This papcr presents a new genetic algorithms(GAs)-based method for self-learniag fuzzy control rules. An improved GA is used to learn to optimally select the fuzzy membership functions of the linguistic labels in the ...This papcr presents a new genetic algorithms(GAs)-based method for self-learniag fuzzy control rules. An improved GA is used to learn to optimally select the fuzzy membership functions of the linguistic labels in the condition portion of each rule, and to automatically generate fuzzy control actions under each condition. The dynamics of the controlled system is unknown to the GA. The only information for evaluating performance is a failure signal indicating that the controlled system is out of control. We compare its performance with that of other learning methods for the same problem. We also examine the ability of the algorithm to adapt to changing conditions. Simulation results show that such an approach for self-learning fuzzy control rules is both effective and robust.展开更多
This paper presents a novel method for constructing fuzzy controllers based on a real time reinforcement genetic algorithm. This methodology introduces the real-time learning capability of neural networks into globall...This paper presents a novel method for constructing fuzzy controllers based on a real time reinforcement genetic algorithm. This methodology introduces the real-time learning capability of neural networks into globally searching process of genetic algorithm, aiming to enhance the convergence rate and real-time learning ability of genetic algorithm, which is then used to construct fuzzy controllers for complex dynamic systems without any knowledge about system dynamics and prior control experience. The cart-pole system is employed as a test bed to demonstrate the effectiveness of the proposed control scheme, and the robustness of the acquired fuzzy controller with comparable result.展开更多
In this paper, the weld pool shape control by intelligent strategy was studied. A neuron self-learning PSD controller for backside width of weld pool in pulsed GTAW with wire filler was designed. The PSD control arith...In this paper, the weld pool shape control by intelligent strategy was studied. A neuron self-learning PSD controller for backside width of weld pool in pulsed GTAW with wire filler was designed. The PSD control arithmetic was analyzed, simulating experiment by MATLAB software was done, and the validating experiments on varied heat sink workpiece and varied gap workpiece were successfully implemented. The study results show that the neuron self-learning PSD control method can attain a perfect control effect under different set values and conditions, and is suitable for the welding process with the varied structure and coefficients of control model.展开更多
The weld pool shape control by intelligent strategy was studied. In order to improve the ability of self-learning and self-adaptation of the ordinary fuzzy control, a self-learning fuzzy neural network controller (FNN...The weld pool shape control by intelligent strategy was studied. In order to improve the ability of self-learning and self-adaptation of the ordinary fuzzy control, a self-learning fuzzy neural network controller (FNNC) for backside width of weld pool in pulsed gas tungsten arc welding (GTAW) with wire filler was designed. In FNNC, the fuzzy system was expressed by an equivalence neural network, the membership functions and inference rulers were decided through the learning of the neural network. Then, the FNNC control arithmetic was analyzed, simulating experiment was done, and the validating experiments on varied heat sink workpiece and varied gap workpiece were implemented. The maximum error between the real value and the given one was 0.39mm, the mean error was 0.014mm, and the root-mean-square was 0.14mm. The real backside width was maintained around the given value. The results show that the self-learning fuzzy neural network control strategy can achieve a perfect control effect under different set values and conditions, and is suitable for the welding process with the varied structure and coefficients of control model.展开更多
Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and...Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.展开更多
BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of ...BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic control.METHODS This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 months.Participants were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as needed.The analysis focused on the success rates of good glycemic control and the associated factors within each group.RESULTS The study showed significant improvements in HbA1c levels in all participants.The most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,respectively.After one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and below.CONCLUSION In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored strategies.Therefore,different and comprehensive treatment approaches are needed for patients with persistent uncontrolled diabetes.展开更多
Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these...Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.展开更多
Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug deliv...Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.展开更多
This paper introduces a self-learning control approach based on approximate dynamic programming. Dynamic programming was introduced by Bellman in the 1950's for solving optimal control problems of nonlinear dynami...This paper introduces a self-learning control approach based on approximate dynamic programming. Dynamic programming was introduced by Bellman in the 1950's for solving optimal control problems of nonlinear dynamical systems. Due to its high computational complexity, the applications of dynamic programming have been limited to simple and small problems. The key step in finding approximate solutions to dynamic programming is to estimate the performance index in dynamic programming. The optimal control signal can then be determined by minimizing (or maximizing) the performance index. Artificial neural networks are very efficient tools in representing the performance index in dynamic programming. This paper assumes the use of neural networks for estimating the performance index in dynamic programming and for generating optimal control signals, thus to achieve optimal control through self-learning.展开更多
