Evaluating the Impact of the Universal Test and Treat Strategy on the Survival of Patients in the Northwest Region of Cameroon

Introduction: The main outcome of efficiently implemented universal test and treat (UTT) program is improved survival. UTT implementation has been ongoing in Cameroon since 2016 but evaluation data are scarce. This study aims to assess the survival of antiretroviral therapy (ART) patients initiated under UTT in Northwest region of Cameroon. Methods: This retrospective cohort study included HIV-positive patients initiated in 2016 at 27 purposefully selected sites and followed until 2021. Data was anonymously abstracted from ART registers and patients’ charts. Kaplan-Meier survival estimates and Cox model were used to compare the survival of patients initiated under UTT with those initiated otherwise, using stata version 14.0. Results: In total, 2490 HIV-positive patients (median age 42.7 years, 94.7% adults, and 69.0% female) participated in the study. Of 1389 patients with viral load (VL) test results, 55% were initiated on ART late. The VL suppression rate of patients initiated late and those initiated early were similar. During follow-up, 1020 (40.9%) participants censored. The survival curves of patients initiated early on ART and those initiated late were similar during the first 2.5 years of follow-up but significantly (p Conclusions: This study confirms the expected impact of UTT. Programs only need to close existing implementation gaps along the critical pathways (diagnosis and treatment) of UTT, focusing more on males.

Treat to target in Crohn’s disease:A practical guide for clinicians

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's disease.The Selecting Therapeutic Targets in Inflammatory Bowel Disease(STRIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these timepoints.Scheduled appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints remains central to determining whether current therapy should be continued or modified.Consensus treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic healing.Although the STRIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all patients.This underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment targets.The use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural healing.Two randomised clinical trials,namely,CALM and STARDUST,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s disease.Findings from these studies reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be clarified.Moreover,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world studies.Despite the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its uptake.This highlights the need to describe strategies,processes,and models of care capable of supporting the integration and execution of a T2T approach in real-world clinical practice.Hence,this review seeks to examine the current and emerging literature to provide clinicians with practical guidance on how to incorporate the principles of T2T into routine clinical practice for the management of Crohn’s disease.

Clinical Study on the Effectiveness of Xian Fang Huo Ming Yin for Treating Cutaneous Infections and Promoting Wound Healing in Patients with Perianal Abscess

Objective:To explore the effect of the Xian Fang Huo Ming Yin(XFHM)for treating cutaneous infections and promoting wound healing in patients with perianal abscesses.Methods:Sixty-one patients with perianal abscesses who were admitted to our hospital(Xinghua City People’s Hospital)from May 2022 to May 2023 were selected and randomly divided into two groups,a control group(30 cases)and a study group(31 cases).Both groups received surgical treatment.The control group received conventional treatment and warm water fumigation,sitz bath,and surgical dressing change after surgery,while the research group received XFHM based on the control group.XFHM was taken orally and replaced with warm water for fumigation and sitz bathing.Both groups received treatment for 4 weeks but discontinued sitz bathing after 2 weeks.Various clinical indicators between the two groups were compared.Results:The total clinical effective rate and wound recovery rate of the study group were higher than that of the control group.There were differences in the wound pain scores,surrounding tissue edema,and wound secretions at different time points.Both groups experienced wound pain.The scores of wound pain,surrounding tissue edema,and wound secretions of the study group were lower than those of the control group,7 and 14 days after surgery.The serum interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)levels,and pH values of the study group were lower than those of the control group 10 days after surgery(P<0.05).Conclusion:The application of XFHM for treating cutaneous infections and promoting wound healing in patients with perianal abscesses improved the treatment outcome,alleviated clinical symptoms,and promoted healing.

