BACKGROUND Lumbar disc herniation(LDH)commonly occurs during spinal surgery;LDH is on the increase in younger patients and is classified as"paralysis"and"back pain."Sanhanchushi Tongbi(SPST)is a cu...BACKGROUND Lumbar disc herniation(LDH)commonly occurs during spinal surgery;LDH is on the increase in younger patients and is classified as"paralysis"and"back pain."Sanhanchushi Tongbi(SPST)is a customized prescription.It disperses cold,relieves pain,removes cold from the meridians and viscera,and treats neuropathic pain.However,few studies have investigated its mechanism of pain relief.AIM To observe the clinical therapeutic effects on LDH treated with self-prescribed SPST.METHODS A total of 211 patients with LDH syndrome were divided into two groups:107 patients in the control group were treated with conventional massage combined with traction,and 104 patients in the observation group were treated with a combination of the control regimen and self-prescribed oral SPST.The patients were treated for 4 wk.Indices of traditional Chinese medicine(TCM)syndrome score and serum inflammatory factor levels were measured.RESULTS After therapy,the TCM syndrome score in the observation group was significantly lower than that in the control group(P<0.05).The main symptoms,clinical signs,daily activities,and Japanese Orthopedic Association scores in the observation group were significantly higher than those in the control group after therapy(P<0.05).The levels of tumor necrosis factor-α,interleukin-6,and C-reactive protein were lower in the observation group than in the control group(P<0.05).In the observation group,superoxide dismutase levels were significantly higher,whereas malondialdehyde levels were significantly lower,compared with the control group(P<0.05).The overall efficacy rate in the observation group was 96.15%,which was substantially higher than that in the control group(88.79%;P<0.05).CONCLUSION Self-prescribed SPST can reduce the levels of inflammatory and pain-causing factors as well as lumbar pain in patients with LDH.展开更多
[目的]探讨和营止痛颗粒能否缓解腰椎间盘突出症(lumbar intervertebral disc herniation,LIDH)患者的临床症状,改善活动能力和功能,提高生活质量。[方法]根据纳入和排除标准,收集在浙江中医药大学附属第一医院骨伤中心门诊或住院治疗的...[目的]探讨和营止痛颗粒能否缓解腰椎间盘突出症(lumbar intervertebral disc herniation,LIDH)患者的临床症状,改善活动能力和功能,提高生活质量。[方法]根据纳入和排除标准,收集在浙江中医药大学附属第一医院骨伤中心门诊或住院治疗的120例LIDH患者的临床资料。将患者分为3组,观察组、治疗组和对照组,每组40例。观察组口服和营止痛颗粒治疗;治疗组口服塞来昔布胶囊、甲钴胺片和盐酸乙哌立松片,联合和营止痛颗粒治疗;对照组口服塞来昔布胶囊、甲钴胺片和盐酸乙哌立松片治疗。以4周为1个疗程。治疗前、治疗1个疗程后、1个疗程结束后1个月分别进行随访,记录每组患者的疼痛视觉模拟(visual analogue scale,VAS)评分、日本骨科协会(Japanese Orthopaedic Association,JOA)评估治疗评分和SF-36健康调查量表(36-item Short Form Health Survey,SF-36)评分。对3组患者的数据进行对照分析,明确和营止痛颗粒治疗LIDH的临床疗效。[结果]各组患者在性别组成、年龄构成、体质量指数(body mass index,BMI)、病程长短、影像学检查突出节段以及治疗前的VAS评分、JOA评分、SF-36评分等方面差异无统计学意义(P>0.05),提示各组患者基线一致,具有可比性。治疗1个疗程后,与治疗前比较,3组患者的VAS评分均降低(P<0.001),JOA评分均升高(P<0.001),SF-36评分均上升(P<0.001)。对照组VAS评分低于观察组,治疗组低于对照组和观察组(P<0.001);对照组JOA评分高于观察组,治疗组高于对照组和观察组(P<0.001);对照组的SF-36评分高于观察组,治疗组高于对照组和观察组(P<0.001)。1个疗程治疗结束后1个月,与治疗前比较,三组患者的VAS评分均降低(P<0.001),JOA评分均升高(P<0.001),SF-36评分均上升(P<0.001)。对照组VAS评分低于观察组,治疗组低于对照组和观察组(P<0.001);对照组JOA评分高于观察组,治疗组高于对照组和观察组(P<0.001);对照组SF-36评分高于观察组,治疗组高于对照组和观察组(P<0.001)。[结论]和营止痛颗粒能有效缓解LIDH患者的临床症状,改善活动能力和功能,提高生活质量,与西药联用时,能提高西药的临床疗效,是临床治疗LIDH的良好中药制剂。展开更多
