organisational structures That the hierarchical structure does not meet as such the performance requiremen ts nor did it relate to these became already clear during case studies performed in the ’70s. The conclusion was drawn that organisational changes should affect working processes before they proof to be viable. This required the development of new approach through empirical studies and base d on literature. This led to the development of the organelle structure. The org anelle structure should connect to the strategy and the product flow. Thereto, a decision model has been developed for revealing these relations and the practic al implication. During a number of case studies this methodology has been refined and includes t he strategic choice between variants for the organelle structure with their own performance capabilities; we distinguish about 20 variants ranging between the f unctional organisation and the product flow organisation. These ranges of choice s however can be connected to different order entry points, stemming from logist ic concepts. This extends the performance to improved lead-times and improved c ontrol. Strategic choices relate the organelle structure to external performance criteria dictated by product/market-combinations: · lead-time · quality · costs and internal choices for performance criteria: · flexibility · productivity · resource utilisation · innovative performance. Case studies reveal the drastic improvements of the performance of operations an d manufacturing. The paper will discuss a few of these implementations to demons trate the impact. They also show how one derives the hierarchical structure from the choice for the organelle structure. Organelle structures do bridge the link of an industrial company to its environm ent and the internal possibilities, dictated by characteristics of product flow and process execution. The link to the environment results in a strategic framew ork for assessment of alternatives and possibilities. Choices for organelle stru ctures depend strongly on choices on the order entry points of the hardware flow and the specification flow. The evaluation of the characteristics takes place a gainst the strategic framework ensuring competitive advantage as well as a high probability of factual implementation and performance improvement.

Exploring Nutritional Compositions,Volatile Compounds,Health Benefits,Emerging Processing Technologies,and Potential Food Products of Glutinous Rice:A Review

Glutinous rice(Oryza sativa var.glutinosa)stands out as one of the most popular rice varieties globally,amidst thousands of rice cultivars.Its increasing popularity is attributed to its rich nutritional compositions and health benefits.This review aims to summarize the nutritional compositions,volatile compounds,and health benefits of glutinous rice.Further,in-depth studies are necessary to explore the utilization of glutinous rice in enhancing processing technologies and developing new food products.Glutinous rice has been shown to possess numerous health benefits,including antioxidant activity,bioactive compounds,anti-cancer properties,anti-inflammatory effects,anti-diabetic potential,and cholesterol-lowering effects.Besides its nutritional compositions,the major volatile compounds identified in glutinous rice could serve as a functional food for human consumption.Emerging processing technologies related to glutinous rice are elaborated to improve the latest developments for incorporating them into various food products.

Combined Insights from Leachate Structure and Microstructure Characteristics for Eating Quality of Convenience Rice Processed by Super-Heated and Pressurized Steam Technologies

Convenience rice has become widely popular due to its easy availability for cooking. This study investigated the starch structure and composition of leachate and the microstructure of reheated convenience rice using novel processing technologies: super-heated steaming(SHS), auto-electric cooking(AEC), and pressurized-steam cooking(PSC). Additionally, the effect of two different target water contents(58% and 63%) was also evaluated. The PSC_63% sample had the highest total solids and amylopectin amount in the leachate. The amylopectin amount in the leachate differed significantly based on the targeted water content. Morphological characterization revealed that the swelling of starch and the coated layer on the surface of rice grains were most pronounced in the PSC_63% sample due to the pressure processing. The textural hardness of the AEC_58% sample was much higher than that of the other samples. The PSC_63% sample had the highest textural adhesiveness value, which can be attributed to the highest amylopectin amount in the leachate. Sensory characterization showed that the PSC_63% sample had the highest glossiness, whiteness, moistness, and overall acceptability. The principal component analysis score plots presented substantial differences in the leachate and textural and sensory characteristics of reheated convenience rice among the different processing technologies.

Flexible Fixture Design for the Top and End Surface Processing of NP2_NP4 Cylinder Heads

This paper focuses on the design of fixtures for NP2 and NP4 cylinder heads on a horizontal machining center of flexible machining automatic lines.It began with an analysis of the diagrams of part processing and working procedure which formed the basis for the design of the processing technology scheme,a selection of suitable machine tools,and the setting of processing parameters.Fixtures tailored to the chosen machine tools were then designed to meet the processing requirements.Additional aspects of the project included the design of part drawings,calculation of working time quota,design of auxiliary guides,support clamping,and hydraulic circuits,all aimed at fulfilling practical production requirements.

