Progress in the generation of spinal cord organoids over the past decade and future perspectives

Spinal cord organoids are three-dimensional tissues derived from stem cells that recapitulate the primary morphological and functional characteristics of the spinal cord in vivo.As emerging bioengineering methods have led to the optimization of cell culture protocols,spinal cord organoids technology has made remarkable advancements in the past decade.Our literature search found that current spinal cord organoids do not only dynamically simulate neural tube formation but also exhibit diverse cytoarchitecture along the dorsal-ventral and rostral-caudal axes.Moreover,fused organoids that integrate motor neurons and other regionally specific organoids exhibit intricate neural circuits that allows for functional assessment.These qualities make spinal cord organoids valuable tools for disease modeling,drug screening,and tissue regeneration.By utilizing this emergent technology,researchers have made significant progress in investigating the pathogenesis and potential therapeutic targets of spinal cord diseases.However,at present,spinal cord organoid technology remains in its infancy and has not been widely applied in translational medicine.Establishment of the next generation of spinal cord organoids will depend on good manufacturing practice standards and needs to focus on diverse cell phenotypes and electrophysiological functionality evaluation.

Progress and prospect of mid-deep geothermal reinjection technology

Mid-deep geothermal reinjection technology is crucial for the sustainable development of geothermal resources,which has garnered significant attention and rapid growth in recent years.Currently,various geothermal reinjection technologies lag behind,lacking effective integration to address issues like low reinjection rates and thermal breakthrough.This paper reviews the basic principles and development history of mid-deep geothermal reinjection technology,focusing on various technical methods used in the process and analyzing their applicability,advantages,and disadvantages under different geological conditions.It highlights the unique challenges posed by deep geothermal resources,including high temperature,high pressure,high stress,chemical corrosion,and complex geological structures.Additionally,it addresses challenges in equipment selection and durability,system stability and operation safety,environmental impact,and sustainable development.Finally,the paper explores future directions for mid-deep geothermal reinjection technology,highlighting key areas for further research and potential pathways for technological innovation.This comprehensive analysis aims to accelerate the advancement of geothermal reinjection technology,offering essential guidance for the efficient reinjection and sustainable development of geothermal resources.

Intellectual Property Protection and High-Quality Development of Xinjiang Melons under the Big Food Concept

The development of diversified foods such as melons under the big food concept can reduce the pressure on staple food grain.Xinjiang has the advantages of building a new development pattern of dual circulation of diversified food industry and establishing a national diversified food safety and high-quality assurance center.The construction of an agricultural power needs the strategic support of an intellectual property power.This paper introduced and studied Xinjiang s melon industry and its agricultural intellectual property resources,analyzed the six main problems,including many idle land resources have not been developed into melon fields and the role of melons in diversified food supply systems not well played.Finally,it proposed to vigorously develop diversified food industries such as melons in Xinjiang and establish an eight-point strategy such as national diversified food safety and high-quality assurance center.

Building a Business and Strategic Intelligence Policy as a Strategy for Promoting Congolese Business Progress and Healthy Economic Development in Eastern DRC

The aim of this study was to verify the existence of business and strategic intelligence policies at the level of Congolese companies and at the state level, likely to foster progress and healthy development in the east of the DRC. The study was based on a mixed perspective consisting of objective analysis of quantitative data and interpretative analysis of qualitative data. The results showed that business and strategic intelligence policies have not been established at either company or state level, as this is an area of activity that is not known to the players in companies and public departments, and there are no units or offices in their organizational structures responsible for managing strategic information for competitiveness on the international market. In addition, there is a real need to establish strategic information management units within companies, upstream, and to set up a national strategic information management department or agency to help local companies compete in the marketplace, downstream. This reflects the importance and timeliness of building business and strategic intelligence policies to ensure economic progress and development in the eastern DRC. Business and strategic intelligence provides companies with an appropriate tool for researching, collecting, processing and disseminating information useful for decision-making among stakeholders, in order to cope with a crisis or competitive situation. The study suggests a number of key recommendations based on its findings. To the government, it is recommended to establish the national policy of business and strategic intelligence by setting up a national agency of strategic intelligence in favor of local companies;and to companies to establish business intelligence units in their organizational structures in favor of stakeholders to foster advantageous decision-making in the competitive market and achieve progress. Finally, the study suggests that studies be carried out to fully understand the opportunities and impact of business and strategic intelligence in African countries, particularly in the DRC.

