Clinical Analysis of Terbutaline and Budesonide Co-Treatment for Chronic Obstructive Pulmonary Disease

Objective: To analyze the clinical effect of terbutaline combined with budesonide in the treatment of chronic obstructive pulmonary disease. Methods: 500 cases of patients with chronic obstructive pulmonary disease admitted to the hospital from January 2022 to December 2023 were selected and divided into 250 cases in the control group and 250 cases in the observation group by randomization method, both groups received conventional symptomatic treatment, with budesonide added to the control group and terbutaline and budesonide to the observation group, and the lung function indexes, therapeutic effects and adverse drug reactions before and after treatment were compared. Results: After treatment, the level of all lung function indexes of patients in the observation group was higher than that of the control group, and the level of total effective rate of treatment was 96.40%, which was higher than that of the control group (P < 0.05), and the difference in the incidence rate of adverse reactions between the two groups was not strong (P > 0.05). Conclusion: In the clinical treatment of chronic obstructive pulmonary disease, the combined use of terbutaline and budesonide can positively improve lung function, with precise effects and few adverse reactions.

Terbutaline对肉仔鸡胴体组成及体内物质代谢的影响

用４２日龄商品代艾维因（Ａｖｉａｎ）肉仔鸡１８０只，随机分为３组，分别向日粮中添加０，０５，１０ｍｇ／ｋｇ的Ｔｅｒｂｕｔａｌｉｎｅ（特布他林），至５６日龄时进行屠宰，并进行血液生化指标测定及肌肉营养成分测定。结果表明，Ｔｅｂｕｔａｌｉｎｅ提高了肉鸡的屠宰率、胸肌率和腿肌率，降低了腹脂率（Ｐ＜００５），并使肌肉中蛋白质成分增高（Ｐ＜００５），肌肉中水分及蛋白质含量无显著变化；血清尿酸氮含量显著降低（Ｐ＜００１），甘油三酯含量下降，游离脂肪酸、胆固醇、转氨酶、总蛋白含量均增加（Ｐ＜００５），葡萄糖含量无显著变化。

Clinical effect of terbutaline injection aerosol inhalation combined with conventional drug therapy for acute attack of bronchial asthma in children

Objective: To study the clinical effect of terbutaline injection aerosol inhalation combined with conventional drug therapy for acute attack of bronchial asthma in children. Methods:Children with acute attack of bronchial asthma who were treated in Wusheng Hospital of Traditional Chinese Medicine and Qiandongnan Prefecture People's Hospital between January 2014 and July 2017 were selected as the study cases for prospective study and randomly divided into the experimental group who received terbutaline + budesonide aerosol inhalation and the control group who received budesonide aerosol inhalation. The expression levels of immune cell transcription factors in peripheral blood as well as the contents of adhesion factors, chemokines, proteases and their inhibitory molecules in serum were determined before treatment and 3 days after treatment. Results: Foxp3 and T-bet expression in peripheral blood as well as TIMP1 and TIMP2 contents in serum of both groups after treatment were higher than those before treatment whereas RORγt and GATA-3 expression in peripheral blood as well as TARC, Eotaxin, ICAM-1, VCAM-1, L-selectin, ADAM8, NE and MMP9 contents in serum were lower than those before treatment, and Foxp3 and T-bet expression in peripheral blood as well as TIMP1 and TIMP2 contents in serum of experimental group after treatment were higher than those of control group whereas RORγt and GATA-3 expression in peripheral blood as well as TARC, Eotaxin, ICAM-1, VCAM-1, L-selectin, ADAM8, NE and MMP9 contents in serum were lower than those of control group. Conclusion: Terbutaline injection aerosol inhalation combined with conventional drug therapy can effectively regulate the immune response and inflammatory response and inhibit the airway remodeling mediated by protease in children with acute attack of bronchial asthma.

Enantioselective extraction of terbutaline enantiomers by lipophilic tartaric acid

Distribution behavior of terbutaline enantiomers was examined in the aqueous and organic solvent of a two-phase system containing L-dibenzoyltartaric acid and lipophilic phase transfer reagent of Na-tetraphenylborate. The influences of pH, organic solvents, concentrations of Na-tetraphenylborate and L-dibenzoyltartaric acid on the partition coefficients and enantioselectivity of terbutaline enantiomers, were investigated. The results show that tetraphenylborate lipophilic anion and terbutaline enantiomers form two lipophilic salt complexes , which facilitates the solubility of the enantiomers in the organic phase. L-dibenzoyltartaric acid forms more stable complexes with enantiomer Ⅱ than with enantiomer I . Enantioselectivity and partition coefficient increase with the addition of the length of alkyl chain of alcohols. pH and concentrations of lipophilic anion and L-dibenzoyltartaric acid influence them obviously and differently.