An approach to net-centric control automation of technological processes within industrial IoT systems

The use of industrial internet networks with net- centric control is the driving trend behind the future material manufacturing of goods and services. The promising future of this approach is provided by these complex net-centric systems functioning with high relia- bility. The problem of intelligent net-centric control and reliable network functioning is fundamental, with the additional requirement that the system should preserve stakeholder security and privacy according to policies. The issue is that such systems are characterized by complex multi-parameter operability modes controlled by various criteria. This study considers an approach to providing reliable management of complicated Internet of things （IoT） systems. This is achieved by solving multi-criteria tasks over many processes of various physical natures. Corresponding methods of hierarchical decomposition of multi-criteria tasks, process levels of multi-criteria opti- mization, specifics of aggregation levels, and the master equation of the optimization process are described.

Fabrication of 80-nm T-gate high indium In_(0.7)Ga_(0.3)As/In_(0.6)Ga_(0.4)As composite channels mHEMT on GaAs substrate with simple technological process

An 80-nm gate length metamorphic high electron mobility transistor （mHEMT） on a GaAs substrate with high indium composite compound-channels Ino.7Ga0.aAs/Ino.6Gao.aAs and an optimized grade buffer scheme is presented. High 2-DEG Hall mobility values of 10200 cm2/（V.s） and a sheet density of 3.5 x 10^12 cm-2 at 300 K have been achieved. The device＇s T-shaped gate was made by utilizing a simple three layers electron beam resist, instead of employing a passivation layer for the T-share gate, which is beneficial to decreasing parasitic capacitance and parasitic resistance of the gate and simplifying the device manufacturing process. The ohmic contact resistance Rc is 0.2 n.mm when using the same metal system with the gate （Pt/Ti/Pt/Au）, which reduces the manufacturing cycle of the device. The mHEMT device demonstrates excellent DC and RF characteristics. The peak extrinsic transconductance of 1.1 S/mm and the maximum drain current density of 0.86 A/mm are obtained. The unity current gain cut-off frequency （fT） and the maximum oscillation frequency （fmax） are 246 and 301 GHz, respectively.

Online pharmaceutical process analysis of Chinese medicine using a miniature mass spectrometer: Extraction of active ingredients as an example

The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.

UV/Vis-based process analytical technology to improve monoclonal antibody and host cell protein separation

Process analytical technology(PAT) is gaining more interest in the biomanufacturing industry because of its potential to improve operational control and compliance through real-time quality assurance.Currently, biopharmaceutical producers mainly monitor chromatographic processes with ultraviolet/visible(UV/Vis) absorbance. However, this measurement has a very limited correlation with purity and quantity. The current study aims to determine the concentration of monoclonal antibody(mAb) and host cell proteins(HCPs) using a build-in UV/Vis monitoring during Protein A affinity chromatography and to optimize the separation conditions for high purity of mAb and minimizing the HCPs content. The eluate was analyzed through in-line UV/Vis at 280 and 410 nm, representing mAb and HCPs concentration,respectively. Each 0.1 column volume(CV) fraction of UV/Vis chromatogram peak area were calculated,and different separation conditions were then compared. The optimum conditions of mAb separation were found as 12 CV loading, elution at pH 3.5, and starting the collection at 0.5 CV point, resulting in high m Ab recovery of 95.92% and additional removal of 49.98% of HCP comparing with whole elution pool. This study concluded that UV/Vis-based in-line monitoring at 280 and 410 nm showed a high potential to optimize and real-time control Protein A affinity chromatography for mAb purification from HCPs.

Process Characterization of the Transesterification of Rapeseed Oil to Biodiesel Using Design of Experiments and Infrared Spectroscopy

For optimization of production processes and product quality,often knowledge of the factors influencing the process outcome is compulsory.Thus,process analytical technology(PAT)that allows deeper insight into the process and results in a mathematical description of the process behavior as a simple function based on the most important process factors can help to achieve higher production efficiency and quality.The present study aims at characterizing a well-known industrial process,the transesterification reaction of rapeseed oil with methanol to produce fatty acid methyl esters(FAME)for usage as biodiesel in a continuous micro reactor set-up.To this end,a design of experiment approach is applied,where the effects of two process factors,the molar ratio and the total flow rate of the reactants,are investigated.The optimized process target response is the FAME mass fraction in the purified nonpolar phase of the product as a measure of reaction yield.The quantification is performed using attenuated total reflection infrared spectroscopy in combination with partial least squares regression.The data retrieved during the conduction of the DoE experimental plan were used for statistical analysis.A non-linear model indicating a synergistic interaction between the studied factors describes the reactor behavior with a high coefficient of determination(R^(2))of 0.9608.Thus,we applied a PAT approach to generate further insight into this established industrial process.

