Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was...Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was to estimate the risk of developing second primary cancers including the risk associated with primary histologic type （seminoma and non-seminoma） among testicular cancer survivors in Germany. We identified 16 990 and 1401 cases of testicular cancer in population-based cancer registries of East Germany （1961-1989 and 1996-2008） and Saarland （a federal state in West Germany; 1970-2008）, respectively. We estimated the risk of a second primary cancer using standardized incidence ratios （SIRs） with 95% confidence intervals （95% Cls）. To determine trends, we plotted model-based estimated annual SIRs. In East Germany, a total of 301 second primary cancers of any location were observed between 1961 and 1989 （SIR： 1.9; 95% Ch 1.7-2.1）, and 159 cancers （any location） were observed between 1996 and 2008 （SIR： 1.7; 95% Ch 1.4-2.0）. The SIRs for contralateral testicular cancer were increased in the registries with a range from 6.0 in Saarland to 13.9 in East Germany. The SIR for seminoma, in particular, was higher in East Germany compared to the other registries. We observed constant trends in the model-based SIRs for contralateral testicular cancers. The majority of reported SIRs of other cancer sites including histology-specific risks showed low precisions of estimated effects, likely due to small sample sizes. Testicular cancer patients are at increased risk especially for cancers of the contralateral testis and should receive intensive follow-ups.展开更多
Schwannoma is a peripheral nerve tumour, occasionally located in the genitourinary tract. We described an extremely rare case of intratesticular neurinoma in a 79-year-old patient. （Asian JAndrol 2006 Jan; 8： 101-103）
Dear Sir, Metastasis of prostatic carcinoma to testis is un- common in the clinical situation, and the involvement of the epididymis is even rarer. Heidrich et al. [1] found only 80 cases of testicular involvement in...Dear Sir, Metastasis of prostatic carcinoma to testis is un- common in the clinical situation, and the involvement of the epididymis is even rarer. Heidrich et al. [1] found only 80 cases of testicular involvement in prostate cancer in published reports. In 1993, Wiebe et al. [2] found only 14 previous cases of epididymal metastasis from prostatic carcinoma in published work. The simulta- neous involvement of testis and epididymis was reported by Suhler and Blanchard in 1980 [3]. To our knowledge, this was the first documented case of a prostatic carcinoma metastasizing to undescended testis and epididymis.展开更多
The therapeutic efficacy of a combinaion of meso 2,3-dimeroaptosuccinic acid (DMSA) and calcium disodium EDTA in protecting testicular disorders in chronic lead intoxication was investigated. The results indicate that...The therapeutic efficacy of a combinaion of meso 2,3-dimeroaptosuccinic acid (DMSA) and calcium disodium EDTA in protecting testicular disorders in chronic lead intoxication was investigated. The results indicate that two five-days courses of the combined therapy produced a more effective recovery in the lead induced biochemical and histopahological disorders compared to conventional single 5 days therapy. No adverse effect of the chelators, when administered individually or in combination, was noticed in the testes of control (without lead exposure) animals.展开更多
目的系统评价超声造影(contrast-enhanced ultrasound,CEUS)对局灶性睾丸病变的诊断价值。方法检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方、维普(VIP)数据库,收集从建...目的系统评价超声造影(contrast-enhanced ultrasound,CEUS)对局灶性睾丸病变的诊断价值。方法检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库(CBM)、中国知网(CNKI)、万方、维普(VIP)数据库,收集从建库至2023年8月10日发表的关于CEUS诊断局灶性睾丸病变的相关文献,根据纳入和排除标准筛选文献、提取数据,并行文献质量评价,采用RevMan5.4、Meta disc1.4及Stata15.0软件分析CEUS在睾丸肿瘤与肿瘤样病变、肿瘤良恶性两个方面的诊断效能。结果最终纳入13篇文献共712个病灶。Meta分析结果显示,CEUS诊断睾丸肿瘤与肿瘤样病变的合并敏感度、特异度、阳性似然比、阴性似然比分别为0.95(95%CI:0.87~0.98)、0.84(95%CI:0.73~0.91)、5.8(95%CI:3.3~10.2)、0.06(95%CI:0.02~0.17),合并受试者工作特征曲线下面积为0.94(95%CI:0.92~0.96);CEUS诊断睾丸良恶性病变的合并敏感度、特异度、阳性似然比、阴性似然比分别为0.95(95%CI:0.85~0.99)、0.81(95%CI:0.65~0.90)、4.9(95%CI:2.5~9.6)、0.06(95%CI:0.02~0.20),合并受试者工作特征曲线下面积为0.96(95%CI:0.94~0.97)。结论CEUS对局灶性睾丸病变具有较高的诊断价值,能为临床诊疗提供参考。展开更多