Since the existing single-layer networked control systems have some inherent limitations and cannot effectively handle the problems associated with unreliable networks, a novel two-layer networked learning control sys...Since the existing single-layer networked control systems have some inherent limitations and cannot effectively handle the problems associated with unreliable networks, a novel two-layer networked learning control system (NLCS) is proposed in this paper. Its lower layer has a number of local controllers that are operated independently, and its upper layer has a learning agent that communicates with the independent local controllers in the lower layer. To implement such a system, a packet-discard strategy is firstly developed to deal with network-induced delay and data packet loss. A cubic spline interpolator is then employed to compensate the lost data. Finally, the output of the learning agent based on a novel radial basis function neural network (RBFNN) is used to update the parameters of fuzzy controllers. A nonlinear heating, ventilation and air-conditioning (HVAC) system is used to demonstrate the feasibility and effectiveness of the proposed system.展开更多
The mathematical model for online controlling hot rolled steel cooling on run-out table (ROT for abbreviation) was analyzed, and water cooling is found to be the main cooling mode for hot rolled steel. The calculati...The mathematical model for online controlling hot rolled steel cooling on run-out table (ROT for abbreviation) was analyzed, and water cooling is found to be the main cooling mode for hot rolled steel. The calculation of the drop in strip temperature by both water cooling and air cooling is summed up to obtain the change of heat transfer coefficient. It is found that the learning coefficient of heat transfer coefficient is the kernel coefficient of coiler temperature control (CTC) model tuning. To decrease the deviation between the calculated steel temperature and the measured one at coiler entrance, a laminar cooling control self-learning strategy is used. Using the data acquired in the field, the results of the self-learning model used in the field were analyzed. The analyzed results show that the self-learning function is effective.展开更多
In machine learning,positive-unlabelled(PU)learning is a special case within semi-supervised learning.In positiveunlabelled learning,the training set contains some positive examples and a set of unlabelled examples fr...In machine learning,positive-unlabelled(PU)learning is a special case within semi-supervised learning.In positiveunlabelled learning,the training set contains some positive examples and a set of unlabelled examples from both the positive and negative classes.Positive-unlabelled learning has gained attention in many domains,especially in time-series data,in which the obtainment of labelled data is challenging.Examples which originate from the negative class are especially difficult to acquire.Self-learning is a semi-supervised method capable of PU learning in time-series data.In the self-learning approach,observations are individually added from the unlabelled data into the positive class until a stopping criterion is reached.The model is retrained after each addition with the existent labels.The main problem in self-learning is to know when to stop the learning.There are multiple,different stopping criteria in the literature,but they tend to be inaccurate or challenging to apply.This publication proposes a novel stopping criterion,which is called Peak evaluation using perceptually important points,to address this problem for time-series data.Peak evaluation using perceptually important points is exceptional,as it does not have tunable hyperparameters,which makes it easily applicable to an unsupervised setting.Simultaneously,it is flexible as it does not make any assumptions on the balance of the dataset between the positive and the negative class.展开更多
Reinforcement learning(RL) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with RL and ...Reinforcement learning(RL) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with RL and its applications to various advanced control fields. First, the background of the development of ADP is described, emphasizing the significance of regulation and tracking control problems. Some effective offline and online algorithms for ADP/adaptive critic control are displayed, where the main results towards discrete-time systems and continuous-time systems are surveyed, respectively.Then, the research progress on adaptive critic control based on the event-triggered framework and under uncertain environment is discussed, respectively, where event-based design, robust stabilization, and game design are reviewed. Moreover, the extensions of ADP for addressing control problems under complex environment attract enormous attention. The ADP architecture is revisited under the perspective of data-driven and RL frameworks,showing how they promote ADP formulation significantly.Finally, several typical control applications with respect to RL and ADP are summarized, particularly in the fields of wastewater treatment processes and power systems, followed by some general prospects for future research. Overall, the comprehensive survey on ADP and RL for advanced control applications has d emonstrated its remarkable potential within the artificial intelligence era. In addition, it also plays a vital role in promoting environmental protection and industrial intelligence.展开更多
