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基于肿瘤相关巨噬细胞的宫颈癌免疫学病理机制研究 被引量:4
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作者 陈星 吴为玲 +5 位作者 陈姗姗 叶丽娅 梅双双 王静 何钰 柴泽英 《中国临床药理学与治疗学》 CAS CSCD 2017年第12期1394-1399,共6页
目的:分析肿瘤相关巨噬细胞(TAMs)在宫颈癌发病中的作用机制,明确其与Th1/Th2比值、Th17/CD4^+CD25^+Foxp3^+Treg比值的相关性。方法:以27例宫颈癌患者和53例宫颈上皮内瘤变(CINⅡ22例、CINⅢ31例)患者为研究对象,治疗前抽取患者空腹肘... 目的:分析肿瘤相关巨噬细胞(TAMs)在宫颈癌发病中的作用机制,明确其与Th1/Th2比值、Th17/CD4^+CD25^+Foxp3^+Treg比值的相关性。方法:以27例宫颈癌患者和53例宫颈上皮内瘤变(CINⅡ22例、CINⅢ31例)患者为研究对象,治疗前抽取患者空腹肘静脉血,采用流式细胞仪测定Th1/Th2、Th17/CD4^+CD25^+Foxp3^+Treg比值,采用ELISA试剂盒测定血清IFN-γ、IL-4、IL-17A、IL-17F、TGF-β1、IL-10水平;术中留取病理组织,采用免疫组化实验测定TAMs CD68表达。结果:宫颈癌患者外周血Th1/Th2与Th17/CD4^+CD25^+Foxp3^+Treg比值低于CINⅢ,CINⅢ低于CINⅡ,各组之间的差异有统计学意义(P<0.05)。宫颈癌患者血清IL-4、TGF-β1、IL-10水平高于CINⅢ,CINⅢ高于CINⅡ,血清INF-γ、IL-17A、IL-17F水平低于CINⅢ,CINⅢ低于CINⅡ,各组之间的差异有统计学意义(P<0.05)。宫颈癌患者病灶组织TAMs CD68表达水平高于CINⅢ,CINⅢ高于CINⅡ,各组之间差异均有统计学意义(P<0.05)。相关性分析结果显示TAMs CD68表达水平与Th1/Th2比值、Th17/CD4^+CD25^+Foxp3^+Treg比值及IL-17A水平呈负相关性,与IL-10、IL-4水平呈正相关性(P<0.05)。结论:宫颈癌TAMs与Th1/Th2、Th17/CD4^+CD25^+Foxp3^+Treg密切相关,可能通过影响这两大体系的平衡介导宫颈癌的发生与发展。 展开更多
关键词 肿瘤相关巨噬细胞 宫颈癌 Th1/Th2比值 Th17/CD4^+CD25^+Foxp3^+Treg比值
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血管活性肠肽调控CD4^+CD25^+Treg/Th17平衡对实验性自身免疫性脑脊髓炎防治作用的影响 被引量:1
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作者 杨元 袁正洲 +3 位作者 吕志宇 张淑江 李晓红 李作孝 《中国比较医学杂志》 CAS 北大核心 2016年第11期66-71,54,共7页
目的探讨血管活性肠肽(vocative intestinal peptide,VIP)调控CD4^+CD25^+Treg/Th17平衡对防治实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE)的影响。方法 60只健康雌性wistar大鼠随机分成正常对照组、EAE... 目的探讨血管活性肠肽(vocative intestinal peptide,VIP)调控CD4^+CD25^+Treg/Th17平衡对防治实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE)的影响。方法 60只健康雌性wistar大鼠随机分成正常对照组、EAE对照组、VIP低剂量防治组和VIP高剂量防治组。利用髓鞘碱性蛋白(MBP)^+完全福氏佐剂(CFA)诱导建立EAE模型。自造模当日起,每隔一日分别对VIP低、高剂量防治组大鼠腹腔注射VIP 4nmol/kg(0.2 m L)、16 nmol/kg(0.8 m L),正常对照组及EAE对照组注射0.8 m L生理盐水,连续10 d。观察大鼠发病情况;HE染色观察脑组织基本病理改变;流式细胞仪检测脾组织CD4^+CD25^+Treg、Th17细胞比例;ELISA法检测脑组织中TGF-β1、IL-17A因子含量变化。结果与EAE对照组比较,VIP各剂量防治组大鼠发病潜伏期延长、进展期缩短、发病高峰期神经功能障碍评分(NDS)降低;HE染色显示正常对照组大鼠脑组织中未见炎细胞浸润,VIP各剂量防治组大鼠脑组织中炎细胞浸润程度较EAE组明显下降;与EAE对照组比较,VIP各剂量组大鼠脾组织中CD4^+CD25^+Treg细胞亚群比例升高,Th17细胞亚群比例降低,且各组间存一定的量效关系;VIP各剂量组大鼠脑组织中TGF-β1含量较EAE组明显升高,IL-17A含量较EAE组明显降低,且各组间存在一定剂量依赖关系。结论 VIP通过上调CD4^+CD25^+Treg细胞比例,促进TGF-β1因子分泌,同时下调Th17细胞比例,抑制IL-17A因子表达,从而减轻脑组织炎症细胞的浸润程度,发挥对EAE的防治作用。 展开更多
关键词 血管活性肠肽 实验性自身免疫性脑脊髓炎 CD4+CD25+Treg/Th17 TGF-β1 IL-17A
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白色圣诞节——REEBOK FREESTYLE 25TH“SNOW FLAKE”
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作者 夏日男 KICKS(图) 《中国服装(北京)》 2007年第12X期90-91,共2页
不知不觉中2007已经走到了尾声,REEBOK在这一年最重要的纪念活动——FREESTYLE 25TH也进入了收尾阶段,而即将到来的07年圣诞无疑将是FREESTYLE 25TH的最高潮。
关键词 圣诞节 纪念活动 FREESTYLE 25TH REEBOK 2007年 FREESTYLE-SNOW FLAKE雪花鞋 运动鞋
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The Discussion of Tibet's Paintings in Dunhuang During A.D. 786-907 And the Mural Painting on the North Side ofthe No.14 Cave of the Mogao Caves
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作者 ZHANG Ya-sha LI Nan 《Journal of Literature and Art Studies》 2018年第4期614-627,共14页
