Design and Fabrication of Drug Delivery Devices with Complex Architectures Based on Three-dimensional Printing Technique

A new type of implantable drug delivery devices （ DDD ） with complicated architectures were fubricated by three-dimensional printing technique, employing levofloxacin （LVFX） as a model drug. Processing parameters were optimized in riew of the layer thickness, spucing between printed lines, flow rate of liquid binder and the fast axis speed. The prepared DDD prototype consists of a double-layer structure, of which the upper region is a reservoir system and the lower region is a matrix one. The in vitro release test revealed that LVFX was released in a dual-puse pattern. This DDD may present a new strategy for the prophylaxis and treatment of diseases such as bone infection in the near future.

Synthesis and Crystal Structure of a Three-dimensional (3D) Complex Mn(H_2O)_2(HNic)_2 (HNic=2-Hydroxynicotinic Acid)

The title complex Mn（H2O）2（HNic）2 （C22H12MnN2O8, Mr = 367.18） crystallizes in monoclinic, space group P21/c with a = 7.5735（8）, b = 12.5295（13）, c = 7.6466（8）A.β = 101.2790（10）°, Z = 2, V= 711.59（13） A^3, D, = 1.714 g/cm^3,μ（MoKa） = 0.974 mm^-1, F（000） = 374, R1 （1255 observed reflections （Ⅰ 〉 2σ（Ⅰ）） = 0.0250） and wR2 = 0.0662 （all data）. In this paper, we report the complexation of Mn（Ⅱ） by the bidentate ligand 2-hydroxynicotinic acid （HNic）. In the crystal the Mn（Ⅱ） ion exhibits a deformed octahedron structure. The title complex Mn（H2O）2（HNic）2 has a three-dimensional （3D） network structure extended by hydrogen bonds, which are formed by two typical eight-membered hydrogen-bonded rings.

Structure and Bonding in Some Gd(Ⅲ) Metal Complexes Studied by Three-Dimensional X-Ray Analysis and ^(155)Gd Mssbauer Spectroscopy

Some functional lanthanide metal complexes, such as acetylacetonato complexes, ethylenediaminetetraacetato complexes, were successfully applied for diagnostic technique. The authors are interested in investigating the structure and bonding in lanthanide and actinide metal complexes using 166Er, t55Gd, and 237Np Mtissbauer spectroscopies in connection with single-crystal and/or powder X-ray diffraction, making clear the differences on their structures as well as the differences in the participation of 4f and 5f orbitals in the chemical bonds. In this article, the crystal structures of two novel Gd（Ⅲ） acetylacetonato complexes, Gd（pta）3 · 2H2O （pta = 1,1,1 -trifluoro-5,5-dimethy 1-2,4-hexanedione） and Gd（bfa）3 · 2H2O （bfa = 1, 1, 1 -trifluoro-4-phenyl-2-4-butanedione） were reported. Though both of them were dihydrate and had distorted square antiprismatical structure, Gd（pta）3 · 2H2O crystallizes in the P 2 1/n （#14） monoclinic space group and its lattice parameters are a = 1.4141（6） nm, b = 1.0708（3） nm, c =2.2344（4） nm, β =952.4（2）°, and Gd（bfa）3· 2H2O crystallizes in P 212121 orthorhombic space group and its lattice parameters were a = 1.322 （1） nm, b = 2.295 （1） nm, c = 1. 0786（8） nm. In the meantime, the authors had finished a systematic investigation on the ^155Gd Mossbauer isomer shift （δ） of various Gd（Ⅲ） metal complexes having a different coordination number （C.N.） and different ratios coordinating oxygen to nitrogen. A tendency for the 6 value to decrease with an increase in the C.N, and the number of the nitrogen atom coordinating to Gd was confirmed. This indicated that the Gd-O and/or Gd-N bond in the investigated Gd（Ⅲ） metal complexes had a small covalent contribution, which was possible to be deduced from the O and/or N atoms of the lisands donating electrons to 6s, 5d, and 4f orbitals of Gd.

