BACKGROUND Epithelioid trophoblastic tumor(ETT) is the rarest type of gestational trophoblastic tumor(GTT). It has been reported that more than 50% of ETTs arise in the uterine cervix or the lower uterine segment. Her...BACKGROUND Epithelioid trophoblastic tumor(ETT) is the rarest type of gestational trophoblastic tumor(GTT). It has been reported that more than 50% of ETTs arise in the uterine cervix or the lower uterine segment. Here, we report a case of ETT within the lower uterine segment and cervical canal and discuss its manifestations,possible causes, and related influencing factors.CASE SUMMARY A 35-year-old woman(gravida 7, miscarriage 3, induction 2 with 1 being twins,para 2 of cesarean section, live 2), who had amenorrhea for 9 mo after breastfeeding for 22 mo after the last cesarean section, was diagnosed with ETT. The lesion was present in the lower uterine segment and endocervical canal with severe involvement of the anterior wall of the lower uterine segment and the front wall of the lower uterine segment where the cesarean incisions were made.Laboratory tests showed slight elevation of serum beta-human chorionic gonadotropin. Intraoperative exploration showed the presence of a normal-sized uterus body with an enlarged tumor in the lower uterine segment. The surface of the lower uterine segment was light blue, the entire lesion was approximately about 8cm × 8 cm × 9 cm, with compression and displacement of the surrounding tissue.Histological examination diagnosed ETT. Immunohistochemical analysis showed positive expression of p63, with a Ki-67 proliferation index of 40%.CONCLUSION A search of the PubMed database using the search terms "cesarean section" and "epithelioid trophoblastic tumor" retrieved nine articles, including 13 cases of ETT and ETT-related lesions, all 13 cases had a history of cesarean section, and the lesions were all located at the cesarean section incision on the anterior wall of the lower uterine segment. The present case is the 14th reported case of ETT after cesarean section. Therefore, we deduced that cesarean section trauma had an important effect on the occurrence of ETT at this site.展开更多
Purpose: To evaluate the accuracy of sonographic measurements of the lower uterine segment (LUS) thickness at term in predicting uterine scar defects in women with previous Cesarean delivery (CD). Methods: Eighty-nine...Purpose: To evaluate the accuracy of sonographic measurements of the lower uterine segment (LUS) thickness at term in predicting uterine scar defects in women with previous Cesarean delivery (CD). Methods: Eighty-nine pregnant women who underwent CD between 37 and 41 weeks of gestation from 2013 to 2015 were enrolled in this study and divided into two groups. Group A consisted of women with previous CD, and Group B consisted of women with previous vaginal deliveries. We performed an ultrasound evaluation of the myometrial and full thickness of LUS (mLUS and fLUS) transvaginally before a CD and evaluated the appearance of LUS during surgery, which was defined as follows: grade I, well-developed;grade II, thin without visible content;grade III, translucent with visible content;and grade IV, either dehiscence or rupture. Results: The median mLUS and fLUS were 1.50 and 4.07 mm in the group A, and 2.75 and 5.37 mm in the group B. We observed significant differences in the median mLUS and fLUS between grades I/II (2.07 and 4.37 mm) and grades III/IV (0.67 and 2.52 mm). Both mLUS and fLUS were predictive factors for grades III/IV and cutoff values were 0.97 mm of mLUS and 3.13 mm of fLUS, having a sensitivity of 87.5% and 75.0%, and a specificity of 87.7% and 91.4% in mLUS and fLUS measurement, respectively. Conclusion: Sonographic measurements of LUS at term may be a feasible and reliable method to predict uterine rupture or uterine dehiscence in women with prior CD.展开更多
目的:探讨剖宫产术后瘢痕子宫孕妇再次剖宫产时妊娠晚期或分娩期子宫下段不完全性破裂的超声检查情况、高危因素及妊娠结局。方法:回顾性分析华中科技大学同济医学院附属同济医院2016年5月至2020年1月行剖宫产手术的747例剖宫产术后瘢...目的:探讨剖宫产术后瘢痕子宫孕妇再次剖宫产时妊娠晚期或分娩期子宫下段不完全性破裂的超声检查情况、高危因素及妊娠结局。方法:回顾性分析华中科技大学同济医学院附属同济医院2016年5月至2020年1月行剖宫产手术的747例剖宫产术后瘢痕子宫孕妇的临床资料,根据术中所见子宫下段情况,分为不全破裂组(145例)、未破裂组(602例)。采用单因素及多因素分析子宫下段不完全性破裂的高危因素,并比较两组产妇及新生儿结局。结果:(1)与未破裂组比较,不全破裂组超声测量的子宫下段肌层厚度更薄(0.145±0.097 cm vs.0.225±0.070 cm),凶险性前置胎盘、胎盘植入的发生率更高,而羊水过少的发生率较低,差异均有统计学意义(P<0.05)。(2)Logistic回归分析示:凶险性前置胎盘、胎盘植入是子宫下段不完全性破裂的独立危险因素(OR>1,P<0.05)。(3)不全破裂组患者的子宫动脉上行支结扎、子宫下段环形缩窄缝合、子宫切除、术中出血量、术中输血、缩宫素使用量、手术时间、术后入住ICU、产后出血、术后肛门排气时间及住院时间均高于未破裂组(P<0.05)。不全破裂组早产、低出生体质量儿、新生儿窒息及入住新生儿科的发生率高于未破裂组(P<0.05),新生儿出生孕周、新生儿出生体质量低于未破裂组(P<0.05)。结论:超声测量子宫下段肌层厚度较薄时发生瘢痕子宫下段不完全性破裂的概率较高。凶险性前置胎盘、胎盘植入是瘢痕子宫下段不完全性破裂危险因素。瘢痕子宫下段不完全性破裂的孕产妇及新生儿的结局更差。展开更多
目的:探讨子宫下段全层缝合术在剖宫产中的应用及对子宫切口憩室(PCSD)形成的影响。方法:选取2020年6月—2022年6月于我院行剖宫产产妇78例,按随机数字表法分为两组,各39例。对照组予以子宫下段分层缝合术,观察组予以子宫下段全层缝合...目的:探讨子宫下段全层缝合术在剖宫产中的应用及对子宫切口憩室(PCSD)形成的影响。方法:选取2020年6月—2022年6月于我院行剖宫产产妇78例,按随机数字表法分为两组,各39例。对照组予以子宫下段分层缝合术,观察组予以子宫下段全层缝合术。比较两组手术相关指标、术后并发症、PCSD发生率、PCSD容积及周围厚度。结果:两组手术时间、24h出血量、恶露持续天数及产后血红素相比,差异无统计学意义(P>0.05);观察组术后并发症总发生率、PCSD发生率较对照组低(P<0.05);观察组子宫切口憩室容积为(0.31±0.04)mm2,低于对照组的(0.45±0.06)mm2,子宫切口憩室周围厚度为(7.35±0.76)mm,高于对照组的(6.02±0.62)mm( P <0.05)。 结论: 子宫下段全层缝合术在剖宫产术中应用效果更佳,可降低并发症风险,减少PCSD形成。展开更多
目的探讨腹横肌平面阻滞联合静脉注射艾司氯胺酮对高龄产妇剖宫产术后镇痛的影响。方法选择2022年8月至2023年8月在东莞市妇幼保健院接受子宫下段剖宫产的产妇72例进行随机对照试验。采用随机数字表法将入组产妇分为对照组与观察组,每...目的探讨腹横肌平面阻滞联合静脉注射艾司氯胺酮对高龄产妇剖宫产术后镇痛的影响。方法选择2022年8月至2023年8月在东莞市妇幼保健院接受子宫下段剖宫产的产妇72例进行随机对照试验。采用随机数字表法将入组产妇分为对照组与观察组,每组36例。对照组(40.42±9.43)岁,体质量指数(23.59±7.49)kg/cm^(2);观察组(41.91±9.32)岁,体质量指数(23.62±7.51)kg/cm^(2)。两组产妇均采用腰硬联合麻醉,术毕后实施超声引导腹横肌平面阻滞;观察组在胎儿娩出后静脉注射艾司氯胺酮0.5 mg/kg,对照组则在同一时间段静脉注射等量生理盐水。记录两组产妇术后2、4、6、12、24、48 h静息疼痛视觉模拟量表(VAS)评分;记录两组产妇首次患者自控镇痛(PCA)时间、48 h PCA总次数、氟比洛芬酯补救镇痛例数;记录两组产妇48 h下床活动次数、首次肛门排气时间;记录两组产妇眩晕、噩梦等镇痛相关不良反应发生情况。符合正态分布的计量资料两组间比较采用独立样本t检验,计数资料两组间比较采用χ^(2)检验。结果观察组术后6、12 h静息VAS评分低于对照组[(1.12±0.37)分比(1.74±0.45)分、(1.14±0.38)分比(1.78±0.47)分,均P<0.05];观察组首次PCA时间长于对照组[(9.82±1.94)h比(5.13±1.47)h,P<0.05];观察组48 h PCA总次数、氟比洛芬酯补救镇痛例数低于对照组[(7.14±1.44)次比(10.62±2.92)次、2.78%(1/36)比25.00%(9/36),均P<0.05]。观察组48 h下床活动次数多于对照组[(10.27±2.13)次比(8.14±1.68)次,P<0.05];观察组首次肛门排气时间短于对照组[(8.52±1.63)h比(12.35±2.41)h,P<0.05];观察组眩晕发生率低于对照组[5.56%(2/36)比27.78%(10/36),P<0.05]。结论腹横肌平面阻滞联合静脉注射艾司氯胺酮对高龄产妇剖宫产术后的镇痛效果显著,可降低术后VAS评分,延长首次PCA时间,减少PCA总次数,促进术后恢复。展开更多
