Study on the Impact of Massive Refracturing on the Fracture Network in Tight Oil Reservoir Horizontal Wells

Class III tight oil reservoirs have low porosity and permeability,which are often responsible for low production rates and limited recovery.Extensive repeated fracturing is a well-known technique to fix some of these issues.With such methods,existing fractures are refractured,and/or new fractures are created to facilitate communication with natural fractures.This study explored how different refracturing methods affect horizontal well fracture networks,with a special focus on morphology and related fluid flow changes.In particular,the study relied on the unconventional fracture model(UFM).The evolution of fracture morphology and flow field after the initial fracturing were analyzed accordingly.The simulation results indicated that increased formation energy and reduced reservoir stress differences can promote fracture expansion.It was shown that the length of the fracture network,the width of the fracture network,and the complexity of the fracture can be improved,the oil drainage area can be increased,the distance of oil and gas seepage can be reduced,and the production of a single well can be significantly increased.

Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

Tyrosine kinase inhibitors(TKIs)have emerged as the first-line small molecule drugs in many cancer therapies,exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling pathways.However,there exists a substantial inter-individual variability in the concentrations of certain TKIs and their metabolites,which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments,alongside other potential side effects or adverse reactions.Therefore,an urgent need exists for an up-to-date review concerning the biological matrices relevant to bioanalysis and the sampling methods,clinical pharmacokinetics,and therapeutic drug monitoring of different TKIs.This paper provides a comprehensive overview of the advancements in pretreatment methods,such as protein precipitation(PPT),liquid-liquid extraction(LLE),solid-phase extraction(SPE),micro-SPE(μ-SPE),magnetic SPE(MSPE),and vortex-assisted dispersive SPE(VA-DSPE)achieved since 2017.It also highlights the latest analysis techniques such as newly developed high performance liquid chromatography(HPLC)and high-resolution mass spectrometry(HRMS)methods,capillary electrophoresis(CE),gas chromatography(GC),supercritical fluid chromatography(SFC)procedures,surface plasmon resonance(SPR)assays as well as novel nanoprobes-based biosensing techniques.In addition,a comparison is made between the advantages and disadvantages of different approaches while presenting critical challenges and prospects in pharmacokinetic studies and therapeutic drug monitoring.

Development and refinement of diagnostic and therapeutic strategies for managing patients with cardiogenic stroke:An arduous journey

Cardioembolic stroke,referred to as cardiogenic stroke,is a clinical syndrome in which emboli from the heart pass through the circulatory system and cause cerebral artery embolism and corresponding brain dysfunction.Compared to other subtypes of ischemic stroke,cardiogenic stroke presents with more etiologies,greater severity,worse prognosis,and a higher recurrence rate.In this minireview,we provide new insights into the etiological classification,diagnostic methods,and interventions of cardiogenic stroke.

Exploring the Role of Serum Cystatin C in Early Detection of Acute Kidney Injury among On-Pump Cardiac Surgery Patients: A Single-Center Investigation in Bangladesh

