Causal relationship between feelings and cognitive decline:An univariable and multivariable Mendelian randomization study

BACKGROUND While the impact of depression on cognition is well-documented,the relationship between feelings and cognition has received limited attention.AIM To explore the potential association between feelings and cognition with a twosample Mendelian randomization(MR)analysis.METHODS Our analysis utilized genome-wide association data on various feelings(fed-up feelings,n=453071;worrier/anxious feelings,n=450765;guilty feelings,n=45-0704;nervous feelings,n=450700;sensitivity/hurt feelings,n=449419;miserableness,n=454982;loneliness/isolation,n=455364;happiness,n=152348)in the European population and their impact on cognitive functions(intelligence,n=269867).Conducting a univariable MR(UVMR)analysis to assess the relationship between feelings and cognition.In this analysis,we applied the inverse variance weighting(IVW),weighted median,and MR Egger methods.Additionally,we performed sensitivity analysis(leave-one-out analysis),assessed heterogeneity(using MR-PRESSO and Cochran’s Q test),and conducted multiple validity test(employing MR-Egger regression).Subsequently,a multivariable MR(MVMR)analysis was employed to examine the impact of feelings on cognition.IVW served as the primary method in the multivariable analysis,complemented by median-based and MR-Egger methods.RESULTS In this study,UVMR indicated that sensitivity/hurt feelings may have a negative causal effect on cognition(OR=0.63,95%CI:0.43-0.92,P=0.017).After adjustment of other feelings using MVMR,a direct adverse causal effect on cognition was observed(OR_(MVMR)=0.39,95%CI:0.17-0.90,P_(MVMR)=0.027).While a potential increased risk of cognitive decline was observed for fed-up feelings in the UVMR analysis(ORUVMR=0.64,95%CI:0.42-0.97,PUVMR=0.037),this effect disappeared after adjusting for other feelings(OR_(MVMR)=1.42,95%CI:0.43-4.74,P_(MVMR)=0.569).These findings were generally consistent across MV-IVW,median-based,and MR-Egger analyses.MR-Egger regression revealed pleiotropy in the impact of worrier/anxious feelings on cognition,presenting a challenge in identifying the effect.Notably,this study did not demonstrate any significant impact of guilty feelings,nervous feelings,miserableness,or loneliness/isolation on cognition.Due to a limited number of instrumental variables for happiness,this study was unable to analyze the relationship between happiness and cognition.CONCLUSION This MR study finds that sensitivity/hurt feelings are associated with cognitive decline,while the link between worrier/anxious feelings and cognition remains inconclusive.Insufficient evidence supports direct associations between happiness,guilty feelings,nervous feelings,miserableness,loneliness/isolation,and cognition.

“Neo-Confucian(ism)”概念的翻译、流传与阐发——以冯友兰的学术生涯为中心

冯友兰在美国留学期间(1920-1923)使用并阐发了西方创造的“Neo-Confucian(ism)”概念,回国后(1924-1926)首次将其翻译为中文“新儒家(学)”概念。其后由于建构宋明儒学史的需要,加上“新儒学”概念意义的不确定性,1932年底以后,冯友兰在其中论著中转而使用包括程朱理学与陆王心学在内的传统“道学”概念来指称宋明新儒学。但李石岑(1926)、谢扶雅(1928)、陈寅恪(1934)等人都在冯友兰的影响下使用了这一概念。20世纪40年代以后,“新儒家(学)”概念又被用来指称现当代等其他时代的新儒家(学),标志着这一概念在当时国内学术界通行起来。20世纪50年代前后,卜德翻译冯友兰的《中国哲学简史》《中国哲学史》等论著的流行,又促进了“Neo-Confucian(ism)”概念的普及。在“Neo-Confucian(ism)”概念的传播及阐发过程中,继承宋明新儒学并倡导返本开新的海内外现代新儒家(以冯友兰、狄百瑞为代表)起到了关键作用。