Numerical study on three-dimensional flow field of continuously rotating detonation in a toroidal chamber

Gaseous detonation propagating in a toroidal chamber was numerically studied for hydrogen/oxygen/nitrogen mixtures. The numerical method used is based on the three-dimensional Euler equations with detailed finiterate chemistry. The results show that the calculated streak picture is in qualitative agreement with the picture recorded by a high speed streak camera from published literature. The three-dimensional flow field induced by a continuously rotating detonation was visualized and distinctive features of the rotating detonations were clearly depicted. Owing to the unconfined character of detonation wavelet, a deficit of detonation parameters was observed. Due to the effects of wall geometries, the strength of the outside detonation front is stronger than that of the inside portion. The detonation thus propagates with a constant circular velocity. Numerical simulation also shows three-dimensional rotating detonation structures, which display specific feature of the detonation- shock combined wave. Discrete burning gas pockets are formed due to instability of the discontinuity. It is believed that the present study could give an insight into the interest- ing properties of the continuously rotating detonation, and is thus beneficial to the design of continuous detonation propulsion systems.

Two kinds of contact problems in three-dimensional icosahedral quasicrystals

Two kinds of contact problems, i.e., the frictional contact problem and the adhesive contact problem, in three-dimensional （3D） icosahedral quasicrystals are dis- cussed by a complex variable function method. For the frictional contact problem, the contact stress exhibits power singularities at the edge of the contact zone. For the adhe- sive contact problem, the contact stress exhibits oscillatory singularities at the edge of the contact zone. The numerical examples show that for the two kinds of contact problems, the contact stress exhibits singularities, and reaches the maximum value at the edge of the contact zone. The phonon-phason coupling constant has a significant effect on the contact stress intensity, while has little impact on the contact stress distribution regu- lation. The results are consistent with those of the classical elastic materials when the phonon-phason coupling constant is 0. For the adhesive contact problem, the indentation force has positive correlation with the contact displacement, but the phonon-phason cou- pling constant impact is barely perceptible. The validity of the conclusions is verified.

Synthesis and Crystal Structure of One-dimensional Chain Complexes [K(18-C-6)]_2[M(mnt)_2](M=Zn,Hg)

The reactions of 18 crown 6 with each of K 2(M=Zn, Hg; mnt=1,2 dicyanoethene 1,2 dithiolate, C 2S 2(CN) 2- 2) were studied and novel complexes [K(18 C 6)] 2[Zn(mnt) 2](1) and [K(18 C 6)] 2[Hg(mnt) 2](2) were characterized by elemental analysis, IR spectrum and X ray diffraction analysis. Complex 1 displays a one dimensional chain of [K(18 C 6)] 2[Zn(mnt) 2] bridged by K O interactions between adjacent [K(18 C 6)] + units. Complex 2 is also a one dimensional chain of [K(18 C 6)] 2[Hg(mnt) 2] bridged by K...S weak interactions between adjacent [K(18 C 6)] + and [Hg(mnt) 2] 2- .

A combined numerical model of three-dimensional tidal motion and sediment transport in tidal current and its application

A calculation scheme, which combines a horizontal upwind finite element method with vertical implicit differences, is used to establish a three-dimensional mathematical model of tidal motion and sediment transport in tidal current. Compared with those of the relative theoretical formula, the results are satisfactory. The model mentioned above has been applied to the water area of the Lianzhou Bay, Guangxi Province. On the basis of the analysis and comparison with the field data, it shows clearly that the model calculation results are reasonable.

Synthesis and One-dimensional Structure of Cobalt(Ⅱ) Complex [(NaOC_2H_5)CoL_2]_n

The treatment of bis(2-hydroxybenzyl)-amine(HL) with NaOH and Co(Ⅱ)(NO) 2 gives isostructural one-dimensional coordination polymers [(NaOC2H5)CoL2]n(1). The cobalt ions have an octahedral geometry and are coordinated by two crystallographically independent ligands which are further linked by μ -O\-\{phenol\} bridged Co and Na atoms to give a one-dimentional structure.