Background: Acute Kidney Injury (AKI) stands as a prominent postoperative complication in on-pump cardiac surgery, with repercussions on morbidity, mortality, and hospitalization duration. Current diagnostic criteria relying on serum creatinine levels exhibit a delayed identification of AKI, prompting an exploration of alternative biomarkers. Aims and Objectives: This study is designed to overcome diagnostic constraints and explore the viability of serum Cystatin C as an early predictor of Acute Kidney Injury (AKI) in individuals undergoing on-pump cardiac surgery. The investigation aims to establish the relationship between serum Cystatin C levels and the onset of AKI in patients subjected to on-pump cardiac surgery. Primary objectives involve the assessment of the diagnostic effectiveness of serum Cystatin C, its comparison with serum creatinine, and the exploration of its potential for the early identification and treatment of AKI. Methodology: Conducted as a single-center study at the cardiac surgery department of BSMMU in Bangladesh from September 2020 to August 2022, a comparative cross-sectional analysis involved 31 participants categorized into No AKI and AKI groups based on Kidney Disease: Improving Global Outcomes (KDIGO) criteria. Data collection encompassed preoperative, post-CBP (cardiopulmonary bypass) conclusion at 2 hours, postoperative day 1, and postoperative day 2 intervals. Statistical analyses included Chi-squared tests, independent Student’s t-tests, and one-sample t-tests. Significance was set at P Results: The study revealed no significant differences in baseline characteristics between the No AKI and AKI groups, except for CPB time and cross-clamp time. Serum Cystatin C levels in the AKI group exhibited statistical significance at various time points, highlighting its potential as an early detector. Conversely, Serum Creatinine levels in the AKI group showed no statistical significance. The Receiver Operating Characteristic (ROC) curve analysis further supported the efficacy of serum Cystatin C, with an Area under the ROC Curve of 0.864 and a cut-off value of 0.55 (p Conclusion: This study supports the superior utility of serum Cystatin C as an early detector of AKI in on-pump cardiac surgery patients compared to serum creatinine. Its ability to identify AKI several hours earlier may contribute to reduced morbidity, mortality, and healthcare costs. The findings underscore the significance of exploring novel biomarkers for improved post-cardiac surgery renal function assessment.

Basic philosophy of three essences theory in traditional Mongolian medicine

Traditional Mongolian medicine(TMM)integrates Tibetan and Chinese medicine with indigenous Mongolian practices,focusing on the balance of three core essences:Khii,Shar,and Badgan,derived from the Five Elements-earth,water,fire,wind,and space.These essences regulate both physical and psychological processes,and their imbalance,often caused by diet,behavior,or environment,leads to disease.TMM utilizes holistic diagnostic methods such as pulse diagnosis,visual inspection,and lifestyle evaluation to identify imbalances of three essences.Treatments include herbal remedies,dietary adjustments,behavior modification,and accessory therapies like moxibustion and massage to restore balance.This mini review examines the philosophical underpinnings,diagnostic techniques,and therapeutic strategies to Khii,Shar,and Badgan,highlighting their importance in both traditional and modern integrative healthcare.

Current Problems of the Diagnostics and Treatment of Sepsis and Burn Injuries: The Modified Pathogenetic Concept

Background: The deep understanding of pathogenesis is a key moment in the formation of the modern strategy of modern medicine. We conducted the thorough analysis of the microscopic processes occurring in the bodies of patients with purulent-septic complications. The modified pathogenetic concept of the diagnostic and treatment model of diseases with septic complications is presented. The obtained information about the mechanisms of origin and development of these diseases is fundamentally important for finding the modern effective methods of treating patients. The aim of the research is to modify treatment tactics for patients with sepsis and burn injuries based on the modified pathogenetic concept using modern diagnostics, i.e. the method of fluorescence spectroscopy (MFS) and biomarkers. Materials and Methods: The proposed modified pathogenetic concept of the diagnostic and treatment model of diseases with purulent-septic complications along with standard methods was used successfully for effective treatment of 15 patients with sepsis and 25 with burn injuries. Results: 3 main scenarios of behaviour of spectral-fluorescence characteristics of patients with sepsis are illustrated. Spectral-fluorescence markers of sepsis were studied, which are informative 24 to 48 hours before the appearance of obvious clinical and laboratory signs of significant changes in the general somatic status of patients. Conclusions: The proposed diagnostic and therapeutic approach is new and fundamentally important for diagnostics and monitoring of the process of treatment of patients with purulent-septic diseases and burn injuries. An in-depth understanding of the dynamics of septic complications and the corresponding changes of the main markers of these diseases during treatment is especially relevant. The use of infusion therapy with solutions of donor albumin as an effective pathogenetic treatment is scientifically justified.

Research Progress of Noninvasive Diagnostic Methods for Nonalcoholic Steatohepatitis

Distinguishing between nonalcoholic steatohepatitis(NASH) and advanced liver fibrosis is the key for clinical diagnosis of non-alcoholic fatty liver disease(NAFLD). Liver biopsy, which is widely used for diagnosis of liver diseases at present, has many drawbacks, such as being invasive, expensive and unstable. This article compares and summarizes the commonly used non-invasive diagnostic methods, including their diagnostic parameters, advantages and disadvantages, in order to provide a useful reference for the diagnosis of NASH.