Performance Evaluation of Two Series Vertical Flow Filters for Wastewater Treatment: A Case Study of the Prototype Installed at Gaston Berger University, Saint-Louis, Senegal

This paper evaluates the efficacy of two sequential vertical flow filters (VFF), FV1 and FV2, implanted with Typha, in a pilot-scale wastewater treatment system. FV1 comprises three cells (FV1a, FV1b, and FV1c), while FV2 consists of two cells (FV2a and FV2b), each designed to reduce various physicochemical and microbiological pollutants from wastewater. Quantitative analyses show significant reductions in electrical conductivity (from 1331 to 1061 μS/cm), biochemical oxygen demand (BOD5 from 655.6 to 2.3 mg/L), chemical oxygen demand (COD from 1240 to 82.2 mg/L), total nitrogen (from 188 to 37.3 mg/L), and phosphates (from 70.9 to 14.6 mg/L). Notably, FV2 outperforms FV1, particularly in decreasing dissolved salts and BOD5 to remarkably low levels. Microbiological assessments reveal a substantial reduction in fecal coliforms, from an initial concentration of 7.5 log CFU/100mL to 3.7 log CFU/100mL, and a complete elimination of helminth eggs, achieving a 100% reduction rate in FV2. The study highlights the impact of design parameters, such as filter material, media depth, and plant species selection, on treatment outcomes. The findings suggest that the judicious choice of these components is critical for optimizing pollutant removal. For instance, different filtration materials show varying efficacies, with silex plus river gravel in FV1c achieving superior pollutant reduction rates. In conclusion, VFFs emerge as a promising solution for wastewater treatment, underscoring the importance of design optimization to enhance system efficiency. Continuous monitoring and adaptation of treatment practices are imperative to ensure water quality, allowing for safe environmental discharge or water reuse. The research advocates for ongoing improvements in wastewater treatment technologies, considering the environmental challenges of the current era. The study concludes with a call for further research to maximize the effectiveness of VFFs in water management.

Case Report of a Pseudoaneurysm of Ascending Aorta Treated by Stent

Pseudoaneurysms of the ascending aorta are a rare complication of aortic and cardiac surgery. In this article, we present a clinical case of a 56-year-old patient with a fortuitous diagnosis of a pseudoaneurysm of ascending aorta that was treated by an endovascular stent-graft. We discuss in this article the diagnostic and therapeutic aspect of the case and the place of endovascular treatment for the ascending aorta.

Scientific connotation of “treating different diseases with the same method” from the perspective of metabolic-immune dysregulation in inflammation-mediated carcinogenesis of digestive organs

Inflammation-mediated carcinogenesis develops in the context of chronic inflammation and is a significant cause of cancer within the digestive system.In the chronic inflammation microenvironment,the metabolic activity of tissue cells undergoes extensive changes,which interfere with the normal function of immune cells.Dysregulation of cell metabolism and immune function has been identified as a key factor contributing to inflammation-mediated carcinogenesis within the major digestive organs,such as the stomach,liver,and colorectum.This metabolic-immune imbalance also corresponds to traditional Chinese medicine(TCM)theories of“yin-yang disharmony”and“disharmony between Ying-nutrients and Wei-defense.”The metabolic-immune imbalance has also been regarded as the key factor supporting“treatment of different diseases with the same method”,in which the same approach is adopted in the treatment of different conditions.In the TCM treatment process,it is necessary to first identify TCM patterns and then apply the corresponding TCM to correct the dysregulated metabolic and immune function,thereby blocking the progression from inflammation to malignancy.Our study findings deepen the TCM understanding of metabolic-immune dysregulation and the relationship between metabolic-immune dysregulation,pattern identification,and treatment method.They also provide new insights for the treatment of inflammation-mediated carcinogenesis in major digestive organs and help us further explore the scientific connotation of the TCM strategy of“treating different diseases with the same method”.

Potential risk of soil irrigation with treated wastewater over 40 years:a field experiment under semi-arid conditions in northeastern Tunisia