文摘BACKGROUND Epithelioid trophoblastic tumor(ETT) is the rarest type of gestational trophoblastic tumor(GTT). It has been reported that more than 50% of ETTs arise in the uterine cervix or the lower uterine segment. Here, we report a case of ETT within the lower uterine segment and cervical canal and discuss its manifestations,possible causes, and related influencing factors.CASE SUMMARY A 35-year-old woman(gravida 7, miscarriage 3, induction 2 with 1 being twins,para 2 of cesarean section, live 2), who had amenorrhea for 9 mo after breastfeeding for 22 mo after the last cesarean section, was diagnosed with ETT. The lesion was present in the lower uterine segment and endocervical canal with severe involvement of the anterior wall of the lower uterine segment and the front wall of the lower uterine segment where the cesarean incisions were made.Laboratory tests showed slight elevation of serum beta-human chorionic gonadotropin. Intraoperative exploration showed the presence of a normal-sized uterus body with an enlarged tumor in the lower uterine segment. The surface of the lower uterine segment was light blue, the entire lesion was approximately about 8cm × 8 cm × 9 cm, with compression and displacement of the surrounding tissue.Histological examination diagnosed ETT. Immunohistochemical analysis showed positive expression of p63, with a Ki-67 proliferation index of 40%.CONCLUSION A search of the PubMed database using the search terms "cesarean section" and "epithelioid trophoblastic tumor" retrieved nine articles, including 13 cases of ETT and ETT-related lesions, all 13 cases had a history of cesarean section, and the lesions were all located at the cesarean section incision on the anterior wall of the lower uterine segment. The present case is the 14th reported case of ETT after cesarean section. Therefore, we deduced that cesarean section trauma had an important effect on the occurrence of ETT at this site.
文摘Purpose: To evaluate the accuracy of sonographic measurements of the lower uterine segment (LUS) thickness at term in predicting uterine scar defects in women with previous Cesarean delivery (CD). Methods: Eighty-nine pregnant women who underwent CD between 37 and 41 weeks of gestation from 2013 to 2015 were enrolled in this study and divided into two groups. Group A consisted of women with previous CD, and Group B consisted of women with previous vaginal deliveries. We performed an ultrasound evaluation of the myometrial and full thickness of LUS (mLUS and fLUS) transvaginally before a CD and evaluated the appearance of LUS during surgery, which was defined as follows: grade I, well-developed;grade II, thin without visible content;grade III, translucent with visible content;and grade IV, either dehiscence or rupture. Results: The median mLUS and fLUS were 1.50 and 4.07 mm in the group A, and 2.75 and 5.37 mm in the group B. We observed significant differences in the median mLUS and fLUS between grades I/II (2.07 and 4.37 mm) and grades III/IV (0.67 and 2.52 mm). Both mLUS and fLUS were predictive factors for grades III/IV and cutoff values were 0.97 mm of mLUS and 3.13 mm of fLUS, having a sensitivity of 87.5% and 75.0%, and a specificity of 87.7% and 91.4% in mLUS and fLUS measurement, respectively. Conclusion: Sonographic measurements of LUS at term may be a feasible and reliable method to predict uterine rupture or uterine dehiscence in women with prior CD.