文摘BACKGROUND Lumbar disc herniation(LDH)commonly occurs during spinal surgery;LDH is on the increase in younger patients and is classified as"paralysis"and"back pain."Sanhanchushi Tongbi(SPST)is a customized prescription.It disperses cold,relieves pain,removes cold from the meridians and viscera,and treats neuropathic pain.However,few studies have investigated its mechanism of pain relief.AIM To observe the clinical therapeutic effects on LDH treated with self-prescribed SPST.METHODS A total of 211 patients with LDH syndrome were divided into two groups:107 patients in the control group were treated with conventional massage combined with traction,and 104 patients in the observation group were treated with a combination of the control regimen and self-prescribed oral SPST.The patients were treated for 4 wk.Indices of traditional Chinese medicine(TCM)syndrome score and serum inflammatory factor levels were measured.RESULTS After therapy,the TCM syndrome score in the observation group was significantly lower than that in the control group(P<0.05).The main symptoms,clinical signs,daily activities,and Japanese Orthopedic Association scores in the observation group were significantly higher than those in the control group after therapy(P<0.05).The levels of tumor necrosis factor-α,interleukin-6,and C-reactive protein were lower in the observation group than in the control group(P<0.05).In the observation group,superoxide dismutase levels were significantly higher,whereas malondialdehyde levels were significantly lower,compared with the control group(P<0.05).The overall efficacy rate in the observation group was 96.15%,which was substantially higher than that in the control group(88.79%;P<0.05).CONCLUSION Self-prescribed SPST can reduce the levels of inflammatory and pain-causing factors as well as lumbar pain in patients with LDH.
文摘[目的]探讨和营止痛颗粒能否缓解腰椎间盘突出症(lumbar intervertebral disc herniation,LIDH)患者的临床症状,改善活动能力和功能,提高生活质量。[方法]根据纳入和排除标准,收集在浙江中医药大学附属第一医院骨伤中心门诊或住院治疗的120例LIDH患者的临床资料。将患者分为3组,观察组、治疗组和对照组,每组40例。观察组口服和营止痛颗粒治疗;治疗组口服塞来昔布胶囊、甲钴胺片和盐酸乙哌立松片,联合和营止痛颗粒治疗;对照组口服塞来昔布胶囊、甲钴胺片和盐酸乙哌立松片治疗。以4周为1个疗程。治疗前、治疗1个疗程后、1个疗程结束后1个月分别进行随访,记录每组患者的疼痛视觉模拟(visual analogue scale,VAS)评分、日本骨科协会(Japanese Orthopaedic Association,JOA)评估治疗评分和SF-36健康调查量表(36-item Short Form Health Survey,SF-36)评分。对3组患者的数据进行对照分析,明确和营止痛颗粒治疗LIDH的临床疗效。[结果]各组患者在性别组成、年龄构成、体质量指数(body mass index,BMI)、病程长短、影像学检查突出节段以及治疗前的VAS评分、JOA评分、SF-36评分等方面差异无统计学意义(P>0.05),提示各组患者基线一致,具有可比性。治疗1个疗程后,与治疗前比较,3组患者的VAS评分均降低(P<0.001),JOA评分均升高(P<0.001),SF-36评分均上升(P<0.001)。对照组VAS评分低于观察组,治疗组低于对照组和观察组(P<0.001);对照组JOA评分高于观察组,治疗组高于对照组和观察组(P<0.001);对照组的SF-36评分高于观察组,治疗组高于对照组和观察组(P<0.001)。1个疗程治疗结束后1个月,与治疗前比较,三组患者的VAS评分均降低(P<0.001),JOA评分均升高(P<0.001),SF-36评分均上升(P<0.001)。对照组VAS评分低于观察组,治疗组低于对照组和观察组(P<0.001);对照组JOA评分高于观察组,治疗组高于对照组和观察组(P<0.001);对照组SF-36评分高于观察组,治疗组高于对照组和观察组(P<0.001)。[结论]和营止痛颗粒能有效缓解LIDH患者的临床症状,改善活动能力和功能,提高生活质量,与西药联用时,能提高西药的临床疗效,是临床治疗LIDH的良好中药制剂。