Application of A New Spectrophotometric Method Manipulating Ratio Spectra for Determination of Bambuterol Hydrochloride in the Presence of Its Degradation Product Terbutaline

A simple,specific,accurate and precise spectrophotometric stability indicating method is developed for determination of bambuterol hydrochloride(BH)in the presence of its degradation product terbutaline(TERB)and in pharmaceutical formulations.A newly developed spectrophotometric method called ratio difference method by measuring the difference in amplitudes between 245 and 260nm of ratio spectra.The calibration curves are linear over the concentration range of 0.1~1mg·mL-1 for BH and 0.1~0.7mg·mL-1 for TERB with mean percentage recovery of 100.56±0.751 and 99.88±1.183,respectively.The selectivity of the proposed method is checked using laboratory prepared mixtures.The proposed method has been successfully applied to the analysis of BH in pharmaceutical dosage forms without interference from other dosage form additives and the results have been statistically compared with pharmacopeial method.

Analysis of effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children

Objective:To explore the effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children.Methods:One hundred and fifty children with acute attack of asthma and lobar pneumonia were randomly divided into routine group(seventy-five cases)and combined group(seventy-five cases).The routine group was given routine treatment.The study group was treated with routine therapy plus terbutaline sulfate plus shunning.The changes of pulmonary function and serum inflammatory factors before and after treatment,clinical effect and safety were compared between the two groups.Results:Respiratory time/inspiratory time(Ti/Te),peak time ratio(TPTEF/TE),peak volume ratio(VPEF/VE),tidal volume per kilogram(Vt/kg)were increased in both groups after treatment(P<0.05),which in the combined group were higher than the routine group after treatment(P<0.05).After treatment,serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in both groups decreased significantly(P<0.05),and those in the combined group were lower than those in the routine group(P<0.05).There was a significant difference in clinical effect distribution between the two groups(P<0.05).The total effective rate of the combined group was higher than that of the routine group(P<0.05).The incidence of adverse reactions in the combined group was slightly higher than that in the routine group(P>0.05).Conclusion:On the basis of routine treatment,terbutaline sulfate combined with shunning can significantly improve pulmonary function and serum inflammatory factors in children with acute attack of asthma and lobar pneumonia,with ideal effect and safe.

Voltammetric Method Using Multi-Walled Carbon Nanotubes Modified Glassy Carbon Electrode for the Determination of Terbutaline Sulfate in Pork Sample

Electrochemical properties of terbutaline sulfate (TBS) at the glassy carbon electrode modified with multi-walled carbon nanotubes (MWNTs) were explored by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The response was evaluated with respect to pH, scan rate and other variables. Some electrochemical parameters, such as the charge number and proton number, were calculated. The results indicated that TBS underwent irreversible oxidation at the modified electrode, which was an adsorption-controlled process with two protons and two electrons. The reductive peak current of TBS significantly increased and the peak potential shifted negatively at the modified electrode, thus resulting in an electrode for TBS. The current was proportional to the concentration of TBS over 1.12 and 141 μM with a detection limit of 0.34 μM (at S/N = 3). The modified electrode showed good sensitivity, selectivity and stability for the determination of TBS in pork sample.

Effect of azithromycin combined with terbutaline on the infection and systemic conditions in children with mycoplasma pneumonia