In Tunisia,water scarcity is only adding pressure on water demand in agriculture.In the context of sustainable development goals,Tunisia has been reusing treated wastewater(TWW)as a renewable and inexpensive source for soil fertigation and groundwater(GW)recharge.However,major risks can be expected when the irrigation water is of poor quality.This study aims for evaluating the potential risk of TWW and GW irrigation on soil parameters.Accordingly,we evaluated the suitability of water quality through the analysis of major and minor cations and anions,metallic trace elements(MTEs),and the sodium hazard by using the sodium adsorption ratio(SAR)and the soluble sodium percentage(SSP).The risk of soil sodicity was further assessed by SAR and the exchangeable sodium percentage(ESP).The degree of soil pollution caused by MTEs accumulation was evaluated using geoaccumulation index(Igeo)and pollution load index(PLI).Soil maps were generated using inverse spline interpolation in ArcGIS software.The results show that both water samples(i.e.,TWW and GW)are suitable for soil irrigation in terms of salinity(electrical conductivity<7000μS/cm)and sodicity(SAR<10.00;SSP<60.00%).However,the contents of PO_(4)^(3-),Cu^(2+),and Cd^(2+)exceed the maximum threshold values set by the national and other standards.Concerning the soil samples,the average levels of SAR and ESP are within the standards(SAR<13.00;ESP<15.00%).On the other hand,PLI results reveal moderate pollution in the plot irrigated with TWW and no to moderate pollution in the plot irrigated with GW.Igeo results indicate that Cu^(2+)is the metallic trace element(MTE)with the highest risk of soil pollution in both plots(Igeo>5.00),followed by Ni^(2+)and Pb^(2+).Nevertheless,Cd^(2+)presents the lowest risk of soil pollution(Igeo<0.00).Statistical data indicates that Ca^(2+),Na+,Ni^(2+),and Pb^(2+)are highly distributed in both plots(coefficient of variation>50.0%).This study shows that the use of imagery tools,such as ArcGIS,can provide important information for evaluating the current status of soil fertility or pollution and for better managing soil irrigation with TWW.

以痈论治溃疡性结肠炎理论阐释及临床思路探析

于永铎认为,痈为火毒生,下利脓血为热毒本质,提出“病由毒起,热毒伤肠”为溃疡性结肠炎病机关键,“邪踞火毒”“湿热毒邪”“正虚伏毒”为溃疡性结肠炎的核心病机演变规律,体现热毒伤肠络,毒邪由实致虚,虚实夹杂的病邪转变过程。结合从肠黏膜屏障损伤、免疫功能紊乱、细胞自噬、凋亡、焦亡的病变特点及交叉转化的因果联系,提出以痈论治溃疡性结肠炎的核心治法,采用清热解毒、凉血消痈,清热利湿、解毒消痈,健脾益气、托毒消痈等辨治策略,并结合临床验案进行分析,以期为溃疡性结肠炎的治疗提供参考。

Screen-and-Treat Approach in Secondary Prevention of Cervical Cancer among HIV-Infected Women in Faith Alive Hospital, Jos Nigeria

Background: Cervical cancer is the fourth most common cancer among women globally, the second most common cancer in Nigeria and the most common cause of cancer-related death in Africa. In 2020, World Health Organization in its updated guidelines recommended cervical cancer screening using HPV DNA, HPV mRNA tests and subsequent treatment as appropriate. However, in resource-poor settings, Visual Inspections with Acetic Acid (VIA), Lugol’s Iodine (VILI) and subsequent treatment of precancerous lesions with thermal ablation remain the practical approaches. Objectives: To determine the prevalence of precancerous cervical lesions and associated risk factors among Women Living with HIV (WLHIV). Methods: A retrospective study on sexually active WLHIV aged 16 - 55 years screened for cervical cancer using VIA and VILI within 16 months period in Faith Alive Hospital Jos. Data were analyzed using IBM-SPSS 26. Sociodemographic characteristics of the study participants and the screening results were presented in frequency tables, and logistic regression was performed to determine risk factors of pre-cancerous lesions. Results: 1113 women were screened for cervical cancer using VIA/VILI. 994 (89.3%) were negative, 101 (9.1%) were positive for precancerous lesions, and 18 (1.6%) were suspicious of cervical cancer. The mean age of clients with pre-cancerous lesions was 41.32 ± 9.89 years. A higher positivity yield (69.4%) was found in ages between 36 and ≥55 years while a less positivity yield (30.6%) was found in age’s ≤ 35 years. History of STI had 1.64 fold risk association with precancerous lesions. Conclusion: Our study demonstrated a high prevalence of precancerous cervical lesions among WLHIV;bimodal age distribution for cancer-suspicious lesions and risk associated with STI. Thus, a “screen-and-treat” approach to cervical cancer prevention by VIA and thermal ablation in resource-poor settings should be undertaken until widespread HPV testing to triage clients is feasible.

