Interleukin-17(IL-17),IL-21,IL-22 and IL-23 can be grouped as T helper 17(Th17)-related cytokines because they are either produced by Th17/Th22 cells or involved in their development.Here,we review Th17-related cytoki...Interleukin-17(IL-17),IL-21,IL-22 and IL-23 can be grouped as T helper 17(Th17)-related cytokines because they are either produced by Th17/Th22 cells or involved in their development.Here,we review Th17-related cytokines/Th17-like cells,networks/signals and their roles in immune responses or immunity against Mycobacterium tuberculosis(Mtb)infection.Published studies suggest that Th17-related cytokine pathways may be manipulated by Mtb microorganisms for their survival benefits in primary tuberculosis(TB).In addition,there is evidence that immune responses of the signal transducer and activator of transcription 3(STAT3)signal pathway and Th17-like T-cell subsets are dysregulated or destroyed in patients with TB.Furthermore,Mtb infection can impact upstream cytokines in the STAT3 pathway of Th17-like responses.Based on these findings,we discuss the need for future studies and the rationale for targeting Th17-related cytokines/signals as a potential adjunctive treatment.展开更多
基金This work was supported by the following research grants:The National Key Research and Development Program of China(2016YFA0502204)the National Institutes of Health R01 grants(NIH R01 HL64560/OD015092/HL129887 to ZWC).
文摘Interleukin-17(IL-17),IL-21,IL-22 and IL-23 can be grouped as T helper 17(Th17)-related cytokines because they are either produced by Th17/Th22 cells or involved in their development.Here,we review Th17-related cytokines/Th17-like cells,networks/signals and their roles in immune responses or immunity against Mycobacterium tuberculosis(Mtb)infection.Published studies suggest that Th17-related cytokine pathways may be manipulated by Mtb microorganisms for their survival benefits in primary tuberculosis(TB).In addition,there is evidence that immune responses of the signal transducer and activator of transcription 3(STAT3)signal pathway and Th17-like T-cell subsets are dysregulated or destroyed in patients with TB.Furthermore,Mtb infection can impact upstream cytokines in the STAT3 pathway of Th17-like responses.Based on these findings,we discuss the need for future studies and the rationale for targeting Th17-related cytokines/signals as a potential adjunctive treatment.