Objective: To study the effect of azithromycin combined with terbutaline on the infection and systemic conditions in children with mycoplasma pneumonia. Methods: A total of 80 children with pneumonia who were treated in the hospital between August 2014 and February 2017 were collected and divided into control group and observation group according to the random number table method, 40 cases in each group. The control group received azithromycin therapy, the observation group received azithromycin combined with terbutaline therapy, and both therapies lasted for 6 d. The differences in systemic inflammatory response, myocardial enzyme spectrum, and liver function and so on were compared between the two groups before and after treatment. Results: Before treatment, differences in serum levels of inflammatory factors, myocardial enzyme spectrum indexes and liver function indexes were not statistically significant between the two groups. After 6 d of treatment, serum IL-2, IL-4, IL-8, IL-13, PCT, CK-MB, LDH, HBDH, ALT, AST and ALP levels of both groups of patients were significantly lower than those before treatment, and serum IL-2, IL-4, IL-8, IL-13, PCT, CK-MB, LDH, HBDH, ALT, AST and ALP levels of observation group were significantly lower than those of control group. Conclusion: Azithromycin combined with terbutaline therapy can effectively control the systemic inflammatory response and protect the heart and liver function in patients with mycoplasma pneumonia.

Effects of terbutaline combined with methylprednisolone on pulmonary function, blood gas analysis and inflammatory factors in patients with chronic obstructive pulmonary disease

Objective: To investigate the effects of terbutaline combined with methylprednisolone on pulmonary function, blood gas analysis and inflammatory factors in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 100 patients with COPD were randomly divided into control group (n=50) and observation group (n=50) according to the lottery method. Both groups were treated with conventional therapy. On this basis, the control group was given inhalation of terbutaline. The observation group was given terbutaline inhalation and combination therapy with methylprednisolone. The changes of lung function, changes of blood gas analysis and inflammatory factors were measured before and after treatment in both groups. Results: There were no significant differences in lung function between the two groups before treatment. After treatment, the levels of FVC and FEV1 in both groups were significantly higher than those before treatment, and that of the observation group was higher than those of the control group. Before treatment, there was no significant difference between the two groups. After treatment, PaO2 levels in both groups were significantly higher than those before treatment, and that of the observation group was higher than those of the control group. After treatment, PaCO2 levels in both groups were significantly lower than those before treatment, and the observation group was lower than the control group after treatment. There were no significant differences in the levels of inflammatory factors between the two groups before treatment. After treatment, the levels of PCT and TNF-α in both groups were significantly lower than those before treatment, and those of the observation group was lower than those of the control group after treatment. Conclusion: The effect of Terbutaline combined with methylprednisolone treatment of COPD is better, which can significantly improve lung function, stable blood gas analysis, reduce the concentration of inflammatory factors, and be a potential effective treatment programs.

阿奇霉素联合特布他林对支原体肺炎患儿体液免疫及炎症水平的影响

目的阿奇霉素联合特布他林对支原体肺炎(MPP)患儿体液免疫及炎症水平的影响。方法选取2020年3月-2021年3月在本院确诊的98例MPP患儿,随机把所有患儿分成观察组、对照组,各49例,对照组采用阿奇霉素治疗,观察组采用阿奇霉素联合特布他林进行治疗,均持续治疗14d。比较两组患儿临床疗效、临床症状、体液免疫及炎症水平。结果观察组治疗的有效率明显高于对照组的有效率(χ^(2)=4.346,P=0.037);观察组患儿各种症状消失和住院时间均更短(P<0.05)。治疗后两组患儿免疫球蛋白A(IgA)、免疫球蛋白G(IgG)均低于治疗前,但观察组高于对照组(P<0.05)。治疗后两组患儿血清白细胞介素-6(IL-6)、超敏C反应蛋白(CRP)水平均低于治疗前,且观察组低于对照组(P<0.05)。结论阿奇霉素联合特布他林临床疗效较好,可以改善MPP患儿体液免疫及炎症水平。

阿奇霉素联合特布他林雾化吸入治疗肺炎支原体肺炎患儿的临床疗效研究

分析阿奇霉素联合特布他林雾化吸入在肺炎支原体肺炎患儿治疗中的应用效果.选取2020年6月-2023年7月南宁市第一人民医院儿科收治的50例肺炎支原体肺炎患儿为研究对象,随机将患儿分为对照组和观察组两组,每组各25例,对照组实施阿奇霉素治疗,观察组在对照组治疗基础上联合特布他林雾化吸入治疗.比较两组患儿治疗效果.结果显示,观察组患儿临床治疗总有效率高于对照组(P<0.05);治疗后,观察组TNF-α、IL-17、PCT指标水平均低于对照组(P<0.05);治疗后,观察组患儿咳嗽症状积分低于对照组(P<0.05);观察组各项临床症状消失时间均短于对照组(P<0.05);治疗后,观察组患儿CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平均高于对照组(P<0.05).研究发现,阿奇霉素与特布他林雾化吸入联合治疗肺炎支原体肺炎患儿效果显著,可减轻患儿炎症反应,降低咳嗽评分,缩短临床症状消失时间,改善细胞免疫功能,且不会增加不良反应,值得推广应用.