Situational Analysis of Malaria Control Following the 2021 Distribution of Long Lasting Insecticide-Treated Bed Nets in the Tiko Health District, South West Region, Cameroon

Malaria is still a major public health concern in Cameroon as more than 20 million people are at risk of the disease. Despite the government’s effort to scale up the distribution of long lasting insecticide-treated bed nets (LLINs), full ownership and optimal use is still limited. In 2021, over a million LLINs were made available for distribution in the South West Region. However, the current situation of malaria has not yet been ascertained following the 2021 mass distribution campaign (MDC). Therefore, the aim of this study was to determine LLIN ownership, coverage, usage and the prevalence of malaria following the 2021 MDC in the Tiko Health District (THD), South West Region of Cameroon. A cross-sectional study was carried from May 1 to 27, 2022 in which a multi-stage sampling technique was used to enroll eligible participants. Data were collected from household heads using questionnaires and capillary blood samples collected from consented household members were used to test for malaria. Data were analyzed using SPSS version 25 at 0.05 significance level. From the 150 households surveyed, 96 (64.0%) owned a mosquito net before the recent MDC. There was an overall significant increase (p p = 0.644) in LLINs ownership between areas where door-to-door (79.5%) and fixed “Hit and Run” (75.8%) strategies were used in the distribution of LLINs in THD. The prevalence of malaria was 10.2%. The regular use of LLINs was significantly associated (p = 0.007) with low malaria prevalence. The 2021 MDC had an impact on malaria prevalence in those who properly used them.

基于“肝脾同调”阐析慢性肝病的中医治疗

慢性肝病是临床常见疾病,“郁、虚、湿、毒、瘀”是其核心病机,在疾病的不同阶段各有侧重,其中,以“郁、虚”为核心的肝脾失调是慢性肝病发生发展的关键。“肝脾同调”是治疗慢性肝病的基本治法,在慢性肝病不同阶段,其“肝脾同调”内涵同中有异。根据肝、脾生理病理特性,治脾明辨虚实,厘清轻重,活用运脾、健脾、温脾、醒脾、补脾等法;调肝体用并重,精准辨证,活用疏肝、缓肝、散肝、柔肝等法。临床上,治脾与调肝相辅相成,治调并举,常获良效。

辛夷的法象药理及其临床意义

“药象”是中药在自然生长和形成过程中产生的固有性质,也是形成药性药效的基础。辛夷独特的药象特征一直是古人细致观察与重点关注的内容。辛夷“必至四序并经,乃刳苞以出”的物候之象,可谓花木之独一份,也奠定了其独特的药性特点;辛夷形若毛桃,苞片坚韧而密被绒毛的药材之象,也是探讨其“以形治形”论治痼积癌肿的法象特征。经典本草古籍中辛夷广泛用于治疗风邪郁滞、经脉不通等诸多病证的作用机制皆与其药象特点密切相关。虽然后世受“舍鼻塞、鼻渊之症,无他用”之论所囿,但从其“法象药理”而言,辛夷不仅可轻宣升散,又善于内入脏腑以宣达阴伏之邪,深入巢窟以驱逐结聚之滞,可广泛应用于气血郁滞、沉寒痼冷、瘀毒结聚等病证。而这些功效主治的拓展,正是辛夷“象性合参”的意义所在。

慢性萎缩性胃炎的中医辨治思路与对策

慢性萎缩性胃炎(CAG)是临床上公认的胃癌前疾病,中医药治疗CAG具有明显的优势及鲜明的特色。从CAG病因病机等方面的研究入手,对中医药治疗CAG提出治本独取阳明,补虚泻实,顾护脾胃,升降气机,调气和血,祛瘀通络,祛邪解毒,甘平凉润,和胃护络的辨治思路与对策,以期进一步提高中医药治疗CAG的临床疗效。