During A.D. 776 to 848, Dunhuang was occupied and ruled by Tubo political power, a special painting style, spread via the Tibetan silk road, appeared at same time, and which is related to the art style of India and Ne... During A.D. 776 to 848, Dunhuang was occupied and ruled by Tubo political power, a special painting style, spread via the Tibetan silk road, appeared at same time, and which is related to the art style of India and Nepal; It is worth noting that the Tibetan painting style during this period have no relative unified model actually, especially the mural and the silk painting preserved in Library Cave, the painting style of which had obvious difference between each other, and the reason behind this is very hard to explain. Until the late Tang Dynasty (A.D. 848-907), sheer Pala style of eastern India appeared in Dunhuang, however, whether those East India painting style still belong to Tubo remain for further discussion. The art style of East India appeared in Dunhuang during from the late Tang Dynasty to the early period of Northern Song Dynasty, probably propagated from the ways other than Tubo, and this art style was deemed as the one has nothing to do with Tibet's art in this study. 展开更多
关键词 Tibetan painting system silk painting the mural painting on the west of the 25th cave of the YulinCaves the mural painting on the north side of the No.14 cave of the Mogao Caves
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我用KV杀病毒
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《电脑知识与技术(过刊)》 2004年第3期37-37,共1页
关键词 KV KakWorm 蠕虫病毒 Holiday家族 传统DOS病毒 SMDM.A 宏病毒 MARCH 25th Lentin.i 网络蠕虫 文件型病毒
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The 25th China Harbin Summer Music Festival
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《China & The World Cultural Exchange》 2000年第5期48-48,共1页
关键词 The 25th China Harbin Summer Music Festival
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CD4^+ T细胞亚群在支气管哮喘病理机制中作用的新认识 被引量:4
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作者 张琳 梁庆红 王烨 《中国微生态学杂志》 CAS CSCD 2013年第1期100-103,共4页
CD4+T细胞对病原微生物可产生有效免疫应答,依据其产生细胞因子不同分为辅助I型T细胞(Th1)和辅助II型T细胞(Th2),目前其他亚型已被鉴定,包括Th17、调节性T细胞(Treg),滤泡型T细胞和Th9细胞等。调节性T细胞既抑制Th1,也抑制Th2发育。最... CD4+T细胞对病原微生物可产生有效免疫应答,依据其产生细胞因子不同分为辅助I型T细胞(Th1)和辅助II型T细胞(Th2),目前其他亚型已被鉴定,包括Th17、调节性T细胞(Treg),滤泡型T细胞和Th9细胞等。调节性T细胞既抑制Th1,也抑制Th2发育。最近研究报道,在过敏性疾病和哮喘患者中Treg细胞数量减少,并认为是通过下调Th1和Th2细胞以外的其他亚类细胞而抑制过敏和哮喘发作的。在这篇综述中,我们将进一步探讨Th1、Th2、Th17、Th9以及Treg在过敏性和哮喘疾病中的作用。 展开更多
关键词 支气管哮喘 TH1 TH2细胞亚群 Treg Th17细胞亚群 TH9细胞 th25细胞 INKT细胞
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An ongoing journey: review of ICPD + 25 in China
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作者 Baochang Gu Zhuoyan Mao Mengyun Hu 《China Population and Development Studies》 2020年第4期1-24,共24页
The present review is the first to be conducted since the adoption of UN 2030 Agenda for Sustainable Development;it examines the implementation of the PoA/ICPD in China since 1994 and its contributions to the achievem... The present review is the first to be conducted since the adoption of UN 2030 Agenda for Sustainable Development;it examines the implementation of the PoA/ICPD in China since 1994 and its contributions to the achievement of the SDGs in China in the areas of population and development,gender equality,and health improvement.The review demonstrated that China has made tremendous progress in implementing the principles of the PoA in its national context over the past 25 years since ICPD in Cairo in 1994.Still,the ICPD agenda remains unfinished in some respects and further efforts are required,particularly given the changing situation in China. 展开更多
