The extensive chemical investigation on the branches and leaves of Terminalia chebula var.tomentella(Combretaceae)led to the isolation of two new lignan glucosides with a furofuran skeleton,termitomenins F(1)and G(2)....The extensive chemical investigation on the branches and leaves of Terminalia chebula var.tomentella(Combretaceae)led to the isolation of two new lignan glucosides with a furofuran skeleton,termitomenins F(1)and G(2).In addition,19 known compounds including five lignan glucosides(3-7),six hydrolyzable tannins(8-13)and eight simple phenolics(14-21)were also identified.Their structures were determined by comprehensive spectroscopic analyses.It is noted that 8 and 9 were C-glycosidic hydrolyzable tannins with one hexahydroxydiphenoyl and one gallagyl group linked to an open-chain glucosyl C-1/O-2/O-3 and O-4/O-6,respectively,which were rarely found in plants.Nine known compounds,6-9,13,and 18-21,were procured from the titled plant for the first time,while 3-5,10-12 and 14-17 were also found in the fruits.Notably,the known hydrolyzable tannins 8-13 exhibited strongerα-glucosidase inhibitory activities with IC_(50) values ranging from 0.10 to 3.12μM,than the positive control,quercetin(IC_(50)=9.38±0.33μM).展开更多
目的:研究绒毛诃子果实中多酚类化学成分及其抗氧化活性。方法:采用Toyopearl HW-40和MCI gel CHP-20P柱分离并结合制备型高效液相色谱,对诃子70%丙酮提取部分进行分离纯化,利用MS、1H-NMR和13CNMR进行结构鉴定;以紫外分光光度法测定诃...目的:研究绒毛诃子果实中多酚类化学成分及其抗氧化活性。方法:采用Toyopearl HW-40和MCI gel CHP-20P柱分离并结合制备型高效液相色谱,对诃子70%丙酮提取部分进行分离纯化,利用MS、1H-NMR和13CNMR进行结构鉴定;以紫外分光光度法测定诃子多酚类对DPPH·和ABTS+·的清除率。结果:从诃子果实中分离鉴定了9个化合物,分别鉴定为:诃黎勒酸(1)、诃子酸(2)、1,3,4,6-四-O-没食子酰-β-D-葡萄糖苷(3)、1,3,6-三-O-没食子酰-β-D-葡萄糖苷(4)、没食子酸(5)、诃子素(6)、1,2,3,4,6-五-O-没食子酰-β-D-葡萄糖苷(7)、新诃黎勒鞣花酸甲酯(8)、新诃黎勒鞣花酸酯(9)。其中4、8为首次从诃子中分离得到。抗氧化实验中,化合物4的TEAC值为(3.912±0.21)mmol·g-1,抗氧化活性最强,与其他单体化合物比较,差异具有统计学意义(P<0.01),化合物3、5和6的TEAC值与对照品维生素C接近,有较强的抗氧化活性,与对照组比较差异没有统计学意义,但是与其他化合物比较差异具有统计学意义(P<0.01),化合物8的抗氧化活性最低。展开更多
文摘The extensive chemical investigation on the branches and leaves of Terminalia chebula var.tomentella(Combretaceae)led to the isolation of two new lignan glucosides with a furofuran skeleton,termitomenins F(1)and G(2).In addition,19 known compounds including five lignan glucosides(3-7),six hydrolyzable tannins(8-13)and eight simple phenolics(14-21)were also identified.Their structures were determined by comprehensive spectroscopic analyses.It is noted that 8 and 9 were C-glycosidic hydrolyzable tannins with one hexahydroxydiphenoyl and one gallagyl group linked to an open-chain glucosyl C-1/O-2/O-3 and O-4/O-6,respectively,which were rarely found in plants.Nine known compounds,6-9,13,and 18-21,were procured from the titled plant for the first time,while 3-5,10-12 and 14-17 were also found in the fruits.Notably,the known hydrolyzable tannins 8-13 exhibited strongerα-glucosidase inhibitory activities with IC_(50) values ranging from 0.10 to 3.12μM,than the positive control,quercetin(IC_(50)=9.38±0.33μM).
文摘目的:研究绒毛诃子果实中多酚类化学成分及其抗氧化活性。方法:采用Toyopearl HW-40和MCI gel CHP-20P柱分离并结合制备型高效液相色谱,对诃子70%丙酮提取部分进行分离纯化,利用MS、1H-NMR和13CNMR进行结构鉴定;以紫外分光光度法测定诃子多酚类对DPPH·和ABTS+·的清除率。结果:从诃子果实中分离鉴定了9个化合物,分别鉴定为:诃黎勒酸(1)、诃子酸(2)、1,3,4,6-四-O-没食子酰-β-D-葡萄糖苷(3)、1,3,6-三-O-没食子酰-β-D-葡萄糖苷(4)、没食子酸(5)、诃子素(6)、1,2,3,4,6-五-O-没食子酰-β-D-葡萄糖苷(7)、新诃黎勒鞣花酸甲酯(8)、新诃黎勒鞣花酸酯(9)。其中4、8为首次从诃子中分离得到。抗氧化实验中,化合物4的TEAC值为(3.912±0.21)mmol·g-1,抗氧化活性最强,与其他单体化合物比较,差异具有统计学意义(P<0.01),化合物3、5和6的TEAC值与对照品维生素C接近,有较强的抗氧化活性,与对照组比较差异没有统计学意义,但是与其他化合物比较差异具有统计学意义(P<0.01),化合物8的抗氧化活性最低。