文摘目的:探讨剖宫产术后瘢痕子宫孕妇再次剖宫产时妊娠晚期或分娩期子宫下段不完全性破裂的超声检查情况、高危因素及妊娠结局。方法:回顾性分析华中科技大学同济医学院附属同济医院2016年5月至2020年1月行剖宫产手术的747例剖宫产术后瘢痕子宫孕妇的临床资料,根据术中所见子宫下段情况,分为不全破裂组(145例)、未破裂组(602例)。采用单因素及多因素分析子宫下段不完全性破裂的高危因素,并比较两组产妇及新生儿结局。结果:(1)与未破裂组比较,不全破裂组超声测量的子宫下段肌层厚度更薄(0.145±0.097 cm vs.0.225±0.070 cm),凶险性前置胎盘、胎盘植入的发生率更高,而羊水过少的发生率较低,差异均有统计学意义(P<0.05)。(2)Logistic回归分析示:凶险性前置胎盘、胎盘植入是子宫下段不完全性破裂的独立危险因素(OR>1,P<0.05)。(3)不全破裂组患者的子宫动脉上行支结扎、子宫下段环形缩窄缝合、子宫切除、术中出血量、术中输血、缩宫素使用量、手术时间、术后入住ICU、产后出血、术后肛门排气时间及住院时间均高于未破裂组(P<0.05)。不全破裂组早产、低出生体质量儿、新生儿窒息及入住新生儿科的发生率高于未破裂组(P<0.05),新生儿出生孕周、新生儿出生体质量低于未破裂组(P<0.05)。结论:超声测量子宫下段肌层厚度较薄时发生瘢痕子宫下段不完全性破裂的概率较高。凶险性前置胎盘、胎盘植入是瘢痕子宫下段不完全性破裂危险因素。瘢痕子宫下段不完全性破裂的孕产妇及新生儿的结局更差。
文摘目的:探讨子宫下段全层缝合术在剖宫产中的应用及对子宫切口憩室(PCSD)形成的影响。方法:选取2020年6月—2022年6月于我院行剖宫产产妇78例,按随机数字表法分为两组,各39例。对照组予以子宫下段分层缝合术,观察组予以子宫下段全层缝合术。比较两组手术相关指标、术后并发症、PCSD发生率、PCSD容积及周围厚度。结果:两组手术时间、24h出血量、恶露持续天数及产后血红素相比,差异无统计学意义(P>0.05);观察组术后并发症总发生率、PCSD发生率较对照组低(P<0.05);观察组子宫切口憩室容积为(0.31±0.04)mm2,低于对照组的(0.45±0.06)mm2,子宫切口憩室周围厚度为(7.35±0.76)mm,高于对照组的(6.02±0.62)mm( P <0.05)。 结论: 子宫下段全层缝合术在剖宫产术中应用效果更佳,可降低并发症风险,减少PCSD形成。
文摘目的探讨腹横肌平面阻滞联合静脉注射艾司氯胺酮对高龄产妇剖宫产术后镇痛的影响。方法选择2022年8月至2023年8月在东莞市妇幼保健院接受子宫下段剖宫产的产妇72例进行随机对照试验。采用随机数字表法将入组产妇分为对照组与观察组,每组36例。对照组(40.42±9.43)岁,体质量指数(23.59±7.49)kg/cm^(2);观察组(41.91±9.32)岁,体质量指数(23.62±7.51)kg/cm^(2)。两组产妇均采用腰硬联合麻醉,术毕后实施超声引导腹横肌平面阻滞;观察组在胎儿娩出后静脉注射艾司氯胺酮0.5 mg/kg,对照组则在同一时间段静脉注射等量生理盐水。记录两组产妇术后2、4、6、12、24、48 h静息疼痛视觉模拟量表(VAS)评分;记录两组产妇首次患者自控镇痛(PCA)时间、48 h PCA总次数、氟比洛芬酯补救镇痛例数;记录两组产妇48 h下床活动次数、首次肛门排气时间;记录两组产妇眩晕、噩梦等镇痛相关不良反应发生情况。符合正态分布的计量资料两组间比较采用独立样本t检验,计数资料两组间比较采用χ^(2)检验。结果观察组术后6、12 h静息VAS评分低于对照组[(1.12±0.37)分比(1.74±0.45)分、(1.14±0.38)分比(1.78±0.47)分,均P<0.05];观察组首次PCA时间长于对照组[(9.82±1.94)h比(5.13±1.47)h,P<0.05];观察组48 h PCA总次数、氟比洛芬酯补救镇痛例数低于对照组[(7.14±1.44)次比(10.62±2.92)次、2.78%(1/36)比25.00%(9/36),均P<0.05]。观察组48 h下床活动次数多于对照组[(10.27±2.13)次比(8.14±1.68)次,P<0.05];观察组首次肛门排气时间短于对照组[(8.52±1.63)h比(12.35±2.41)h,P<0.05];观察组眩晕发生率低于对照组[5.56%(2/36)比27.78%(10/36),P<0.05]。结论腹横肌平面阻滞联合静脉注射艾司氯胺酮对高龄产妇剖宫产术后的镇痛效果显著,可降低术后VAS评分,延长首次PCA时间,减少PCA总次数,促进术后恢复。