Diagnostic Study of Apparent Heat Sources and Moisture Sinks in the South China Sea and its Adjacent Areas during the Onset of 1998 SCS Monsoon

The apparent heat sources (?Q1 ?) and moisture sinks (?Q2 ?) are calculated based on the reanalyzed data of the South China Sea Monsoon Experiment (SCSMEX) from May 1 to August 31, 1998. It is found that the formation and distribution of the atmospheric heat sources are important for the monsoon onset. The earlier onset of the SCS monsoon is the result of enduring atmospheric heating in the Indo–China Peninsula and South China areas. The atmospheric heating firstly appears in the Indo–China Peninsula area and the sensible heat is the major one. The 30–50 day periodic oscillation of atmospheric heat sources between the SCS area and the western Pacific warm pool has a reverse phase distribution before the middle of July and the low frequency oscillation of heat sources in SCS area has an obvious longitudinal propagation. The 30–50 day low frequency oscillation has vital modificatory effects on the summer monsoon evolution during 1998. Key words Apparent heat sources - Apparent moisture sinks - The South China Sea monsoon - Diagnostic Study Sponsored by the National Key Project of Fundamental Research “ SCSMEX” and the Research Fund for the Doctoral Program of Higher Education: “ Study of the Air-sea Interaction in the SCS Monsoon Region”.

Study of Failure Diagnostic Methods and Intelligent Diagnostic System for Reciprocating Compressors

Three categories of failure diagnostic methods for reciprocating compressors are classified according to the signals adopted by the diagnosis. They are parameter method, vibration method, and oil analysis method. In this paper, the applicable range and operational difficulties of these methods are discussed on the basis of analysis and induction upon normal failure. It is proposed that a compressor's normal failure can be divided into thermodynamical property failure and mechanical function failure. As to the former, the parameter method that takes a cylinder pressure signal as the main diagnostic signal may be applied; and as to the latter, the vibration signal frequency spectrum can be used to diagnose. At the same time, the structure of an intelligent diagnostic system based on neural networks is introduced, and its schematic is given.

Diagnostic study of the summer thermocline depth in the Huanghai Sea and the East China Sea

In this paper, the depth of the summer thermocline of the South Huanghai Sea and the East China Sea is calculated with two kinds of one-dimentional models, and the formation reasons are explained for the summer thermocline depth distribution characteristics in the study area. It is proved that in the shelf area of the East China Sea, tidal mixing has an important impact on the thermocline depth. And a new explanation for certain phenomena of the so-called coastal upwelling in the East China Sea is proposed.

Case Study of a Chinese Girl's English Learning Methods in the American Elementary School

The goal of this research is to explore a more successful method for Mainland Chinese students to learn English.This newmethod will be illustrated by using the experiences of my daughter while a student in an elementary school in the United States for oneyear.From the analysis of her learning experiences,the following conclusions were drawn:1) Immerse language learning is important tolanguage input.2) Phonics is an effective tool to improve reading for Chinese English

Comparison study on calculation methods of bending behavior of Chinese reinforced concrete beams from 1912 to 1949

In order to study the calculation methods of bending behavior of Chinese reinforced concrete beams from 1912 to 1949, tests on the mechanical performance of 66 rebars from different modem Chinese concrete buildings, the concrete compressive strength of 12 modem Chinese concrete buildings, and the concrete cover thickness of 9 modem Chinese concrete buildings are carried out; and the actual material properties and structural conformations of modem Chinese concrete buildings are obtained. Then, the comparison on calculation methods of bending behavior including the original Chinese calculation method, the present Chinese calculation method, the present American calculation method and the present European calculation method is studied. The results show that the original Chinese calculation method of bending behavior is based on the allowable stress calculation method, and the design safety factors are 3.55 to 4. 0. In term of the calculation area of longitudinal rebars of reinforced concrete beams, without considering earthquake action, the original Chinese structural calculation method is safer than the present Chinese structural calculation method, the present European structural calculation method, and the present American structural calculation method. The results can provide support for the structural safety assessments of modem Chinese reinforced concrete buildings.