SYNTHESIS AND CRYSTAL STRUCTURE OF THE FIRST THREE DIMENSIONAL NETWORK CU(Ⅱ) COMPLEX BRIDGED BY BOTH OXAMIDE AND AZIDE

A novel three dimensional network complex polymer [Cu_4(oxen)_2(N_3)_3]_n(ClO_4)_n·2nH_2O, where oxen is N,N' -bis(2-aminoethyl)oxamide dianion, has been synthesized. It crystallizes in triclinic system, space group P, with a=11.486(2), b=11.706(3), c=12.291(3) , α=77.42(2), β=67.59(2), γ=77.96(2)°, and z=2. The least-square refinements converged at R=0.047, with 3416 observed unique reflections. The complex has a pronounced three-dimensional character and can be viewed as the tetranuclear asymmetric repeating units through inversion and translation operations to extend a three-dimensional network. The structure of Cu_4 asymmetric unit consists of two square planar and two square pyramidal Cu central atoms linked by both azide ligands in end-on and end-to-end bonding modes, and oxamidate bridge in trans conformation.

量化三维网格模型复杂度的Fractal Dimension^(+)方法

对三维网格模型复杂度的评估及应用进行研究,提出基于Fractal Dimension^(+)方法量化三维网格模型复杂度。该方法利用分形几何学的分形维度来确定三维网格模型的不规则性;为了全面量化复杂度并且提高量化的准确性和可信度,在分形维度算法中添加孔隙比和亏格数的概念,全面考虑介质内部空间分布和几何结构的连接性以及孔洞分布的信息。对大量三维网格模型进行实验,结果表明Fractal Dimension^(+)方法可以有效计算出准确的复杂度。

Dimensional Complexity and Algorithmic Efficiency

This paper uses the concept of algorithmic efficiency to present a unified theory of intelligence. Intelligence is defined informally, formally, and computationally. We introduce the concept of dimensional complexity in algorithmic efficiency and deduce that an optimally efficient algorithm has zero time complexity, zero space complexity, and an infinite dimensional complexity. This algorithm is used to generate the number line.

One-dimensional Copper（Ⅱ） Complex Constructed with Nitrate Counter-anion as Bitopic Connector

Coordination polymer {[Cu（NPPCA）3（NO3）（H20）]-NOyH20}n 1 （ NPPCA = N-（4＇- nitrophenyl）-4-pyridinecarboxamide） has been synthesized by the reaction of NPPCA with copper（H） nitrate in ethanol-water solution and characterized by X-ray diffraction. 1 crystallizes in the monoclinic space, group P21/n, a = 17.341（6）A, b = 6.744（2）A, c = 34.555（12）A, β = 100.493（6）°, V = 3974（2） A^3, Z = 4. Each copper（H） ion has a distorted octahedral coordination geometry. Nitrate anion adopts the unusual coordination mode linking two adjacent copper（H） ions to form a one-dimensional coordination polymer and these chains are further linked by noncovalent interactions.

Exact analytic solutions for an elliptic hole with asymmetric collinear cracks in a one-dimensional hexagonal quasi-crystal

Using the complex variable function method and the technique of conformal mapping, the anti-plane shear problem of an elliptic hole with asymmetric colfinear cracks in a one-dimensional hexagonal quasi-crystal is solved, and the exact analytic solutions of the stress intensity factors （SIFs） for mode Ⅲ problem are obtained. Under the limiting conditions, the present results reduce to the Griffith crack and many new results obtained as well, such as the circular hole with asymmetric collinear cracks, the elliptic hole with a straight crack, the mode T crack, the cross crack and so on. As far as the phonon field is concerned, these results, which play an important role in many practical and theoretical applications, are shown to be in good agreement with the classical results.

Enhanced effect of dimension of receptor-ligand complex and depletion effect on receptor-mediated endocytosis of nanoparticles

We present an extended analytical model including the depletion effect and the dimension of ligand-receptor complex, aiming to elucidate their influences on endocytosis of spherocylindrical nanoparticles （NPs）. It is found that the dimension of ligand-receptor complex （δ） and the depletion effect interrelatedly govern the optimal conditions of NP endocytosis. The endocytosis phase diagram constructed in the space of NP radius and relative aspect ratio indicates that the endocytosis of NP is enhanced evidently by reducing the optimal radius and the threshold radius of endocytosed NP. Meanwhile, through thermodynamic and kinetic analysis of the diffusion of receptors, the dependence of diffusion length on depletion effect and the dimension of ligand-receptor complex can be identified in great detail. For small aspect ratio, diffusion length decreases with increasing concentration c of small bioparticles in cellular environment. Endocytosis speed corresponding to large radius R and high concentration c of small bioparticles strongly depends on the increasing （2r-δ）. These results may show some highlights into the conscious design of NPs for diagnostic agents and therapeutic drug delivery applications.

