Study on Three-layered Grid Conceptual Prototype Using Ecological Network Computing Environment

Next generation grid systems where the emphasis shifts to distributed global collaboration, a service-oriented approach and information layer issues exhibit a strong sense of automation. Requirements for these systems resemble the self-organizing and the healing properties of natural ecosystems. Some key ecological concepts and mechanisms are introduced into the design for the third generation grid computing architectures by inspiration of this resemblance. Also, an Ecological Network-based Computing Environment (ENCE) platform is designed in this paper. Based on the ENCE platform, a grid-computing model of three-layered grid conceptual prototype that embeds the ENCE layers is presented from the viewpoint of implementation. The implementation model should be useful to the design of the third generation grid systems.

Application of virtual reality technology improves the functionality of brain networks in individuals experiencing pain

Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment responses.AIM To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural networks.METHODS Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus.Mitochondrial genes were sourced from the MitoCarta3.0 database.The discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation cohort.Using the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were predicted.RESULTS In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy model.The average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation cohort.The average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation cohort.CONCLUSION The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected limb.However,differences among reconstruction strategies at the brain network level have not been elucidated.This study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve transfer.Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper trunk.Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery.The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component.Alterations in intra-network resting-state functional connectivity were compared among the groups.Target muscle reinnervation was assessed by behavioral observation(elbow flexion)and electromyography.The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway.Nerve repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation.The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer.Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer.Our study revealed important brain networks related to different nerve reconstructions.These networks may be potential targets for enhancing motor recovery.

Direct-chill semi-continuous casting process of three-layer composite ingot of 4045/3004/4045 aluminum alloys

Three-layer composite ingot of 4045/3004/4045 aluminum alloys was prepared by direct-chill semi-continuous casting process,the temperature field distribution near the composite interface,macro-morphology,microstructure and composition distribution of the composite interface were investigated.The results show that semi-solid layer with a certain thickness forms near the interface due to the effect of cooling plate,which ensures successful implementation of casting the composite ingot.Two different aluminum alloys are well bonded metallurgically.The mechanical properties of composite interface were measured,the tensile and shearing strengths of composite interface are 105 and 88 MPa,respectively,which proves that the composite interface is a kind of metallurgical bonding.

Improving electrochemical performances of LiFePO_4 /C cathode material via a novel three-layer electrode

As an improvement on the conventional two-layer electrode （active material layerlcurrent collector）, a novel sandwich-like three-layer electrode （conductive layerlactive material layertcurrent collector） for cathode material LiFePO4/C was introduced in order to improve its electrochemical performance. LiFePO4/C in the three-layer electrode exhibited superior rate capability in comparison with that in the two-layer electrode in accordance with charge-discharge examination. Cyclic voltammetry and electrochemical impedance spectroscopy indicated that Fe3＋/Fe2＋ redox couple for LiFePO4 in the three-layer electrode displayed faster kinetics, better reversibility and much lower charge transfer resistance than that in the two-layer electrode in electrochemical process. For three-layer electrode, the holes in the surface of active material layer were filled by smaller acetylene black grains, which formed electrical connections and provided more pathways to electron transport to/from LiFePO4/C particles exposed to the bulk electrolyte.

Deformation and heat treatment ability of three-layer 6009/7050/6009 Al alloy clad slab prepared by direct-chill casting

Three-layer6009/7050/6009aluminum alloy clad slab was fabricated by an innovative direct-chill casting process.To study the response of the clad slab to plastic deformation and heat treatments,homogenization annealing,hot rolling,solution and aging were successively performed on the as-cast6009/7050/6009clad samples.The results revealed that excellent metallurgical bonding between7050alloy layer and6009alloy layer was achieved under optimal parameters.The clad ratio obviously decreased when the annealed sample was rolled to55%hot reduction level,and then changed slightly with further rolling.Furthermore,the content of rodlike Zn-rich phases increased significantly in7050alloy layer in the homogenized clad samples after rolling at55%,65%and75%hot reduction levels,and the higher level of hot reduction resulted in narrower diffusion layer.Subsequent solution and aging significantly improved the hardness in7050alloy layer,interfaces and6009alloy layers of the rolled samples except for the thin side for the75%hot reduction sample.