To respond to the further development of college English reforms,many universities employed network-based selflearning classes to aid the traditional classroom teaching,especially in teaching listening,but as time wen...To respond to the further development of college English reforms,many universities employed network-based selflearning classes to aid the traditional classroom teaching,especially in teaching listening,but as time went by,some universities gradually gave them up.The paper intends to reflect on the employment of network-based self-learning listening classes,analyz ing the learning with and without its aid,and meanwhile introduce the need to re-employ it,and discuss how we can improve the network-based self-learning classes to help with students' listening.展开更多
This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown nonlinearities.To eli...This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown nonlinearities.To eliminate nonlinearities,neural networks are applied to approximate the inherent dynamics of the system.In addition,due to the limitations of the actual working conditions,each follower agent can only obtain the locally measurable partial state information of the leader agent.To address this problem,a neural network state observer based on the leader state information is designed.Then,a finite-time prescribed performance adaptive output feedback control strategy is proposed by restricting the sliding mode surface to a prescribed region,which ensures that the closed-loop system has practical finite-time stability and that formation errors of the multi-agent systems converge to the prescribed performance bound in finite time.Finally,a numerical simulation is provided to demonstrate the practicality and effectiveness of the developed algorithm.展开更多
Control precision of coiling temperature is one of the key factors affecting the profile shape and surface quality during the cooling process of hot rolled steel strip.For this reason,the core of temperature control p...Control precision of coiling temperature is one of the key factors affecting the profile shape and surface quality during the cooling process of hot rolled steel strip.For this reason,the core of temperature control precision is to establish an effective cooling mathematical model with self-learning function.Starting from this point,a cooling mathematical model with nonlinear structural characteristics is established in this paper for the cooling process of hot rolled steel strip.By the analysis of self-learning ability,key parameters of the mathematical model could be constantly corrected so as to improve temperature control precision and adaptive capability of the model.The site actual application results proved the stable performance and high control precision of the proposed mathematical model,which would lay a solid foundation to improve the steel product qualities.展开更多
A design idea was proposed that it was about intelligent digital welding machine with self-learning and self- regulation functions. The overall design scheme of software and hardware was provided. It was introduced th...A design idea was proposed that it was about intelligent digital welding machine with self-learning and self- regulation functions. The overall design scheme of software and hardware was provided. It was introduced that a parameter self-learning algorithm was based on large-step calibration and partial Newton interpolation. Furthermore, experimental verification was carried out with different welding technologies. The results show that weld bead is pegrect. Therefore, good welding quality and stability are obtained, and intelligent regulation is realized by parameters self-learning.展开更多
An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control...An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control precision.Specifically,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each subsystem.Three direction interference observers are designed to track the timevarying boundary disturbance.On this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead zone.In addition,the stability of the closed-loop system is proven by Lyapunov stability theory.All the system states are bounded,and the vibration offset of the riser converges to a small area of the initial position.Finally,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.展开更多
The stamping-out strategy has been used to control highly pathogenic avian influenza viruses in many countries,driven by the belief that vaccination would not be successful against such viruses and fears that avian in...The stamping-out strategy has been used to control highly pathogenic avian influenza viruses in many countries,driven by the belief that vaccination would not be successful against such viruses and fears that avian influenza virus in vaccinated birds would evolve more rapidly and pose a greater risk to humans.In this review,we summarize the successes in controlling highly pathogenic avian influenza in China and make suggestions regarding the requirements for vaccine selection and effectiveness.In addition,we present evidence that vaccination of poultry not only eliminates human infection with avian influenza virus,but also significantly reduces and abolishes some harmful characteristics of avian influenza virus.展开更多
文摘This papcr presents a new genetic algorithms(GAs)-based method for self-learniag fuzzy control rules. An improved GA is used to learn to optimally select the fuzzy membership functions of the linguistic labels in the condition portion of each rule, and to automatically generate fuzzy control actions under each condition. The dynamics of the controlled system is unknown to the GA. The only information for evaluating performance is a failure signal indicating that the controlled system is out of control. We compare its performance with that of other learning methods for the same problem. We also examine the ability of the algorithm to adapt to changing conditions. Simulation results show that such an approach for self-learning fuzzy control rules is both effective and robust.