Solid Material Formula of Small Fragrant Chicken Soup Stock and Improvement of Boiling Process

[Objectives]To study the solid material formula and boiling process of Small Fragrant Chicken Soup Stock.[Methods]Small fragrant chicken and edible fungi were used as the main raw materials to prepare instant chicken and Morchella esculenta soup stock,and the influencing factors such as solid material ratio,ratio of liquid to material,time and temperature were studied,and the optimal formula and process of the soup stock were screened out through sensory and instrument evaluation experiments.[Results]The optimal formula and process of Small Fragrant Chicken Soup Stock were as follows:small fragrant chicken 40%,M.esculenta 6%,Lyophyllum decastes 3%and Lentinus edodes 1.5%;the ratio of liquid to material was 2.5:1,the boiling time was 2 h,and the boiling temperature was 120℃.Under these conditions,the sensory score of Small Fragrant Chicken Soup Stock was the best.[Conclusions]This study provided a theoretical basis for the industrial production of edible mushroom prepared dishes.

Processing Technology and Quality of Low-fluoride Brick tea

In order to promote the quality of brick tea and reduce its fluoride content, the fluoride contents in leaves of 25 tea varieties at the .stage of one bud and five leaves were determined by the method of fluodde-ion selective electrode method. The results showed that the fluodde contents in the 25 varieties were in the range of 181.92-345.06 mg/kg, end the fluoride content in ＇Zhongcha 302＇ was the lowest. Based on traditional production process of brick tea, 3 new low-fluoride brick tea production processes with ＇Zhongcha 302＇ as the raw material at the stage of one bud and five leaves were constructed. The fluoride content, physicochemical in- dex, sensory end main chemical contents in the brick tea samples were determined. The best processing process of Iow-fluodde brick tea was process 3, which included aldng, fixing, rolling, second fixing, second roiling, sun-drying, pile-fermentation, steaming, pile-fermentation, drying and shaping into brick by vapor treating. The re- sults showed that the fluoride content and physicochemical index of the brick tea sample of the third low-fluoride brick tea production process accorded with National Standard GB/T 9833.4-2013. The sensory evaluation of the brick tea sample was better than that of brick tea manufacture by the traditional process. The water extract, tea polyphenols, amino acids, caffeine and water-soluble sugar in the brick tea sample increased by 9.41%, 36.39%, 26.94%, 27.23% and 15.29%, respectively. Low-fluodds bdck tea could be produced by selecting low fluoride tea varieties, controlling the tondemess of fresh leaves, and optimizing the processing technique.

Innovations and applications of the thermal recovery techniques for heavy oil

Heavy oil represents a vital petroleum resource worldwide.As one of the major producers,China is facing great challenges in effective and economic production of heavy oil due to reservoir complexity.Plenty of efforts have been made to promote innovative advances in thermal recovery modes,methods,and processes for heavy oil in the country.The thermal recovery mode has been shifted from simple steam injection to a more comprehensive“thermal+"strategy,such as a novel N2-steam hybrid process and CO_(2)-enhanced thermal recovery techniques.These advanced techniques break through the challenges of heavy oil extraction from less accessible reservoirs with thinner oil layers and greater burial depths.Regarding thermal recovery methods,China has developed the steam-assisted gravity drainage method integrating flooding and drainage(also referred to as the hybrid flooding-drainage SAGD technology)for highly heterogeneous ultra-heavy oil reservoirs and the fire flooding method for nearly depleted heavy oil reservoirs,substantially improving oil recovery.Furthermore,a range of processes have been developed for heavy oil production,including the open hole completion process using sand control screens for horizontal wells,the process of integrated injection-recovery with horizontal pump for horizontal wells,the steam dryness maintenance,measurement,and control process,efficient and environment-friendly circulating fluidized bed(CFB)boilers with high steam dryness,the recycling process of produced water,and the thermal recovery process for offshore heavy oil.Based on the advances in methodology,technology,and philosophy,a series of supporting technologies for heavy oil production have been developed,leading to the breakthrough of existing technical limit of heavy oil recovery and the expansion into new exploitation targets.For the future heavy oil production in China,it is necessary to embrace a green,low-carbon,and energy-efficient development strategy,and to expand heavy oil extraction in reservoirs with larger burial depth,more viscous oil,thinner oil layers,and lower permeability.Moreover,it is highly recommended to collaboratively maximize oil recovery and oil-to-steam ratio through technological innovations,and boost intelligentization of heavy oil production.