The Positive Significance of Confucian Civilization in Peace Building

The Confucian emphasis on benevolence and empathy can be applied in conflict resolution processes.When parties in conflict embrace these values,it becomes easier to find common ground,compromise,and work towards peaceful solutions.Confucian civilization,with its emphasis on ethics,harmony,and diplomacy,offers valuable contributions to peace-building efforts in the contemporary world.By promoting virtuous leadership,fostering cross-cultural understanding,and emphasizing ethical governance,Confucianism can play a positive role in achieving and maintaining global peace.Confucianism continues to exert significant influence in the contemporary world,particularly in the context of peace-building efforts.This article explores the positive significance of Confucian civilization in contributing to peace-building endeavors globally.

翻译、流传与阐发——冯友兰与“Neo-Confucian(ism)”概念

冯友兰在留美期间(1920—1923)吸收了西方“Neo-Confucian(ism)”概念,回国后(1924—1926)最早将其翻译为中文“新儒家(学)”,指出宋明新儒学受佛道影响在本体工夫论上与先秦儒家不同,但在人生观上一致。随后李石岑(1926)、谢扶雅(1928)、陈寅恪(1934)等人也阐发了“新儒家(学)”概念,从而使其成为流行的学术名词。虽然由于构建中国哲学史概念体系的需要,加上“新儒学”概念意义的不确定性,1932年底以后,冯友兰在其中文论著中转而使用包括程朱理学与陆王心学在内的“道学”概念。但卜德又将冯友兰论著中的“道学”翻译为“Neo-Confucian(ism)”,从而促进了其在学术界的传播。随后以狄百瑞为首的哥伦比亚学派致力于阐发宋明新儒学的现代价值,又进一步促进了这一概念在海内外的普及。

On Aesthetic Feelings of Synaesthesia

Synaesthesia is both a common daily life phenomenon and a controversial rhetoric one.Respective evidence may be found in 'Wounded fingers may cause pain in heart' and 'The breeze blows away birds' sweet voice from under the flower'.Other examples,like 'the liquid stillness of the night,noise color,sweet voice,icy look,sharp cry,sour remark,oily-tongued…' are so frequently seen in both Chinese and foreign poems especially classic poems.Without doubt,use of synaesthesia blows a fresh air into essay and poem writing,let alone the accurate and aesthetic feelings it arouses among readers.However,when people try to find out the reason why it can arouse such aesthetic feelings,they seem to encounter difficulties.This paper makes an attempt to offer a different explanation based on psychological analysis.

A Study on Feelings of Worriment Due to Middle-Sized Robot in Living Space

Recently, the demand of services for architectural space is more increasing due to the diversification and complication of people＇s needs. In this research, it is assumed that the robot will support people＇s various needs and people＇s lives in the near future. In this study, the authors investigated the relationship between a robot and a person in quasi space close to actual life space. The authors carried out an experiment to clarify the feelings of worriment due to a robot in the living room in the case of Japanese males. This research aims to establish architecture techniques for robots and humans living together. In this experiment, the robot approached a male sitting on a sofa in quasi space. At different distances between the robot and the male, the subject evaluated his feelings of worriment from ＂no worriment＂ to ＂worriment＂ in five steps from one to five. The robot used in this experiment is middle-sized （380 mm （L） × 380 mm （W） × 350 mm （H））. In this experiment, it is considered that the robot asks for help outside when an emergency occurs. In this experiment, the authors had three situations for the subject： watching television, reading a magazine and just sitting.