Intellectual Property Protection and High-quality Development of Grape Industrial Clusters in Xinjiang

This paper introduced the grape industry in Xinjiang and its agricultural intellectual property resources,and analyzed six major problems such as the ineffective leading role of intellectual property rights in high-quality development.Finally,it proposed eight strategies to build a national-level regional fine-grain breeding base for grapes and develop“agricultural chips”in the context of the strategy of strengthening the country with intellectual property and innovation-driven development strategy.

Intellectual Property Protection and New Development Pattern Construction of Xinjiang Jujube

"Three new developments"is the guiding ideology of Chinese-style high-quality development in the new era.Jujube(Zizyphus jujube Mill.)is a plant of Zizyphus of Rhamnaceae,which originated in China and has been listed as one of the"five fruits"since ancient times.Xinjiang is the most important jujube producing area in China,and its yield has accounted for 50%of the national jujube yield.In the five prefectures and cities of southern Xinjiang,as well as the regimental farms of southern and eastern Xinjiang of Xinjiang Production and Construction Corps,the jujube industry is an advantageous characteristic industry in agriculture.This paper studied Xinjiang jujube industry and its agricultural intellectual property resources,analyzed six major issues to be further implemented,such as the"three new developments"thinking and the strategy of building an intellectual property power,and puts forward eight strategies such as coordinating the two markets and two resources to accelerate the construction of a new development pattern and dual circulation of jujube.

Research Progress on the Development and Utilization of Proteins in Edible Insects

The recent progress on the proteins in edible insects was summarized, in- cluding the nutritional value, healthy value, food safety, extraction and content mea- surement of the proteins in edible insects, as well as the main development direc- tion of edible insect proteins. And we also pointed out the bottlenecks that restricted the development and utilization of proteins in edible insects, and proposed the prospect of the research, development and utilization of edible insects proteins.

Progress in the development and application of plant-based antiviral agents

Plant virus disease is one of the major causes of biological disasters in agriculture worldwide. Given the complexity of transmission media and plant disease infection mechanisms, the prevention and control of plant viral diseases is a great challenge, and an efficient green pesticide is urgently needed. For this reason, when developing candidate drug leads to regulate plant viruses, pesticide experts have focused on characteristics such as low pesticide resistance, eco-friendliness, and novel mechanism. Researchers have also theoretically investigated the molecular targets of viruses infecting agricultural crops. Antiviral screening models have been constructed based on these molecular targets, and the mechanisms of commercial drugs and high-activity compounds have been extensively investigated. After screening, some compounds have been applied in the field and found to have good commercial prospects; these drugs may be used to create new green antiviral pesticides to control plant viruses. This paper reviews the screening, mode of action, development and application of recently used plant-based antiviral agents.

MicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression

Background: MicroRNA?506(miR?506) has been reported to function in several tumors as a tumor suppressor gene or oncogene. However, the expression and role of miR?506 in pancreatic ductal adenocarcinoma(PDAC) remains unclear. In this study, we aimed to evaluate the phenotype of miR?506 in PDAC.Methods: Using mi RNA in situ hybridization, we examined the expression of miR?506 in 113 PDACs and 87 paired normal pancreatic tissues. We evaluated mi R?506 expression in PDAC cells, normal pancreatic ducts, and acinus/islands, and we analyzed the associations between miR?506 expression and the clinicopathologic characteristics of PDAC patients.Results: miR?506 expression was higher in PDAC than in matched normal pancreatic ductal cells(P < 0.001). On the other hand, the combined group of well and moderately diferentiated PDACs showed higher levels of mi R?506 than the poorly diferentiated ones(P = 0.023). Moreover, mi R?506 expression was negatively associated with pathologic T category(P = 0.004) and lymph node metastasis(P = 0.033), suggesting that mi R?506 might inhibit the progression of PDAC.Conclusions: Our results suggest that mi R?506 either plays a role as an oncogene in the tumorigenesis and a tumor suppressor in the progression or serves as a house?keeping, tumor?suppressing mi RNA, whose expression can be activated by oncogenic signals in early development to hinder the progression of PDAC.