Ecosystem Services of Grazed Grasslands in the Flooding Pampa

The Flooding Pampa grasslands are the last remnant of the Rio de la Plata grasslands in Argentina.Anthropo-genic interventions have led to severe degradation and,as a result,the ecosystem services provided by the grass-lands are declining,in terms of provisioning,regulating,and supporting services.We synthesized the existing literature on the ecosystem goods and services provided by these grasslands under grazing in different conditions and conservation status.We found that plant and animal diversity and primary production are the most studied ecosystem services,while climate regulation,water supply,nutrient cycling,meat production and erosion control,in that order,are less studied.Cultural services are under-researched.Continuous grazing and glyphosate spraying are the main drivers of grassland degradation.Controlled grazing and conservative stocking rates have been shown to reverse degradation and demonstrate that livestock production is compatible with ecosystem conserva-tion by maintaining regulating and provisioning services.As these management strategies are poorly integrated,improving their implementation will require important changes in farmers’decisions and the development of policies that create the economic conditions for this to happen.Research is needed to understand the conditions that prevent the knowledge generated from being transferred to producers and translated into practices that would improve the provision of ecosystem services.

Mathematical Apparatus for Selection of Optimal Parameters of Technical, Technological Systems and Materials Based on Vector Optimization

We presented Mathematical apparatus of the choice of optimum parameters of technical, technological systems and materials on the basis of vector optimization. We have considered the formulation and solution of three types of tasks presented below. First, the problem of selecting the optimal parameters of technical systems depending on the functional characteristics of the system. Secondly, the problem of selecting the optimal parameters of the process depending on the technological characteristics of the process. Third, the problem of choosing the optimal structure of the material depending on the functional characteristics of this material. The statement of all problems is made in the form of vector problems of mathematical (nonlinear) programming. The theory and the principle of optimality of the solution of vector tasks it is explained in work of https://rdcu.be/bhZ8i. The implementation of the methodology is shown on a numerical example of the choice of optimum parameters of the technical, technological systems and materials. On the basis of mathematical methods of solution of vector problems we developed the software in the MATLAB system. The numerical example includes: input data (requirement specification) for modeling;transformation of mathematical models with uncertainty to the model under certainty;acceptance of an optimal solution with equivalent criteria (the solution of numerical model);acceptance of an optimal solution with the given priority of criterion.

Manufacturing Process of Floating Flower Art

Floating flower art belongs to a category of embossing art,which is a kind of garden art that makes plant materials into flower decorations after treatment.In this paper,the whole technological process of making floating flower products was described in detail,and the unique manufacturing process of Japanese embossing brand "Sola Cube" was analyzed,in order to provide some theoretical reference for floating flower lovers and promote its development in China.

Raman spectroscopy as process analytical tool in downstream processing of biotechnology

Downstream processing or product recovery plays a vital role in the development of bioprocesses.To improve the bioprocess efficiency,some unconventional methods are much required.The continuous manufacturing in downstream processing makes the Process Analytical Technologies(PATs)as an important tool.Monitoring and controlling bioprocess are an essential factor for the principles of PAT and quality by design.Spectroscopic methods can apply to monitor multiple analytes in real-time with less sample processing with significant advancements.Raman spectroscopy is an extensively used technique as an analytical and research tool owing to its modest process form,non-destructive,non-invasive optical molecular spectroscopic imaging with computer-based analysis.Generally,its application is essential for the analysis and characterization of biological samples,and it is easy to operate with minimal sample.The innovation on various types of enhanced Raman spectroscopy was designed to enhance the Raman analytical technique.Raman spectroscopy could couple with chemometrics to provide reliable alternative analysis method of downstream process analysis.Thus,this review aims to provide useful insight on the application of Raman spectroscopy for PAT in downstream processing of biotechnology and Raman data analysis in biological fields.

Investigation of the processing technology and mechanism of Kansui radix by licorice based on response surface methodology and integrative pharmacology