基于“血实宜决之”应用咽部刺营治疗慢性咽炎探析

慢性咽炎是耳鼻喉科常见疾病,临床发病率高,其病因复杂,慢性感染性因素是慢性咽炎的主要病因之一。基于《黄帝内经》“血实宜决之”理论,认为邪滞咽喉、气郁痰阻、血瘀阻络、津伤络瘀是慢性咽炎的主要病机,其中“邪滞、气郁、痰阻、血瘀”是“血实”的病理基础,刺营是“决之”的治疗手段,通过针刺咽后壁淋巴滤泡、迂曲明显的浅表血管、咽侧索,使局部少量出血,可以达到“祛邪、通阳、化滞、散瘀”的目的,改善咽部症状,具有短期疗效明显,长期疗效稳定,操作简便,安全性高的特点。其作用机制可能是通过咽部针刺放血后改善咽部局部微循环,促进炎症吸收,调节免疫功能及咽部神经生理有关。对咽部刺营作用机制的探析,以期为临床治疗慢性咽炎提供新的思路和方法。

弱酸性蓝AS 染料排放的废盐制碳基吸附剂及利用

将染料弱酸性蓝AS(AS)生产排放的含盐废水喷雾干燥后制成废盐,再将其有机污染物煅烧制备成类活性炭吸附剂(LAC),用于AS染料生产过程中产生的洗涤废水的吸附脱色净化,同时回收粗盐NaCl可循环用于AS工业生产的盐析过程。对LAC进行吸附过程动力学、热力学研究,并研究AS染料废水溶液初始浓度、温度及pH对吸附性能的影响。在40 mg/L的AS染料废水中,温度为318 K的条件下,平衡吸附量为29.22 mg/g。在酸性及温度较高时吸附能力较强。Langmuir等温线方程能更好拟合吸附实验结果。另外,采用一锅混合法,添加四水合乙酸镁对LAC进行改性,改性后的吸附剂LACMg0.75比表面积较LAC提升了近5倍,饱和吸附量能够达到550.02 mg/g,较LAC提升了接近20倍。

双相Ⅰ型障碍和双相Ⅱ型患者人口学和临床特征的比较

目的:比较双相Ⅰ型障碍和双相Ⅱ型障碍患者的人口学特征、临床特征、治疗特征和生理指标。方法:选取符合美国精神障碍诊断与统计手册第5版(DSM-5)双相障碍的患者381例,其中Ⅰ型302例(79.27%),Ⅱ型74例(19.42%),其他特定及相关障碍5例(1.31%)。用自编临床资料访谈表收集人口学资料及临床特征数据。采用多因素logistic回归和多重线性回归分析方法进行因素分析。结果:与双相II型障碍相比,双相I型障碍患者更容易伴有精神病性特征(OR=5.75,95%CI:2.82~11.76),病程更长,接受重复经颅磁刺激治疗较多(OR=3.09,95%CI:1.02~9.35),尿酸、总胆固醇、高密度脂蛋白浓度更高,汉族更常见(OR=11.50,95%CI:1.76~75.30)、受教育程度更低(OR=10.22,95%CI:1.16~89.77),更少有精神病家族史(OR=2.34,95%CI:1.01~5.42)。结论:双相Ⅰ型障碍和双相Ⅱ型障碍的人口学特征、临床特征、治疗情况和生理指标有差异,可为探讨双相障碍的发病机制提供线索。

糯米浆灰土无侧限压缩和三轴剪切离散元分析

糯米浆灰土是一种常见的遗址保护建筑材料,为研究糯米浆灰土压缩加载过程中的糯米-石灰胶结破坏和接触组构演化情况,采用离散单元法开展了糯米浆灰土无侧限压缩和三轴剪切离散元模拟。首先基于软胶结模型考虑糯米浆-石灰的强度特征,制备了糯米浆灰土离散元试样;然后通过参数敏感性分析为试样赋予合理的接触模型等效模量和胶结强度参数,最后对试样开展无侧限和三轴压缩模拟。结果表明:离散元模拟能再现糯米浆灰土加载试验的主要特征;加载过程中胶结破坏数量先缓后快增加,最终趋于平缓,胶结破坏呈现一定的聚集效应;无侧限压缩下胶结接触主要发生拉伸破坏,随着围压增加,剪切破坏接触数量增加;试样偏组构快速增加段为胶结破坏诱发。