小儿肺咳颗粒在支气管肺炎患儿中的应用效果

目的 探讨小儿肺咳颗粒联合硫酸特布他林雾化液雾化吸入对支气管肺炎患儿心肌酶与血小板参数的影响。方法 将2020年2月-2022年6月南京江北医院收治的支气管肺炎患儿86例按随机数字表法分为对照组和试验组,各43例。2组均给予常规治疗,对照组在此基础上给予硫酸特布他林雾化吸入用溶液进行治疗,试验组在对照组的基础上给予小儿肺咳颗粒进行治疗,2组均连续治疗1周。比较2组治疗1周后的临床疗效,症状恢复情况,治疗前和治疗1周后的炎症指标、心肌酶指标及血小板参数。结果 治疗1周后的总有效率试验组(90.70%)高于对照组(74.42%)(P <0.05)。试验组咳嗽咳痰缓解、肺部湿啰音消退、体温恢复和胸部X线片病变吸收时间均短于对照组(P <0.05)。治疗1周后,2组血清白细胞介素-4(IL-4)、白细胞介素-13(IL-13)、干扰素-γ(IFN-γ)、肌酸激酶同工酶MB(CK-MB)、乳酸脱氢酶(LDH)、肌酸激酶(CK)水平及全血血小板计数(PLT)、血小板分布宽度(PDW)与治疗前比较均降低,试验组更低(P <0.05);2组全血平均血小板体积(MPV)升高,试验组更高(P <0.05)。结论 小儿肺咳颗粒联合硫酸特布他林雾化液雾化吸入可有效调节支气管肺炎患儿血小板参数,减轻机体炎症及心肌损伤,进而有利于促进患儿症状恢复,提高疗效。

布地奈德+阿奇霉素+特布他林雾化吸入治疗支原体肺炎患儿的效果及对炎症反应、肺功能、T淋巴细胞亚群的影响

目的观察布地奈德+阿奇霉素+特布他林雾化吸入治疗支原体肺炎患儿的效果及对炎症反应、肺功能及T淋巴细胞亚群的影响。方法选择2021年1月至12月收治的84例支原体肺炎患儿作为研究对象,随机将其分为对照组和观察组,各42例。对照组给予阿奇霉素+特布他林治疗,观察组在对照组基础上给予布地奈德治疗。比较两组的治疗效果。结果观察组的咳嗽、体温升高、肺部啰音、肺部病灶消失时间及支原体-IgM抗体转阴时间均短于对照组(P<0.05)。治疗后,观察组的降钙素原(PCT)、粒细胞集落刺激因子(G-CSF)、白细胞介素-6(IL-6)、铁蛋白水平均低于对照组(P<0.05)。治疗后,观察组的用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、用力呼出50%肺活量时的平均呼气流速(MEF50)、最大呼气流速峰值(PEF)均高于对照组(P<0.05)。治疗后,观察组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组(P<0.05)。结论布地奈德+阿奇霉素+特布他林雾化吸入治疗支原体肺炎患儿的效果显著,可显著改善患儿症状、体征,降低炎症因子水平,提高肺功能及免疫功能。

布地奈德、特布他林与噻托溴铵联合治疗对老年慢阻肺患者呼吸功能及机体炎性反应的影响

目的探讨布地奈德、特布他林联合噻托溴铵治疗老年慢阻肺患者的临床效果。方法156例老年慢阻肺患者随机分为两组各78例,对照组采用布地奈德治疗,观察组采用布地奈德、特布他林联合噻托溴铵治疗,比较两组的呼吸功能以及机体炎性反应。结果治疗后,观察组的FVC、MVV及FEV_(1)/FVC均明显高于对照组,CRP、PCT水平均明显低于对照组(P<0.05)。结论布地奈德、特布他林与噻托溴铵联合治疗可明显减轻老年慢阻肺患者的机体炎性反应,促进患者的呼吸功能恢复。

