Objective: To analyze the distribution characteristics and clinical significance of SLCO1B1 and ApoE gene polymorphisms of the Li people in Hainan Island. Method: Selecting 502 high school students of the Li people fr...Objective: To analyze the distribution characteristics and clinical significance of SLCO1B1 and ApoE gene polymorphisms of the Li people in Hainan Island. Method: Selecting 502 high school students of the Li people from five cities and counties in Hainan Island (namely, Qiongzhong County, Dongfang City, Ledong County, Baoting County and Wuzhishan City) as research subjects in September, 2019;Applying PCR-fluorescence probe method to detect SLCO1B1 and ApoE genotypes of the Li people in Hainan Island, and statistically analyzing the distribution characteristics of gene frequency and the distribution differences in gene polymorphisms between different genders. Meanwhile, detecting the SLCO1B1 and ApoE gene of 527 people from the Han people in five regions mentioned before, so as to analyze the distribution differences of the SLCO1B1 and ApoE gene between the Han people and the Li people. Results: The frequency of each genotype of SLCO1B1 in the Li people in Hainan Island is: *1a/*1a 6.77%, *1a/*1b 27.09%, *1b/1b 41.63%, *1a/*5 0.00%, *1a/*15 4.78%, *1b/15 16.93%., *5/*5 0.00%, *5/*15 0.00%, *15/*15 2.79%;And that of ApoE is: e2/e2 0.40%, e2/e3 17.73%, e2/e4 2.39%, e3/e3 65.54%, e3/e4 12.55%, e4/e4 1.39%. There is no significant difference (P > 0.05) in other genotypes except weak metabolic genotypes (*5/*5, *5/*15 and *15/*15) between the Han and the Li peoples. Conclusion: The gene frequency of SLCO1B1 weak metabolic genotype is dramatically higher in the Li people of Hainan Island than that of the Han people in both Hainan Island and Central and South China, but there is no significant difference in ApoE gene frequency among them. Therefore, clinicians should adjust the dosage of statins and select the types of lipid-lowering drugs according to the differences in patients’ genotypes, and strengthen the management of patients with ApoE4 risk gene.展开更多
Blood stasis,or stagnation,is a pathological product formed in the course of certain diseases as well as a pathogenic factor of other diseases.The Li ethnic region is known as the“Natural Medicine Bank”and is the pr...Blood stasis,or stagnation,is a pathological product formed in the course of certain diseases as well as a pathogenic factor of other diseases.The Li ethnic region is known as the“Natural Medicine Bank”and is the primary production base of South China’s medicinal plants.Hainan Island is the home to the vast majority of the Li Culture;the Hainan Li ethnic region is located on the northern edge of the tropics and mostly lies in the mountainous areas of Wuzhi Mountain.This region is frost-free and snow-free year-round,with plenty of heat and rain.Wuzhi Mountain’s terrain is mountainous:high and steep in the middle and low around the foothills.It has fertile soil,rich vegetation,and is rich in animal and plant medicinal materials.The traditional medicine of the Li Culture has named blood stasis“Tun Duo.”Because few studies have been conducted regarding the traditional medicine of the Li Culture in the field of blood stasis,this article began with the collection of commonly-used compound recipes of the Li Culture.It then discussed the differentiation of syndromes through these compound recipes to expand the research results in the field of blood stasis in the traditional medicine of the Li Culture.展开更多
HISTORICALLY, Hainan Island has been the land of the Li people. It was only during the Western Han Dynasty (206 B.C.-A.D.25), when the centralizedgovernment established two prefectures here caned Zhuya and Dan’er, th...HISTORICALLY, Hainan Island has been the land of the Li people. It was only during the Western Han Dynasty (206 B.C.-A.D.25), when the centralizedgovernment established two prefectures here caned Zhuya and Dan’er, that the Han people began to come southward to this remote island. So when anthropologists study the history and local customs of Hainan, the earliest information concerns the development of the Li nationality. There is a museum which provides clues to this history,展开更多
文摘Objective: To analyze the distribution characteristics and clinical significance of SLCO1B1 and ApoE gene polymorphisms of the Li people in Hainan Island. Method: Selecting 502 high school students of the Li people from five cities and counties in Hainan Island (namely, Qiongzhong County, Dongfang City, Ledong County, Baoting County and Wuzhishan City) as research subjects in September, 2019;Applying PCR-fluorescence probe method to detect SLCO1B1 and ApoE genotypes of the Li people in Hainan Island, and statistically analyzing the distribution characteristics of gene frequency and the distribution differences in gene polymorphisms between different genders. Meanwhile, detecting the SLCO1B1 and ApoE gene of 527 people from the Han people in five regions mentioned before, so as to analyze the distribution differences of the SLCO1B1 and ApoE gene between the Han people and the Li people. Results: The frequency of each genotype of SLCO1B1 in the Li people in Hainan Island is: *1a/*1a 6.77%, *1a/*1b 27.09%, *1b/1b 41.63%, *1a/*5 0.00%, *1a/*15 4.78%, *1b/15 16.93%., *5/*5 0.00%, *5/*15 0.00%, *15/*15 2.79%;And that of ApoE is: e2/e2 0.40%, e2/e3 17.73%, e2/e4 2.39%, e3/e3 65.54%, e3/e4 12.55%, e4/e4 1.39%. There is no significant difference (P > 0.05) in other genotypes except weak metabolic genotypes (*5/*5, *5/*15 and *15/*15) between the Han and the Li peoples. Conclusion: The gene frequency of SLCO1B1 weak metabolic genotype is dramatically higher in the Li people of Hainan Island than that of the Han people in both Hainan Island and Central and South China, but there is no significant difference in ApoE gene frequency among them. Therefore, clinicians should adjust the dosage of statins and select the types of lipid-lowering drugs according to the differences in patients’ genotypes, and strengthen the management of patients with ApoE4 risk gene.
基金funded by the Inheritance and Develop-ment Project of TCM in 2021(No.SGW210003).
文摘Blood stasis,or stagnation,is a pathological product formed in the course of certain diseases as well as a pathogenic factor of other diseases.The Li ethnic region is known as the“Natural Medicine Bank”and is the primary production base of South China’s medicinal plants.Hainan Island is the home to the vast majority of the Li Culture;the Hainan Li ethnic region is located on the northern edge of the tropics and mostly lies in the mountainous areas of Wuzhi Mountain.This region is frost-free and snow-free year-round,with plenty of heat and rain.Wuzhi Mountain’s terrain is mountainous:high and steep in the middle and low around the foothills.It has fertile soil,rich vegetation,and is rich in animal and plant medicinal materials.The traditional medicine of the Li Culture has named blood stasis“Tun Duo.”Because few studies have been conducted regarding the traditional medicine of the Li Culture in the field of blood stasis,this article began with the collection of commonly-used compound recipes of the Li Culture.It then discussed the differentiation of syndromes through these compound recipes to expand the research results in the field of blood stasis in the traditional medicine of the Li Culture.
文摘HISTORICALLY, Hainan Island has been the land of the Li people. It was only during the Western Han Dynasty (206 B.C.-A.D.25), when the centralizedgovernment established two prefectures here caned Zhuya and Dan’er, that the Han people began to come southward to this remote island. So when anthropologists study the history and local customs of Hainan, the earliest information concerns the development of the Li nationality. There is a museum which provides clues to this history,