文摘This paper presents a novel method for constructing fuzzy controllers based on a real time reinforcement genetic algorithm. This methodology introduces the real-time learning capability of neural networks into globally searching process of genetic algorithm, aiming to enhance the convergence rate and real-time learning ability of genetic algorithm, which is then used to construct fuzzy controllers for complex dynamic systems without any knowledge about system dynamics and prior control experience. The cart-pole system is employed as a test bed to demonstrate the effectiveness of the proposed control scheme, and the robustness of the acquired fuzzy controller with comparable result.
文摘In this paper, the weld pool shape control by intelligent strategy was studied. A neuron self-learning PSD controller for backside width of weld pool in pulsed GTAW with wire filler was designed. The PSD control arithmetic was analyzed, simulating experiment by MATLAB software was done, and the validating experiments on varied heat sink workpiece and varied gap workpiece were successfully implemented. The study results show that the neuron self-learning PSD control method can attain a perfect control effect under different set values and conditions, and is suitable for the welding process with the varied structure and coefficients of control model.
文摘The weld pool shape control by intelligent strategy was studied. In order to improve the ability of self-learning and self-adaptation of the ordinary fuzzy control, a self-learning fuzzy neural network controller (FNNC) for backside width of weld pool in pulsed gas tungsten arc welding (GTAW) with wire filler was designed. In FNNC, the fuzzy system was expressed by an equivalence neural network, the membership functions and inference rulers were decided through the learning of the neural network. Then, the FNNC control arithmetic was analyzed, simulating experiment was done, and the validating experiments on varied heat sink workpiece and varied gap workpiece were implemented. The maximum error between the real value and the given one was 0.39mm, the mean error was 0.014mm, and the root-mean-square was 0.14mm. The real backside width was maintained around the given value. The results show that the self-learning fuzzy neural network control strategy can achieve a perfect control effect under different set values and conditions, and is suitable for the welding process with the varied structure and coefficients of control model.
基金National Natural Science Foundation of China(32201491)Young Elite Scientists Sponsorship Program by CAST(2023QNRC001)The authors extend their appreciation to the Deanship of Scientific Research at Northern Border University,Arar,KSA for funding this research work through the project number“NBU-FPEJ-2024-1101-02”.
文摘Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass materials.These materials offer numerous advantages such as being lightweight,porous,and hierarchical.Due to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding materials.Despite concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding materials.In particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be valuable.The preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and analyzed.The composite methods and fillers of various biomass materials were reviewed.this paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.