氨茶碱结合特布他林治疗稳定期慢性阻塞性肺疾病患者的临床效果及对血清PCT、TNF-α水平的影响

目的探讨氨茶碱结合特布他林治疗稳定期慢性阻塞性肺疾病(COPD)的临床效果。方法选取2020年1月至2021年12月收治的80例稳定期COPD患者为研究对象,依据入院编号的奇偶性将其分为对照组与观察组,各40例。对照组给予常规对症及特布他林治疗,观察组在对照组基础上给予氨茶碱治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、最大通气量(MVV)及呼气峰流速(PEF)均高于对照组(P<0.05)。治疗后,观察组的白细胞介素-6(IL-6)、、C反应蛋白(CRP)、降钙素原(PCT)及肿瘤坏死因子-α(TNF-α)水平低于对照组,白细胞介素-10(IL-10)水平高于对照组(P<0.05)。治疗后,观察组的膈肌厚度、膈肌活动度、氧合指数高于对照组,二氧化碳分压(PaCO_(2))、慢性阻塞性肺疾病评估测试(CAT)评分低于对照组(P<0.05)。结论氨茶碱结合特布他林治疗稳定期COPD的临床效果理想。

重症AECOPD患者的特布他林结合布地奈德治疗作用及对炎症介质、睡眠质量的影响

目的:探究应用特布他林+布地奈德治疗重症慢性阻塞性肺疾病急性加重(AECOPD)患者的临床疗效。方法:选取2020年2月至2023年3月太仓市第一人民医院重症AECOPD患者84例作为研究对象,按照随机数字表法分为对照组和观察组,每组42例。对照组患者在常规治疗基础上给予硫酸特布他林雾化吸入治疗,观察组患者在对照组治疗基础上联合布地奈德混悬液共同进行雾化治疗,比较2组不同用药方法对患者炎症介质、睡眠质量以及临床疗效等方面的影响。结果:治疗前2组炎症介质水平比较,差异均无统计学意义(均P>0.05),治疗后观察组患者C-反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)水平低于对照组,差异均有统计学意义(均P<0.05);治疗前2组患者睡眠质量差异无统计学意义(P>0.05),治疗后观察组患者睡眠时间、觉醒次数和匹兹堡睡眠质量指数(PSQI)评分明显优于对照组,差异均有统计学意义(均P<0.05);观察组患者临床疗效率明显高于对照组,差异有统计学意义(P<0.05);治疗前2组患者肺功能,差异均无统计学意义(均P>0.05),治疗后观察组患者用力呼气容积(FEV_1)、用力肺活量(FVC)、最大呼气中期流速(MMEF)和呼气峰流速(PEF)水平均高于对照组,差异均有统计学意义(均P<0.05)。结论:通过对重症AECOPD患者开展联合用药治疗(特布他林+布地奈德)后,可达到显著临床治疗效果,对于机体健康恢复有着积极作用。

特布他林联合阿奇霉素在小儿支原体肺炎中的治疗效果

目的探讨特布他林联合阿奇霉素在小儿支原体肺炎中的治疗效果。方法选取2022年1月至2023年3月西安交通大学第二附属医院儿童病院收治的92例支原体肺炎患儿为研究对象,按照随机数字表法分为对照组(46例)和观察组(46例)。对照组采用阿奇霉素治疗,观察组采用特布他林联合阿奇霉素治疗,比较两组治疗效果、症状消失时间以及炎症因子水平。结果观察组治疗总有效率高于对照组(P<0.05);治疗后,观察组症状消失时间短于对照组,炎症因子水平低于对照组(P<0.05)。结论特布他林联合阿奇霉素在小儿支原体肺炎中的治疗效果显著,能够改善症状,减轻炎症反应,值得推广应用。