Negative feelings experienced by people with mental disorder in the workplace: A qualitative study

Mental disorders are a significant cause of disability and loss of workplace productivity. Many people with mental illness want to work. Occupational health in the world has to face up to psychosocial risks to protect the health of employees. My study aims are to improve negative feelings in work place and work functioning and to stimulate better coping mechanisms. Participants were collected from “Mental health daycare facility”, “Regional living assistance center” and “B-type employment assistance office” in Japan. I took interviews with 25 members. The content of the interviews was categorized about negative feelings in work place. A total of 33 small category negative feelings of mental disorder were extracted and were classified into 11 subcategories. These subcategories were then classified into two higher-level categories: inward-directed feelings and outward-directed feelings. Inward-directed feelings include “reserve or timidity,” “hesitation about being open about the illness,” “anxiety about being dismissed,” “regrets about resigning,” “sense of isolation,” “feelings of remorse,” and “suffering.” Outward-directed feelings include “failure in interpersonal relationships,” “distrust,” “frustrations,” “negative feelings toward those with mental disorder.” Employment has been linked to having better social networks, to enhanced quality of life and to overall wellbeing. We will have to defend them legally. The legal and moral obligations placed on the employer require that it provides a healthy, harassment-free work environment.

Empirical Study on the Empowerment of Families Raising Children with Severe Motor and Intellectual Disabilities in Japan: The Association with Positive Feelings towards Child Rearing

Background: “Children with severe motor and intellectual disabilities” refers to children with markedly limited activity due to severe overlapping of physical and intellectual disabilities. The physical and mental burden placed on families raising severely disabled children, particularly the primary caregivers, is great in home settings. For families to effectively utilize services and over-come child rearing problems, the families themselves need the “strength” to cooperate with others for the purpose of raising a severely disabled child. The ultimate goal of family support is to enable such families to achieve satisfaction and self-growth in child rearing. Methods: We used a questionnaire to survey 75 primary caregivers to empirically elucidate the empowerment and positive feelings towards child rearing of families raising children with severe motor and intellectual disabilities and the related factors. The t-test and Spearman’s rank correlation coefficient were used to examine the association with bivariates. A multiple regression analysis was conducted for empowerment and positive feelings. Results: Results revealed that life events, livelihood, awareness of social support and the child’s sleep problems were factors related to empowerment. Of these, awareness of social support from outside of the family was found to contribute the most to empowerment. Furthermore, improvement and maintenance of positive feelings towards child rearing reaffirmed the existence of empowerment in addition to reducing negative feelings towards child rearing and ensuring social support. Conclusions: Raising children with severe motor and intellectual disabilities requires specialist knowledge and skills. Support from professionals to empower the entire family is therefore important in order to strengthen positive feelings towards child rearing.

How Do We Have Feelings?

For centuries, the question of how a physical structure (the brain) generates the subjective feeling of consciousness has plagued neuroscientists, physiologists, psychologists, linguists, and philosophers. This has become known as the “hard problem of consciousness” and has been the subject of many publications. Although lots of answers have been proposed, none has been completely satisfactory. The focus of most of these studies has been on the neuronal structures and activities. Experiential consciousness emerges from neural processes, but it has not been explained with models that have been based solely on the electro-mechanical aspects of the processes. There must be some other dynamic features of neuronal activity to explain the emergence of experiential consciousness. I argue that a likely answer to the dilemma resides in the added dimension of the neurochemistry of the brain that has, so far, received little attention.

The Missing of Emotional Feelings in the Translation of Ci Works——A Comparison between Yulingling and Its Translation

Yulinling is a famous piece of Ci by Liu Yong of the Song Dynasty.It is one long-cherished classical in lamenting the sorrow of departure.The author pictures a gloomy scene of separation:the cold autumn,the long corridor,the misty sea and the lonely boat,all the scenes depicting the sorrow and unwillingness of the separation between the two who are in deep love.The translator translated it into Eng lish in order to express his depressive feelings but he did not convey the depressive meaning of the original Ci in full extend.He lost some of the intentional feelings of the original in his translation.Through the comparison between Yulingling and its translation,the paper dis cusses the missing of emotional feelings in the translation of Ci works.