文摘BACKGROUND Inadequate glycemic control in patients with type 2 diabetes(T2DM)is a major public health problem and a significant risk factor for the progression of diabetic complications.AIM To evaluate the effects of intensive and supportive glycemic management strategies over a 12-month period in individuals with T2DM with glycated hemoglobin(HbA1c)≥10%and varying backgrounds of glycemic control.METHODS This prospective observational study investigated glycemic control in patients with poorly controlled T2DM over 12 months.Participants were categorized into four groups based on prior glycemic history:Newly diagnosed,previously well controlled with recent worsening,previously off-target but now worsening,and HbA1c consistently above 10%.HbA1c levels were monitored quarterly,and patients received medical,educational,and dietary support as needed.The analysis focused on the success rates of good glycemic control and the associated factors within each group.RESULTS The study showed significant improvements in HbA1c levels in all participants.The most significant improvement was observed in individuals newly diagnosed with diabetes:65%achieved an HbA1c target of≤7%.The results varied between participants with different glycemic control histories,followed by decreasing success rates:39%in participants with previously good glycemic control,21%in participants whose glycemic control had deteriorated compared to before,and only 10%in participants with persistently poor control,with mean HbA1c levels of 6.3%,7.7%,8.2%,and 9.7%,respectively.After one year,65.2%of the“newly diagnosed patients”,39.3%in the“previously controlled group”,21.9%in the“previously off-target but now worsened'”group and 10%in the“poorly controlled from the start”group had achieved HbA1c levels of 7 and below.CONCLUSION In poorly controlled diabetes,the rate at which treatment goals are achieved is associated with the glycemic background characteristics,emphasizing the need for tailored strategies.Therefore,different and comprehensive treatment approaches are needed for patients with persistent uncontrolled diabetes.
基金supported by the Fundamental Research Funds for Central Public Welfare Research Institute,No.2020CZ-5(to WS and GS)the National Natural Science Foundation of China,No.31970970(to JSR)Fundamental Research Funds for the Central Universities,No.YWF-23-YG-QB-010(to JSR)。
文摘Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface electromyography.In this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord injury.Eleven patients with chronic complete thoracic spinal cord injury were recruited.Surface electromyography data from eight major leg muscles were acquired and compared before and after the passive activity protocol.The results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of activation.Although the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically significant.These findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.
基金supported by the Natural Science Foundation of Shandong Province,No.ZR2023MC168the National Natural Science Foundation of China,No.31670989the Key R&D Program of Shandong Province,No.2019GSF107037(all to CS).
文摘Vascular endothelial growth factor and its mimic peptide KLTWQELYQLKYKGI(QK)are widely used as the most potent angiogenic factors for the treatment of multiple ischemic diseases.However,conventional topical drug delivery often results in a burst release of the drug,leading to transient retention(inefficacy)and undesirable diffusion(toxicity)in vivo.Therefore,a drug delivery system that responds to changes in the microenvironment of tissue regeneration and controls vascular endothelial growth factor release is crucial to improve the treatment of ischemic stroke.Matrix metalloproteinase-2(MMP-2)is gradually upregulated after cerebral ischemia.Herein,vascular endothelial growth factor mimic peptide QK was self-assembled with MMP-2-cleaved peptide PLGLAG(TIMP)and customizable peptide amphiphilic(PA)molecules to construct nanofiber hydrogel PA-TIMP-QK.PA-TIMP-QK was found to control the delivery of QK by MMP-2 upregulation after cerebral ischemia/reperfusion and had a similar biological activity with vascular endothelial growth factor in vitro.The results indicated that PA-TIMP-QK promoted neuronal survival,restored local blood circulation,reduced blood-brain barrier permeability,and restored motor function.These findings suggest that the self-assembling nanofiber hydrogel PA-TIMP-QK may provide an intelligent drug delivery system that responds to the microenvironment and promotes regeneration and repair after cerebral ischemia/reperfusion injury.
基金Supported by the National Science Foundation (U.S.A.) under Grant ECS-0355364
文摘This paper introduces a self-learning control approach based on approximate dynamic programming. Dynamic programming was introduced by Bellman in the 1950's for solving optimal control problems of nonlinear dynamical systems. Due to its high computational complexity, the applications of dynamic programming have been limited to simple and small problems. The key step in finding approximate solutions to dynamic programming is to estimate the performance index in dynamic programming. The optimal control signal can then be determined by minimizing (or maximizing) the performance index. Artificial neural networks are very efficient tools in representing the performance index in dynamic programming. This paper assumes the use of neural networks for estimating the performance index in dynamic programming and for generating optimal control signals, thus to achieve optimal control through self-learning.
