The mortality rate from snakebites in West Bengal is very high and most of the deaths are caused by the Daboia russelli and Naja naja envenomation. Twenty-three plants from the seventeen families were collected from t...The mortality rate from snakebites in West Bengal is very high and most of the deaths are caused by the Daboia russelli and Naja naja envenomation. Twenty-three plants from the seventeen families were collected from the traditional healers and explored for the first time for antisnake venom activity. In our previous report, the methanolic root extract of the Indian medicinal plants Pluchea indica, Hemidesmus indicus, Vitex negundo and Emblica officinalis significantly neutralized the Viper and Cobra venom-induced pathophysiological changes [1][2]. In the present study, we explored four plant extracts (Curcuma aromatica, Aristolochia indica, Androgrphis paniculata and Curcuma zeodaria) for the antisnake venom activity. The plant extracts significantly antagonized Daboia russelli, Echis carinatus, Ophiophagus hannah and Naja kaouthia venom-induced lethal activity both in in vitro and in vivo studies. Daboia russellii venom-induced haemorrhage, coagulant, defibrinogenating and PLA2 activity were significantly neutralized by the extracts. No precipitating bands were observed between the plant extract and venom. This observation confirmed the role of active constituents of plants and plant materials involved in snake venom inhibition. Further studies are going on in our laboratory for the identification of active molecules as well as their mechanism of venom inhibition.展开更多
本文综述了毒蛇咬伤常见的长期并发症以及中医药应用于毒蛇咬伤长期并发症的治疗情况。使用以下主题词或关键词,包括毒蛇咬伤、迟发、残疾、持续、永久、长期、远期、慢性、中医、中药、草药,并对电子文献数据库,包括PubMed、Cochrane L...本文综述了毒蛇咬伤常见的长期并发症以及中医药应用于毒蛇咬伤长期并发症的治疗情况。使用以下主题词或关键词,包括毒蛇咬伤、迟发、残疾、持续、永久、长期、远期、慢性、中医、中药、草药,并对电子文献数据库,包括PubMed、Cochrane Library、Web of Science、Embase、中国生物医学数据库、中国知网、万方数据库、维普数据库进行文献检索,检索时间为数据库建立至2022年12月。毒蛇咬伤常见的长期并发症包括慢性骨骼肌肉残疾、皮肤疾病症状、心肌损伤、凝血功能障碍、偏头痛样综合征(头痛、眩晕、光敏感)、慢性肾功能不全、垂体功能障碍、缺氧或颅内出血引起的脑损伤(肢体麻木、感觉异常、感觉障碍、偏瘫等)、脱髓鞘型多发性神经病、视力受损等,但国内对毒蛇咬伤长期并发症的关注度较低。中医药在减轻或治疗毒蛇咬伤长期并发症方面具有一定的疗效,但相关机制阐述尚不够清楚;而且使用中医药治疗毒蛇咬伤相关的长期并发症的研究仍然较少,没有形成充分的中医药治疗毒蛇咬伤长期并发症的应用证据。展开更多
文摘The mortality rate from snakebites in West Bengal is very high and most of the deaths are caused by the Daboia russelli and Naja naja envenomation. Twenty-three plants from the seventeen families were collected from the traditional healers and explored for the first time for antisnake venom activity. In our previous report, the methanolic root extract of the Indian medicinal plants Pluchea indica, Hemidesmus indicus, Vitex negundo and Emblica officinalis significantly neutralized the Viper and Cobra venom-induced pathophysiological changes [1][2]. In the present study, we explored four plant extracts (Curcuma aromatica, Aristolochia indica, Androgrphis paniculata and Curcuma zeodaria) for the antisnake venom activity. The plant extracts significantly antagonized Daboia russelli, Echis carinatus, Ophiophagus hannah and Naja kaouthia venom-induced lethal activity both in in vitro and in vivo studies. Daboia russellii venom-induced haemorrhage, coagulant, defibrinogenating and PLA2 activity were significantly neutralized by the extracts. No precipitating bands were observed between the plant extract and venom. This observation confirmed the role of active constituents of plants and plant materials involved in snake venom inhibition. Further studies are going on in our laboratory for the identification of active molecules as well as their mechanism of venom inhibition.
文摘本文综述了毒蛇咬伤常见的长期并发症以及中医药应用于毒蛇咬伤长期并发症的治疗情况。使用以下主题词或关键词,包括毒蛇咬伤、迟发、残疾、持续、永久、长期、远期、慢性、中医、中药、草药,并对电子文献数据库,包括PubMed、Cochrane Library、Web of Science、Embase、中国生物医学数据库、中国知网、万方数据库、维普数据库进行文献检索,检索时间为数据库建立至2022年12月。毒蛇咬伤常见的长期并发症包括慢性骨骼肌肉残疾、皮肤疾病症状、心肌损伤、凝血功能障碍、偏头痛样综合征(头痛、眩晕、光敏感)、慢性肾功能不全、垂体功能障碍、缺氧或颅内出血引起的脑损伤(肢体麻木、感觉异常、感觉障碍、偏瘫等)、脱髓鞘型多发性神经病、视力受损等,但国内对毒蛇咬伤长期并发症的关注度较低。中医药在减轻或治疗毒蛇咬伤长期并发症方面具有一定的疗效,但相关机制阐述尚不够清楚;而且使用中医药治疗毒蛇咬伤相关的长期并发症的研究仍然较少,没有形成充分的中医药治疗毒蛇咬伤长期并发症的应用证据。