关键词 ICPD 25th Anniversary China Program of action Reproductive health Reproductive rights Quality of care POPULATION Sustainable development
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Strategic Communications of the Muslim Brotherhood in Egypt
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作者 Zhaohui Yu Yaohong Liu 《Asian Journal of Middle Eastern and Islamic Studies》 2019年第1期93-109,I0007,共18页
As the oldest and largest religious political organization and a political opposition,the Muslim Brotherhood has long been active in the Egyptian political arena.The eruption of the‘January 25th Revolution’in 2011 e... As the oldest and largest religious political organization and a political opposition,the Muslim Brotherhood has long been active in the Egyptian political arena.The eruption of the‘January 25th Revolution’in 2011 enabled the Muslim Brotherhood to successfully move from behind the scenes to the stage,and the Freedom and Justice Party under the Muslim Brotherhood was highlighted in Egyptian politics and succeed in the administration of the Egyptian regime.The successful development model of the Muslim Brotherhood is closely related to its strategic communication tactics.This article explores the various strategic communication tactics of the Muslim Brotherhood targeting the internal public,the international community and the stakeholders,including vertical word-of-mouth strategic communications,joint organization strategic communications and social media strategic communications.After the‘January 25th Revolution’,the Muslim Brotherhood began to adjust to the previous strategic communications,focusing on accelerating the Islamization of the Egyptian legal system,government departments and official media,and new strategic communications have trapped it into a difficult position and it has been faced with more hurdles. 展开更多
关键词 Muslim brotherhood Strategic communication Egyptian studies the‘January 25th Revolution’
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Vice-President Lin Yi Attends Concert Celebrating the 25th Anniversary of Diplomatic Relations Between China and Georgia and Georgia’s Independence Day
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作者 Zheng Chen 《Voice of Friendship》 2017年第3期5-5,共1页
Aconcert was held at the Beijing Concert Hall on June 14 to celebrate the 25th anniversary of China-Georgia diplomatic relations and Georgia’s Independence Day. It was jointly organized by the CPAFFC, China’s Minist... Aconcert was held at the Beijing Concert Hall on June 14 to celebrate the 25th anniversary of China-Georgia diplomatic relations and Georgia’s Independence Day. It was jointly organized by the CPAFFC, China’s Ministry of Culture and the Georgia embassy. Li Huilai, assistant minister of Foreign Affairs; Lin Yi, vice-president 展开更多
关键词 Vice-President Lin Yi Attends Concert Celebrating the 25th Anniversary of Diplomatic Relations Between China and Georgia and Georgia’s Independence Day
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Prices of Chemical Futures in China as of February 25th,2009
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《China Chemical Reporter》 2009年第7期19-19,共6页
关键词 Prices of Chemical Futures in China as of February 25th 2009
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