基金Supported by National Natural Science Foundation of China(60774059)Project of Science &Technology Commission of Shanghaiunicipality(061107031,06DZ22011,06ZR14131)+1 种基金the Sunlight Plan Following Project of Shanghai Municipal Education Commission and Shanghai Edu-ational Development Foundation(06GG10)Shanghai Leading Academic Disciplines(T0103)
文摘Since the existing single-layer networked control systems have some inherent limitations and cannot effectively handle the problems associated with unreliable networks, a novel two-layer networked learning control system (NLCS) is proposed in this paper. Its lower layer has a number of local controllers that are operated independently, and its upper layer has a learning agent that communicates with the independent local controllers in the lower layer. To implement such a system, a packet-discard strategy is firstly developed to deal with network-induced delay and data packet loss. A cubic spline interpolator is then employed to compensate the lost data. Finally, the output of the learning agent based on a novel radial basis function neural network (RBFNN) is used to update the parameters of fuzzy controllers. A nonlinear heating, ventilation and air-conditioning (HVAC) system is used to demonstrate the feasibility and effectiveness of the proposed system.
基金Item Sponsored by National Natural Science Foundation of China(50474016)
文摘The mathematical model for online controlling hot rolled steel cooling on run-out table (ROT for abbreviation) was analyzed, and water cooling is found to be the main cooling mode for hot rolled steel. The calculation of the drop in strip temperature by both water cooling and air cooling is summed up to obtain the change of heat transfer coefficient. It is found that the learning coefficient of heat transfer coefficient is the kernel coefficient of coiler temperature control (CTC) model tuning. To decrease the deviation between the calculated steel temperature and the measured one at coiler entrance, a laminar cooling control self-learning strategy is used. Using the data acquired in the field, the results of the self-learning model used in the field were analyzed. The analyzed results show that the self-learning function is effective.
基金supported in part by National Natural Science Foundation of China(61533017,61273140,61304079,61374105,61379099,61233001)Fundamental Research Funds for the Central Universities(FRF-TP-15-056A3)the Open Research Project from SKLMCCS(20150104)
文摘In machine learning,positive-unlabelled(PU)learning is a special case within semi-supervised learning.In positiveunlabelled learning,the training set contains some positive examples and a set of unlabelled examples from both the positive and negative classes.Positive-unlabelled learning has gained attention in many domains,especially in time-series data,in which the obtainment of labelled data is challenging.Examples which originate from the negative class are especially difficult to acquire.Self-learning is a semi-supervised method capable of PU learning in time-series data.In the self-learning approach,observations are individually added from the unlabelled data into the positive class until a stopping criterion is reached.The model is retrained after each addition with the existent labels.The main problem in self-learning is to know when to stop the learning.There are multiple,different stopping criteria in the literature,but they tend to be inaccurate or challenging to apply.This publication proposes a novel stopping criterion,which is called Peak evaluation using perceptually important points,to address this problem for time-series data.Peak evaluation using perceptually important points is exceptional,as it does not have tunable hyperparameters,which makes it easily applicable to an unsupervised setting.Simultaneously,it is flexible as it does not make any assumptions on the balance of the dataset between the positive and the negative class.
基金supported in part by the National Natural Science Foundation of China(62222301, 62073085, 62073158, 61890930-5, 62021003)the National Key Research and Development Program of China (2021ZD0112302, 2021ZD0112301, 2018YFC1900800-5)Beijing Natural Science Foundation (JQ19013)。
文摘Reinforcement learning(RL) has roots in dynamic programming and it is called adaptive/approximate dynamic programming(ADP) within the control community. This paper reviews recent developments in ADP along with RL and its applications to various advanced control fields. First, the background of the development of ADP is described, emphasizing the significance of regulation and tracking control problems. Some effective offline and online algorithms for ADP/adaptive critic control are displayed, where the main results towards discrete-time systems and continuous-time systems are surveyed, respectively.Then, the research progress on adaptive critic control based on the event-triggered framework and under uncertain environment is discussed, respectively, where event-based design, robust stabilization, and game design are reviewed. Moreover, the extensions of ADP for addressing control problems under complex environment attract enormous attention. The ADP architecture is revisited under the perspective of data-driven and RL frameworks,showing how they promote ADP formulation significantly.Finally, several typical control applications with respect to RL and ADP are summarized, particularly in the fields of wastewater treatment processes and power systems, followed by some general prospects for future research. Overall, the comprehensive survey on ADP and RL for advanced control applications has d emonstrated its remarkable potential within the artificial intelligence era. In addition, it also plays a vital role in promoting environmental protection and industrial intelligence.
