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The antibody preparation and expression of human Pescadillo 被引量:3
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作者 ZHANG Hao1, LI JiePing1, WANG XiaoHui1, SUN Yan1, YUAN Bin1, YANG ZhiHong1, JIANG YanChao1, ZENG Min1, DING LiHua1, NING Kang1, ZHU JianHua2, LI JieZhi1, HUANG CuiFen1, LIU AiJun3 & YE QiNong1 1 Beijing Institute of Biotechnology, Beijing 100850, China 2 Cancer Division, First Affiliated Hospital of the General Hospital of PLA, Beijing 100373, China 3 Pathology Division, General Hospital of PLA, Beijing 100373, China 《Science China(Life Sciences)》 SCIE CAS 2007年第3期298-304,共7页
To explore the biological roles of human Pescadillo and investigate its potential effect on tumorigene- sis, the cDNA of Pescadillo was fused with that of GST. After purification and elution, the purified GST-Pescadil... To explore the biological roles of human Pescadillo and investigate its potential effect on tumorigene- sis, the cDNA of Pescadillo was fused with that of GST. After purification and elution, the purified GST-Pescadillo fusion protein was obtained, and the antibody against the fusion protein was generated. Endogenous Pescadillo protein was observed to be remarkably induced by estrogen. It was mainly distributed in the tissues such as breast, ovary and intestine, all of which contain proliferating cells, and was also detected in many cell lines of human cancer: renal carcinoma, hepatoma, ovarian cancer, colon carcinoma, and breast cancer. The expression level of Pescadillo was increased significantly in breast cancer tissues compared with their paired margin tissues. Taken together, these data suggest that Pescadillo may play important roles in the initiation and development of cancer and may be a po- tential target in cancer diagnosis and therapy. 展开更多
关键词 the antibody preparation and expression of human Pescadillo FIGURE GST
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