Grouting theories and technologies for the reinforcement of fractured rocks surrounding deep roadways

Grouting is an effective method to improve the integrity and stability of fractured rocks that surround deep roadways.After years of research and practice,various theories and a complete set of grouting technologies for deep roadways with fractured rocks have been developed and are widely applied in Chinese coal mining production.This paper systematically summarizes and analyzes the research results concerning the theory,design,materials,processes,and equipment for the grouting and reinforcement of fractured rocks surrounding deep roadways.Specifically,in terms of grouting methods,pregrouting,groutingwhile-excavation,and postgrouting methods are explored;in terms of grouting theory,backfill grouting,compaction grouting,infiltration grouting,and fracture grouting theories are studied.In addition,this paper also studies grouting borehole arrangement,water-cement ratio,grouting pressure,grouting volume,grout diffusion radius,and other grouting parameters and their determination methods.On this basis,this paper explores the physical and mechanical properties of organic and organic-inorganic composite grouting materials,and assess grouting reinforcement quality testing methods and instruments.Taken as the field cases,the application of pregrouting in front of heading faces,groutingwhile-excavation,and postgrouting in the Kouzidong coal mine are then introduced,and the effects of the grouting reinforcements are evaluated.This paper proposes a development direction for grouting technology based on problems existing in the grouting reinforcement of fractured rocks surrounding deep roadways.

A Study of the Technique of Western Blot for Diagnosis of Lyme Disease caused by Borrelia afzelii in China

Objective To study the technique of Western blot for the diagnosis of Lyme disease caused by Borrelia afzelii in China and to establish the standard criteria by operational procedure. Methods FP1, which is the representative strain of B. afzelii in China, was analyzed by SDS-PAGE, electro transfer and irnmunoblotting assays. The molecular weights of the protein bands of FP1 were analyzed by Gel-Pro analysis software. In a study using 451 serum samples （159 patients with Lyme disease and 292 controls）, all observed bands were recorded. The accuracy of the WB as a diagnostic test was established by using the ROC curve and Youden index. Results Criteria for a positive diagnosis of Lyme disease were established as at least one band of P83/100, P58, P39, OspB, OspA, P30, P28, OspC, P17, and P14 in the IgG test and at least one band of P83/100, P58, P39, OspA, P30, P28, OspC, P17, and P41 in the IgM test. For IgG criteria, the sensitivity, specificity and Youden index were 69.8%, 98.3%, and 0.681, respectively; for IgM criteria, the sensitivity, specificity and Youden index were 47%, 94.2%, and 0.412, respectively.

Diagnostic value of interleukin-8 in colorectal cancer:A case-control study and meta-analysis

AIM: To assess the diagnostic value of serum interleukin-8 (IL-8) in the detection of colorectal cancer (CRC).

Endosonography with linear array instead of endoscopic retrograde cholangiography as the diagnostic tool in patients with moderate suspicion of common bile duct stones

AIM: To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS).METHODS: 55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done in single blind method in the clinical and biochemical data of patients. EUS was done with echo-endoscope Pentax FG 32-UA (f=5-7,5 MHz) and Hitachi EUB 405 ultrasound machine. Patients diagnosed with CBDS by EUS were excluded from this study and treated with ERC. All the other patients were included to the follow up study obtained by mail every 6 months for clinical evaluation (need of ERC or surgery).RESULTS: CBDS was found in 4 patients by EUS. Diagnosis was confirmed in all cases on ERC. The remaining 51 patients without CBDS on EUS were followed up for 6-26 months (meanly 13 months) There were: 40 women, 42cholecystectomized patients, aged: 55 (mean). Biochemical values (mean values) were as follows: bilirubin: 14,9 μmol.L-1,alkaline phosphatase: 95 IU.L-,1 γ-GTP: 131 IU.L-1, ALT: 50IU.L-1, AST: 49 IU.L-1, Only 1 patient was lost for follow up.In the remaining 50 patients with follow up, there was only 1 (2 %) patient with persistent biliary symptoms in whom CBDS was finally diagnosed by ERC with ES. All other patients remained symptoms free on follow up and did not require ERC or biliary surgery.CONCLUSION: Vast majority of patients with moderate suspicion of CBDS and no stones on EUS with linear array can avoid invasive evaluation of biliary tree with ERC.

