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Degradation of FAK-targeting by proteolytic targeting chimera technology to inhibit the metastasis of hepatocellular carcinoma
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作者 XINFENG ZHANG SHUANG LI +8 位作者 MEIRU SONG YUE CHEN LIANGZHENG CHANG ZHERUI LIU HONGYUAN DAI YUTAO WANG GANGQI YANG YUN JIANG YINYING LU 《Oncology Research》 SCIE 2024年第4期679-690,共12页
Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expr... Liver cancer is a prevalent malignant cancer,ranking third in terms of mortality rate.Metastasis and recurrence primarily contribute to the high mortality rate of liver cancer.Hepatocellular carcinoma(HCC)has low expression of focal adhesion kinase(FAK),which increases the risk of metastasis and recurrence.Nevertheless,the efficacy of FAK phosphorylation inhibitors is currently limited.Thus,investigating the mechanisms by which FAK affects HCC metastasis to develop targeted therapies for FAK may present a novel strategy to inhibit HCC metastasis.This study examined the correlation between FAK expression and the prognosis of HCC.Additionally,we explored the impact of FAK degradation on HCC metastasis through wound healing experiments,transwell invasion experiments,and a xenograft tumor model.The expression of proteins related to epithelial-mesenchymal transition(EMT)was measured to elucidate the underlying mechanisms.The results showed that FAK PROTAC can degrade FAK,inhibit the migration and invasion of HCC cells in vitro,and notably decrease the lung metastasis of HCC in vivo.Increased expression of E-cadherin and decreased expression of vimentin indicated that EMT was inhibited.Consequently,degradation of FAK through FAK PROTAC effectively suppressed liver cancer metastasis,holding significant clinical implications for treating liver cancer and developing innovative anti-neoplastic drugs. 展开更多
关键词 Hepatocellular carcinoma(HCC) Focal adhesion kinase(FAK) Proteolytic targeting chimera technology(PROTAC) Epithelial-mesenchymal transformation(EMT) METASTASIS
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Goals and Key Technology of Fertilizer-pesticide "Double Reduction" and Synergism for Greenhouse Strawberry
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作者 王建华 成玮 +1 位作者 邬劼 吉沐祥 《Agricultural Science & Technology》 CAS 2017年第11期2113-2117,2122,共6页
In order to develop green good, reduce the use of chemical fertilizer and pesticide, realize "double reduction" and synergism, improve safety and quality of products, protect the ecological environment and promote t... In order to develop green good, reduce the use of chemical fertilizer and pesticide, realize "double reduction" and synergism, improve safety and quality of products, protect the ecological environment and promote the healthy and steady development of strawberry industry, the goals and key technology of fertilizer-pesticide "double reduction" and synergism for greenhouse strawberry are summed up in this paper targeting at the current situation of strawberry production and combined with the new technology achievements at home and abroad. The key technology includes six items: healthy seedling cultivating technique, soil improvement and continuous cropping obstacle treatment technique, agricultural ecological prevention tech- nique, physicochemical trap of pest control technique, biological control technique and low residual risk chemical control technique. 展开更多
关键词 Greenhouse strawberry Green development "Double reduction" and synergism Technology target Key technology
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Next Investment Spree Venture capitalists and private investors target China’s clean technology, medical and 3G services markets
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作者 DING WENLEI 《Beijing Review》 2009年第31期32-33,共2页
chinese economic growth accelerated in the second quarter of this year as a massive stimulus package paid off. Accordingly,
关键词 IPO Next Investment Spree Venture capitalists and private investors target China’s clean technology medical and 3G services markets
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