A Short-Term Traffic Flow Forecasting Method Based on a Three-Layer K-Nearest Neighbor Non-Parametric Regression Algorithm

Short-term traffic flow is one of the core technologies to realize traffic flow guidance. In this article, in view of the characteristics that the traffic flow changes repeatedly, a short-term traffic flow forecasting method based on a three-layer K-nearest neighbor non-parametric regression algorithm is proposed. Specifically, two screening layers based on shape similarity were introduced in K-nearest neighbor non-parametric regression method, and the forecasting results were output using the weighted averaging on the reciprocal values of the shape similarity distances and the most-similar-point distance adjustment method. According to the experimental results, the proposed algorithm has improved the predictive ability of the traditional K-nearest neighbor non-parametric regression method, and greatly enhanced the accuracy and real-time performance of short-term traffic flow forecasting.

Structure Design and Properties of Three-Layer Particleboard Based on High Voltage Electrostatic Field(HVEF)

In this study,the effects of three different particle sizes of wood wastes(A=–8+12 mesh;B=–12+20 mesh;C=–20+30 mesh)and factory shavings(D)on the properties of particleboard were investigated.According to the test results,three-layer particleboard was designed.Particleboard face layers made with mixture of A,B,and C.The core layer made with D.The ratio of core layer to face layers is 50:50.Three-layer particleboard were fabricated with 12%urea-formaldehyde(UF)resins and three different high voltage electrostatic field intensities(0 kv,30 kv,60 kv).The internal bond(IB)strength,modulus of rupture(MOR),modulus of elasticity(MOE),thickness swelling(TS),and water absorption(WA)of particleboard were evaluated.The density distribution of the three-layer particleboard were examined by vertical density profiles(VDP),and the bonding mechanism and functional groups changes in the particles were analyzed by FTIR analysis.The results showed that HVEF treatment intensity play a remarkable role in properties of particleboard.The particleboard with higher electrostatic field intensities treatment has higher MOE,MOR,IB,and TS.Under HVEF treatment(60 kv),the MOR,modulus of MOE,and IB of three-layer particleboard were 23.61 N/mm^(2),2787.09 N/mm^(2),and 0.86 N/mm^(2),respectively.FTIR indicated that the surface activity of wood particles was increased electric field treatment.

Characteristics Analysis of Chemical Concentration Sensor Based on Three-layer FBG

The three-layer structure model of the fiber Bragg grating is proposed in this paper. And through experimental study and reasoning calculation to verify the three layer structure of the optical waveguide model, so the sensitivity characteristic of the Bragg wavelength to the refractive index of chemical solution is obtained. And the relationships between the concentration and the shift of Bragg wavelength of sucrose, ethanol, and Nacl solution are achieved. Finally the shifts of the Bragg wavelength with the external concentration are obtained by experiments. A kind of simple structure, small size, good stability, high sensitivity chemical concentration sensor is obtained.

Pluggable multitask diffractive neural networks based on cascaded metasurfaces

Optical neural networks have significant advantages in terms of power consumption,parallelism,and high computing speed,which has intrigued extensive attention in both academic and engineering communities.It has been considered as one of the powerful tools in promoting the fields of imaging processing and object recognition.However,the existing optical system architecture cannot be reconstructed to the realization of multi-functional artificial intelligence systems simultaneously.To push the development of this issue,we propose the pluggable diffractive neural networks(P-DNN),a general paradigm resorting to the cascaded metasurfaces,which can be applied to recognize various tasks by switching internal plug-ins.As the proof-of-principle,the recognition functions of six types of handwritten digits and six types of fashions are numerical simulated and experimental demonstrated at near-infrared regimes.Encouragingly,the proposed paradigm not only improves the flexibility of the optical neural networks but paves the new route for achieving high-speed,low-power and versatile artificial intelligence systems.

Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning

Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal co rd injury.They can greatly affect nerve regeneration and functional recovery.However,there is still limited understanding of the peripheral immune inflammato ry response in spinal cord inju ry.In this study.we obtained microRNA expression profiles from the peripheral blood of patients with spinal co rd injury using high-throughput sequencing.We also obtained the mRNA expression profile of spinal cord injury patients from the Gene Expression Omnibus(GEO)database(GSE151371).We identified 54 differentially expressed microRNAs and 1656 diffe rentially expressed genes using bioinformatics approaches.Functional enrichment analysis revealed that various common immune and inflammation-related signaling pathways,such as neutrophil extracellular trap formation pathway,T cell receptor signaling pathway,and nuclear factor-κB signal pathway,we re abnormally activated or inhibited in spinal cord inju ry patient samples.We applied an integrated strategy that combines weighted gene co-expression network analysis,LASSO logistic regression,and SVM-RFE algorithm and identified three biomarke rs associated with spinal cord injury:ANO10,BST1,and ZFP36L2.We verified the expression levels and diagnostic perfo rmance of these three genes in the original training dataset and clinical samples through the receiver operating characteristic curve.Quantitative polymerase chain reaction results showed that ANO20 and BST1 mRNA levels were increased and ZFP36L2 mRNA was decreased in the peripheral blood of spinal cord injury patients.We also constructed a small RNA-mRNA interaction network using Cytoscape.Additionally,we evaluated the proportion of 22 types of immune cells in the peripheral blood of spinal co rd injury patients using the CIBERSORT tool.The proportions of naive B cells,plasma cells,monocytes,and neutrophils were increased while the proportions of memory B cells,CD8^(+)T cells,resting natural killer cells,resting dendritic cells,and eosinophils were markedly decreased in spinal cord injury patients increased compared with healthy subjects,and ANO10,BST1 and ZFP26L2we re closely related to the proportion of certain immune cell types.The findings from this study provide new directions for the development of treatment strategies related to immune inflammation in spinal co rd inju ry and suggest that ANO10,BST2,and ZFP36L2 are potential biomarkers for spinal cord injury.The study was registe red in the Chinese Clinical Trial Registry(registration No.ChiCTR2200066985,December 12,2022).

Trapped Modes in a Three-Layer Fluid

In this work,trapped mode frequencies are computed for a submerged horizontal circular cylinder with the hydrodynamic set-up involving an infinite depth three-layer incompressible fluid with layer-wise different densities.The impermeable cylinder is fully immersed in either the bottom layer or the upper layer.The effect of surface tension at the surface of separation is neglected.In this set-up,there exist three wave numbers:the lowest one on the free surface and the other two on the internal interfaces.For each wave number,there exist two modes for which trapped waves exist.The existence of these trapped modes is shown by numerical evidence.We investigate the variation of these trapped modes subject to change in the depth of the middle layer as well as the submergence depth.We show numerically that two-layer and single-layer results cannot be recovered in the double and single limiting cases of the density ratios tending to unity.The existence of trapped modes shows that in general,a radiation condition for the waves at infinity is insufficient for the uniqueness of the solution of the scattering problem.

Social-ecological perspective on the suicidal behaviour factors of early adolescents in China:a network analysis

Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To explore the risk and protective factors of suicidal behaviours(ie,suicidal ideation,plans and attempts)in early adolescence in China using a social-ecological perspective.Methods Using data from the cross-sectional project‘Healthy and Risky Behaviours Among Middle School Students in Anhui Province,China',stratified random cluster sampling was used to select 5724 middle school students who had completed self-report questionnaires in November 2020.Network analysis was employed to examine the correlates of suicidal ideation,plans and attempts at four levels,namely individual(sex,academic performance,serious physical llness/disability,history of self-harm,depression,impulsivity,sleep problems,resilience),family(family economic status,relationship with mother,relationship with father,family violence,childhood abuse,parental mental illness),school(relationship with teachers,relationship with classmates,school-bullying victimisation and perpetration)and social(social support,satisfaction with society).Results In total,37.9%,19.0%and 5.5%of the students reported suicidal ideation,plans and attempts in the past 6 months,respectively.The estimated network revealed that suicidal ideation,plans and attempts were collectively associated with a history of self-harm,sleep problems,childhood abuse,school bullying and victimisation.Centrality analysis indicated that the most influential nodes in the network were history of self-harm and childhood abuse.Notably,the network also showed unique correlates of suicidal ideation(sex,weight=0.60;impulsivity,weight=0.24;family violence,weight=0.17;relationship with teachers,weight=-0.03;school-bullying perpetration,weight=0.22),suicidal plans(social support,weight=-0.15)and suicidal attempts(relationship with mother,weight=-0.10;parental mental llness,weight=0.61).Conclusions This study identified the correlates of suicidal ideation,plans and attempts,and provided practical implications for suicide prevention for young adolescents in China.Firstly,this study highlighted the importance of joint interventions across multiple departments.Secondly,the common risk factors of suicidal ideation,plans and attempts were elucidated.Thirdly,this study proposed target interventions to address the unique influencing factors of suicidal ideation,plans and attempts.