Regular Observation of De-Acclimatization and Randomized Controlled Research of Diagnostic Criteria of High Altitude De-Acclimatization Syndrome among Different Plateau Migrants Crowd after Their Return to the Plain

Objective: The objective of this study was to investigate the diagnostic methods of high altitude de-acclimatization syndrome and to formulate diagnostic criteria. Methods: This study was conducted using epidemiological surveys and a multi-center randomized controlled clinical trial. A total of 3011 subjects were studied, and the following indices were collected after their return to low altitude areas from the plateau: general health status, blood, urine and stool samples, myo-cardial enzyme levels, liver and kidney function, nerve function, sex hormone levels, microalbuminuria, electrocardiogram (ECG), echocardiography, pulmonary function, and hemorheological markers. These data were compared to those of randomized healthy subjects in the same age range who lived at the same altitude to determine the characteristics of high altitude de-acclimatization syndrome. Based on these characteristics, diagnostic criteria for high altitude de-acclimatization syndrome were formulated. Results: This study demonstrated that the incidence of high altitude de-acclimatization syndrome was 84.36%. Sixty percent of the cases were mild, 30% were medium, and 10% were severe. The incidence was higher among those who returned to a place of lower altitude, resided at a high altitude for a longer period of time, or engaged in heavy labor while at high altitude. Patients with high altitude de-acclimatization syndrome manifested hematological abnormalities and abnormal ventricular function, notably a right ventricular diastolic function, which recovered to baseline function after one to five years. Exposure to long-term hypoxia often caused obvious changes in cardiac morphology, i.e., left and right ventricular hypertrophy, particularly within the right ventricle. In addition, patients with high altitude de-acclimatization syndrome often presented with low blood pressure, low pulse pressure, and microalbuminuria. A few patients presented with occult blood in their feces. The diagnosis of high altitude de-acclimatization syndrome can be made if a patient who recently returns to the plain from the plateau complains of dizziness, weakness, sleepiness, chest tightness, edema, memory loss, and other symptoms and signs that do not alleviate under short-term rehabilitation or symptomatic treatment, and if organic diseases of the heart, lung, kidney, and other organs have been excluded. Conclusion: The diagnosis of high altitude de-acclimatization syndrome should be made after a comprehensive analysis of the patient’s clinical symptoms and signs.

On Analysis of English Language Education in China from the Research Questions and Research Methods

The present paper first reviewed the major concepts and practices involves in research. A small study was conducted to survey on the prevailing research questions and methods in ELT studies in China, showing a major paradigm shift from qualitative studies to quantitative research and mixed methods, with little critical research identified.

Geophysical and Petro-Structural Characteristics of the Tarkwaïan and Associated Formations of the Gontougo Region (Northeastern Côte d’Ivoire)

Studies carried out in the Gontougo region aimed to describe the physical and petro-structural properties of the Tarkwaian formations of northeastern Côte d’Ivoire. The methodology developed is focused on the one hand on the gravimetric geophysical method and on the other hand, on petro-structural studies. The geophysical results highlighted two gravimetric facies characterized respectively by high density (ΔBg > 121 mGal) and low density (ΔBg < 114 mGal) anomalies. From a lithological point of view, the denser domains are made up of intrusive rocks dominated by granodiorites and tonalites cutting low density facies composed of Tarkwaian formations (polygenic conglomerates and arkosic sandstones) and volcanics (tuffs and cinerites). Structurally, these different lithological groups are affected by brittle (fractures, faults, strike-slip) and ductile (folds, schistosities and mineral lineations) deformations. These structures are mainly oriented NNW-SSW, WNW-ESE and NE-SW. The description of the sulphide minerals reveals a style of gold mineralization of the Tarkwaian formations.