On Gorenstein Resolution Dimensions of Complexes

Let W be a self-orthogonal class of R-modules. We prove that W-Gorenstein resolution dimension of a complex X is equivalent to the supremum of W-Gorenstein resolution dimension of modules X_i for all i ∈ Z.

Gear-like array of (H_2O)_(12) as building blocks in one-dimensional supramolecular assembly

The preparation and crystal structure of complex Co（Hsae）2·2H2O （1, H2sae = N-salicylidene-2-iminoethanol） are reported. X- ray analysis revealed that every six Co（Hsae）2 forms a cyclic chip and every 12 water forms a novel gear-like cluster. Acting as building blocks, the gear-like water cluster and complex chip are connected in A-B fashion and extend into one-dimensional supramolecular chain. Hydrogen bond is the primary bridging force in the formation of supramolecular framework.

基于多维度注意力机制和复数Conformer的单通道语音增强方法

为提高被噪声干扰的语音的可理解性和语音质量,针对用于语音增强的深度复数网络对语音复数谱中关键声学特征提取不充分、关联信息建模不合理的问题,提出了基于多维度注意力机制和复数Conformer的单通道语音增强方法(SE-MDACC)。在复数U-Net架构下引入复数Conformer,对语音幅度和相位的相关性进行建模;利用多维度注意力机制,构造更加丰富的特征来增强卷积层的表示能力;在残差连接中加入注意力门控机制强化重构语音的细节信息。实验结果显示,相比于深度复数卷积递归网络,SE-MDACC的客观评价指标语音质量感知评估和短时客观可懂度分别提升15.299%、1.462%,表明SE-MDACC可充分提取语音声学特征并对幅度和相位相关性进行合理建模,有效提升语音质量和可理解性。

基于磁共振成像的女性肛门括约肌复合体数字化三维模型构建

目的利用磁共振成像(magnetic resonance imaging,MRI)影像数据和计算机三维重建技术构建女性肛门括约肌复合体三维数字化模型并探讨其意义。方法自2021年3月1日至2023年3月1日,应用3.0 T MRI扫描健康女性志愿者肛管,将采集的Dicom 3.0数据集导入Mimics 21.0软件中进行三维几何模型构建。结果成功构建出肛门括约肌复合体三维几何模型,该模型仿真度高,耻骨直肠肌前侧缺损,大致呈“U”形,外括约肌后侧较肥厚,模型可任意缩放和360°旋转,便于观察理解肛门括约肌复合体的解剖形态。结论基于肛管MRI影像数据及计算机三维重建软件可构建出肛门括约肌复合体的三维几何模型,该模型可辅助解剖教学,利于肛瘘等肛管疾病的临床诊断和评估,并为下一步力学分析提供条件。

基于街区演替对出行拥堵影响的城市更新启示——以江苏淮安为例

城市街区演替的多维现象是各种城市问题持续劣化的微观成因,探明其中影响是实施城市更新行动的重要依据。针对江苏省淮安市107处城市街区,利用时空多源数据,采用逻辑降维、关联分析、地理加权回归等方法,构建可表征空间规模、交通设施、日常出行、社会经济及公共交通等演替现象的多维复合要素体系,揭示城市街区演替对交通出行拥堵的时空影响机理。影响机理表明空间规模与日常出行演替具有显著一致的正向影响,公共交通演替具有显著一致的负向影响,交通设施与社会经济的演替则不具显著影响。依循时空影响机理,结合可预见变化、官方指导意见和近期实践经验,情景模拟了全局性交通出行改善下各类街区更新的空间增容阙值,作为城市更新启示。