Leveraging Confucian and Daoist Wisdom for Biodiversity Education: A Pathway to Sustainable Decision Making

The vitality of biodiversity,an essential pillar of a thriving biosphere,is currently at risk.This paper investigates the potential of ancient philosophies,specifically Confucianism and Daoism,as pathways to mitigate this issue.We delve into the intricate connections between these philosophies and the natural world,and how they can inform our understanding of biodiversity threats in the context of cultural and technological evolution.Recognizing the inevitable progression of technology and its influence on human evolution and the biosphere,we turn to traditional philosophies to establish guiding principles for sustainable decision-making.We advocate for the principle:"Decisions must not result in the artificial reduction of biodiversity within the framework of evolutionary time."This principle is substantiated by reciprocal arguments that lay the foundation for the essential analyses to protect biodiversity.By adhering to this principle,we can ensure a sustainable biosphere conducive to ongoing human evolution.This study underscores the importance of integrating ancient wisdom with modern decision-making processes to address the pressing issue of biodiversity loss.

Feelings and Spiritual Practices of Patients with Mastectomy: A Qualitative Study from Turkey

Purpose: This study was conducted to describe feelings and spiritual practices of patients with mastectomy. Method: The study was employed a qualitative design at a private university hospital oncology unit in Ankara, Turkey. Interviews were performed with 20 mastectomized women. Results: The findings indicated that commonly used in several spiritual practices;prayer was used by 96%, of the patients, and 94% requested that others pray for their health, the practice to positive reframing (76%), the practice to planning for family-friends activities (74%), visiting mos-que-shrine (73%), and the practice to reading Quran (71%). The categorization of the data led to identification of three thematic units. The first we described as “Experiencing the consequences of illness as a disorder”. The second was “Restoring a sense of order to life”, and the third was “Living with the new condition”. Conclusion: We concluded that a having mastectomy was difficult for the subjects. In this respect, nurses’ role is vital to help women with breast cancer in such a difficult and modifying process as breast removal.

A Brief Analysis on the Causes of the Chinese Nation's Strong Feelings toward their Home and Country

"The love for our children as well as the love for our country and people"are the common emotions of all human beings.The Chinese nation's feelings toward their relatives,hometown,and country are immensely deep and strong that they have surpassed all other nations.This article analyzed the causes of the Chinese nation's strong feelings toward their home and country based on China's development history and geopolitics.

Muslim Confucian Philosophy:Islamic-Confucian Dialogue and the Integration of Civilizations

At the end of the Ming Dynasty and at the beginning of the Qing Dynasty,a new theory of learning was created-Muslim Confucian Study(Chinese Islamic Philosophy)-on the basis of Islamic philosophy and under the influence of Confucianism.Wang Daiyu(1570-1660)and Liu Zhi(1660-1739)were two great Huiru(Muslim Confucian)scholars at that time.They published Zhengjiao zhenquan(The real commentary on the tire teaching),Tianfang xingli(Nature and principle in Islam)major books.Their approach is distinguished from that of other Muslim scholars in that they addressed the basic articles of Islamic thought with Confucian terminology and categories.The study deals with the Islamic worldview,and with the practices that make it possible for people to bring themselves into conformity with that worldview.However,the teaching of the Muslim Confucian was continuous with those of Mainstream Islam.In my research,I attempted to answer two questions:(a)How did Muslim Confucian Study Inherit the Mainstream Islamic Thought?(b)What is the value and contribution of the World Islamic philology and civilization?

Common Emulsifier Combination Skin Feeling Research and Recommendation

Emulsifier is an important component of emulsified skin care BASE(matrix),and the common influencing factors affecting the skin feel of BASE are:emollient,thickeners,and emulsifier.The choice of emulsifier is crucial to the skin feel of cosmetics.In this paper,12 classical emulsifiers were selected and 13 combinations of them were made.Thirteen creams were designed using the same formulation structure,their physicochemical indexes were determined,and their skin feel was tested and evaluated using five expert panel scores,with the test site being the hand.Physicochemical parameters included pH and viscosity.Skin feel indicators include:stickiness,silkiness,whiteheads,greasiness at the end of application,absorption,softness after use,etc.The BASE formulations of the creams were tested and evaluated by five experts.Recommendations were also made for the selection of emulsifier combinations in the design of cream BASE formulations.