布地奈德联合特布他林、异丙托溴铵雾化吸入治疗小儿支气管肺炎的效果

目的探析支气管肺炎小儿采用布地奈德联合特布他林、异丙托溴铵雾化吸入治疗的效果。方法选取2021年5月至2022年5月收治的支气管肺炎小儿84例为研究对象,依据随机数字表法分2组,每组42例。对照组采用布地奈德联合特布他林治疗,观察组在对照组加入异丙托溴铵雾化吸入治疗。比较2组炎症指标、症状改善时间及不良反应发生率。结果2组治疗前炎症指标比较差异无统计学意义(P>0.05),观察组治疗后TNF-α(3.12±0.65)μg/L、IL-10(4.21±1.52)μg/L、IL-6(3.68±1.12)μg/L水平低于对照组,差异有统计学意义(P<0.05),观察组症状改善时间包括体温恢复时间(3.12±0.35)d、咳嗽消失时间(3.05±1.21)d、气喘消失时间(2.72±1.05)d、肺部啰音消失时间(2.02±0.65)d及X线片阴影消失时间(4.78±0.23)d明显短于对照组,差异有统计学意义(P<0.05),治疗前观察组呼吸功能指标水平较对照组差异无统计学意义(P>0.05),治疗后观察组FVC(3.12±0.13)L、FEV1(2.99±0.35)L、PEF(3.99±0.65)L/s水平较对照组高(P<0.05),观察组不良反应发生率4.76%低于对照组的23.81%,差异有统计学意义(P<0.05)。结论布地奈德联合特布他林、异丙托溴铵雾化吸入应用在支气管肺炎小儿治疗中效果显著,患儿机体炎症水平明显减轻,缩短症状改善时间,防止其发生不良反应,临床上可借鉴及推广。

特布他林、布地奈德联合异丙托溴铵治疗慢阻肺效果研究

目的:研究特布他林、布地奈德联合异丙托溴铵治疗慢阻肺效果。方法:本次研究从山东大学齐鲁医院2021年3月-2023年1月收入的慢阻肺患者中随机抽取70例,按照随机数表法将其分为对照组和观察组两组。对照组接受布地奈德雾化、特布他林吸入治疗,观察组接受特布他林、布地奈德联合异丙托溴铵雾化治疗,对比治疗结果。结果:对照组综合有效27例(77.14%),观察组综合有效33例(94.29%),(P<0.05);对照组无效8例(22.86%),观察组无效2例(5.71%),观察组综合治疗有效率显著高于对照组,差异有统计学意义,(P<0.05);观察组的肺功能、CAT评分和血气指标结果显著优于对照组,差异有统计学意义,(P<0.05)。结论:特布他林、布地奈德联合异丙托溴铵雾化治疗可有效应对慢阻肺疾病,患者临床综合治疗有效率高且患者的肺功能、CAT评分和血气指标改善结果显著,可推广。

布地奈德、特布他林、异丙托溴铵雾化对哮喘患儿影响

目的 研究布地奈德、特布他林、异丙托溴铵雾化吸入对哮喘患儿影响。方法 选择彭州市人民医院2018年1月至2020年12月收治的哮喘患儿120例,按随机数表法分为观察组和对照组各60例,其中对照组使用布地奈德+特布他林雾化吸入治疗,观察组在对照组基础上加用异丙托溴铵雾化吸入治疗,均连续治疗7 d。观察两组患儿治疗前后肺功能指标为用力肺活量(FVC)、第1s用力呼气容积(FEV1)、最大呼气流量(PEF)、血清免疫球蛋白M(IgM)、血清免疫球蛋白G(iIgG)、血清免疫球蛋白A(IgA)、痰液及血清中嗜酸性粒细胞(EOS)和嗜酸性细胞阳离子蛋白(ECP)含量,统计治疗后气喘消失、咳嗽消失、哮鸣音消失及住院时间,并于治疗后实施为期6月(截止2021年6月)随访调查,采用儿童哮喘控制测试量表(C-ACT)记录疾病控制情况。结果 观察组治疗后FVC、FEV1、PEF均高于对照组,差异有统计学意义(P<0.05),观察组治疗后IgM、IgG、IgA含量均高于对照组,差异有统计学意义(P<0.05),观察组治疗后痰诱导液及血清中EOS、ECP含量均低于对照组,差异有统计学意义(P<0.05)。观察组治疗后气喘消失、咳嗽消失、哮鸣音消失、住院时间均低于对照组,差异有统计学意义(P<0.05),观察组随访3月哮喘控制情况优于对照组,差异有统计学意义(P<0.05),两组随访6月哮喘控制情况相当,差异无统计学意义(P>0.05)。结论 哮喘患儿使用布地奈德联合特布他林及异丙托溴铵雾化吸入治疗能有效改善患儿肺功能、血清免疫球蛋白含量及气道炎症反应,进而缩短临床症状缓解时间,并在一定程度上改善疾病控制情况。