Effects of anisotropy on quantum fluctuation of a three-layer system with mutisublattice

The quantum fluctuations of a three-layer Heisenberg model with six sublattices are studied by the retarded Green＇s function method and the spin-wave theory. The effects of anisotropy on the quantum fluctuations at zero temperature are discussed. The results show that the interlayer anisotropy plays an important role in balancing the quantum competitions.

The three-layer model of the thermohaline structure in the shallow seas

A three-layer model of the thermohaline structure is developed on the basis of the two -layer model of thermocline. The model is able to simulate the depth,thickness and intensity of both thermocline and halocline, and the temperature and salinity of both upper layer and lower layer in the shallow seas.Camparison of simulation with data is favorable.Detailed analysis is made on a variety of factors affecting the intensity of the thermocline.

Wave Scattering by a Submerged Sphere in Three-Layer Fluid

Using linear water wave theory,three-dimensional problems concerning the interaction of waves with spherical structures in a fluid which contains a three-layer fluid consisting of a layer of finite depth bounded above by freshwater of finite depth with free surface and below by an infinite layer of water of greater density are considered.In such a situation timeharmonic waves with a given frequency can propagate with three wavenumbers.The sphere is submerged in either of the three layers.Each problem is reduced to an infinite system of linear equations by employing the method of multipoles and the system of equations is solved numerically by standard technique.The hydrodynamic forces(vertical and horizontal forces)are obtained and depicted graphically against the wavenumber.When the density ratio of the upper and middle layer is made to approximately one,curves for vertical and horizontal forces almost coincide with the corresponding curves for the case of a two-layer fluid with a free surface.This means that in the limit,the density ratio of the upper and middle layer goes to approximately one,the solution agrees with the solution for the case of a two-layer fluid with a free surface.

A Three-layered Contrasting Analysis of the Theme in Once more to the lake

Once more to the lake is a representative work of the American Writer, Elwyn Brooks White, and has been acclaimed by people in the world. The paper offers a three-layered contrasting analysis of the essay. By detailed analysis of the contrasts running through the whole essay, the author finds that those contrasts are symbol of White's internal struggle and reflection for life.On the foundation of the three-layered contrasts, the paper presents the theme analysis and clarifies the content of the essay.

One-step hydrothermal synthesis of 2,5-PDCA-containing MgAl-LDHs three-layer composite coating with high corrosion resistance on AZ31

The addition of 2,5-pyridinedicarboxylic acid(2,5-PDCA)to the Mg-Al LDH coating,which was prepared by one-step hydrothermal synthesis,had extremely enhanced the corrosion protection of AZ31 Mg alloy,although the 2,5-PDCA could not be intercalated into the interlayer spacing.The corrosion current density of 0.05 mol L^(−1)2,5-PDCA LDH containing LDH coating is 3.18 nA cm^(−2),reduced by two orders of magnitude compared to the LDH coating without inhibitor,and the corrosion inhibition efficiency of the coating is 98.05%.The coating formed on the surface of AZ31 was peeled off from the substrate by using a mechanical method and SEM observation of the cross-section showed that the coating consisted of three different layers.The innermost layer is a thick layer that consists of Mg(OH)_(2)and the intermediate layer is LDH,which is vertical to the substrate and the outmost layer is a thin but very dense deposit layer of LDH agglomerates with complexes of 2,5-PDCA and Mg.This kind of sediment/LDH/Mg(OH)_(2)three-layer composite structure was accountable for the increase in the corrosion resistance of AZ31 Mg alloy.

Third-order Stokes wave solutions for interfacial internal waves in a three-layer density-stratified fluid

Interracial internal waves in a three-layer density-stratified fluid are investigated using a singular perturbation method, and third-order asymptotic solutions of the velocity potentials and third-order Stokes wave solutions of the associated elevations of the interfacial waves are presented based on the small amplitude wave theory. As expected, the third-order solutions describe the third-order nonlinear modification and the third-order nonlinear interactions between the interracial waves. The wave velocity depends on not only the wave number and the depth of each layer but also on the wave amplitude.