文摘To respond to the further development of college English reforms,many universities employed network-based selflearning classes to aid the traditional classroom teaching,especially in teaching listening,but as time went by,some universities gradually gave them up.The paper intends to reflect on the employment of network-based self-learning listening classes,analyz ing the learning with and without its aid,and meanwhile introduce the need to re-employ it,and discuss how we can improve the network-based self-learning classes to help with students' listening.
基金the National Natural Science Foundation of China(62203356)Fundamental Research Funds for the Central Universities of China(31020210502002)。
文摘This paper studies the problem of time-varying formation control with finite-time prescribed performance for nonstrict feedback second-order multi-agent systems with unmeasured states and unknown nonlinearities.To eliminate nonlinearities,neural networks are applied to approximate the inherent dynamics of the system.In addition,due to the limitations of the actual working conditions,each follower agent can only obtain the locally measurable partial state information of the leader agent.To address this problem,a neural network state observer based on the leader state information is designed.Then,a finite-time prescribed performance adaptive output feedback control strategy is proposed by restricting the sliding mode surface to a prescribed region,which ensures that the closed-loop system has practical finite-time stability and that formation errors of the multi-agent systems converge to the prescribed performance bound in finite time.Finally,a numerical simulation is provided to demonstrate the practicality and effectiveness of the developed algorithm.
基金Project supported by the National Key Technology Research and Development Program (Grant No.2006BAE03A08)
文摘Control precision of coiling temperature is one of the key factors affecting the profile shape and surface quality during the cooling process of hot rolled steel strip.For this reason,the core of temperature control precision is to establish an effective cooling mathematical model with self-learning function.Starting from this point,a cooling mathematical model with nonlinear structural characteristics is established in this paper for the cooling process of hot rolled steel strip.By the analysis of self-learning ability,key parameters of the mathematical model could be constantly corrected so as to improve temperature control precision and adaptive capability of the model.The site actual application results proved the stable performance and high control precision of the proposed mathematical model,which would lay a solid foundation to improve the steel product qualities.
文摘A design idea was proposed that it was about intelligent digital welding machine with self-learning and self- regulation functions. The overall design scheme of software and hardware was provided. It was introduced that a parameter self-learning algorithm was based on large-step calibration and partial Newton interpolation. Furthermore, experimental verification was carried out with different welding technologies. The results show that weld bead is pegrect. Therefore, good welding quality and stability are obtained, and intelligent regulation is realized by parameters self-learning.
基金financially supported by the Sichuan Science and Technology Program(Grant No.2023NSFSC1980)。
文摘An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental disturbances.The control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control precision.Specifically,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each subsystem.Three direction interference observers are designed to track the timevarying boundary disturbance.On this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead zone.In addition,the stability of the closed-loop system is proven by Lyapunov stability theory.All the system states are bounded,and the vibration offset of the riser converges to a small area of the initial position.Finally,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.
基金This work was supported by the National Key Research andDevelopment Programof China(2021YFD1800200 and2021YFC2301700).
文摘The stamping-out strategy has been used to control highly pathogenic avian influenza viruses in many countries,driven by the belief that vaccination would not be successful against such viruses and fears that avian influenza virus in vaccinated birds would evolve more rapidly and pose a greater risk to humans.In this review,we summarize the successes in controlling highly pathogenic avian influenza in China and make suggestions regarding the requirements for vaccine selection and effectiveness.In addition,we present evidence that vaccination of poultry not only eliminates human infection with avian influenza virus,but also significantly reduces and abolishes some harmful characteristics of avian influenza virus.