Two macrocyclic polyoxazoles with different sizes and numbers of side chains were designed and synthesized from the linear-type precursors obtained by the iterative application of oxazole formation reaction via effect...Two macrocyclic polyoxazoles with different sizes and numbers of side chains were designed and synthesized from the linear-type precursors obtained by the iterative application of oxazole formation reaction via effective trimerization or dimerization respectively under highly diluted conditions in one pot.展开更多
We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functi...We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functionalities such as phosphonate ester,acid,and salt at the macrocyclic ring periphery.Such unprecedented macrocyclic compounds are anticipated to be appealing candidates as telomerase inhibitors.展开更多
基金Supported by the Hundred Talent Program of Chinese Academy of Sciences and the National Natural Science Foundation of China（No.21272225）.
文摘Two macrocyclic polyoxazoles with different sizes and numbers of side chains were designed and synthesized from the linear-type precursors obtained by the iterative application of oxazole formation reaction via effective trimerization or dimerization respectively under highly diluted conditions in one pot.
基金the National Natural Science Foundation of China(No.21272225)the Key Lab of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,is acknowledged.
文摘We present the design and synthesis of polyoxazole-based macrocycles containing a phosphonate group.A reliable route was established that allows for convenient and versatile incorporation of various phosphonate functionalities such as phosphonate ester,acid,and salt at the macrocyclic ring periphery.Such unprecedented macrocyclic compounds are anticipated to be appealing candidates as telomerase inhibitors.