WATER ENVIRONMENT AND SUSTAINABLE DEVELOPMENT ALONG THE BELT OF XINJIANG SECTION OF THE NEW EURASIAN CONTINENTAL BRIDGE

The opening of the new Eusasian Continental Bridge not only brings about great opportunities for development of Xinjjang, but the plays a major role in reducing the gap between the western and eastern parts of China. In general, Xinjiang section of the new Eusasian Continental Bridge goes ahead along the oasis belt of northern slope of the Tianshan Mountains with advanced economy and concentrated populattion. The main factor to determine the fate of oasis is water. There are relativdy more rivers in Xinjiang section Of the Eurasia Continental Bridge. But as far as the region is concerned, if we take Ururmqi as the boundary, river runoff of the western section accounts for 90%,the eastern section just occupies 10%, so surface runoff is highly concentrated in the west. In this paper, river water envirotnment and ground water environment are evaluated emphatical . On the whole,the status of water environment of seven rivers being evaluated is gradually improved and ground water quality of main cities along the bridge is good. In the future, carrying out sustainable development strategy and doing well in compositive prevention and cure should be long-term guidelines so as to ensure the normal running of the new Eurasia Continental Bridge and economic development along the continental bridge.

Research Progress on the Development of Modern Agricultural Science and Technology Park

This paper summarizes the typical models,construction theory and development status of modern agricultural science and technology parks at home and abroad,in order to provide a reference for the sustainable development of modern agricultural science and technology parks in China.It is found that at present,the agricultural science and technology park in China is in the stage of quantitative development,neglecting the qualitative construction of the park.This paper points out that the balanced relationship among ecology,economy and society should be adjusted to promote the sustainable development of the park.

Developability assessment of the therapeutic antibodies studies: are they druggable?

In recent years,with the continuous development of biotechnology and medical science and technology,therapeutic antibodies,as new biologics,have shown great potential and have become a research hotspot in the fields of oncology,autoimmune diseases,cardiovascular and neuroscience.Therapeutic antibodies refer to drugs or therapeutic methods for the treatment of diseases with specificity,high affinity and high efficiency antibody molecules prepared by biotechnological means.In this paper,we will systematically review the types of therapeutic antibodies,research progress,problems in research and development,mechanisms of action,and challenges faced in clinical applications.

Prediction of atrial fibrillation development and progression:current perspectives

Atrial fibrillation(AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression(from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF.

Current Development Situations of Ziziphus Jujuba Industry in South Xinjiang and Recommendations

Through surveying current development situations and existing problems of planting and processing of Ziziphus jujuba in south Xinjiang,this paper discussed planting,processing mode of Ziziphus Jujuba in south Xinjiang and development direction of enterprises in Ziziphus Jujuba production. It is expected to ensure and increase quality and sales volume of Ziziphus Jujuba and promote sound and sustainable development of Ziziphus Jujuba industrial chain in south Xinjiang.

New Progress on the Coal Fines Affecting the Development of Coalbed Methane

Objective The production of coal fines is very common in the development of coalbed methane（CBM）in the eastern margin of the Ordos Basin,China.A large amount of produced coal fines seriously affect the productivity of CBM wells（Wei Yingchun et al.,2013）.Therefore,the production problems of CBM wells caused by coal fines have attracted extensive attention.

Eco-geographic Environment and Regional Development in Xinjiang of China

The study on relationship between eco-geographic environment （EGE） and regional development （RD） is of theoretical and practical significance to promote the comprehensive study on nature and human factors and regional coordination development. Based on the evaluation index system and models of EGE and RD, Quadrant Analysis Method （QAM） and the Coordination Degree and Coordinated Development Degree Model （CDCDDM） were applied to studying the relationship between EGE and RD in Xinjiang in this paper. The results show that Xinjiang can be divided into four type regions according to the relationship between EGE and RD, namely high coordination region （HCR）, overloading development region （ODR）, low coordination region （LCR） and potential development region （PDR）. Most areas of Xinjiang belong to LCR which can not bear a larger population and support large-scale economic development. HCR, ODR and PDR, which are mainly distributed in piedmont oases and take basin as unit, should be focused on in the development of Xinjiang. The EGE has great influence on RE）, and there is serious contradiction between them. Relevant suggestions on development strategies were put forward according to the character of different type regions, and the key regions of macro-layout of RD in Xinjiang were pointed out.