目的:睾丸恶性淋巴瘤临床较为少见,本文总结了该病的临床特点、诊断、治疗方法及其预后。方法:26例睾丸恶性淋巴瘤,原发22例(84.6%),继发4例(15.4%),所有患者均接受睾丸手术切除治疗,病理诊断明确。原发睾丸恶性淋巴瘤患者中可随访的为1...目的:睾丸恶性淋巴瘤临床较为少见,本文总结了该病的临床特点、诊断、治疗方法及其预后。方法:26例睾丸恶性淋巴瘤,原发22例(84.6%),继发4例(15.4%),所有患者均接受睾丸手术切除治疗,病理诊断明确。原发睾丸恶性淋巴瘤患者中可随访的为19例,其中3例仅接受手术治疗,14例接受了手术和化疗,2例患者接受了手术联合化疗和放疗。4例继发患者均接受了局部放疗和全身化疗。结果:全组原发患者的中位年龄57岁,首发症状均为无痛性睾丸肿大,主要病理类型为弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL),占84.6%(22/26),少见病理类型包括NK/T细胞淋巴瘤、淋巴母细胞淋巴瘤和B细胞不能分型者。所有原发患者的5年生存率为72%,Ann-Arbor分期Ⅰ～Ⅱ期患者的中位生存时间(median survival time,MST)为95.8个月,Ⅲ～Ⅳ期的MST时间为21.5个月。接受手术和化疗的患者的中位复发和MST分别为78.8和92.3个月。继发患者的中位复发时间为7.5个月,MST为25.0个月。结论:睾丸恶性淋巴瘤好发于老年男性,其预后可能与临床分期、病理类型和治疗方法有关。建议对所有患者在手术后进行放疗,并给予4～6个疗程的CHOP/CHOP-like方案化疗。展开更多
文摘Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was to estimate the risk of developing second primary cancers including the risk associated with primary histologic type （seminoma and non-seminoma） among testicular cancer survivors in Germany. We identified 16 990 and 1401 cases of testicular cancer in population-based cancer registries of East Germany （1961-1989 and 1996-2008） and Saarland （a federal state in West Germany; 1970-2008）, respectively. We estimated the risk of a second primary cancer using standardized incidence ratios （SIRs） with 95% confidence intervals （95% Cls）. To determine trends, we plotted model-based estimated annual SIRs. In East Germany, a total of 301 second primary cancers of any location were observed between 1961 and 1989 （SIR： 1.9; 95% Ch 1.7-2.1）, and 159 cancers （any location） were observed between 1996 and 2008 （SIR： 1.7; 95% Ch 1.4-2.0）. The SIRs for contralateral testicular cancer were increased in the registries with a range from 6.0 in Saarland to 13.9 in East Germany. The SIR for seminoma, in particular, was higher in East Germany compared to the other registries. We observed constant trends in the model-based SIRs for contralateral testicular cancers. The majority of reported SIRs of other cancer sites including histology-specific risks showed low precisions of estimated effects, likely due to small sample sizes. Testicular cancer patients are at increased risk especially for cancers of the contralateral testis and should receive intensive follow-ups.
文摘Schwannoma is a peripheral nerve tumour, occasionally located in the genitourinary tract. We described an extremely rare case of intratesticular neurinoma in a 79-year-old patient. （Asian JAndrol 2006 Jan; 8： 101-103）
文摘Dear Sir, Metastasis of prostatic carcinoma to testis is un- common in the clinical situation, and the involvement of the epididymis is even rarer. Heidrich et al. [1] found only 80 cases of testicular involvement in prostate cancer in published reports. In 1993, Wiebe et al. [2] found only 14 previous cases of epididymal metastasis from prostatic carcinoma in published work. The simulta- neous involvement of testis and epididymis was reported by Suhler and Blanchard in 1980 [3]. To our knowledge, this was the first documented case of a prostatic carcinoma metastasizing to undescended testis and epididymis.
文摘The therapeutic efficacy of a combinaion of meso 2,3-dimeroaptosuccinic acid (DMSA) and calcium disodium EDTA in protecting testicular disorders in chronic lead intoxication was investigated. The results indicate that two five-days courses of the combined therapy produced a more effective recovery in the lead induced biochemical and histopahological disorders compared to conventional single 5 days therapy. No adverse effect of the chelators, when administered individually or in combination, was noticed in the testes of control (without lead exposure) animals.
文摘目的:睾丸恶性淋巴瘤临床较为少见,本文总结了该病的临床特点、诊断、治疗方法及其预后。方法:26例睾丸恶性淋巴瘤,原发22例(84.6%),继发4例(15.4%),所有患者均接受睾丸手术切除治疗,病理诊断明确。原发睾丸恶性淋巴瘤患者中可随访的为19例,其中3例仅接受手术治疗,14例接受了手术和化疗,2例患者接受了手术联合化疗和放疗。4例继发患者均接受了局部放疗和全身化疗。结果:全组原发患者的中位年龄57岁,首发症状均为无痛性睾丸肿大,主要病理类型为弥漫大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL),占84.6%(22/26),少见病理类型包括NK/T细胞淋巴瘤、淋巴母细胞淋巴瘤和B细胞不能分型者。所有原发患者的5年生存率为72%,Ann-Arbor分期Ⅰ～Ⅱ期患者的中位生存时间(median survival time,MST)为95.8个月,Ⅲ～Ⅳ期的MST时间为21.5个月。接受手术和化疗的患者的中位复发和MST分别为78.8和92.3个月。继发患者的中位复发时间为7.5个月,MST为25.0个月。结论:睾丸恶性淋巴瘤好发于老年男性,其预后可能与临床分期、病理类型和治疗方法有关。建议对所有患者在手术后进行放疗,并给予4～6个疗程的CHOP/CHOP-like方案化疗。