Background:The herbs should be processed by different methods before use,and the efficacy and toxicity of Chinese herbal medicines may change,which may enhance efficacy and reduce toxicity after processing.Gansui(Kansui radix)is a common clinical herbal medicine,and there are considerable changes in its toxicity and efficacy after processing.Gaocao(Glycyrrhizae radix et rhizome)has a detoxifying effect.Methods:Using the contents of euphorbiadienol and the alcohol-soluble extract of Glycyrrhizae radix-processed Kansui radix as evaluation indexes,response surface methodology was used to optimize the processing technology of Kansui radix by exploring the effects of Glycyrrhizae radix et rhizoma-addition amount,frying temperature,and frying time on the processing technology of Kansui radix.Meanwhile,response surface software was used to analyze experimental data to determine the processing parameters of Kansui radix by Glycyrrhizae radix et rhizoma.Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine is used to analysis the potential ingredients of Kansui radix and verify the potential ingredients by western blotting.Results:The technology of Glycyrrhizae radix et rhizoma-processed Kansui radix was optimized for the Glycyrrhizae radix et rhizoma-addition amount of 27%,frying temperature of 180℃,and frying time of 11 min.The network pharmacology analysis revealed that Kansui radix could cause kidney,liver,and heart injury by the PI3K/AKT signaling pathway.Kansui radix at high or low dose could decrease the ratio of p-AKT/AKT while Glycyrrhizae radix et rhizoma-processed Kansui could increase it.Conclusion:The model established by response surface methodology is relatively accurate and can predict the contents of euphorbiadienol and alcohol extract of processed Kansui radix.The toxic effects and its mechanism of action of Kansui radix and processed Kansui radix on kidney,liver,and heart,from the perspective of systems biology,have provided scientific evidence to its clinical application.

A comprehensive review of bioactive compounds and processing technology of sesame seed

Sesame seeds are promulgated as traditional high-quality edible oil crops,rich in lipid(40–65%),protein(19–35%),and bioactive compounds.The review starts with bioactive components(fatty acid,tocopherol,phytosterol,sesamin,sesamolin,and sesamol)of sesame seeds.It considers processing techniques for extracting oil(aqueous extraction and pressing)from seeds.Novel technologies,such as enzyme-assisted aqueous,supercritical CO_(2),and microwave-assisted solvent extraction,are also discussed.The methods of utilization of sesame seed cake are also analyzed.In the future,the processing technology of sesame seed will be further developed in the direction of improving comprehensive utilization rate to meet new consumption demand.

The Rice Processing Industry in Nepal: Constraints and Opportunities

A rice mill survey covering diverse rice processing companies in terms of their milling output, type of technology and year of establishment was conducted to understand the current situation of the rice milling industry and to identify enablers and barriers to its growth in Nepal. Coarse rice varieties dominate Nepal’s rice processing industry, with a 42% share by total weight, followed by medium rice (34%) and fine varieties (less than 7%). Polished white rice (Arwa) was the dominant rice type in Nepal in the survey, followed by parboiled and steamed rice. The price and profit margins increased from coarse to fine rice varieties and from Arwa to parboiled and steamed rice. The cost of milling also followed a similar trend. The rice milling industry in Nepal largely influences the adoption or non-adoption of any specific type of rice variety by dictating specific brands in the market and this has important implications for rice research and development. The rice processing industry of Nepal was unable to compete with the Indian rice milling industry because of: 1) low profit margins due to the high cost of rice production and procurement, 2) a lack of economies of scale, 3) a lack of milling technologies for long and extra-long and steamed rice in the country and a lack of investment to modernize rice milling technology, and 4) unavailability of paddy throughout the year locally. Millers were willing to upgrade their rice milling technology to include high throughput parboiling, steamed rice as well as long and extra-long grain rice. This will be a strategic decision in counteracting the ever-increasing rice imports in Nepal. We believe that the findings of the study will be vital for formulating an appropriate rice research, development and rice processing strategy for Nepal to achieve food and nutritional security and the Sustainable Development Goals.

Development and Processing of Millettia speciosa Instant Tea

This paper analyzed the effect of raw material crushing fineness,cooking time,ethanol content during ethanol precipitation and other factors on the preparation of raw material extract from Millettia speciosa Champ. instant tea. The raw materials of Millettia speciosa Champ.,Philippine flemingia root and radix fici simplicissimae were crushed into 10 mesh or finer powder,and cooked for 60 min. During ethanol precipitation,the ethanol content was about 50% to 70%,standing 12 h. The ophiopogon root was cooked in 1∶ 15 boiling water for 45 min,and chrysanthemum was leached for 45 min with 1∶ 20 demineralized water at 80 ℃. After concentration,preparation and spray drying,the finished Millettia speciosa Champ. instant tea was created. The detection of each product index indicated that Millettia speciosa Champ. instant tea had good taste and flavor,and there were no heavy metals,harmful substances and excessive microbes,thereby showing that the raw material of Millettia speciosa Champ. instant tea was selected reasonably,the mixture ratio was rational,and the processing technology was of some security,stability and maturity,which provided a theoretical basis for its development and application.