A Review of the History and Development of Integrated Pest Management(IPM)

The evolvement of IPM has experienced several significant stages. IPM is an ecosystem as a governance unit. It allows the presence of low numbers of pests because a direct or indirect relationship between biological species and their associated environmental living conditions could keep a long-term ecological balance. IPM also emphasizes overall benefits; it is necessary to integrate all kinds of safe, effective, economic, and simple managements as far as possible. When synthesizing and coordinating various managements, effective control object, effective time limit, effective scope, and effective degree of the individual method should be analysed first. The ultimate goal of IPM is for the sustainable development of agriculture. In the future IPM system engineering, crop resistance, the role of natural enemies, agricultural control, and the application of biological control technologies will be greatly strengthened, and the role of chemical pesticides will be significantly reduced. Safe, effective, and long-lasting control of pest populations will be below the level of harm caused, which could protect the ecological environment and the health of people and livestock, and promote the development of production.

Major progress in the natural gas exploration and development in the past seven decades in China

China has made significant progress in the exploration and development of natural gas in the past 70 years,from the gas-poor country to the world’s sixth largest gas production country.In 1949,the annual gas output in China was 1117×104 m3,the proved gas reserves were 3.85×108 m3,and the average annual gas consumption and available reserves of per person were 0.0206 m3 and 0.7107 m3,respectively.By 2018,the average domestic annual gas production per person was 114.8576 m3 and the reserves were 12011.08 m3,and the average domestic annual gas production and reserves per person in the past 70 years increased by 5575 times and 16900 times,respectively.The exploration and development of large gas fields is the main way to rapidly develop the natural gas industry.72 large gas fields have been discovered in China so far,mainly distributed in three basins,Sichuan(25),Ordos(13)and Tarim(10).In 2018,the total gas production of the large gas fields in these three basins was 1039.26×108 m3,accounting for 65%of the total gas production in China.By the end of 2018,the cumulative proved gas reserves of the 72 large gas fields had amounted to 124504×108 m3,accounting for 75%of the total national gas reserves(16.7×1012 m3).New theories of natural gas have promoted the development of China’s natural gas industry faster.Since 1979,the new theory of coal-derived gas has boosted the discovery of gas fields mainly from coal-measure source rocks in China.In 2018,the gas production of large coal-derived gas fields in China accounted for 50.93%and 75.47%of the total national gas production and total gas production of large gas fields,respectively.Guided by shale gas theories,shale gas fields such as Fuling,Changning,Weiyuan and Weirong have been discovered.In 2018,the total proved geological reserves of shale gas were 10455.67×108 m3,and the annual gas production was 108.8×108 m3,demonstrating a good prospect of shale gas in China.

Progress and Problems of Development Research and Application of Sand Barriers

Due to the restrictions on the conditions for afforestation and sand control,the development research,and application of sand barriers have accelerated in recent years,but some problems that cannot be ignored have emerged in practice. In this paper,the functions of wind prevention,sand blocking and fixation,improving soil physical and chemical properties and increasing plant diversity of sand barriers,accretion coefficient and capacity between sand barriers,and mobile sand barriers were analyzed firstly,and then several issues that should be noted in the development and application of sand barriers were proposed. The results show that sand barriers can fix sand on the spot and maintain the stability of sand surface. As an auxiliary measure before afforestation on a mobile sand surface,they are practical and feasible. The biggest drawback of sand barriers is that they are easy to be saturated. Although they can increase plant diversity and surface roughness,they lose the function of blocking sand flow after being saturated,and their function of in-situ sand fixation also rapidly decreases with the degradation of sand barriers. Mobile sand barriers overcome the disadvantage of sand barriers being easy to be saturated to some extent,but the cost greatly increases. In terms of desertification prevention and control by plants,plants are used as sand barriers to study their functions of sand blocking and sand fixation in many researches and practices,but the more important ecological functions of adjusting temperature on sand surface and achieving surface thermodynamic equilibrium of plants are ignored.