基于“痰瘀同治”理论治疗超重/肥胖糖耐量异常

目的基于“痰瘀同治”理论,运用痰瘀同调方治疗超重/肥胖糖耐量异常人群,评价痰瘀同调方治疗超重/肥胖糖耐量异常人群的临床有效性及安全性。方法选择超重/肥胖糖耐量异常痰湿瘀滞证患者72例,随机分为对照组与治疗组,各36例,对照组予基础治疗,治疗组在对照组基础上联合痰瘀同调方治疗。治疗3个月后观察2组体质量指数(BMI)、腰围(WC)、腰臀比(WHR)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbAlc)、空腹血清胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)、血脂以及中医痰湿瘀滞症状积分等指标变化,客观评价痰瘀同调方的临床疗效。结果治疗组治疗后BMI、WC、WHR、FPG、2 h PG、HbAlc、FINS、HOMA-IR、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C),均较治疗前有明显改善,且改善程度均优于对照组(P<0.05);治疗组治疗后改善患者形体肥胖、腹部增大、脘腹胀满、倦怠乏力、胸闷、便溏、口淡无味或黏腻等中医症状方面均优于对照组(P<0.05);治疗组中医证候综合疗效总有效率明显高于对照组(P<0.05)。2组研究过程中均未出现不良事件。结论痰瘀同调方干预治疗超重/肥胖糖耐量异常效果明显,安全性良好。

“导引调神”对肺癌患者心肺耐力及情绪的影响

目的:通过对肺癌术后患者进行肺肿瘤导引康复法联合中药治疗,观察肺癌患者心肺耐力及精神症状自评量表(SCL-90)评分变化,探讨形神并调对肺癌术后患者心肺耐力及心理健康的影响。方法:采用随机数字表法、对照临床试验,将93例患者分为中药对照组(TCM组)44例及中药联合“肺肿瘤导引康复法”组(TCM+DY组)49例,TCM组给予中药治疗,TCM+DY组给予中药配合肺肿瘤导引康复,观察治疗前后两组患者最大摄氧量(VO_(2)Max)、最大代谢当量(METs Max)、最大摄氧量/预计值(VO_(2)Max/VO_(2)预计值)、无氧阈摄氧量(VO_(2)@AT)、无氧阈摄氧量/预计值(VO_(2)@AT/VO_(2)预计值)、无氧阈代谢当量(METs@AT)、最大肺活量(VC Max)、用力肺活量(FVC)、一秒钟用力呼气容积(FEV1)、一秒钟用力呼气容积与用力肺活量比值(FEV1/FVC)、SCL-90评分变化。结果:治疗3个月后,TCM组与TCM+DY组比较,VO_(2)Max、VO_(2)Max/VO_(2)预计值、METs Max、VC Max、VC Max%、FVC%、FEV1%均显著升高(P<0.05),且TCM+DY组疗效优于单纯TCM组;两组治疗后SCL-90总分均较前下降,且在抑郁、躯体化、睡眠与饮食因子方面,TCM+DY组较TCM组下降显著,差异具有统计学意义(P<0.05)。结论:中药联合肺肿瘤导引康复法形神并调能够有效改善患者最大摄氧量,提升患者心肺耐力,促进心理健康。

王庆其从“年长则求之于府”论治老年性便秘经验撷要

介绍名老中医王庆其运用“年长则求之于府”理论论治老年性便秘经验。从理论溯源、论治要点、用药规律、临床验案等方面系统阐述了王庆其教授辨治老年性便秘的学术思想和独到经验。王教授认为论治老年性便秘首要固护胃气,不宜峻下,调五脏可通“府”。其从“府”论治老年性便秘,用药配伍特点有四:补泻互寓以通“府”;调节升降以平“府”;养血生津以润“府”;阴阳互滋以和“府”,取得令人满意的疗效。